Shifting a complex debate onγ-secretase cleavage and Alzheimer's disease

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

(2012) Lucía Chávez-Gutiérrez et al.   EMBO JOURNAL

Dissociation between the Processivity and Total Activity of γ-Secretase: Implications for the Mechanism of Alzheimer's Disease-Causing Presenilin Mutations

(2011) Omar Quintero-Monzon et al.   BIOCHEMISTRY

Presenilins in synaptic function and disease

(2011) Angela Ho et al.   TRENDS IN MOLECULAR MEDICINE

 -Secretase Gene Mutations in Familial Acne Inversa

(2010) B. Wang et al.   SCIENCE

 -Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of  -Carboxyl Terminal Fragment

(2009) M. Takami et al.   JOURNAL OF NEUROSCIENCE

Rational targeting of Notch signaling in cancer

(2008) P Rizzo et al.   ONCOGENE