Article
Immunology
Siyuan Weng, Zaoqu Liu, Xiaofeng Ren, Hui Xu, Xiaoyong Ge, Yuqing Ren, Yuyuan Zhang, Qin Dang, Long Liu, Chunguang Guo, Richard Beatson, Jinhai Deng, Xinwei Han
Summary: The study identified that the SCG2 gene is closely associated with the chemotherapy response in colorectal cancer patients, with high expression predicting poorer prognosis and showing significantly higher expression in the APC non-mutation group. The SCG2 high expression subgroup is more suitable for immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yan Lin, Xiaoli Liao, Yumei Zhang, Guobin Wu, Jiazhou Ye, Shanshan Luo, Xinxin He, Min Luo, Mingzhi Xie, Jinyan Zhang, Qian Li, Yu Huang, Sina Liao, Yongqiang Li, Rong Liang
Summary: This study suggests that the mutant type (HR-MUT) of the Homologous recombination (HR) pathway may impact the chemotherapy sensitivity and prognosis of colorectal cancer (CRC) patients. HR-MUT patients have a lower probability of tumor metastasis after chemotherapy, and HR-MUT can be used as an independent predictor of chemotherapy prognosis for CRC patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Genetics & Heredity
Yali Liu, Harry Cheuk-Hay Lau, Wing Yin Cheng, Jun Yu
Summary: Colorectal cancer (CRC) is a common and deadly form of cancer, with both genetic and environmental factors playing a role in its development. Dysbiosis in the gut microbiome has been identified as a risk factor for CRC. Recent data has shown that the gut microbiome is directly involved in DNA damage, inflammation, and drug resistance in CRC, suggesting that modulating the gut microbiome could be a powerful tool in prevention and therapy. This article provides an overview of the relationship between the gut microbiome and CRC, explores the mechanisms of colorectal tumorigenesis, and discusses the potential of bacterial species as clinical biomarkers.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2023)
Article
Medical Laboratory Technology
Qian Gong, Xiuming Zhang, Aifeng Liang, Sinian Huang, Guangang Tian, Mengjiao Yuan, Qing Ke, Yijun Cai, Bin Yan, Jin Wang, Jinjin Wang
Summary: This study identified potential tumor markers for CRC through quantitative glycoproteomics analysis of CRC tissues and serum samples. Results indicate that ICAM1 and APMAP show promise as early immune diagnosis markers for CRC with excellent sensitivity and specificity. Ultimately, these findings suggest the potential use of ICAM1 and APMAP as valuable biomarkers for colorectal cancer.
CLINICA CHIMICA ACTA
(2021)
Article
Oncology
Chengxing Wang, Xiaoping Li, Liangliang Ren, Changyi Ma, Meimei Wu, Weijun Liang, Jinglin Zhao, Shangren Li, Qunying Tan, Yuehua Liao, Lixia Sun, Xin Zhang, Yaoming He
Summary: Elevated Gankyrin expression was confirmed in CRC patients, which was positively correlated with disease progression and liver metastasis, leading to worse prognosis. Therefore, Gankyrin may serve as a potential biomarker for early diagnosis of CRC with occult liver metastasis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Christopher Schrecker, Sophia Behrens, Rebecca Schoenherr, Anne Ackermann, Daniel Pauli, Guido Plotz, Stefan Zeuzem, Angela Brieger
Summary: This study highlights the significance of SPTAN1 in CRC development and chemotherapy response, identifying it as a potential biomarker for predicting patient survival and treatment outcomes.
Article
Medicine, General & Internal
Farah J. Nassar, Zahraa S. Msheik, Maha M. Itani, Remie El Helou, Ruba Hadla, Firas Kreidieh, Rachelle Bejjany, Deborah Mukherji, Ali Shamseddine, Rihab R. Nasr, Sally N. Temraz
Summary: CRC is the second leading cause of cancer deaths worldwide, with poor prognosis for Stage IV patients and liver metastasis as the main cause of mortality. miRNA shows potential as non-invasive diagnostic biomarkers for CRC, with specific panels of miRNA having diagnostic accuracy for advanced CRC and liver metastasis.
Article
Biology
Andrea Gsur, Andreas Baierl, Stefanie Brezina
Summary: The CORSA study in Austria aims to discover prognostic and diagnostic biomarkers for colorectal cancer using omics research. With over 13,500 participants recruited, the study has generated valuable data and established a comprehensive database for ongoing and future research collaborations nationally and internationally. Additionally, the study is closely connected with a two-stage CRC screening project in Burgenland, involving FIT tests for initial screening and further recruitment of participants.
