Article
Multidisciplinary Sciences
Cindy Poo, Gautam Agarwal, Niccolo Bonacchi, Zachary F. Mainen
Summary: The study demonstrates that posterior piriform cortex neurons can carry a spatial representation of the environment, showing features of a learned cognitive map that is stable across behavioral contexts and independent of olfactory drive or reward availability. The accuracy of spatial information carried by individual piriform neurons is predicted by their functional coupling strength to the hippocampal theta rhythm, and ensembles of piriform neurons concurrently represent odor identity and spatial locations of animals.
Article
Neurosciences
Elizabeth Hanson, Katie L. Brandel-Ankrapp, Benjamin R. Arenkiel
Summary: Sensory perception is crucial for internalizing and interacting with the external world, and top-down regulation from the cholinergic basal forebrain plays a key role in modulating neural networks for sensory cue detection, learning, and memory. Cholinergic signaling in the basal forebrain dynamically changes in response to reward-seeking behaviors and positive reinforcement, impacting downstream circuitry that modulates olfaction.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Gozde Filiz, Daphnee Poupon, Sarah Banks, Pauline Fernandez, Johannes Frasnelli
Summary: Brain plasticity is crucial for experts to acquire necessary abilities. In this study, a longitudinal design was used to investigate the brain plasticity of sommelier students. It was found that the volume of the olfactory bulb increased in sommelier students, while there were no significant changes in cortical thickness and olfactory performance. This is the first longitudinal study to report the effects of training-related brain plasticity on the olfactory bulb volume in olfaction experts.
HUMAN BRAIN MAPPING
(2022)
Article
Multidisciplinary Sciences
Jonathan H. Lindsay, Laura D. Mathies, Andrew G. Davies, Jill C. Bettinger
Summary: Alcohol intoxication can affect learning and contribute to problematic alcohol use. Information learned while intoxicated is more effectively recalled when tested while intoxicated. Two genes, HEN-1 and SCD-2, are required for alcohol state-dependent learning (SDL). Expression of hen-1 in ASER neuron and scd-2 in AIA neurons is sufficient for their functions in SDL. ASER activation can signal ethanol intoxication to the olfactory learning circuit. The effects of ethanol on learning and recall rely on distinct signals.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Evan R. Harrell, Anthony Renard, Brice Bathellier
Summary: This study shows that mice can use their whiskers to discriminate object orientation, and that fast cortical dynamics extract orientation information more closely resembling concurrent psychophysical measurements than single neuron orientation tuning curves, conveying both stimulus and choice-related information.
Article
Biology
Jung-Hwa Choi, Erik R. Duboue, Michelle Macurak, Jean-Michel Chanchu, Marnie E. Halpern
Summary: This study reveals the role of a small cluster of cholinergic neurons in the dorsal habenula of zebrafish in the processing of repulsive olfactory cues and modulating the resultant behavioral response. Asymmetric hemispheric identity in the brain affects the processing of aversive olfactory cues.
Article
Biology
Bin Wan, Seyma Bayrak, Ting Xu, H. Lina Schaare, Richard A. Bethlehem, Boris C. Bernhardt, Sofie L. Valk
Summary: The functional organization of the human cerebral cortex exhibits asymmetry, which is linked to language and higher order cognitive functions. This asymmetry is heritable and phylogenetically conserved between humans and macaques.
Article
Multidisciplinary Sciences
Tobias Ackels, Andrew Erskine, Debanjan Dasgupta, Alina Cristina Marin, Tom P. A. Warner, Sina Tootoonian, Izumi Fukunaga, Julia J. Harris, Andreas T. Schaefer
Summary: Researchers have found that the mammalian olfactory system can extract information about the environment using the temporal structure in odours. Mice in experiments were able to discriminate temporal correlations of rapidly fluctuating odours, and this information could be extracted from the activity of mitral and tufted cells.
Article
Environmental Sciences
Ingrid A. Ekstrom, Debora Rizzuto, Giulia Grande, Tom Bellander, Erika J. Laukka
Summary: The study found that older adults exposed to air pollutants such as PM2.5 and NOx have a faster decline in olfactory ability, suggesting a potential association between air pollution and olfactory decline.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2022)
Article
Neurosciences
Marco de Curtis, Laura Librizzi, Laura Uva
Summary: Seizures affecting the limbic regions, such as the hippocampus, are common and often resistant to medication. This study examines the network mechanisms involved in the generation of olfactory-limbic epileptiform patterns and discusses the potential relevance of these findings for human focal epilepsy. The interactions within olfactory-limbic circuits, including region-specific seizure-like events and cortical control, are investigated using in vitro preparations and pro-convulsive drugs.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Cell Biology
Yaroslav Sych, Aleksejs Fomins, Leonardo Novelli, Fritjof Helmchen
Summary: By training mice in a tactile discrimination task, we found that the functional networks in the brain undergo dynamic reorganization and establish mesoscale network dynamics suitable for goal-oriented behavior.
Article
Multidisciplinary Sciences
Robert Luke, Hamish Innes-Brown, Jaime A. Undurraga, David McAlpine
Summary: Sounds generated by different sources are received as a mixture of energy. Listeners can distinguish different sources by extracting cues, including interaural coherence (IAC), which is how similar sounds arrive at the two ears. The study found that listeners cannot reliably distinguish two completely interaurally coherent sounds from a single sound with reduced IAC. The perception of sounds with supra-ethological spatial cues as more diffuse is accounted for by a computational model, and sounds with low IAC impose elevated cortical load.
