Article
Multidisciplinary Sciences
Joyce Pinto, Malgorzata Debowska, Rafael Gomez, Jacek Waniewski, Bengt Lindholm
Summary: In non-anuric patients undergoing peritoneal dialysis, urine volume correlates positively with removed solute masses and weekly residual renal clearances, suggesting that it can be used as an estimator of typical values of residual solute removal indices in these patients.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Parsaoran Siahaan, Nurwarrohman Andre Sasongko, Retno Ariadi Lusiana, Vivitri Dewi Prasasty, Muhamad Abdulkadir Martoprawiro
Summary: The study investigated the interaction of chitosan dimer with urea and creatinine using DFT, revealing that creatinine easily binds to chitosan and transports electrons more efficiently than urea due to stronger hydrogen bond interaction. This suggests that creatinine can be transported more effectively through the chitosan membrane during hemodialysis process.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Materials Science, Multidisciplinary
M. A. Parvez Mahmud, Sajad Razavi Bazaz, Soroush Dabiri, Ali Abouei Mehrizi, Mohsen Asadnia, Majid Ebrahimi Warkiani, Zhong Lin Wang
Summary: Energy harvesting from ambient sources such as mechanical vibrations, thermal gradients, electromagnetic radiations, and solar radiations has made significant progress in recent times. The use of micro-electromechanical system (MEMS) and microfluidics technologies has allowed for downsizing of energy harvesters while ensuring a stable and portable power supply. This paper reviews advancements in energy harvesting technologies and discusses the potential applications and challenges in MEMS and microfluidics for energy harvesting.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Review
Chemistry, Analytical
Jianyu Han, Songqin Liu, Zhi Wang, Yafeng Wu
Summary: This review systematically summarizes the recent advances in micro/nanofluidic-electrochemical biosensors for in situ tumor cell analysis, including circulating tumor cells, biomarkers on tumor cells, and biomarkers secreted by tumor cells. The technology offers advantages of high sensitivity, easy integration, and low cost.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Article
Medicine, General & Internal
Ha-Jin Lim, Seung-Yeob Lee, Hyun-Jung Choi
Summary: The accuracy of ABL90 FLEX PLUS in measuring creatinine and blood urea nitrogen was evaluated, and suitable candidate specimens were identified. The results showed that ABL90 FLEX PLUS had mean differences of -0.10 and -3.51 mg/dL for creatinine and blood urea nitrogen, respectively, compared to other analyzers. Serum was found to be suitable for creatinine testing using ABL90 FLEX PLUS, while citrated whole-blood did not meet the acceptance criteria.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Food Science & Technology
Mehdi Sadeghian, Sepideh Rahmani, Arash Jafarieh, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: A meta-analysis was conducted to evaluate the effect of oral curcumin on serum levels of creatinine and blood urea nitrogen (BUN). The results showed that oral curcumin supplementation significantly improved creatinine levels but increased BUN levels. Subgroup analysis indicated that longer duration of curcumin intervention had a more favorable effect on serum BUN levels. This suggests that oral curcumin with high bioavailability can positively impact creatinine and BUN levels in patients with inflammatory diseases when supplemented for > 8 weeks.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Engineering, Aerospace
Steven Pugia, Anthony Cofer, Alina Alexeenko
Summary: Compact micronewton thrusters can provide attitude control and enhance mission duration and precision pointing. The novel micropropulsion device, FEMTA, generates thrust by heating water capillary and has been tested under high vacuum. The research shows controllable thrust and long specific impulse, but the current design has an issue of undesired propellant loss rate.
Article
Biophysics
Laszlo Kekedy-Nagy, James M. Perry, Samuel R. Little, Oriol Y. Llorens, Steve C. C. Shih
Summary: We have developed a new on-off, cost-effective, and rapid electrochemical aptasensor combined with a microfluidics cartridge system for the detection of Delta(9)-THC in human saliva. The sensor showed a high sensitivity to Delta(9)-THC and can detect it at a concentration as low as 1 nM in PBS. However, the presence of raw human saliva significantly increased the limit of detection due to interfering elements. With saliva filtration, the limit of detection improved to 5 nM, which is lower than the concentrations associated with impairment.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Physical
Guo-Lin Yang, Chi -Tien Hsieh, Yeu-Shiuan Ho, Tung-Chun Kuo, Youngkook Kwon, Qi Lu, Mu-Jeng Cheng
Summary: By coelectrolysis of CO2 with nitrogen compounds, molecules containing C-N bonds can be generated and synthesized on Cu(111). It has been discovered that the first C-N bond formation occurs through the coupling of gaseous CO2 with surface-bound N1 intermediates generated during the reduction of NO3-/NO2- to NH3, rather than through intermediates from CO2 electrochemical reduction (CO2ER) to CO. The reaction follows the Eley-Rideal mechanism and only requires a single active site.