Review
Medicine, General & Internal
Jia-Ming Wu, Ao Zhang, Yu Dong, Si-Hong Lin, Jin-Cheng Meng, Can-Tu Fang
Summary: Colorectal cancer is the second leading cause of cancer-related deaths worldwide, with a high rate of metastasis. This case study reports a rare occurrence of testicular metastasis from ascending colon cancer.
Review
Oncology
Katyana Amilca-Seba, Michele Sabbah, Annette K. Larsen, Jerome A. Denis
Summary: The mortality of colorectal cancer is linked to metastatic disease and undetectable micro-metastasis growth. Therapeutic strategies are efficient for locally advanced cancer but struggle to cure metastatic disease due to drug resistance and aggressive phenotype. Osteopontin is emerging as a valuable biomarker in various cancer types, including CRC, and shows potential as a therapeutic target.
Article
Biology
Aojia Zhuang, Aobo Zhuang, Yijiao Chen, Zhaoyu Qin, Dexiang Zhu, Li Ren, Ye Wei, Pengyang Zhou, Xuetong Yue, Fuchu He, Jianmin Xu, Chen Ding
Summary: This study used LC-MS/MS to analyze proteins in tumor samples from T1 CRC patients and established a classifier for predicting LNM. Additionally, the study found that the expression patterns of certain proteins are associated with metastasis in T1 CRC and explored the underlying mechanisms.
Article
Cell Biology
Guillermo Solis-Fernandez, Ana Montero-Calle, Javier Martinez-Useros, Alvaro Lopez-Janeiro, Vivian de los Rios, Rodrigo Sanz, Jana Dziakova, Elena Milagrosa, Maria Jesus Fernandez-Acenero, Alberto Pelaez-Garcia, Jose Ignacio Casal, Johan Hofkens, Susana Rocha, Rodrigo Barderas
Summary: In this study, quantitative spatial proteomics analysis was used to investigate lymph nodes, liver, and lung metastasis in colorectal cancer (CRC). The results revealed dysregulation of protein abundance and localization in these metastatic sites, with proteins such as GLG1 and MUC5AC being associated with poor prognosis and diagnosis of CRC.
Article
Oncology
Jiaxin Luo, Lingxi Jiang, Changyu He, Minmin Shi, Zhong-Yin Yang, Min Shi, Sheng Lu, Chen Li, Jun Zhang, Min Yan, Zheng-Gang Zhu, Chao Yan
Summary: This study found that the expression levels of microRNAs in peritoneal lavage samples of gastric cancer patients are associated with peritoneal metastasis. Specifically, hsa-let-7g-3p and hsa-miR-10395-3p have been identified as biomarkers predicting peritoneal metastasis and the efficacy of intraperitoneal chemotherapy.
Article
Cell Biology
Ana Montero-Calle, Sofia Jimenez de Ocana, Ruth Benavente-Naranjo, Raquel Rejas-Gonzalez, Ruben A. Bartolome, Javier Martinez-Useros, Rodrigo Sanz, Jana Dziakova, Maria Jesus Fernandez-Acenero, Marta Mendiola, Jose Ignacio Casal, Alberto Pelaez-Garcia, Rodrigo Barderas
Summary: SPRYD7 is a novel protein associated with CRC progression and metastasis, and its overexpression is associated with poor survival and an aggressive phenotype in CRC patients.
Article
Multidisciplinary Sciences
Jinyao Shi, Zhouqiao Wu, Xiaolong Wu, Longtao Huangfu, Ting Guo, Xiaojing Cheng, Jing Han, Ziyu Li, Xiaofang Xing, Jiafu Ji
Summary: This study used multi-omics data of 2471 gastric cancer samples to identify glycometabolic subtypes and immune clustering subgroups of gastric cancer, and established a scoring system to predict the survival and response of chemotherapy and immunotherapy. The assessment of tumor glucose metabolism and immune microenvironment in gastric cancer has application value for predicting curative effects and formulating combined treatment strategies.
