Article
Engineering, Multidisciplinary
Sameh Sherif, Yehya H. Ghallab, Mohamed T. El-Wakad, Yehea Ismail
Summary: Dielectrophoresis force offers an effective way to control particles, particularly for cell manipulation and separation. It has been applied in cell sorting and drug development. Dielectrophoresis force is used in cell trapping, alignment, separation, and isolation of particles of different sizes, which have various biological applications.
ALEXANDRIA ENGINEERING JOURNAL
(2023)
Article
Chemistry, Analytical
Seito Shijo, Daiki Tanaka, Tetsushi Sekiguchi, Jun-ichi Ishihara, Hiroki Takahashi, Masashi Kobayashi, Shuichi Shoji
Summary: We developed a microfluidic device that utilizes dielectrophoresis to selectively trap and extract droplets from multiple trapping pockets. The device includes a main microchannel, five droplet-trapping pockets with side channels, and drive electrode pairs positioned around the trapping pockets. Agarose droplets containing biological samples were successfully trapped in the pockets due to flow resistance differences. Under an applied voltage of 500 V, target droplets were selectively extracted using dielectrophoretic force. The device allows for the screening of encapsulated single cells and the targeted extraction of desired droplets.
Article
Biophysics
Sura A. Muhsin, Muthana Al-Amidie, Zhenyu Shen, Zahar Mlaji, Jiayu Liu, Amjed Abdullah, Majed El-Dweik, Shuping Zhang, Mahmoud Almasri
Summary: A microfluidic based biosensor was used for rapid and simultaneous detection of Salmonella, Legionella, and Escherichia coli O157:H7 in tap water and wastewater. The biosensor concentrated and detected bacteria at both low and high concentrations. The results showed that the biosensors could detect the three bacterial pathogens simultaneously with a detection limit of 3 bacterial cells/mL in 30-40 minutes.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biochemical Research Methods
Ruben Van den Eeckhoudt, An-Sofie Christiaens, Frederik Ceyssens, Vasileios Vangalis, Kevin J. Verstrepen, Nico Boon, Filip Tavernier, Michael Kraft, Irene Taurino
Summary: This paper introduces a microfluidic device for full-electric cell capturing, analyzing, and selectively releasing single cells. The device was experimentally demonstrated on Saccharomyces cerevisiae, showing potential for small-scale, high-throughput single-cell analysis and sorting.
Article
Biochemical Research Methods
Ruben van den Eeckhoudt, An-Sofie Christiaens, Frederik Ceyssens, Vasileios Vangalis, Kevin J. Verstrepen, Nico Boon, Filip Tavernier, Michael Kraft, Irene Taurino
Summary: This paper presents a microfluidic device that combines a method for capturing, analyzing, and selectively releasing single cells with full-electricity. The device validates a new Two-Voltage method for capturing single cells by positive dielectrophoresis (pDEP) and utilizes broadband electrochemical impedance spectroscopy for cell analysis. The device also allows for selective release of trapped cells by turning off the pDEP signal in their trap.
Article
Nanoscience & Nanotechnology
Ngoc-Viet Nguyen, Tu Le Manh, Tang Son Nguyen, Viet Thong Le, Nguyen Van Hieu
Summary: DEP is a cost-effective technique for manipulating biological particles in microfluidics. This study presents an advanced solution strategy for focusing and separating cancerous cells, with theoretical calculations and a simulation model determining optimal parameters. The proposed method shows potential as a simple, low-cost approach to enhance cancer detection at early stages.
JOURNAL OF SCIENCE-ADVANCED MATERIALS AND DEVICES
(2021)
Article
Energy & Fuels
Reza Derakhshan, Arash Mahboubidoust, Abas Ramiar
Summary: This paper introduces a novel design for high-throughput and efficient separation of different cell populations using Traveling Surface Acoustic Wave (TSAW) and Dielectrophoresis (DEP) simultaneously. Through numerical simulation and experimental studies, the effectiveness of the design was demonstrated, which could play an important role in microfluidic chip and clinical diagnostic applications.
CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION
(2021)
Article
Engineering, Electrical & Electronic
Martin Hantschke, Iasonas F. Triantis
Summary: This study investigates the effects of electrode topology and configuration on tetrapole electrical impedance measurement systems in microfluidic devices. Different electrode configurations were found to exhibit fundamental differences in sensitivity distribution, affecting performance when measuring heterogeneous fluids.
IEEE SENSORS JOURNAL
(2021)
Article
Biotechnology & Applied Microbiology
Po-Yu Chu, Chia-Hsun Hsieh, Chih-Yu Chen, Min-Hsien Wu
Summary: Optically induced dielectrophoresis (ODEP) is effective for cell manipulation but limited by low conductivity solutions. This study found that using sucrose solution in ODEP operation can decrease cell viability significantly. However, supplementing sucrose solution with bovine serum albumin (BSA) can improve cell viability and operational efficiency.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Mathematics, Applied
Vladislav V. Kravchenko, Victor A. Vicente-Benitez
Summary: The Sturm-Liouville equation is studied in this article, focusing on the characterization of spectral data and the solution with a specific boundary condition. The Jost solution is represented by a power series with a parameter, and this representation provides an explicit expression for spectral data and an analytic method for computation.
MATHEMATICAL METHODS IN THE APPLIED SCIENCES
(2023)
Article
Engineering, Multidisciplinary
Liangzhu Yuan, Jinying Li, Yongmei Huang, Piao Wen, Jianliang Shi, Huayang Xia, Rongqi Ma
Summary: This paper proposes an analytical inverse solution method for a rotational achromatic Risley prism system based on Fourier series fitting, aiming to solve the time-consuming problem of the current numerical iteration method. By inversely fitting the expression of the difference between the rotation angle and elevation angle with the forward solution model, the analytical inverse solution is achieved through a two-step method. Simulation results show that the maximum azimuthal error is less than 2.23e 8 arcsec and the maximum elevation error is less than 1.33e 4 arcsec. Experimental results demonstrate that the proposed method achieves 1 arcsec pointing accuracy with a time consumption of only 0.108 ms, while the previous numerical-iteration-based method requires 1.480 ms.
PRECISION ENGINEERING-JOURNAL OF THE INTERNATIONAL SOCIETIES FOR PRECISION ENGINEERING AND NANOTECHNOLOGY
(2023)
Article
Automation & Control Systems
Hyunwook Lee, Jee-Hwan Ryu, Jinoh Lee, Sehoon Oh
Summary: This article provides a new insight into the achievable stiffness limitation of series elastic actuators (SEAs) by comparing energy ports and passivity control frameworks. It is found that the load port passivity has less conservatism, allowing for larger achievable stiffness in impedance-controlled SEAs. This novel port passivity analysis and control framework can achieve a much higher maximum rendered stiffness than previously perceived.
IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS
(2021)
Article
Biochemical Research Methods
Chang-Ho Han, Jaesung Jang
Summary: An immunosensor utilizing electrohydrodynamic focusing and DEP concentration was developed for continuous and label-free detection of flowing Staphylococcus aureus. The sensor demonstrated good linearity in detecting S. aureus concentrations, with a capture time of 35 min and a limit of detection of 150 CFU mL(-1). The use of electrical manipulation and biological interaction also provided high specificity in measurements.
Article
Engineering, Biomedical
Can Huang, Song- Han, Han Zhang, Arum Han
Summary: Microfluidic lab-on-a-chip systems provide cost-effective and time-efficient biological assays at a small volume scale. Dielectrophoretic (DEP)-based manipulation technologies, due to their label-free and high selectivity natures, have been extensively developed for accurate and specific cell and reagent control. This article provides a tutorial on developing DEP-based microfluidic systems, including theory, simulation, microfabrication, and applications. Possible future directions on utilizing DEP-based technologies to overcome challenges and improve microfluidic lab-on-a-chip systems are suggested.
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
(2023)
Article
Computer Science, Information Systems
Chinnapalli Likith Kumar, A. Vimala Juliet, Bandaru Ramakrishna, Shubhangi Chakraborty, Mazin Abed Mohammed, Kalakanda Alfred Sunny
Summary: Microfluidic channels are crucial in separating analytes like bacteria and platelet cells and a computational model was specifically designed to study the effects of design parameters for the separation of E. coli from blood constituents. The study found that electrode potentials and placement, as well as electric potential, play a role in optimizing selective particle separation. Multiple governing parameters in computer aided simulations can aid in design optimization for precise bioparticle separation.
