Article
Agriculture, Multidisciplinary
Aiwen Jiang, Hongyun Guo, Wangjun Wu, Honglin Liu
Summary: This study found that during myogenic differentiation, the level of autophagy was consistent with apoptosis, with increased apoptosis activating autophagy, which in turn inhibited apoptosis to prevent excessive cell death and maintain cell stability. The interaction between autophagy and apoptosis determines the balance of cell death and survival during skeletal muscle cell differentiation.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Nick J. Spencer, Damien J. Keating
Summary: This article discusses the recent findings regarding the functional role of endogenous 5-HT in enterochromaffin cells and enteric neurons in gut motility and other major homeostatic pathways. The advancements in recording techniques and access to genetically modified animals have led to significant changes in our understanding of the role of gut-derived 5-HT. Experimental data suggests that the major patterns of GI motility and transit still occur even without endogenous 5-HT, and 5-HT3 receptor antagonists are more potent in inhibiting GI motility in segments lacking endogenous 5-HT.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Neurosciences
Xiang Li, Dan Feng, Shenglu Ma, Mingxing Li, Shulei Zhao, Man Tang
Summary: This study investigated the effects of fluoxetine on neurochemical, neurobiological, and neurobehavioral changes in different subregions of the hippocampus. The results showed that fluoxetine increased dialysate 5-HT, decreased membrane 5-HTT protein, and increased cytoplasmic fraction. Additionally, fluoxetine reduced immobility times in behavioral tests, with greater effects observed in the ventral subregion compared to the dorsal subregion.
Article
Medicine, Research & Experimental
I Erkizia-Santamaria, R. Alles-Pascual, I Horrillo, J. J. Meana, J. E. Ortega
Summary: The study found that psilocin showed similar affinities for 5HT2AR, 5HT2CR, and 5HT1AR in both human and mice brain. Psilocybin induced a dose-dependent head-twitch response (HTR) and affected body temperature, which were both mediated by 5HT2AR, 5HT2CR, and 5HT1AR. These findings provide key insights into the mechanism of action of psilocybin and its therapeutic effects.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Jing Guan, Xin Tong, Yi Zhang, Fan Xu, Yuxin Zhang, Xiurui Liang, Jiaqi Jin, Hongyan Jing, Liuxian Guo, Xinrui Ni, Jihua Fu
Summary: This study uncovered the relationship between ROS accumulation induced by cisplatin and 5-HT degradation, with a focus on the involvement of 5-HT2AR in proximal tubular epithelial cells. Inhibition of 5-HT2AR attenuated cisplatin-induced nephrotoxicity by regulating MAO-A, Tph1, and AADC expression levels.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Medicine, Research & Experimental
Jiaqi Jin, Fan Xu, Yi Zhang, Jing Guan, Xiurui Liang, Yuxin Zhang, Ansheng Yuan, Runkun Liu, Jihua Fu
Summary: This study investigated the relationship between RIRI and the activation of the renal 5-HT degradation system, revealing that inhibiting 5-HT2AR and 5-HT synthases can alleviate RIRI-induced damage, highlighting the involvement of 5-HT2AR in this process.