Article
Multidisciplinary Sciences
Yan Li, Mitchell Swerdloff, Tianyu She, Asiyah Rahman, Naveen Sharma, Reema Shah, Michael Castellano, Daniel Mogel, Jason Wu, Asim Ahmed, James San Miguel, Jared Cohn, Nikesh Shah, Raddy L. Ramos, Gonzalo H. Otazu
Summary: In this study, researchers found that mice were able to accurately identify known odors in new environments, but the performance of Cntnap2(-/-) mice decreased when faced with novel background odors. This suggests that mice use a robust algorithm to detect odors in new environments, and this computation is impaired in Cntnap2(-/-) mice.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Julia Rogge, Gerhard Jocham, Markus Ullsperger
Summary: The lateralization of alpha and beta power reflects the integration of decision evidence, while the LRP is more closely related to motor performance. These neural signals encode decision information in motor areas.
Article
Neurosciences
Sarah L. West, Justin D. Aronson, Laurentiu S. Popa, Kathryn D. Feller, Russell E. Carter, William M. Chiesl, Morgan L. Gerhart, Aditya C. Shekhar, Leila Ghanbari, Suhasa B. Kodandaramaiah, Timothy J. Ebner
Summary: Motor behavior involves complex exchanges of motor and sensory information across cortical regions. A study using mesoscopic Ca2+ imaging in mice reveals increased activation of the dorsal cerebral cortex during locomotion. The study also found that the functional connectivity of the cortex changes during the transition from rest to locomotion and vice versa, with increased correlations among most nodes. However, once a steady state of locomotion is reached, certain nodes show decreased correlations while others show increased correlations.
Article
Neurosciences
Mariko Saito, John F. Smiley, Maria Hui, Kurt Masiello, Judith Betz, Maria Ilina, Mitsuo Saito, Donald A. Wilson
Article
Anatomy & Morphology
Emmanuelle Courtiol, Michelle Neiman, Gloria Fleming, Catia M. Teixeira, Donald A. Wilson
BRAIN STRUCTURE & FUNCTION
(2019)
Article
Behavioral Sciences
Gloria Fleming, Beverly A. Wright, Donald A. Wilson
Article
Neurosciences
Maya Opendak, Patrese Robinson-Drummer, Anna Blomkvist, Roseanna M. Zanca, Kira Wood, Lily Jacobs, Stephanie Chan, Stephen Tan, Joyce Woo, Gayatri Venkataraman, Emma Kirschner, Johan N. Lundstrom, Donald A. Wilson, Peter A. Serrano, Regina M. Sullivan
NEUROPSYCHOPHARMACOLOGY
(2019)
Article
Multidisciplinary Sciences
Guangyu Zhou, Gregory Lane, Torben Notoe, Ghazaleh Arabkheradmand, Jay A. Gottfried, Stephan U. Schuele, Joshua M. Rosenow, Jonas K. Olofsson, Donald A. Wilson, Christina Zelano
NATURE COMMUNICATIONS
(2019)
Article
Behavioral Sciences
Jonas K. Olofsson, Maria Larsson, Catalina Roa, Donald A. Wilson, Erika Jonsson Laukka
Article
Neurosciences
Donald A. Wilson, Gloria Fleming, Samantha M. Vervoordt, Gerard Coureaud
Article
Multidisciplinary Sciences
Maya Opendak, Emma Theisen, Anna Blomkvist, Kaitlin Hollis, Teresa Lind, Emma Sarro, Johan N. Lundstrom, Nim Tottenham, Mary Dozier, Donald A. Wilson, Regina M. Sullivan
NATURE COMMUNICATIONS
(2020)
Review
Behavioral Sciences
Ioannis Kontaris, Brett S. East, Donald A. Wilson
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2020)
Article
Neurosciences
Justin Apuzzo, Mariko Saito, Donald A. Wilson
Editorial Material
Biochemistry & Molecular Biology
Donald A. Wilson, Brett S. East
Summary: Recent research has uncovered a direct pathway from the olfactory bulb to the ventral striatum that drives odor-mediated reward responses.
Article
Neurosciences
Behzad Iravani, Artin Arshamian, Mikael Lundqvist, Leslie M. Kay, Donald A. Wilson, Johan N. Lundstrom
Summary: Neuronal oscillations facilitate bidirectional information flow between the olfactory bulb (OB) and piriform cortex (PC) in healthy humans, aiding in odor perception. Data demonstrate that odor identity can be decoded from neural oscillations as early as 100 ms after odor onset.
Meeting Abstract
Behavioral Sciences
Donald Wilson, Janina Seubert
Article
Neurosciences
Jonas K. Olofsson, Guangyu Zhou, Brett S. East, Christina Zelano, Donald A. Wilson
Article
Psychology, Developmental
Rosemarie E. Perry, Eric D. Finegood, Stephen H. Braren, Meriah L. Dejoseph, David F. Putrino, Donald A. Wilson, Regina M. Sullivan, C. Cybele Raver, Clancy Blair
DEVELOPMENT AND PSYCHOPATHOLOGY
(2019)