Journal
ELECTROCHEMISTRY COMMUNICATIONS
Volume 42, Issue -, Pages 6-8Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.elecom.2014.01.021
Keywords
Biliaty tract cancer; Golgi protein 73; Tumor marker; Electrochemistry
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Funding
- National Science Fund for Distinguished Young Scholars [20925520]
- National Natural Science Foundation of China [21235003, 81172503]
- Medical Innovation Team and Leading Talent Program of Jiangsu Province [LJ201134]
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In this work, we have developed an electrochemical immunosensor for the assay of Golgi Protein 73 (GP73), which is a newly-established and highly sensitive biomarker for biliary tract cancer. Intrinsic specificity and sensitivity of this immunosensor can be achieved due to the good conductivity of electrochemically reduced graphene oxide, and the prominent electrochemical signal of quantum dots. So, our sensor can enable a limit of detection as low as 12 pM, and it can make direct serum assay possible, the results of which may clearly predict the effect of surgical removal of the primary tumor, indicating potential clinical application of our sensor in the future. (c) 2014 Elsevier B.V. All rights reserved.
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