Article
Critical Care Medicine
M. Volbeda, L. Hessels, R. A. Posma, S. J. Bakker, M. W. Nijsten
Summary: Baseline urinary creatinine excretion (UCE) is associated with ICU outcome, but its time course is not known. Changes in UCE, plasma creatinine, measured creatinine clearance (mCC) and estimated glomerular filtration (eGFR) over 30 days in ICU patients without acute kidney injury stage 3 were examined. UCE decreased by 1% per day, potentially corresponding to muscle mass decline, while eGFR estimates increased progressively during ICU stay.
JOURNAL OF CRITICAL CARE
(2021)
Article
Engineering, Environmental
Taner Yildiz, Ilknur Erucar
Summary: In this study, the adsorption-based uremic toxin separation performance of bio-compatible MOFs was assessed and it was found that certain bio-MOFs outperformed traditional adsorbents. Furthermore, the multi-component adsorption of uremic toxins in bio-MOFs was examined and it was observed that the amount of adsorbed water slightly increased while the amount of adsorbed urea significantly decreased.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Engineering, Chemical
Wenyan Li, Shen Chao, Yumei Li, Fuquan Bai, Yakun Teng, Xiang Li, Lijuan Li, Ce Wang
Summary: The dual-layer composite nanofiber membrane prepared in the study exhibits good adsorption capacity for creatinine and urea, with maximum adsorption capacities of 100.50 mg/g and 152.44 mg/g respectively. The membrane also shows excellent blood compatibility.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Chemistry, Analytical
Renjie Wang, Xuewei Wang
Summary: This review focuses on the widespread adoption of microfluidics for chemical analysis in the past two decades, with a particular emphasis on the sensing of inorganic ions in microfluidic devices. Various ion sensing schemes and microfluidic platforms are covered, providing insights into the development and potential advancements of microfluidic ion sensors.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Environmental Sciences
Nida Sohail, Khan Hira, Junaid Ahmed Kori, Hafiza Farhat, Faizah Urooj, Waqas Khan, Viqar Sultana, Muhammad Shaiq Ali, Syed Ehteshamul-Haque
Summary: Ethanol extract of Ulva fasciata has a nephroprotective effect and can attenuate cisplatin-induced renal dysfunction. It is more effective than its solvent fractions and may be used as a dietary supplement.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Nanoscience & Nanotechnology
Albert Cisquella-Serra, Marc Galobardes-Esteban, Manuel Gamero-Castano
Summary: This article introduces a microfabrication technique for creating scalable multiemitter electrospray sources and demonstrates their excellent propulsive performance through testing. Design elements such as a network of microfluidic channels, accurate alignment, and a pipe-flow configuration contribute to the improved performance and protection of propellant.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Analytical
Yu-Jen Cheng, Chih-Hung Wang, Keng-Fu Hsu, Gwo-Bin Lee
Summary: In this study, an integrated microfluidic system was developed to automatically capture and quantify the methylation level of cfDNA. The system achieved high capture rate and low limit of quantification, allowing for efficient detection of methylated cfDNA from plasma samples in a short time.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemical Research Methods
Rishabh Gandotra, Hung-Bin Wu, Priya Gopinathan, Yi-Cheng Tsai, Feng-Chih Kuo, Mel S. Lee, Gwo-Bin Lee
Summary: Periprosthetic joint infections (PJIs) are serious complications that are difficult to diagnose accurately, but a newly developed HNP 1 aptamer and associated assay may help improve diagnostic accuracy and assess treatment responses for PJI.
Article
Chemistry, Analytical
Yu-Hung Cheng, Chih-Hung Wang, Keng-Fu Hsu, Gwo-Bin Lee
Summary: Ovarian cancer is one of the most severe gynecologic cancers with asymptomatic early stages. This study developed an integrated microfluidic chip that can extract cfDNA from plasma, detect and quantify mutations in the OvCa biomarker BRCA1. By automating the cfDNA extraction and qPCR processes, this chip can be used for clinical screening of OvCa-associated mutations.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Yi-Sin Chen, Chihchen Chen, Charles Pin-Kuang Lai, Gwo-Bin Lee
Summary: This study developed a membrane-based EV isolation/counting platform that can efficiently isolate and quantify specific EVs from blood. The platform has a limit of detection of 105 EVs/mL, demonstrating high sensitivity for disease diagnostics.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
You-Ru Jhou, Chih-Hung Wang, Huey-Pin Tsai, Yan-Shen Shan, Gwo-Bin Lee
Summary: An integrated microfluidic platform utilizing real-time reverse-transcription loop-mediated isothermal amplification was developed for detection and quantification of three genes of SARS-CoV-2, providing a useful tool for COVID-19 diagnostics.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Biophysics
Rishabh Gandotra, To -Wen Chen, Feng-Chih Kuo, Mel S. Lee, Gwo-Bin Lee