CMC-COMPUTERS MATERIALS & CONTINUA
(2021)
Article
Chemistry, Analytical
Abed Mourad, Aissa Abderrahmane, Obai Younis, Riadh Marzouki, Anas Alazzam
Summary: This paper presents a numerical study of magnetohydrodynamics natural convection and entropy production of Cu-water nanofluid in a porous annulus between a heated Koch snowflake and wavy cylinder. The impacts of various parameters on distributions of isotherms, streamlines, mean Nusselt number, and entropy production are thoroughly examined.
Review
Materials Science, Multidisciplinary
Abdulrahman Agha, Waqas Waheed, Nahla Alamoodi, Bobby Mathew, Fadi Alnaimat, Eiyad Abu-Nada, Aissa Abderrahmane, Anas Alazzam
Summary: COC is a special thermoplastic material composed of cyclic olefin monomers and linear olefins, with advantages such as low water absorption and high electrical insulation. It has been widely used in the fabrication of microfluidic devices.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Muayad Abujabal, Heba Abunahla, Baker Mohammad, Anas Alazzam
Summary: This study reports the fabrication of a novel planar reduced graphene oxide memristor device, with tunable resistive switching behavior controlled by the reduction time. The device has analog switching characteristics and can be precisely controlled by adjusting the reduction period.
Review
Energy & Fuels
Abed Mourad, Abderrahmane Aissa, Zafar Said, Obai Younis, Misbah Iqbal, Anas Alazzam
Summary: This review presents recent advancements in integrating PCMs into solar collectors and discusses strategies and improvement approaches to enhance their performance.
JOURNAL OF ENERGY STORAGE
(2022)
Review
Biochemical Research Methods
Abdulla Al-Ali, Waqas Waheed, Eiyad Abu-Nada, Anas Alazzam
Summary: Particle separation plays a vital role in various systems, and microfluidics offers a promising method for achieving this. Microfluidics enables precise manipulation and separation of particles at the micrometer scale using well-defined structures and controlled force fields. Depending on the types of forces involved, microfluidic particle manipulation can be classified as active or passive. Active microfluidics allows real-time control and placement of particles, while passive microfluidics offers simplicity and high throughput. Hybrid techniques combining both active and passive processes have been developed to optimize particle separation. This study provides a comprehensive review and evaluation of hybrid devices based on dielectrophoresis, discussing their principles, advantages, and disadvantages. Additionally, it offers a thorough explanation of dielectrophoresis concepts and operating procedures, along with an examination of the advantages and disadvantages of DEP-based separation devices. The challenges and future prospects of the hybrid separation sector are also discussed.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Article
Multidisciplinary Sciences
Nosayba Al-Azzam, Anas Alazzam
Summary: The wettability of a polymer surface is crucial for cell-cell interaction and behavior. This article investigated two techniques, oxygen plasma treatment and graphene oxide coating, to pattern the surface wettability of a COC substrate in order to create hydrophilic patterned regions on a hydrophobic surface. Comparing the two techniques, GO coating resulted in a more stable wettability and increased roughness of the patterned area. Both techniques effectively modulated cell adhesion and achieved micropatterning of cell growth.
Article
Materials Science, Multidisciplinary
Ahmad Chaim, Heba Abunahla, Baker Mohammad, Nahla Alamoodi, Anas Alazzam
Summary: The development of flexible memristor devices using paper-based graphene oxide has great potential for wearable electronics. The PrMem device, made of cellulose and reduced graphene oxide, demonstrates resistive switching properties and eliminates the need for additional pumping structures due to its hydrophilic nature. The research opens up new possibilities for using paper-based memristor devices in various applications.