Article
Surgery
Zi-Le Shen, Zhang Liu, Wang-Fu Zang, Peng Zhang, Hong-Bo Zou, Wen-Xi Dong, Wen-Hao Chen, Xia-Lin Yan, Zhen Yu
Summary: This study aimed to evaluate the prognostic effect of thoracic sarcopenia on adverse outcomes after coronary artery bypass grafting (CABG). The results showed a significant association between thoracic sarcopenia and postoperative complications as well as long-term survival rates in patients underwent CABG. Therefore, preoperative evaluation of thoracic sarcopenia based on chest CT should be included in the risk assessment of CABG.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Multidisciplinary Sciences
Haiyue Liu, Jie-Shun Lin, Zhenpeng Luo, Jongho Sun, Xiaowei Huang, Yang Yang, Ji Xu, Yong-Fei Wang, Peng Zhang, Giles E. D. Oldroyd, Fang Xie
Summary: Nuclear Ca2+ oscillations play a crucial role in plant recognition of beneficial microsymbionts, and DMI1 and CNGC15 coordinate the oscillations. Gain-of-function mutations in DMI1 activate the channel complex, leading to spontaneous nuclear Ca2+ oscillations and nodulation. These mutations destabilize the hydrogen bond or salt-bridge network between RCK domains, resulting in structural changes and activation of the channel complex.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Nutrition & Dietetics
Zhang Liu, Zile Shen, Wangfu Zang, Jian Zhou, Zhen Yu, Peng Zhang, Xialin Yan
Summary: The Global Leadership Initiative on Malnutrition (GLIM) has achieved a consensus for the diagnosis of malnutrition. This study aimed to determine the prognostic effect of GLIM after cardiac surgery and developed a nomogram for survival prediction based on independent prognostic predictors.
Article
Neurosciences
Xingyue Liu, Juhua Zhang, Shuzhi Peng, Mengyun Pei, Chunying Dai, Tingting Wang, Peng Zhang
Summary: This study found a significant relationship between menopause and stroke risk factors among natural menopausal women. The average sleep duration, especially night sleep duration, partially mediated the association between menopause and stroke risk, providing a novel insight into the progression of stroke risk in women. Suitable prevention methods and interventions for sleep in menopausal women may reduce the risk of stroke.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Engineering, Civil
Junjun Guo, Penghui Zhang, Jingquan Wang, Shuai Li, Zhongguo Guan
Summary: A novel framework combining Box-Cox transformation and Bayesian inference is proposed for seismic fragility analysis, aiming to enhance the performance of current methodologies. By establishing a numerical model of a cable-stayed bridge within the OpenSees platform, probabilistic seismic demand models are developed using Bayesian inference for Box-Cox transformed data, and fragility models are built using binary Bayesian regression analysis. The results demonstrate that this framework can establish nonlinear probabilistic seismic demand models and improve the performance of classical methods. Furthermore, the binary Bayesian logistic regression-based fragility model eliminates assumptions made by classical analytical approaches and yields robust results. Based on the derived fragility curves, the proposed framework accurately predicts seismic demands at high intensity levels.
ENGINEERING STRUCTURES
(2023)
Article
Surgery
Zhang Liu, Wangfu Zang, Peng Zhang, Zile Shen
Summary: This study aimed to investigate the prognostic implications of malnutrition defined by the Global Leadership Initiative on Malnutrition in older patients who underwent cardiac surgery. The results showed that patients with Global Leadership Initiative on Malnutrition-defined malnutrition had higher risks of postoperative complications and poor overall survival. Therefore, the comprehensive preoperative risk assessment of cardiac surgery using the Global Leadership Initiative on Malnutrition assessment is necessary.
Article
Engineering, Biomedical
Xianglong Li, Cong Jiang, Xinlin Jia, Yuanyuan Cao, Yuanqing Mao, Ji-Na Hao, Yang Yang, Peng Zhang, Yongsheng Li
Summary: This study proposes a dual unlocking strategy to overcome the lack of blood vessels in solid tumors, using engineered hybrid nanoparticles and dexamethasone. The results show that pretreatment with dexamethasone can increase intratumoral micro-vessel density, enhance the delivery efficiency of the nanoparticles, and decrease HIF-1 alpha expression. Furthermore, the platinum in the nanoparticles can catalyze H2O2 to produce oxygen, addressing hypoxia and achieving efficient photodynamic therapy in vivo. Additionally, the nanoparticles can reverse the immunosuppressive tumor microenvironment and promote the therapeutic effect of anti-PD-L1 immunotherapy. This dual unlocking strategy provides an innovative approach to enhance nanomedicine delivery and hypoxia relief in tumor therapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Oncology
Tong Han, Xujun Wang, Sailing Shi, Wubing Zhang, Jue Wang, Qiu Wu, Ziyi Li, Jingxin Fu, Rongbin Zheng, Jiamin Zhang, Qin Tang, Peng Zhang, Chenfei Wang
Summary: This study performed IFNy sensitivity screens in over 40 cancer cell lines and discovered that activation of double-strand break repair genes could lead to resistance to IFNy in cancer cells. Suppression of single-strand break repair genes increased the reliance on DSB repair genes after IFNy treatment. Inhibition of the DSB repair pathway exhibited a synergistic effect with IFNy treatment both in vitro and in vivo. The relationship between the activation of DSB repair genes and IFNy resistance was further confirmed in clinical tumor profiles. This study provides comprehensive resources and evidence to elucidate a mechanism of IFNy resistance in cancer and has the potential to inform combination therapies to overcome immunotherapy resistance.
