Large conformational changes in MutS during DNA scanning, mismatch recognition and repair signalling

Atomic force microscopy captures MutS tetramers initiating DNA mismatch repair

(2011) Yong Jiang et al.   EMBO JOURNAL

Human MSH2 (hMSH2) Protein Controls ATP Processing by hMSH2-hMSH6

(2011) Christopher D. Heinen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemical Trapping of the Dynamic MutS-MutL Complex Formed in DNA Mismatch Repair inEscherichia coli

(2011) Ines Winkler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MutS switches between two fundamentally distinct clamps during mismatch repair

(2011) Cherlhyun Jeong et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Native mass spectrometry provides direct evidence for DNA mismatch-induced regulation of asymmetric nucleotide binding in mismatch repair protein MutS

(2011) Maria Chiara Monti et al.   NUCLEIC ACIDS RESEARCH

Beyond the Random Coil: Stochastic Conformational Switching in Intrinsically Disordered Proteins

(2011) Ucheor B. Choi et al.   STRUCTURE

Single-Molecule FRET TACKLE Reveals Highly Dynamic Mismatched DNA−MutS Complexes

(2010) Lauryn E. Sass et al.   BIOCHEMISTRY

Optimizing Methods to Recover Absolute FRET Efficiency from Immobilized Single Molecules

(2010) James J. McCann et al.   BIOPHYSICAL JOURNAL

Four-color single-molecule fluorescence with noncovalent dye labeling to monitor dynamic multimolecular complexes

(2010) Vanessa C. DeRocco et al.   BIOTECHNIQUES

Magnesium Coordination Controls the Molecular Switch Function of DNA Mismatch Repair Protein MutS

(2010) Joyce H. G. Lebbink et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction between the Msh2 and Msh6 Nucleotide-binding Sites in the Saccharomyces cerevisiae Msh2-Msh6 Complex

(2010) Victoria V. Hargreaves et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Probing DNA- and ATP-mediated Conformational Changes in the MutS Family of Mispair Recognition Proteins Using Deuterium Exchange Mass Spectrometry

(2010) Marc L. Mendillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Three-dimensional molecular modeling with single molecule FRET

(2010) Axel T. Brunger et al.   JOURNAL OF STRUCTURAL BIOLOGY

Single-molecule FRET–derived model of the synaptotagmin 1–SNARE fusion complex

(2010) Ucheor B Choi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Effects of Cisplatin Binding to DNA on the Dynamics of the E. coli MutS Dimer

(2010) Freddie R. Salsbury Jr.   PROTEIN AND PEPTIDE LETTERS

Conformational Change in MSH2-MSH6 upon Binding DNA Coupled to ATPase Activity

(2009) Shayantani Mukherjee et al.   BIOPHYSICAL JOURNAL

Mechanism of MutS Searching for DNA Mismatches and Signaling Repair

(2008) Ingrid Tessmer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA mismatch repair: Molecular mechanism, cancer, and ageing

(2008) Peggy Hsieh et al.   MECHANISMS OF AGEING AND DEVELOPMENT