Review
Cell Biology
Xiaoyan Zhang
Summary: The Golgi apparatus serves as a major processing station in the cell and requires a well-organized structure for proper protein glycosylation. Altered glycosylation is a hallmark of most cancer cells, and Golgi structural proteins are associated with tumor progression. Understanding Golgi structural and functional defects may help determine whether glycosylation defect is a cause or effect of oncogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Spectroscopy
Ao Li, Yalan Liu, Labapuchi, Zhe Chen, Songjiao Li, Rongbin Zhong, Dan Cheng, Linxi Chen, Longwei He
Summary: The Gol-Cou-Fe2+ chemosensor was designed for sensitive and selective detection of Fe2+ in Golgi apparatus. It showed excellent capacity of detecting both exogenous and endogenous Fe2+ and could be used to track Golgi Fe2+ and elucidate Golgi stress-related diseases.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Neurosciences
Guo Cheng, Jin Chang, Hui Gong, Wei Zhou
Summary: GM130 is a conserved matrix protein involved in the structure of the Golgi apparatus. It has a unique Golgi-targeting mechanism, as shown by its localization in both the Golgi apparatus and dendritic Golgi outposts (GOs). In this study, the Golgi-targeting mechanism of the GM130 homologue, dGM130, was investigated in Drosophila neurons. The results revealed two independent Golgi-targeting domains (GTDs) in dGM130, which determine its precise localization in both the soma and dendrites. GTD1 predominantly targets somal Golgi, while GTD2 dynamically targets Golgi in both soma and dendrites. These findings provide new insights into neuronal polarity and the structural differences between the Golgi apparatus and GOs.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Biology
Qianqian Pang, Chunyi Liu, Yulong Qiao, Jian Zhao, Sin Man Lam, Mei Mei, Guanghou Shui, Shilai Bao, Qiuling Li
Summary: Deletion of the GM130 gene disrupts the Golgi structure, impairing the secretion of lung surfactant proteins and lipids. This leads to an enlargement of alveolar airspace and increased alveolar epithelial autophagy, which can be partially rescued by surfactant repletion in GM130-deficient mice.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Review
Medicine, Research & Experimental
Jianyang Liu, Yan Huang, Ting Li, Zheng Jiang, Liuwang Zeng, Zhiping Hu
Summary: The Golgi apparatus plays a crucial role in cellular homeostasis and is linked to various diseases. Mutations in genes encoding Golgi resident proteins can lead to diseases, typically involving defects in membrane trafficking, protein mislocalization, and impaired glycosylation. Detection of Golgi resident proteins in human serum samples may serve as a diagnostic tool, while the central role of Golgi apparatus in membrane trafficking pathways presents potential targets for disease therapy.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Review
Cell Biology
Akihiko Nakano
Summary: The structure of the Golgi apparatus varies among different species, but its functions remain conserved. In addition to the core layers of cisternae, the Golgi is accompanied by neighboring compartments on its cis and trans sides. High-resolution live imaging has revealed striking similarities in the behaviors of these compartments, indicating the presence of conserved mechanisms.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Zheng Li, Weiwei Zhang, Ji Xu, Xiaoye Mo
Summary: Increasing evidence suggests that the Golgi apparatus (GA) plays a role in the development of cerebral ischemia-reperfusion (IR) injury. This study reveals that Cdk1 protects against GA fragmentation and cell apoptosis induced by IR through mediating the phosphorylation of GM130 protein.
JOURNAL OF MOLECULAR HISTOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Lana Buzuk, Doris Hellerschmied
Summary: The Golgi apparatus plays a crucial role in the secretory pathway of eukaryotic cells, processing proteins and organizing their transportation to other cellular compartments. It is involved in cell surface formation, cell polarity, cell-cell communication, immune signaling, DNA damage response, and mitosis. Maintaining Golgi integrity and protein homeostasis is essential, as Golgi fragmentation and dysfunction are linked to neurodegenerative diseases and certain cancers. Recent studies have revealed the importance of ubiquitin signaling in maintaining Golgi integrity and protein quality control, similar to the endoplasmic reticulum. Ubiquitination helps prevent the accumulation of toxic protein aggregates and regulates Golgi structural rearrangements in response to cellular stress.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Meilan Chen, Lu Xu, Yi Wu, Peter Soba, Chun Hu
Summary: Dendrites are specialized compartments in neurons that sense, integrate, and transfer information. Abnormal dendrite development is strongly linked to neurological disorders. The Golgi apparatus, located at the center of the secretory pathway, plays a crucial role in posttranslational modifications, sorting, transport, and signal transduction. It also forms distinct structures known as Golgi outposts in dendrites. However, the organization and function of Golgi in dendrite development and its impact on neurological disorders are still not well understood and lack a comprehensive summary.