CANCER IMMUNOLOGY RESEARCH
(2023)
Article
Oncology
Tao Ge, Shuncang Zhu, Liangdong Sun, Laibo Yin, Jie Dai, Jiayi Qian, Xiangru Chen, Peng Zhang, Jialong Zhu, Gening Jiang
Summary: In this study, we developed and validated nomograms for individually predicting overall survival (OS) and lung cancer-specific survival (LCSS) in early-stage T1-2N0M0 small cell lung cancer (SCLC) patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yicheng Xiong, Dongliang Bian, Zhida Huang, Huansha Yu, Jie Huang, Peng Zhang, Wenxin He, Hongcheng Liu
Summary: This study aimed to assess the feasibility of neoadjuvant EGFR-TKI followed by radical surgery for stage IIIB EGFR-mutant NSCLC. The results showed that neoadjuvant EGFR-TKI followed by radical surgery significantly improved progression-free survival, especially for patients with N2 disease and harboring L858R mutation.
FRONTIERS IN ONCOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Jinglin Zou, Cong Jiang, Xianglong Li, Tianyu Zhong, Shuqi Wang, Bo Wang, Dapeng Zhang, Ji-Na Hao, Yuanyuan Cao, Mengjia Guan, Peng Zhang, Bin Dai, Yongsheng Li
Summary: Gallbladder cancer is a highly fatal and common biliary tract cancer with no uniform chemotherapy regimen. This study designed a paclitaxel-loaded nanocarrier modified with hyaluronidase to enhance the delivery and therapeutic efficiency of paclitaxel in gallbladder cancer. The nanocarrier degrades excess hyaluronic acid to soften extracellular matrix and facilitate nanomedicine penetration for chemotherapy. This study provides a promising direction for gallbladder cancer treatment.
APPLIED MATERIALS TODAY
(2023)
Article
Public, Environmental & Occupational Health
Shuzhi Peng, Juhua Zhang, Xingyue Liu, Mengyun Pei, Tingting Wang, Peng Zhang
Summary: This study investigated the factors influencing burnout among grassroots medical staff in China. The findings suggest that health conditions, working conditions, psychological consequences of the pandemic, wages, and marital status are related to job burnout among medical staff.
Article
Biochemical Research Methods
Peng Zhang, Shikui Tu
Summary: Accurate prediction of drug combination synergistic effects is important for cost reduction and the discovery of novel therapies. This paper proposes a MGAE-DC method based on multi-channel graph autoencoder for predicting drug combination synergistic effects. Experimental results demonstrate that MGAE-DC consistently outperforms existing methods on four benchmark datasets.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jiaojiao Wu, Wenxue Yang, Rui Song, Zhe Li, Xiaowei Jia, Hao Zhang, Penghui Zhang, Xinyu Xue, Shenghui Li, Yuanyuan Xie, Rongfei Zhang, Jinyun Ye, Zhijin Zhou, Chenglong Wu
Summary: This study evaluated the effects of dietary soybean lecithin on the growth, haematological indices, immunities, antioxidant capabilities, and inflammatory and intestinal barrier functions in juvenile largemouth bass. The results showed that 4% dietary soybean lecithin improved growth, haematological indices, antioxidant capabilities, immune responses, and intestinal functions, while also alleviating inflammatory responses.
Article
Engineering, Civil
Mingke Li, Junjun Guo, Penghui Zhang, Zhongguo Guan
Summary: This study investigates the characteristics of vertical components in the near-fault region using 121 pairs of typical near-fault ground motions. It is found that there is a weak positive correlation between vertical and horizontal peak ground acceleration (PGA) and peak ground velocity (PGV). The ratios of vertical to horizontal PGA and PGV follow a lognormal distribution, and the vertical ground motions are stronger at lower periods. The optimal scalar IMs for horizontal and vertical seismic demands of an isolated girder bridge with friction pendulum bearings (FPB isolators) are identified. Acceleration-related scalar IMs perform better for vertical seismic demands, while velocity-related scalar IMs perform better for horizontal seismic demands. The study proposes an optimal vector-valued IM consisting of scalar horizontal and vertical IMs for horizontal seismic demands. The probabilistic seismic demand models (PSDMs) with the optimal vector-valued IMs show improved efficiency compared to the corresponding scalar IMs when considering vertical components. The study also finds that vertical effects significantly influence the shear force of piers, while slightly affecting the curvature of piers and bearing displacements.
ENGINEERING STRUCTURES
(2023)