Article
Plant Sciences
Fen Yang, Nadia Fernandez Jimenez, Joanna Majka, Monica Pradillo, Ales Pecinka
Summary: The study reveals that autotetraploid Arabidopsis plants with loss-of-function mutations in NSE2 and NSE4A subunits of the Structural Maintenance of Chromosomes 5/6 (SMC5/6) complex are almost sterile and produce hexaploid and aneuploid offspring. This suggests that the SMC5/6 complex plays a crucial role in maintaining tetraploid genome stability and that autotetraploid Arabidopsis plants have a higher tolerance for aneuploidy compared to diploids.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Endocrinology & Metabolism
Elena Layunta, Berta Buey, Jose Emilio Mesonero, Eva Latorre
Summary: Disruption of the microbiota-gut-brain axis can lead to various pathologies affecting the brain and intestine. Serotonin is identified as a crucial mediator in the communication between microbiota, gut, and brain, playing a significant role in gastrointestinal and brain physiology. The intestinal microbiota also play a key role in serotonin signaling, highlighting the importance of serotonin as a mediator in microbiota-host interactions.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Psychiatry
Ling Chen, Wan-Kun Gong, Cui-ping Yang, Chan-Chan Shao, Ning-Ning Song, Jia-Yin Chen, Li-Qiang Zhou, Kun-Shan Zhang, Siguang Li, Zhili Huang, Gal Richter-Levin, Lin Xu, Yu-Qiang Ding
Summary: The study suggests that PTEN may serve as an alternative approach for regulating 5-HT neuron activity in the brain and depressive behaviors, compared to selective serotonin reuptake inhibitors (SSRIs) commonly used in depression treatment. Elevated levels of PTEN in 5-HT neurons can induce depressive behaviors in mice, while selective deletion of Pten leads to structural plasticity in these neurons.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Gastroenterology & Hepatology
Zhenhai Chen, Jiangyi Feng, Song Hu, Ye Hua, Shaying Ma, Weijie Fu, Qian Yang, Xin Zhang
Summary: Bacillus subtilis treatment for STC significantly increases the 24 h defecations, fecal moisture, and intestinal transport rate of STC mice, improves pathological colon damage, and shows protective effects on the intestinal tract. Bacillus subtilis promotes the release of 5-HT from ECs and the bile acid receptor TGR5/TRPA1 pathway, regulating intestinal peristalsis through bile acid metabolism and plays a positive role in the treatment of STC.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Immunology
Gui Yang, Gaohui Wu, Wenkai Yao, Li Guan, Xiaorui Geng, Jiangqi Liu, Zhiqiang Liu, Liteng Yang, Qinmiao Huang, Xianhai Zeng, Pingchang Yang
Summary: This study reveals that patients with perennial allergic rhinitis have higher concentrations of 5-HT in their serum. 5-HT can enhance the expression of IL-6 and IL-21 in dendritic cells, leading to the conversion of Tregs to Th17 cells.
CLINICAL IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Elias B. Nascimento Jr., R. L. Romero, Marcela M. G. B. Dutra, Bernd L. Fiebich, Igor D. G. Duarte, Marcio M. Coelho
Summary: The activation of 5-HT1D and 5-HT7 receptors plays a role in mechanical allodynia induced by 5-HT in mice, while peripheral 5-HT3 receptors have an inhibitory role in the nociceptive response induced by 5-HT or carrageenan.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Physical
Manish Yadav Kumar, Arie Borenstein
Summary: Laser-graphitization is a new approach for obtaining high-quality 3D graphene films simply and efficiently. Precarbonization can improve the quality of the graphitization products to a certain extent. Additionally, the surface chemistry and core structure of the carbon nanodots (CNDs) also play a role in the final results.
Article
Fisheries
Xiaoting Liang, Shi Duan, Qing Yang, Xiaoqin Ma, Zhenyu Li, Qiting Yao, Kongyue Wu, Pei Chang, Gongqing Feng, Wentao Hong, Mengxi Cao, Qingchun Zhou, Xueping Zhong, Haobin Zhao
Summary: Prmt5 is an enzyme that catalyzes arginine dimethylation in proteins and is conserved from yeast to humans. It is necessary for embryonic development in mice and maintains embryonic stem cells. However, the knockout of prmt5 in zebrafish does not affect the viability of the embryos, suggesting that prmt5 may be dispensable during embryogenesis in fish. In this study using medaka, a different fish organism, the mutation of prmt5 resulted in down-regulation of stemness genes and up-regulation of genes associated with cell death, indicating that prmt5 is necessary for embryogenesis in medaka by maintaining stemness and repressing apoptosis.
Article
Biochemistry & Molecular Biology
Raffaella di Vito, Alessia Di Mezza, Carmela Conte, Giovanna Traina
Summary: The intestinal epithelium acts as a barrier that selectively allows for absorption of nutrients while defending against bacteria and toxins. Imbalances between the gut microbiota and the immune system can lead to inflammation. Mast cells play a crucial role in this process. A probiotic formulation containing specific strains was found to prevent inflammation and maintain intestinal barrier integrity in co-culture models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