Article
Biochemical Research Methods
Anas Alazzam, Nahla Alamoodi, Bobby Mathew, Mohammad Abutayeh, Saud Khashan
Summary: This research demonstrates the fabrication of electrically tunable graphene oxide (GO) films. GO thin films were deposited and patterned on a cyclic olefin copolymer (COC) substrate using plasma-enhanced liftoff technique. The article discusses thermal, chemical, and photoreduction methods for controlling the electrical conductivity of the patterned film. The patterned graphene oxide films were used to manipulate cells in a microfluidic channel, employing dielectrophoresis (DEP) with patterned reduced graphene oxide (rGO) films of different electrical conductivities.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Review
Thermodynamics
Abderrahmane Aissa, Naef A. A. Qasem, Abed Mourad, Houssem Laidoudi, Obai Younis, Kamel Guedri, Anas Alazzam
Summary: This paper investigates and emphasizes the significance of combining the effect of employing nanofluids and turbulence generators in solar collectors to increase thermal performance and extract more usable solar energy.
APPLIED THERMAL ENGINEERING
(2023)
Article
Chemistry, Analytical
Fatima Alshehhi, Waqas Waheed, Abdulla Al-Ali, Eiyad Abu-Nada, Anas Alazzam
Summary: In this study, the motion of a microparticle in a microchannel under the influence of a standing surface acoustic wave (SSAW) was simulated using the Immersed Boundary-Lattice Boltzmann Method (IB-LBM). The microparticles were found to move towards the pressure node locations when the SSAW was applied. The transient response of the particles was affected by their geometric parameters, such as radius, density, and compressibility.
Article
Chemistry, Multidisciplinary
Heba N. Abunahla, Humaira Zafar, Dalaver H. Anjum, Anas Alazzam, Baker Mohammad
Summary: The study presents a novel fabrication method for graphene oxide (GO)-based memristor devices on an active/shrinkable substrate. The devices are fabricated using standard lithography process on a polymer substrate that can shrink at a certain temperature. The results demonstrate that the shrunk devices maintain their switching ability with improved electrical parameters, while the deposited GO film on the active substrate shows enhanced properties after shrinking. This novel approach offers insights into scaling thin-film electronics postfabrication and enables the realization of GO-based electronic devices with improved electrical properties.
Article
Polymer Science
Abdulrahman Agha, Fadi Dawaymeh, Nahla Alamoodi, Eiyad Abu-Nada, Anas Alazzam
Summary: COC is a promising material for microfluidic applications due to its unique properties. A new fabrication process combining fabrication and bonding processes in a single step was implemented, utilizing COC's swelling behavior and chemical compatibility. The effect of immersion time on microchannel height was investigated, achieving a maximum height of 50 ± 3μm. Bonding quality was evaluated through leakage and tensile tests. Three diverse microfluidic applications were successfully executed, demonstrating the effectiveness of the process.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Biochemical Research Methods
Hyeono Nam, Jong-Eun Park, Waqas Waheed, Anas Alazzam, Hyung Jin Sung, Jessie S. Jeon
Summary: Traveling surface acoustic waves (SAWs) were used for the lysis of cancer cells without any chemical reagents, followed by Raman spectrum profiling to explore detailed cell-derived data. Mechanical cell lysis was achieved using polystyrene microparticles (PSMPs) and the Raman signals from the lysed cells were enhanced by gold nanoparticles (AuNPs) through nanogaps formed by the AuNPs. The lysis efficiency was evaluated by varying the size and concentration of the PSMPs.
Review
Computer Science, Information Systems
Rami Homsi, Nosayba Al-Azzam, Baker Mohammad, Anas Alazzam
Summary: Detecting cancer biomarkers at an early stage is crucial for recovery, and researchers have been interested in developing reliable and cost-effective devices for point-of-care screening. This review focuses on memristive biosensors and compares them to other electrochemical devices for cancer biomarker detection. Memristive biosensors have demonstrated lower limits of detection compared to field effect transistors and electrochemical immunosensors. The fabrication of memristive biosensors using silicon nanowires is common but exploring different materials and structures may improve reproducibility.
Article
Mathematics, Interdisciplinary Applications
Waqas Waheed, Eiyad Abu-Nada, Anas Alazzam
Summary: This study investigates the electrokinetic manipulation of microparticles within microchannels under low Reynolds number conditions. The researchers used the immersed boundary-lattice Boltzmann method (IB-LBM) for simulations and validated their results through benchmarking studies. The experimental data show good agreement with the numerical simulations.
COMPUTATIONAL PARTICLE MECHANICS
(2023)
