Journal
JOURNAL OF PHYSIOLOGY-LONDON
Volume 594, Issue 22, Pages 6573-6582Publisher
WILEY-BLACKWELL
DOI: 10.1113/JP270660
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Funding
- Wellcome Trust [092742/Z/10/Z]
- Motor Neurone Disease Association (MNDA)
- Medical Research Council [MR/J004367/1]
- Euan MacDonald Centre
- NC3Rs (Grant CRACK IT)
- Patrick Wild Centre/RS Macdonald Trust
- Royal Society of Edinburgh Personal Research Fellowship by the Caledonian Research Fund
- MRC [G0902044, MR/J004367/1] Funding Source: UKRI
- Wellcome Trust [092742/Z/10/Z] Funding Source: Wellcome Trust
- Medical Research Council [G0902044, MR/J004367/1] Funding Source: researchfish
- National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) [NC/C011202/1] Funding Source: researchfish
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The in vitro derivation of regionally defined human neuron types from patient-derived stem cells is now established as a resource to investigate human development and disease. Characterization of such neurons initially focused on the expression of developmentally regulated transcription factors and neural markers, in conjunction with the development of protocols to direct and chart the fate of differentiated neurons. However, crucial to the understanding and exploitation of this technology is to determine the degree to which neurons recapitulate the key functional features exhibited by their native counterparts, essential for determining their usefulness in modelling human physiology and disease in vitro. Here, we review the emerging data concerning functional properties of human pluripotent stem cell-derived excitatory cortical neurons, in the context of both maturation and regional specificity.
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