Article
Pediatrics
Katie B. Williams, Michael Horst, Erika A. Hollinger, Jacob Freedman, Matthew M. Demczko, Devyani Chowdhury
Summary: This study investigated the effectiveness of newborn pulse oximetry screening in out-of-hospital settings and found that it can be adapted without compromising sensitivity or significantly increasing false-positive rates.
Article
Biochemistry & Molecular Biology
Jessie F. F. Salter, Robb T. T. Brumfield, Brant C. C. Faircloth
Summary: Humans have significantly affected the distribution of plant and animal species, mainly through the translocation of individuals and the introduction of species to new habitats. This has made it challenging to understand the evolutionary history of populations and their biogeographical patterns. Studies combining genetic data with archaeological, linguistic, and historical evidence have confirmed prehistoric examples of human-mediated dispersal, but it remains uncertain whether these methods can distinguish recent dispersal events.
Article
Robotics
Edoardo Milana, Benjamin Gorissen, Eline De Borre, Frederik Ceyssens, Dominiek Reynaerts, Michael De Volder
Summary: This research proposes a fabrication technique using soft lithography to make out-of-plane bending microactuators. It enables the production of miniaturized and high-performance soft microsystems for applications in microfluidics and micromanipulation.
Article
Biochemistry & Molecular Biology
Yong Kwon Han, Ji Su Kim, GiBong Jang, Kwon Moo Park
Summary: Cisplatin induces lung cell damage, ciliary fragmentation, and increased oxidative stress, but these effects can be prevented by the mitochondria-specific antioxidant Mito-TEMPO.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Multidisciplinary Sciences
Ricardo Fradique, Erika Causa, Clara Delahousse, Jurij Kotar, Laetitia Pinte, Ludovic Vallier, Marta Vila-Gonzalez, Pietro Cicuta
Summary: Cilia density, distribution, and beating frequency are crucial properties of airway epithelial tissues. This article introduces a novel and open-source method for fully characterizing cilia beating frequency and motile cilia coverage in an automated manner without any user intervention. The method successfully differentiates between different coverage densities, identifies small patches of cilia in larger fields of view, and provides a comprehensive characterization of cilia beating frequency in all moving areas.
ROYAL SOCIETY OPEN SCIENCE
(2023)
Article
Crystallography
Liana Vella-Zarb, Ulrich Baisch
Summary: Despite the abundance of reported differences in the physical-chemical properties of various crystal forms of famciclovir, there is still little precise structural analysis available in the literature. The anhydrous form I is used in commercial formulations. Research using commercially available anhydrous famciclovir led to the determination of the crystal structure of form I and the discovery of a new crystal form.
Article
Biochemistry & Molecular Biology
Viktoria Petrenko, Veronika Vrublevskaya, Marina Bystrova, Irina Masulis, Elizaveta Kopylova, Yuri Skarga, Mariya Zhmurina, Oleg Morenkov
Summary: Hsp90 is important in the cell for protein folding, stabilization, and turnover. Knocking out HSP90AA1 and HSP90AB1 genes showed that Hsp90a is dispensable for cell migration, while Hsp900 is necessary for basal cell migration. Knockout of one Hsp90 isoform led to an increase in the other isoform, partially or fully compensating for the decrease in total Hsp90 level.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Mechanics
Chenren Chen, Yinuo Xing, He Wang, Zhigang Zhai, Xisheng Luo
Summary: 'Freeze-out' of amplitude growth is achieved by using a reflected shock to counteract the vorticity deposited by the initial shock. A theoretical model is developed to calculate the required initial parameters. Experimental runs confirm that freeze-out is successfully achieved after the impact of the reflected shock under specific initial conditions.
JOURNAL OF FLUID MECHANICS
(2023)
Article
Biochemistry & Molecular Biology
Keishi Narita, Takuji Oyama
Summary: This study purified the conserved carboxyl-terminal fragment of the Hoatz gene, analyzed its structure and potential binding proteins, and identified its association with the heat-shock protein family A, which may suggest the stress regulation role of HOATZ in cells with motile cilia and flagella.
