Article
Endocrinology & Metabolism
Nuria Casanova-Vallve, Drew Duglan, Megan E. Vaughan, Marie Pariollaud, Michal K. Handzlik, Weiwei Fan, Ruth T. Yu, Christopher Liddle, Michael Downes, Julien Delezie, Rebecca Mello, Alanna B. Chan, Pal O. Westermark, Christian M. Metallo, Ronald M. Evans, Katja A. Lamia
Summary: This study found that chronic nighttime physical activity can significantly alter the daily rhythms of murine muscle gene expression and support the fluctuations in daily exercise performance.
MOLECULAR METABOLISM
(2022)
Article
Oncology
Mireia Vaca-Dempere, Arun Kumar, Valentina Sica, Pura Munoz-Canoves
Summary: Circadian rhythms play a crucial role in regulating skeletal muscle growth, maintenance, and metabolic functions. However, there is still much unknown about the functions, regulatory mechanisms, and interactions of the skeletal muscle molecular clock with other tissues.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yanqiao Zhu, Reena Narsai, Cunman He, Yan Wang, Oliver Berkowitz, James Whelan, Lim Chee Liew
Summary: Mitochondrial retrograde signaling (MRS) regulates photosynthetic function under different conditions by controlling the binding of ANAC017 to promoters and the expression of related transcription factors. The study also found that there is a separate MRS pathway stimulated by antimycin A treatment, which intersects with salicylic acid signaling and chloroplast retrograde signaling. Additionally, the transcriptional responses to antimycin A and myxothiazol in the dark are ANAC017 independent and involve ERF and ZAT transcription factors, resembling biotic challenge and salicylic acid responses.
PLANT COMMUNICATIONS
(2023)
Article
Physiology
Satoshi Oneda, Siyuan Cao, Atsushi Haraguchi, Hiroyuki Sasaki, Shigenobu Shibata
Summary: The circadian clock is crucial for maintaining our health, but social jet lag can disrupt it. Exercise, particularly in individuals with high-fat diets, has been found to improve the disordered body clock caused by social jet lag.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhichao Lu, Haiyang Liu, Yiming Kong, Lizhu Wen, Yang Zhao, Chuanen Zhou, Lu Han
Summary: The LHY gene plays a positive role in salt stress response by modulating the biosynthesis of flavonoids, thereby enhancing plant salt stress tolerance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Biochemistry & Molecular Biology
Michael J. Rust
Summary: The study on circadian clock suggests that it can function even in non-growing cells using minimal components from cyanobacteria. The findings indicate the potential evolution of the circadian clock to adapt to different cellular conditions.
Article
Biochemistry & Molecular Biology
Jiaxin Lei, Keyan Zhu-Salzman
Summary: CCA1 and LHY are core components of the circadian clock in Arabidopsis thaliana with partially redundant roles in regulating plant defense mechanisms against biotic stresses. Their coordinated transcriptional regulation contributes to plant defensive capacity against aphids.
PLANT SIGNALING & BEHAVIOR
(2021)
Editorial Material
Cell Biology
Ueli Schibler
Summary: Mammalian body cells have cell-autonomous and self-sustained circadian oscillators relying on delayed negative feedback loops in gene expression. Transcriptional activation and repression, as well as post-translational mechanisms like phosphorylation and dephosphorylation, play crucial roles in setting the pace of these timekeepers. The study by Klemz and colleagues in Genes & Development demonstrates how dephosphorylation of BMAL1 by protein phosphatase 4 (PPP4) participates in the modulation of circadian timing.
GENES & DEVELOPMENT
(2021)
Review
Endocrinology & Metabolism
Si-Ke He, Jia-Hao Wang, Tao Li, Shan Yin, Jian-Wei Cui, Yun-Fei Xiao, Yin Tang, Jia Wang, Yun-Jin Bai
Summary: This article reviews the relationship between circadian rhythm disturbance and kidney stone disease (KSD), summarizing the risk factors and treatment methods. The results indicate that KSD is associated with systemic disorders such as metabolic syndrome, inflammatory bowel disease, and microbiome dysbiosis, and some chronotherapies have been proven effective.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Francesca Battaglin, Priscilla Chan, Yuanzhong Pan, Shivani Soni, Meng Qu, Erin R. Spiller, Sofi Castanon, Evanthia T. Roussos Torres, Shannon M. Mumenthaler, Steve A. Kay, Heinz-Josef Lenz
Summary: Disruption of the circadian clock pathway is associated with cancer risk, development, and progression. Dysregulation of core circadian clock genes is common in human tumors, with varied effects and mechanisms depending on cancer types. Pharmacological modulation of clock components shows promise as a novel anti-cancer therapeutic approach.
Review
Medical Laboratory Technology
Hui Xu, Lingli Huang, Jiajia Zhao, Sui Chen, Jiarong Liu, Gaofeng Li
Summary: The circadian clock influences physiological processes, including inflammation, and can physically interact with key inflammatory pathways. Inflammation, in turn, can disrupt the circadian rhythm, leading to exacerbated inflammatory responses and tissue damage. This review focuses on the interactions between core circadian clock proteins and inflammatory factors, providing insight into the potential mechanisms behind pathological rhythms observed in inflammatory conditions.
CLINICA CHIMICA ACTA
(2021)
Article
Biology
Holly Kay, Ellen Grunewald, Helen K. Feord, Sergio Gil, Sew Y. Peak-Chew, Alessandra Stangherlin, John S. O'Neill, Gerben van Ooijen
Summary: The cellular landscape undergoes significant changes over a 24-hour period, with the proteome responding directly to daily environmental cycles and being regulated by the circadian clock. Research suggests that transcript oscillations are not strong predictors of protein oscillations, indicating that the cellular spatiotemporal proteome is shaped by rhythmic regulation at various stages of transcription and translation.
COMMUNICATIONS BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Aishwarya Ramakrishnan, Vasu Sheeba
Summary: Innexin2 plays a crucial role in determining the intrinsic period of activity-rest rhythms in Drosophila melanogaster, with knockdown of its expression leading to alterations in the oscillation of core-clock proteins and output molecules. Disrupting the channel-forming ability of Innexin2 causes period lengthening, suggesting it may act as hemichannels or gap junctions in the clock circuit.
Editorial Material
Cell Biology
Zhihui Zhang, Guanghou Shui, Min-Dian Li
Summary: Meal timing can reset cellular circadian clocks in the body, with clocks in different tissues being reset to varying degrees by feeding rhythms, and modulated by the central clock and the liver clock. Tissue-specific regulation and intercellular signaling play essential roles in clock synchronization.
TRENDS IN CELL BIOLOGY
(2021)
Article
Plant Sciences
Yaoyao Huang, Xiaojuan Xing, Yun Tang, Jinyu Jin, Lian Ding, Aiping Song, Sumei Chen, Fadi Chen, Jiafu Jiang, Weimin Fang
Summary: This study reveals that CmERF110 interacts with CmFLK to regulate flowering time and affect circadian clock-related genes in chrysanthemum. These findings provide evidence for the evolutionary conservation of the flowering regulation pathway in chrysanthemum.
PLANT CELL AND ENVIRONMENT
(2022)
