Phosphoproteomic analysis reveals that PP4 dephosphorylates KAP-1 impacting the DNA damage response

KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response

(2011) Aaron A Goodarzi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

What goes on must come off: phosphatases gate-crash the DNA damage response

(2011) Dong-Hyun Lee et al.   TRENDS IN BIOCHEMICAL SCIENCES

A phospho-proteomic screen identifies substrates of the checkpoint kinase Chk1

(2011) Melanie Blasius et al.   GENOME BIOLOGY

Liprin α1 interacts with PP2A B56γ

(2010) Jason D. Arroyo et al.   CELL CYCLE

A Mec1- and PP4-Dependent Checkpoint Couples Centromere Pairing to Meiotic Recombination

(2010) Jill E. Falk et al.   DEVELOPMENTAL CELL

The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax

(2010) Aaron A. Goodarzi et al.   DNA REPAIR

De novo telomere formation is suppressed by the Mec1-dependent inhibition of Cdc13 accumulation at DNA breaks

(2010) W. Zhang et al.   GENES & DEVELOPMENT

Site-specific Phosphorylation Dynamics of the Nuclear Proteome during the DNA Damage Response

(2010) Martin V. Bennetzen et al.   MOLECULAR & CELLULAR PROTEOMICS

Protein Phosphatases Pph3, Ptc2, and Ptc3 Play Redundant Roles in DNA Double-Strand Break Repair by Homologous Recombination

(2010) J.-A. Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Role of ATM and the Damage Response Mediator Proteins 53BP1 and MDC1 in the Maintenance of G2/M Checkpoint Arrest

(2010) A. Shibata et al.   MOLECULAR AND CELLULAR BIOLOGY

Protein Phosphatase 6 Interacts with the DNA-Dependent Protein Kinase Catalytic Subunit and Dephosphorylates  -H2AX

(2010) P. Douglas et al.   MOLECULAR AND CELLULAR BIOLOGY

miR-182-Mediated Downregulation of BRCA1 Impacts DNA Repair and Sensitivity to PARP Inhibitors

(2010) Patryk Moskwa et al.   MOLECULAR CELL

53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair

(2010) Angela T. Noon et al.   NATURE CELL BIOLOGY

A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination

(2010) Dong-Hyun Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SUMOylation of the Transcriptional Co-Repressor KAP1 Is Regulated by the Serine and Threonine Phosphatase PP1

(2010) X. Li et al.   Science Signaling

ATM-Dependent and -Independent Dynamics of the Nuclear Phosphoproteome After DNA Damage

(2010) A. Bensimon et al.   Science Signaling

Magnetic Bead Processor for Rapid Evaluation and Optimization of Parameters for Phosphopeptide Enrichment

(2009) Scott B. Ficarro et al.   ANALYTICAL CHEMISTRY

Improved Electrospray Ionization Efficiency Compensates for Diminished Chromatographic Resolution and Enables Proteomics Analysis of Tyrosine Signaling in Embryonic Stem Cells

(2009) Scott B. Ficarro et al.   ANALYTICAL CHEMISTRY

multiplierz: an extensible API based desktop environment for proteomics data analysis

(2009) Jignesh R Parikh et al.   BMC BIOINFORMATICS

Serine/Threonine Phosphatases: Mechanism through Structure

(2009) Yigong Shi   CELL

A Robust Error Model for iTRAQ Quantification Reveals Divergent Signaling between Oncogenic FLT3 Mutants in Acute Myeloid Leukemia

(2009) Yi Zhang et al.   MOLECULAR & CELLULAR PROTEOMICS

Structure and Activation Mechanism of the CHK2 DNA Damage Checkpoint Kinase

(2009) Zhenjian Cai et al.   MOLECULAR CELL

mzAPI: a new strategy for efficiently sharing mass spectrometry data

(2009) Manor Askenazi et al.   NATURE METHODS

Activation of DNA-PK by Ionizing Radiation Is Mediated by Protein Phosphatase 6

(2009) Jun Mi et al.   PLoS One

Mobility shift detection of phosphorylation on large proteins using a Phos-tag SDS-PAGE gel strengthened with agarose

(2009) Eiji Kinoshita et al.   PROTEOMICS

Phosphorylation at Ser473 regulates heterochromatin protein 1 binding and corepressor function of TIF1beta/KAP1

(2008) Chiung-Wen Chang et al.   BMC MOLECULAR BIOLOGY

Protein phosphatase PP4 is overexpressed in human breast and lung tumors

(2008) Bo Wang et al.   CELL RESEARCH

Control of WHITE COLLAR localization by phosphorylation is a critical step in the circadian negative feedback process

(2008) Joonseok Cha et al.   EMBO JOURNAL

PP4 is a γH2AX phosphatase required for recovery from the DNA damage checkpoint

(2008) Shinichiro Nakada et al.   EMBO REPORTS

PP4R4/KIAA1622 Forms a Novel Stable Cytosolic Complex with Phosphoprotein Phosphatase 4

(2008) Ginny I. Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein phosphatase 4 catalytic subunit regulates Cdk1 activity and microtubule organization via NDEL1 dephosphorylation

(2008) Kazuhito Toyo-oka et al.   JOURNAL OF CELL BIOLOGY

ATM Signaling Facilitates Repair of DNA Double-Strand Breaks Associated with Heterochromatin

(2008) Aaron A. Goodarzi et al.   MOLECULAR CELL

A PP4-Phosphatase Complex Dephosphorylates γ-H2AX Generated during DNA Replication

(2008) Dipanjan Chowdhury et al.   MOLECULAR CELL