Summary: In this study, a new microfluidic platform based on magnetic beads and fluorescent probes was developed to detect α-defensin and human neutrophil protein 1 (HNP 1) in synovial fluid. The method showed high sensitivity and specificity, and could rapidly and accurately detect infection biomarkers within 60 minutes. This compact device with a wide dynamic range has great potential for future diagnostics of periprosthetic joint infection.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
Tsung-Han Lu, Nai-Jung Chiang, Yi-Cheng Tsai, Priya Gopinathan, Chien-Jui Huang, Jui-Lin Chang, Hsiu-Chi Tu, Yan-Shen Shan, Shang-Cheng Hung, Gwo-Bin Lee
Summary: Cancer can have devastating consequences and is often difficult to detect in its early stages. A new automated integrated microfluidic system has been developed to improve the diagnosis of bile duct cholangiocarcinoma (CCA), a type of cancer that is challenging to diagnose. This system uses three CCA-specific affinity reagents to detect tumor cells in a small sample of CCA patient bile and can automate the entire detection process in just 80 minutes.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
To-Wen Chen, Rishabh Gandotra, Hwan-You Chang, Mel S. Lee, Feng-Chih Kuo, Gwo-Bin Lee
Summary: This study developed a novel integrated microfluidic system (IMS) for detecting two common periprosthetic joint infection (PJI) biomarkers, alpha defensin human neutrophil peptide 1 (HNP-1) and C-reactive protein (CRP), from synovial fluid (SF). The system automatically carried out a magnetic bead-based one-aptamer-one-antibody assay within 45 minutes on a single chip, enabling simultaneous detection of both biomarkers at specific concentration ranges. It is the first report to utilize these two biomarkers as targets in an on-chip assay, and the IMS showed promising diagnostic accuracy in clinical samples.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Rishabh Gandotra, Feng-Chih Kuo, Mel S. Lee, Gwo-Bin Lee
Summary: This study introduces a paper-based microfluidic chip for the quantitative detection of HNP 1 in synovial fluid, providing a rapid and cost-effective diagnostic tool for periprosthetic joint infections (PJI) cases. The chip demonstrates high sensitivity and selectivity, with a wide dynamic range, making it a promising solution for PJI diagnosis in clinical settings.
ANALYTICA CHIMICA ACTA
(2023)
Proceedings Paper
Engineering, Electrical & Electronic
Chi-Chien Huang, Chia-Yu Sung, Yi-Sin Chen, Keng-Fu Hsu, Gwo-Bin Lee
Summary: This study reports an integrated microfluidic system for automated extraction and quantification of extracellular vesicle-derived microRNA from ovarian cancer. By using specific beads, the capture rate of extracellular vesicles was improved and two microRNA biomarkers were simultaneously detected and quantified, providing a precise and specific diagnostic tool for OvCa.
2022 IEEE 35TH INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS CONFERENCE (MEMS)
(2022)
Proceedings Paper
Engineering, Electrical & Electronic
Yi-Da Chung, Yuan-Jhe Chuang, Chang-Ni Lin, Keng-Fu Hsu, Gwo-Bin Lee
Summary: An integrated microfluidic platform has been developed for automating the entire process of OCCC diagnosis, discovering the strong correlation between FXYD2 gene expression and OCCC, and proposing a new protocol for FXYD2 gene detection.
2021 34TH IEEE INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS (MEMS 2021)
(2021)
Proceedings Paper
Engineering, Electrical & Electronic
Chi-Chien Huang, Yu-Husan Kuo, Yi-Sin Chen, Gwo-Bin Lee
Summary: Liquid biopsy is a non-invasive method crucial for early diagnosis of breast cancer. The study showed that an integrated microfluidic system using field-effective-transistor biosensors can detect targeted microRNA associated with breast cancer accurately and rapidly.
2021 34TH IEEE INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS (MEMS 2021)
(2021)
Proceedings Paper
Engineering, Electrical & Electronic
Chia-Yu Sung, Chi-Chien Huang, Yi-Sin Chen, Gwo-Bin Lee
Summary: This study used an automated method to detect microRNA-21 in plasma, achieving a very low limit of detection of 1.4 attomolar. The promising device could potentially be used for clinical cancer diagnosis and point-of-care applications in the near future.
2021 34TH IEEE INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS (MEMS 2021)
(2021)
Article
Biochemical Research Methods
Yi-Da Chung, Ting-Hang Liu, Yu-Ling Liang, Chang-Ni Lin, Keng-Fu Hsu, Gwo-Bin Lee
Summary: An integrated microfluidic system was developed for detecting the ovarian clear cell carcinoma biomarker FXYD2 automatically. This system could perform a series of operations from handling ascites to detecting RNA levels on a single microfluidic chip, offering potential for OCCC diagnosis and prognosis.
Article
Biochemical Research Methods
Mohammad Osaid, Yi-Sin Chen, Chih-Hung Wang, Anirban Sinha, Wen-Bin Lee, Priya Gopinathan, Hung-Bin Wu, Gwo-Bin Lee
Summary: The study developed a microfluidic platform for rapid antimicrobial susceptibility testing, including dilution of antibiotics and distribution of bacteria, which can improve efficiency and accuracy of the testing process.