Article
Engineering, Electrical & Electronic
Sadik Cogal, Venkat R. Bhethanabotla
Summary: In this study, a nanocomposite of two-dimensional WSe2 nanosheets with carbon black was prepared and used for electrode modification for the simultaneous electrochemical detection of AA, DA, and UA. The modified electrode exhibited enhanced electrocatalytic properties, wide linear ranges, and low detection limits for the target analytes. Additionally, it demonstrated high reproducibility and stability.
IEEE SENSORS JOURNAL
(2022)
Article
Chemistry, Analytical
Xing Lu, Songnan Li, Wei Guo, Feng Zhang, Fengyu Qu
Summary: The TiO2/TiCT-NUF heterojunctions exhibit high sensing activity for simultaneous detection of dopamine and uric acid, with good selectivity and reproducibility in urine and serum samples. The proposed heterojunctions show promising potential as an electrochemical sensor for the sole and simultaneous detection of DA and UA.
Article
Nanoscience & Nanotechnology
Jahir Ahmed, M. Faisal, S. A. Alsareii, Farid A. Harraz
Summary: In this study, a sensor modified with PPy-CB-Co3O4 nanocomposite was developed for efficient and accurate detection of uric acid in blood serum. The sensor showed excellent sensitivity, wide linear dynamic range, and extremely low detection limit. It also demonstrated high selectivity for uric acid and exhibited good reproducibility, repeatability, and stability.
ADVANCED COMPOSITES AND HYBRID MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Umay Amara, Khalid Mahmood, Maria Hassan, Muhammad Hanif, Muhammad Khalid, Muhammad Usman, Zahid Shafiq, Usman Latif, Muhammad Mahboob Ahmed, Akhtar Hayat, Mian Hasnain Nawaz
Summary: In this study, lanthanum-doped sea sponge-shaped copper oxide nanoparticles were synthesized and wrapped with a unique compound to fabricate a graphite pencil electrode. The electrode exhibited excellent sensing performance for dopamine, with high selectivity, reproducibility, and stability. The electrode also had a low detection limit and improved sensitivity. Moreover, the developed sensing interface was successfully applied for dopamine analysis in tear samples with excellent recovery rates.
Article
Chemistry, Analytical
Zhenying Xu, Jingyao Song, Bingrui Liu, Shaoping Lv, Fengxian Gao, Xiliang Luo, Peipei Wang
Summary: The wearable microfluidic-based electrochemical sensor incorporating conducting polymer PEDOT:PSS hydrogel provides an accurate and sensitive detection of uric acid (UA) in human sweat. It shows ultrahigh sensitivity and low limit of detection, allowing real-time monitoring of UA levels in human sweat samples with high correlation to ELISA results.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Nanoscience & Nanotechnology
ShaoZhen Wang, Mi Zheng, Xue Zhang, MingPeng Zhuo, Qingqing Zhou, Yang Su, Min Zheng, Guotao Yuan, ZuoShan Wang
Summary: In this study, flowerlike CuO/Au nanoparticles with 2D nanomaterial characteristics and excellent glucose sensing performance were prepared through microwave hydrothermal synthesis of sea urchinlike CuO followed by self-generated acid etching in the presence of HAuCl4 and NaBH4. The Au nanoparticles with an average size of 15 nm were uniformly distributed on the surface of CuO nanoflakes during the acid etching process. The green and economical authigenic acid etching method demonstrated controlled preparation of 2D nanomaterials with specific properties.
ACS APPLIED NANO MATERIALS
(2021)
Article
Polymer Science
Aamna Bibi, Sheng-Chieh Hsu, Wei-Fu Ji, Yi-Chi Cho, Karen S. Santiago, Jui-Ming Yeh
Summary: In this study, an electrochemical sensor for uric acid detection was developed using a carbon paste electrode modified with electroactive polyimide synthesized from aniline tetramer and decorated with reduced nanoparticles of Au, Pt, and Ag. The sensor with Au nanoparticles exhibited the best performance with high sensitivity, low detection limit, and a linear detection range. Additionally, the sensor doped with Ag nanoparticles showed the best selectivity for a tertiary mixture of uric acid, dopamine, and ascorbic acid compared to the sensors with Pt and Au nanoparticles.
