Journal
EMBO JOURNAL
Volume 28, Issue 15, Pages 2174-2187Publisher
WILEY
DOI: 10.1038/emboj.2009.176
Keywords
checkpoint; DNA-damage response; telomere
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Funding
- Wellcome Trust [075294]
- Biotechnology and Biological Sciences Research Council [BB/C008200/1]
- Cancer Research UK
- Biotechnology and Biological Sciences Research Council [BB/C008200/1] Funding Source: researchfish
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Telomeres are by definition stable and inert chromosome ends, whereas internal chromosome breaks are potent stimulators of the DNA damage response (DDR). Telomeres do not, as might be expected, exclude DDR proteins from chromosome ends but instead engage with many DDR proteins. However, the most powerful DDRs, those that might induce chromosome fusion or cell-cycle arrest, are inhibited at telomeres. In budding yeast, many DDR proteins that accumulate most rapidly at double strand breaks (DSBs), have important functions in physiological telomere maintenance, whereas DDR proteins that arrive later tend to have less important functions. Considerable diversity in telomere structure has evolved in different organisms and, perhaps reflecting this diversity, different DDR proteins seem to have distinct roles in telomere physiology in different organisms. Drawing principally on studies in simple model organisms such as budding yeast, in which many fundamental aspects of the DDR and telomere biology have been established; current views on how telomeres harness aspects of DDR pathways to maintain telomere stability and permit cell-cycle division are discussed. The EMBO Journal (2009) 28, 2174-2187. doi:10.1038/emboj.2009.176; Published online 23 July 2009
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