Srs2 mediates PCNA-SUMO-dependent inhibition of DNA repair synthesis

Unwinding of synthetic replication and recombination substrates by Srs2

(2012) Victoria Marini et al.   DNA REPAIR

Recognition of SUMO-modified PCNA requires tandem receptor motifs in Srs2

(2012) Anthony A. Armstrong et al.   NATURE

Homologous recombination and its regulation

(2012) L. Krejci et al.   NUCLEIC ACIDS RESEARCH

Dual roles of the SUMO-interacting motif in the regulation of Srs2 sumoylation

(2012) Peter Kolesar et al.   NUCLEIC ACIDS RESEARCH

Srs2 possesses a non-canonical PIP box in front of its SBM for precise recognition of SUMOylated PCNA

(2012) Seong Ok Kim et al.   Journal of Molecular Cell Biology

Srs2 overexpression reveals a helicase-independent role at replication forks that requires diverse cell functions

(2011) Ana María León Ortiz et al.   DNA REPAIR

Reconstitution of DNA repair synthesis in vitro and the role of polymerase and helicase activities

(2011) Marek Sebesta et al.   DNA REPAIR

Inhibition of Homologous Recombination by the PCNA-Interacting Protein PARI

(2011) George-Lucian Moldovan et al.   MOLECULAR CELL

The RAD6 DNA Damage Tolerance Pathway Operates Uncoupled from the Replication Fork and Is Functional Beyond S Phase

(2010) Georgios I. Karras et al.   CELL

Stable interactions between DNA polymerase δ catalytic and structural subunits are essential for efficient DNA repair

(2010) Clémentine Brocas et al.   DNA REPAIR

Role of yeast Rad5 and its human orthologs, HLTF and SHPRH in DNA damage tolerance

(2010) Ildiko Unk et al.   DNA REPAIR

Srs2: The “Odd-Job Man” in DNA repair

(2010) Victoria Marini et al.   DNA REPAIR

Elg1, an alternative subunit of the RFC clamp loader, preferentially interacts with SUMOylated PCNA

(2010) Oren Parnas et al.   EMBO JOURNAL

The Role of Replication Bypass Pathways in Dicentric Chromosome Formation in Budding Yeast

(2010) A. L. Paek et al.   GENETICS

Ubiquitin-dependent DNA damage bypass is separable from genome replication

(2010) Yasukazu Daigaku et al.   NATURE

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

(2010) Yoshitami Hashimoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Replication fork stalling by bulky DNA damage: localization at active origins and checkpoint modulation

(2010) Eugen C. Minca et al.   NUCLEIC ACIDS RESEARCH

ATR/Mec1: coordinating fork stability and repair

(2009) Anna M Friedel et al.   CURRENT OPINION IN CELL BIOLOGY

Mammalian polymerase ζ is essential for post-replication repair of UV-induced DNA lesions

(2009) Jacob G. Jansen et al.   DNA REPAIR

Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination

(2009) R. Prakash et al.   GENES & DEVELOPMENT

Identification of SMARCAL1 as a Component of the DNA Damage Response

(2009) Lisa Postow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Rad51 Recombinase Presynaptic Filament Assembly via Interactions with the Rad52 Mediator and the Srs2 Anti-recombinase

(2009) Changhyun Seong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Localization of recombination proteins and Srs2 reveals anti-recombinase function in vivo

(2009) Rebecca C. Burgess et al.   JOURNAL OF CELL BIOLOGY

PCNA Is Required for Initiation of Recombination-Associated DNA Synthesis by DNA Polymerase δ

(2009) Xuan Li et al.   MOLECULAR CELL

Srs2 Disassembles Rad51 Filaments by a Protein-Protein Interaction Triggering ATP Turnover and Dissociation of Rad51 from DNA

(2009) Edwin Antony et al.   MOLECULAR CELL

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Functional significance of the Rad51-Srs2 complex in Rad51 presynaptic filament disruption

(2009) S. Colavito et al.   NUCLEIC ACIDS RESEARCH

Mechanism of Eukaryotic Homologous Recombination

(2008) Joseph San Filippo et al.   Annual Review of Biochemistry

SUMO modification of PCNA is controlled by DNA

(2008) Joanne L Parker et al.   EMBO JOURNAL

The Srs2 Helicase Activity Is Stimulated by Rad51 Filaments on dsDNA: Implications for Crossover Incidence during Mitotic Recombination

(2008) Pauline Dupaigne et al.   MOLECULAR CELL

PCNA Ubiquitination and REV1 Define Temporally Distinct Mechanisms for Controlling Translesion Synthesis in the Avian Cell Line DT40

(2008) Charlotte E. Edmunds et al.   MOLECULAR CELL

SUMOylation regulates Rad18-mediated template switch

(2008) Dana Branzei et al.   NATURE

Srs2 removes deadly recombination intermediates independently of its interaction with SUMO-modified PCNA

(2008) C. Le Breton et al.   NUCLEIC ACIDS RESEARCH

Architecture and Assembly of Poly-SUMO Chains on PCNA in Saccharomyces cerevisiae

(2007) Hanna Windecker et al.   JOURNAL OF MOLECULAR BIOLOGY