Journal
ELECTROANALYSIS
Volume 25, Issue 12, Pages 2586-2594Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/elan.201300349
Keywords
Anodic stripping voltammetry; Zinc; Lab-on-a-chip sensor; Dopamine; Evaporated Bi film electrode
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Funding
- National Institutes of Health (NIH) [R21ES019255]
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In this work, we report on the development of a lab-on-a-chip electrochemical sensor that uses an evaporated bismuth electrode to detect zinc using square wave anodic stripping voltammetry. The microscale electrochemical cell consists of a bismuth working electrode, an integrated silver/silver chloride reference electrode, and a gold auxiliary electrode. The sensor exhibits a linear response in 0.1M acetate buffer at pH6 with zinc concentrations in the 1-30M range and a calculated detection limit of 60nM. The sensor successfully detected zinc in a bovine serum extract and the results were corfirmed by independent AAS measurements. Our results demonstrate the advantageous qualities of this lab-on-a-chip electrochemical sensor for clinical applications, which include small sample volume (mu L scale), reduced cost, short response time and high accuracy at low concentrations of analyte.
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