PROTEIN AND PEPTIDE LETTERS
(2022)
Article
Multidisciplinary Sciences
Chia-Jung Chang, Hsin Chi, Wai-Tim Jim, Nan-Chang Chiu, Lung Chang
Summary: Accidental out-of-hospital deliveries (OHDs) are associated with a higher risk of neonatal infection, with low birth weight identified as the only independent risk factor. Neonatal infection is more prevalent among OHDs compared to in-hospital deliveries, indicating the need for further medical care and observation for OHD neonates. Social support should be provided for high-risk populations, such as teenage mothers.
Review
Biochemistry & Molecular Biology
Nicolle A. Rosa-Mercado, Joan A. Steitz
Summary: DoGs are long noncoding RNAs produced in response to cellular stress, and their production is regulated by host and viral proteins. The exact role and biogenesis of DoGs are not fully understood, but they can persist and be detected during the stress response period after stress removal.
TRENDS IN BIOCHEMICAL SCIENCES
(2022)
Review
Cell Biology
Maulin M. Patel, Leonidas Tsiokas
Summary: The primary cilium is an important organelle present in most cell types, serving as a signaling center for various cellular processes. Abnormal cilia length can lead to a range of human diseases, known as ciliopathies. While cilia assembly is well understood, the process of cilia disassembly and its biological roles remain less clear and require further investigation for potential therapeutic targets.
Article
Multidisciplinary Sciences
Seiji Ishii, Toru Sasaki, Shahid Mohammad, Hye Hwang, Edwin Tomy, Fahad Somaa, Nobuyuki Ishibashi, Hideyuki Okano, Pasko Rakic, Kazue Hashimoto-Torii, Masaaki Torii
Summary: Primary cilia play a crucial role in protecting immature neurons from environmental stress by activating signaling pathways that inhibit degeneration of dendritic arbors and caspase-mediated cleavage of cytoskeletal proteins in stress-exposed neurons.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Ji-Eun Bae, Daejin Min, Ji Yeon Choi, Hyunjung Choi, Joon Bum Kim, Na Yeon Park, Doo Sin Jo, Yong Hwan Kim, Hye-Won Na, Yoon Jae Kim, Eun Sung Kim, Hyoung-June Kim, Dong-Hyung Cho
Summary: 2-Isopropylmalic acid (2-IPMA) promotes primary ciliogenesis in dermal fibroblasts, ameliorating PM2.5-induced inflammation. Additionally, 2-IPMA inhibits oxidative stress and inflammatory response caused by PM2.5.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Lowenna Rule, Jessica Yang, Holly Watkin, Jeremy Hall, Nichola Marie Brydges
Summary: Early life stress can lead to psychiatric illnesses, with the hippocampus playing a crucial role. Stress in the pre-pubertal period impairs adult hippocampal neurogenesis and related behaviors in rodent models. Environmental enrichment during adolescence can reverse the effects of early stress on hippocampal function.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Sharad Awasthi, Baskar Chakrapani, Arun Mahesh, Pavithra L. Chavali, Sreenivas Chavali, Arunkumar Dhayalan
Editorial Material
Cell Biology
Julia Tischer, Fanni Gergely
JOURNAL OF CELL BIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Valentina Quarantotti, Jia-Xuan Chen, Julia Tischer, Carmen Gonzalez Tejedo, Evaggelia K. Papachristou, Clive S. D'Santos, John V. Kilmartin, Martin L. Miller, Fanni Gergely
Article
Biochemistry & Molecular Biology
Arun Mahesh, Mohd. Imran K. Khan, Gayathri Govindaraju, Mamta Verma, Sharad Awasthi, Pavithra L. Chavali, Sreenivas Chavali, Arumugam Rajavelu, Arunktunar Dhayalan
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2020)
Review
Biochemistry & Molecular Biology
Travis H. Stracker, Ciaran G. Morrison, Fanni Gergely
Article
Multidisciplinary Sciences
Lovorka Stojic, Aaron T. L. Lun, Patrice Mascalchi, Christina Ernst, Aisling M. Redmond, Jasmin Mangei, Alexis R. Barr, Vicky Bousgouni, Chris Bakal, John C. Marioni, Duncan T. Odom, Fanni Gergely