Article
Nanoscience & Nanotechnology
Yuemeng Cheng, Shaoqing Feng, Qihong Ning, Tangan Li, Hao Xu, Qingwen Sun, Daxiang Cui, Kan Wang
Summary: In this research, a small, convenient, and noninvasive paper-based microfluidic sweat sensor was designed and implemented to detect multiple key biomarkers in human sweat simultaneously. The chip's origami structure includes colorimetric and electrochemical sensing regions. Specific chromogenic reagents are used to selectively identify glucose, lactate, uric acid, magnesium ions, and the pH value in different colorimetric sensing regions. The cortisol in sweat is detected by molecular imprinting in the electrochemical sensing regions. The proposed sweat sensor, composed of hydrophilically and hydrophobically treated filter paper, and 3D microfluidic channels formed by folding paper, has been verified to reliably and noninvasively identify a variety of sweat biomarkers through on-body experiments.
MICROSYSTEMS & NANOENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Shiqi Cheng, Jin Yang, Shangying Qin, Li Huang, Yuanjin Xu, Yilin Wang
Summary: Three-dimensional reduced graphene oxide (3DrGO) and a flower-like zinc oxide (ZnO) crystal were prepared using a hydrothermal method. A stable dispersion of the 3DrGO-ZnO composite was formed and applied to modify a glassy carbon electrode for the detection of ascorbic acid (AA), dopamine (DA) and uric acid (UA). The 3DrGO-ZnO electrode exhibited enhanced electrocatalytic properties and could distinguish and enhance the differential pulse voltammetry signals of AA, DA and UA. The modified electrode showed potential for practical application in the analysis of real samples.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Nagaraj Murugan, Rajendran Jerome, Murugan Preethika, Anandhakumar Sundaramurthy, Ashok K. Sundramoorthy
Summary: This study reports the synthesis of mixed phase 2D MXene as a catalytic material for simultaneous detection of important biomolecules such as AA, DA and UA. The Ti-C-T-x modified GCE showed excellent electrocatalytic activity and separated oxidation peaks, enabling the simultaneous detection of these biomolecules with high sensitivity and stability.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2021)
Article
Electrochemistry
Francesca Mazzara, Bernardo Patella, Giuseppe Aiello, Alan O'Riordan, Claudia Torino, Antonio Vilasi, Rosalinda Inguanta
Summary: An electrochemical sensor based on reduced graphene oxide and gold nanoparticles was developed for sensitive and selective detection of uric acid and ascorbic acid. The sensor showed excellent performance in detecting uric acid with good selectivity to interfering species, and simultaneous detection of uric acid and ascorbic acid reached low detection limits. Validation in real samples demonstrated the sensor's accuracy compared to conventional techniques.
ELECTROCHIMICA ACTA
(2021)
Article
Chemistry, Analytical
Rahul Verma, Kshitij R. B. Singh, Ranjana Verma, Jay Singh
Summary: This study demonstrates the hydrothermal synthesis of CuFe2O4/reduced graphene oxide (rGO) nanocomposite for selective detection of UA. The nanocomposite shows excellent sensing performance, making it a promising candidate for rapid detection of uric acid.
Article
Chemistry, Analytical
Ying Wang, Peng Zhao, Bo Gao, Min Yuan, Jiabing Yu, Zeping Wang, Xianping Chen
Summary: Two-dimensional MXene nanosheets were used to functionalize three-dimensional laser-scribed graphene (LSG) and obtain an LSG-MXene hybrid scaffold. Shape-controlled Au-Pd bimetallic nanoparticles were synthesized on the LSG-MXene surface to enhance its catalytic performance. The fabricated sensor showed low detection limits for ascorbic acid, dopamine, and uric acid and can be used for their determination in urine samples.
MICROCHEMICAL JOURNAL
(2023)
Article
Polymer Science
Oznur Gungor, Onur Ozgul, Busra Aksoy, Funda Okusluk, Suleyman Koytepe
Summary: Researchers have prepared a titanium dioxide-multiwalled carbon nanotube/polyimide composite film modified electrode for simultaneous detection of dopamine, uric acid, and ascorbic acid. The modified electrode exhibits good selectivity, durability, and sensitivity.
