Journal
EMBO JOURNAL
Volume 30, Issue 2, Pages 233-234Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/emboj.2010.339
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Eukaryotic centromeres are composed of a combination of nucleosomes containing the histone H3 variant CENP-A and canonical H3 di-methylated at lysine 4 (H3K4me2). Many questions exist over the functional importance of H3K4me2 nucleosomes within the centromere region. In this issue of The EMBO Journal, Bergmann et al (2011) reveal a role for H3K4me2 and transcription in CENP-A maintenance. They also extend the profile of centromeric histone modifications to include H3K36 methylation, typically found at transcribed regions of the genome.
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