NATURE COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Takashi Ochi, Valentina Quarantotti, Huawen Lin, Jerome Jullien, Ivan Rosa e Silva, Francesco Boselli, Deepak D. Barnabas, Christopher M. Johnson, Stephen H. McLaughlin, Stefan M. Freund, Andrew N. Blackford, Yuu Kimata, Raymond E. Goldstein, Stephen P. Jackson, Tom L. Blundell, Susan K. Dutcher, Fanni Gergely, Mark van Breugel
Correction
Cell Biology
Sandeep Singh, Varsheish Raina, Pavithra Lakshminarsimhan Chavali, Taronish Dubash, Sreenath Kadreppa, Pradeep Parab, Samit Chattopadhyay
BMC MOLECULAR AND CELL BIOLOGY
(2020)
Article
Biology
Mamta Verma, Mohd. Imran K. Khan, Rajashekar Varma Kadumuri, Baskar Chakrapani, Sharad Awasthi, Arun Mahesh, Gayathri Govindaraju, Pavithra L. Chavali, Arumugam Rajavelu, Sreenivas Chavali, Arunkumar Dhayalan
Summary: This study demonstrates that protein arginine methyltransferase 3 (PRMT3) interacts with and inhibits retinal dehydrogenase ALDH1A1, negatively regulating the expression of retinoic acid responsive genes. PRMT3 affects diverse biological processes not only by globally regulating protein function through methylation but also by regulating gene expression.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Julia Tischer, Sarah Carden, Fanni Gergely
Summary: Centrosomes consist of a mother and daughter centriole embedded within a proteinaceous matrix known as the pericentriolar material. Mother centrioles in some eukaryotic lineages are distinguished from daughters by appendages at their distal end, which anchor microtubule minus ends and tether Golgi-derived vesicles. In vertebrate cells, centrosomes are surrounded by a system of cytoplasmic granules called centriolar satellites.
CURRENT OPINION IN STRUCTURAL BIOLOGY
(2021)
Review
Neurosciences
Sourav Ganguli, Pavithra L. Chavali
Summary: Intrauterine viral infections during pregnancy can lead to neurodevelopmental disorders, with maternal inflammatory responses playing a significant role in negative outcomes.
FRONTIERS IN NEUROSCIENCE
(2021)
Correction
Neurosciences
Sourav Ganguli, Pavithra L. Chavali
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Peter Tatrai, Fanni Gergely
Summary: This study shows the critical role of CDK5RAP2 and centrosomes in spindle formation during blood production. Lack of CDK5RAP2 leads to defective erythroid differentiation and the emergence of macrocytic anemia. The study suggests that disruption of centrosome and spindle function could contribute to the development of macrocytic anemias.
Article
Neurosciences
Harry Bulstrode, Gemma C. Girdler, Tannia Gracia, Alexander Aivazidis, Ilias Moutsopoulos, Adam M. H. Young, John Hancock, Xiaoling He, Katherine Ridley, Zhaoyang Xu, John H. Stockley, John Finlay, Clement Hallou, Teodoro Fajardo, Daniel M. Fountain, Stijn van Dongen, Alexis Joannides, Robert Morris, Richard Mair, Colin Watts, Thomas Santarius, Stephen J. Price, Peter J. A. Hutchinson, Emma J. Hodson, Steven M. Pollard, Irina Mohorianu, Roger A. Barker, Trevor R. Sweeney, Omer Bayraktar, Fanni Gergely, David H. Rowitch
Summary: Zika virus can infect human developing brain progenitors, leading to epidemic microcephaly, but it has limited infectivity for adult brain cancer glioblastoma. CD11b+ microglia/macrophages derived from glioblastoma are able to protect progenitors against Zika virus infection in a non-cell autonomous manner. Treatment with interferon beta and inhibition of JAK1/2 signaling can enhance the resistance of progenitors to Zika virus. These findings have important implications for neuroprotection and improved treatment of brain cancer.
Article
Cell Biology
Sarah Carden, Elisa Vitiello, Ivan Rosa e Silva, James Holder, Valentina Quarantotti, Kamal Kishore, Valar Nila Roamio Franklin, Clive D'Santos, Takashi Ochi, Mark van Breugel, Fanni Gergely
Summary: This study presents CAPture-MS, a powerful method for efficient purification of centrosome proteomes from mammalian cells, which allows for the analysis of cell type-dependent heterogeneity, hierarchical interactions, and identification of unknown components in centrosomes.
DEVELOPMENTAL CELL
(2023)
