Journal
ELECTROCHIMICA ACTA
Volume 56, Issue 27, Pages 10246-10252Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.electacta.2011.09.019
Keywords
Ferrocene; Boronic acid; Boronate complex; Chemically modified electrode
Categories
Funding
- Ministry of Education, Czech Rep. [LC06030]
- Ministry of Defence, Czech Rep. [0801-8-7010]
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Ferroceneboronic acid (FcBA) was used as a redox-active probe suitable for monitoring of diol-boronate interactions. Voltammetric and amperometric measurements allowed to detect FcBA forms - free and bound in the boronate complex. In this way, the complexation interaction was studied for a set of saccharide molecules as model diols and the corresponding affinity equilibrium constants were determined. A shift of the peak potential on voltammograms accompanying formation of the boronate complex with FcBA was proposed as a probe for electrochemical characterization of surface-confined diol-containing structures. The model experiments were carried out using sorbitol- and 1,6-hexandiol-modified polyepichlorhydrin conjugates deposited on the electrodes; the former compound was able to form the boronate complex while no change of the peak potential for the latter conjugate was observed. This approach seems promising for artificial bioelectronic affinity receptors and technology of reagent-less biosensors where the binding interaction directly stimulates a measurable electrochemical event. (C) 2011 Elsevier Ltd. All rights reserved.
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