Article
Chemistry, Analytical
Qiang Zhao, Yunjiao Wang, Bangyong Sun, Deqiang Wang, Gang Li
Summary: This research presents a dielectrophoretic manipulation technique based on nanogap electrodes, which allows for the capture, enrichment, and sorting of nanometer-sized objects in liquids. The technique shows potential applications in micro/nanofluidics and provides an alternative method for the non-invasive manipulation and characterization of nanoparticles such as DNA, proteins, and viruses.
Review
Biochemical Research Methods
Kel S. Hakim, Blanca H. Lapizco-Encinas
Summary: Nonlinear electrokinetics technologies, such as DEP particle trapping and EROT for particle assessments, have been widely applied in the analysis, sensing, and purification of microorganisms. Recent research has made significant advancements in these technologies, showcasing the potential future developments within the field of microscale EK.
Review
Biochemical Research Methods
Blanca H. Lapizco-Encinas
Summary: This review article discusses the evolution of insulator-based dielectrophoresis (iDEP) and insulator-based electrokinetic (iEK) systems, highlighting recent studies that suggest particle trapping in these systems is mainly due to a balance between electroosmotic and electrophoretic effects under DC and low-frequency AC potentials, rather than dielectrophoresis. The proposed renaming of the field from DC-iDEP to DC-iEK reflects the shift in understanding particle manipulation and separation mechanisms in these systems.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Shreyank Goel, Dipin S. Pillai
Summary: This paper investigates the electrowetting behavior of a charge-carrying droplet and develops a reduced-order electrokinetic model. The dependence of droplet deformation and wetting alteration on electric field parameters is studied numerically. The research findings are important for applications such as biomedical diagnostics.
Review
Biophysics
Vahid Kordzadeh-Kermani, Masoud Madadelahi, Seyed Nezameddin Ashrafizadeh, Lawrence Kulinsky, Sergio O. Martinez-Chapa, Marc J. Madou
Summary: This review introduces the on-board power supply and electrokinetic applications of electrified-LOD (eLOD) devices. By utilizing electrokinetic phenomena, different microfluids can be propelled, separated, and manipulated. While extensive research exists on stationary platforms, the applications on rotating platforms are still underdeveloped.
BIOSENSORS & BIOELECTRONICS
(2022)
Review
Biochemical Research Methods
Jared P. Smithers, Mark A. Hayes
Summary: The development of microfluidic manipulations has led to significant advances in the processing and detection of small volume samples. Effective isolation of single cells and manipulation of complex biomolecule mixtures allows for the utilization of information-rich detection methods. Delivering sub-nanoliter volumes of samples to a detection scheme has been achieved through spraying, meniscus-defined volumes, constrained volumes, and phase changes. This review presents selected publications highlighting the advancements and historical perspectives of these delivery techniques.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Maliha Saleem Bakhshi, Mohsin Rizwan, Ghulam Jilany Khan, Hong Duan, Kefeng Zhai
Summary: In this study, a novel two-stage, label-free, rapid, and continuous CTC separation device based on hydrodynamic inertial focusing and dielectrophoretic separation is proposed. The device can effectively separate CTCs from other blood cells, yielding viable CTCs with high efficiency.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Rodward L. Hewlin Jr, Maegan Edwards
Summary: Cell counting and sorting is crucial in biomedical research. This paper presents a computational simulation study on the continuous separation of red blood cells and platelets using dielectrophoresis in a microfluidic device with saw-tooth profile electrodes. The results suggest that this design can achieve rapid and efficient separation with low voltage and frequency settings.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Chemistry, Physical
Avijit Barik, Xiaoshu Chen, L. James Maher, Arthur E. Warrington, Moses Rodriguez, Sang-Hyun Oh, Nathan J. Wittenberg
Summary: The study demonstrates a gold nanogap electrode platform that utilizes low-voltage dielectrophoresis to rapidly create a linear array of biological particles and combines microfluidic buffer exchange to immobilize particles and introduce protein molecules. The platform can be used to study a variety of biomolecular interactions, making it a potential tool for portable biosensing platforms with improved detection limits in physiological buffers.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Engineering, Aerospace
Robert E. Weber, Janusz J. Petkowski, Monika U. Weber
Summary: Based on evidence of chemical disequilibria and other anomalous observations, it is motivated that there may be life within the Venusian atmosphere. The Fluid-Screen technology, which utilizes dielectrophoretic microbial particle capture, concentration, and separation, is capable of capturing and separating various biological particles. This article discusses the potential implementation of Fluid-Screen in the context of the Venus Life Finder missions and highlights its unique scientific output.
Article
Engineering, Chemical
Reza Derakhshan, Amirhosein Ghasemi, Reza Moradi, Abas Ramiar
Summary: This paper presents a comprehensive numerical investigation on particle/cell separation in circular microchannels using dielectrophoresis (DEP). The results show that the direction of particle deflection can be controlled by varying the geometrical parameters. By applying DEP, efficient separation of particles and cells based on their size and physical properties is achieved.
