Journal
ELECTROMAGNETIC BIOLOGY AND MEDICINE
Volume 27, Issue 3, Pages 230-240Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15368370802269135
Keywords
ion cyclotron resonance; differentiation; keratinocytes
Categories
Funding
- ISPESL-B1 [4/DIPIA/2005]
- NAMED
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The specific aim of the present work concerns the effectiveness of low-frequency, electromagnetic fields treatment to modify biochemical properties of human keratinocytes (HaCaT). Cells exposed to a 7 Hz electromagnetic field, tuned to calcium ion cyclotron resonance (ICR), showed modifications in the cytoskeleton. These Modifications were related to different actin distributions as revealed by phalloidin,fluorescence analysis. Indirect immunofluorescence with fluorescent antibodies against involucrin and beta catenin, both differentiation and adhesion markers, revealed an increase in involucrin and beta-catenin expression, indicating that exposure to electromagnetic field carries keratinocytes to an upper differentiation level. This study confirms our previous observation and supports the hypothesis that a 7 Hz calcium ICR electromagnetic field may modify cell biochemistry and interfere in the differentiation and cellular adhesion of normal keratinocytes, suggesting the possibility to use ICR electromagnetic therapy for the treatment of undifferentiated diseases.
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