Review
Cell Biology
Jaakko Saraste, Kristian Prydz
Summary: This study explores the assembly of coronaviruses in the intermediate compartment at the ER-Golgi interface and their connection with the endocytic recycling system.
Article
Anatomy & Morphology
Daniel Talamas-Lara, Karla Acosta-Virgen, Bibiana Chavez-Munguia, Anel Lagunes-Guillen, Lizbeth Salazar-Villatoro, Martha Espinosa-Cantellano, Adolfo Martinez-Palomo
Summary: The study discovered previously undetected Golgi apparatus components in the cytoplasm of E. histolytica and E. dispar, challenging the traditional view that these amoebae lack Golgi apparatus.
MICROSCOPY RESEARCH AND TECHNIQUE
(2021)
Article
Chemistry, Multidisciplinary
Weiyi Tan, Qiuxin Zhang, Jiaqing Wang, Meihui Yi, Hongjian He, Bing Xu
Summary: Introducing a sulfur atom into phosphopeptides enables rapid targeting of Golgi apparatus and selective killing of cancer cells. The resulting thiophosphopeptide self-assembles after alkaline phosphatase-catalyzed dephosphorylation, enters cells, and accumulates in Golgi apparatus, inhibiting cancer cells effectively.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Rong Sheng Li, Jiahui Liu, Hu Shi, Ping Ping Hu, Yao Wang, Peng Fei Gao, Jian Wang, Moye Jia, Hongwei Li, Yuan Fang Li, Chengde Mao, Na Li, Cheng Zhi Huang
Summary: Golgi apparatus-targeted nano-mechanical disruption is an attractive approach for killing cancer cells by multimodal mechanism and avoiding drug resistance. The transformable peptide C6RVRRF4KY can self-assemble into nontoxic nanoparticles in aqueous medium but transformed into left-handed helical fibrils (L-HFs) after targeting and furin cleavage in the Golgi apparatus of cancer cells, leading to mechanical disruption and death of cancer cells without acquired drug resistance. This nanomechanical disruption concept should also be applicable to multidrug-resistant bacteria and viruses.
Article
Engineering, Biomedical
Haohuan Li, Caifeng Deng, Yulu Tan, Jianxia Dong, Yuanhao Zhao, Xiaorong Wang, Xingyue Yang, Jingwen Luo, Huile Gao, Yuan Huang, Zhi-Rong Zhang, Tao Gong
Summary: This study presents a promising approach for photodynamic immunotherapy of advanced cancers by using chondroitin sulfate-based prodrug nanoparticles to co-deliver a photosensitizer and retinoic acid. This approach can reduce the immunosuppression caused by photodynamic therapy and promote the maturation of dendritic cells. The strategy showed excellent antitumor efficacy in a mouse model.
ACTA BIOMATERIALIA
(2022)
Review
Cell Biology
Aurel George Mohan, Bogdan Calenic, Nicu Adrian Ghiurau, Roxana-Maria Duncea-Borca, Alexandra-Elena Constantinescu, Ileana Constantinescu
Summary: This comprehensive review article delves into the Golgi apparatus, a crucial organelle in cellular biology. It discusses its unique organization and roles in maintaining cellular homeostasis through protein processing, sorting, and lipid biogenesis. The article also explores the relationship between Golgi function and neurodegenerative diseases, particularly Parkinson's, as well as the interplay between Golgi stress and endoplasmic reticulum stress in cellular stress response pathways. Overall, the review emphasizes the importance of further research in understanding Golgi dysfunction and its potential for targeted therapeutic approaches.