ADVANCED POWDER TECHNOLOGY
(2023)
Article
Chemistry, Analytical
Shahriar Shalileh, Mohammad Ali Khayamian, Mohammadreza Ghaderinia, Hamed Abadijoo, Hamed Hassanzadeh-Moghadam, Azam Dalman, Hossein Simaee, Mahsa Faramarzpour, Pooneh Ghaznavi, Pouya Soltan Khamsi, Fereshteh Abbasvandi, Mohammad Faranoush, Robab Anbiaei, Poopak Eftekhari-Yazdi, Mohammad Abdolahad
Summary: The study found that non-cancer cells exhibit a higher electrodeformation response, while malignant cells show a weaker stretch response. Utilizing this difference, a label-free mechanoelectrical chip was proposed for detecting metastatic cancer cells, presenting a new approach for cancer diagnosis and research.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Arash Dalili, Hossein Montazerian, Kabilan Sakthivel, Nishat Tasnim, Mina Hoorfar
Summary: This study investigated the factors affecting the displacement of particles in electrophoresis-based microseparators, finding that volumetric throughput has the greatest impact on particle position, with channel length being the most effective factor. The study also successfully demonstrated size-selective sorting or focusing of particles, providing valuable insights into designing microfluidic platforms for selectively separating different cell types in biofluids.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Biochemical Research Methods
Esra Sengul, Pouya Sharbati, Meltem Elitas, Monsur Islam, Jan G. Korvink
Summary: This article investigates the electrophysiological properties of glioblastoma cells and quantifies their population heterogeneity using dielectrophoresis phenomenon. The study reveals three distinct subpopulations of glioma cells with different dielectrophoretic characteristics.
Article
Nanoscience & Nanotechnology
Shayan Valijam, Alireza Salehi, Magnus Andersson
Summary: In this paper, a compact label-free microfluidic lab-on-a-chip device is proposed for the separation of circulating tumor cells (CTCs) and red blood cells (RBCs) at low voltage. The device utilizes a simple electrode arrangement with non-uniform electric fields generated by two arrays of shifted planar electrodes. The device shows high separation efficiency and allows for brightfield imaging of the channel, making it suitable for the early detection of CTCs.
MICROFLUIDICS AND NANOFLUIDICS
(2023)
Article
Biochemical Research Methods
Hwi Yong Lee, Cedrick Barber, Jessika A. Rogers, Adrienne R. Minerick
Article
Biochemical Research Methods
Chungja Yang, Chun-Jen Wu, Agnes E. Ostafin, Giselle Thibaudeau, Adrienne R. Minerick
Article
Biochemical Research Methods
Hwi Yong Lee, Cedrick Barber, Adrienne R. Minerick
Article
Ophthalmology
Maryam Khaksari, Lynn R. Mazzoleni, Chunhai Ruan, Robert T. Kennedy, Adrienne R. Minerick
EXPERIMENTAL EYE RESEARCH
(2017)
Article
Chemistry, Multidisciplinary
Zhuangqiang Gao, Haihang Ye, Dianyong Tang, Jing Tao, Sanaz Habibi, Adrienne Minerick, Dianping Tang, Xiaohu Xia
Article
Engineering, Chemical
Maryam Khaksari, Lynn R. Mazzoleni, Chunhai Ruan, Peng Song, Neil D. Hershey, Robert T. Kennedy, Mark A. Burns, Adrienne R. Minerick
Article
Materials Science, Multidisciplinary
J. L. Collins, H. Moncada Hernandez, S. Habibi, C. E. Kendrick, Z. Wang, N. Bihari, P. L. Bergstrom, A. R. Minerick
Article
Biochemical Research Methods
Sanaz Habibi, Hwi Yong Lee, Hector Moncada-Hernandez, James Gooding, Adrienne R. Minerick
Article
Chemistry, Multidisciplinary
Sanaz Habibi, Pratik U. Joshi, Xue Mi, Caryn L. Heldt, Adrienne R. Minerick
Article
Chemistry, Analytical
Muhammad Noman Hasan, Ran An, Asya Akkus, Derya Akkaynak, Adrienne R. Minerick, Chirag R. Kharangate, Umut A. Gurkan
Summary: Paper-based microchip electrophoresis shows potential for bringing lab tests to the point of need, but issues with high electrical values causing pH and temperature changes can impact the accuracy and reproducibility of tests. The development of HemeChip aims to provide low-cost, rapid, and accurate electrophoresis tests for hemoglobin analysis. Through pH and temperature characterization, and acid pretreatment of cellulose acetate paper, researchers were able to mitigate shifts and create a stable environment for reproducible hemoglobin electrophoresis separation on HemeChip.
Article
Biochemical Research Methods
Sanaz Habibi, Hwi Yong Lee, Hector Moncada-Hernandez, Adrienne R. Minerick
Summary: The ability to strategically induce or suppress cell lysis is critical for maintaining sub-cellular integrity in diagnostic and therapeutic applications. This study explores the use of a hafnium oxide layer and Triton X-100 surfactant to accurately induce or suppress red blood cell lysis in non-uniform AC electric fields, enhancing the versatility of electrokinetic diagnostics.
Article
Chemistry, Multidisciplinary
Ran An, Adrienne R. Minerick
Summary: This study presents a method for generating stable and spatiotemporally controllable gradients in a microfluidic environment using a reaction-free electrokinetic technique. The results suggest that ion concentration gradients can be established in a fluid by controlling the amplitudes and frequencies of the alternating current electric field. This research is important for both electrokinetic and biological applications.
Article
Chemistry, Analytical
Azade Tahmasebi, Sanaz Habibi, Jeana L. Collins, Ran An, Esmaeil Dehdashti, Adrienne Robyn Minerick
Summary: This research focuses on characterizing pH gradients in microfluidic devices, aiming to extend the parameter space for understanding the effects of microdevice-imposed artifacts on cells in clinical diagnostic devices. The results demonstrate that Faradaic reactions and HfO2 thin films play important roles in pH changes and can be influenced by frequency.
Article
Biochemical Research Methods
Zhichao Wang, Cornelius Ivory, Adrienne R. Minerick
Article
Multidisciplinary Sciences
Maryam Khaksari, Lynn R. Mazzoleni, Chunhai Ruan, Robert T. Kennedy, Adrienne R. Minerick