Article
Chemistry, Analytical
Baojun Long, Yuanmeng Zhao, Peiyu Cao, Wen Wei, Yan Mo, Juejing Liu, Cheng-Jun Sun, Xiaofeng Guo, Changsheng Shan, Ming-Hua Zeng
Summary: The researchers designed a catalyst composed of single-atom Pt supported on Ni(OH)(2) nanoplates/nitrogen-doped graphene for constructing an electrochemical nonenzymatic glucose sensor. The catalyst exhibited low anode peak potential and high sensitivity, with excellent selectivity, short response time, and high stability. The improved performance of the catalyst was attributed to the stronger binding strength of glucose on the single-atom Pt active centers and their surrounding Ni atoms, as well as the fast electron transfer ability of the conductive graphene.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Rodica Doaga, Timothy McCormac, Eithne Dempsey
Article
Materials Science, Multidisciplinary
Asim Mushtaq, Ruibo Zhao, Dandan Luo, Eithne Dempsey, Xiumei Wang, M. Zubair Iqbal, Xiangdong Kong
Summary: Nanoscale magnetic hydroxyapatite nanoparticles have shown great potential in various biomedical applications, especially in cancer theranostics, due to their good stability and biocompatibility. Current research is focused on the controlled fabrication and structure-property relationships, while further exploration and development are needed in areas such as cancer treatment, tissue engineering, antimicrobial activity, etc. The multifunctional capabilities of MHAp nanoparticles and their potential in hybrid nanocarriers for biomedical applications are still being actively studied and improved.
MATERIALS & DESIGN
(2021)
Article
Materials Science, Multidisciplinary
M. Zubair Iqbal, Israt Ali, Waheed S. Khan, Xiangdong Kong, Eithne Dempsey
Summary: The assembly and disassembly of gold nanoparticles involve various forces related to surfactant chemistry, which can be externally triggered for reversible effects. This review emphasizes the use of stimuli like light, pH, temperature, and magnetic fields for reversible assembly of Au NPs, discussing mechanisms and challenges in detail.
MATERIALS & DESIGN
(2021)
Article
Chemistry, Analytical
Ayman Ali Saeed, Mohammed Nooredeen Abbas, Waheed Fathi El-Hawary, Yousry Moustafa Issa, Baljit Singh
Summary: A hydrogen peroxide sensor based on core-shell gold@titanium dioxide nanoparticles and multi-walled carbon nanotubes modified electrode was developed. The sensor exhibited excellent stability and sensitivity, and was successfully tested in human serum and saliva samples.
Article
Nanoscience & Nanotechnology
Indherjith Sakthinathan, Jonas Koehling, Veit Wagner, Timothy McCormac
Summary: In this study, a nanoarchitectural approach was used to create a nanolayer of polyoxometalate (POM) on a glassy carbon electrode (GCE) for improved electrocatalytic activity in the hydrogen evolution reaction (HER). The layer-by-layer (LbL) technique was employed to alternate POM, [(TBA)Mo12(AleThio)4], and poly-ethyleneimine (PEI) polymer adsorption. The nanolayered electrode exhibited higher HER activity with increasing POM layers, lowering the required overpotential by 0.83 V compared to a bare GCE. The eighth PEI/[(TBA)Mo12(AleThio)4] bilayer showed significantly lower HER overpotential at a current density of 10 mA cm-2. Characterization was done using X-ray photoelectron spectroscopy, atomic force microscopy, and scanning electron microscopy. The successful response is attributed to the synergy between the positively charged PEI polymer and catalytically active molybdate POM.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Multidisciplinary
Bushra Ali, Indherjith Sakthinathan, Davide Barreca, Chiara Maccato, Joydeb Goura, Ulrich Kortz, Timothy McCormac
Summary: A Mn-III-substituted Wells-Dawson-type polyoxoanion was immobilised on a glassy carbon electrode surface using the conducting polymer poly(3,4-ethylenedioxythiophene). The immobilised films were characterized by electrochemical techniques and surface analysis methods. The Mn-4(P2W15)(2) showed redox activity within the polymer phase and the conducting polymer films exhibited pH-dependant redox activity and enhanced stability.
Article
Chemistry, Multidisciplinary
Amna Yaqub, Mikhail Vagin, James J. Walsh, Fathima Laffir, Indherjith Sakthinathan, Timothy McCormac, Mustansara Yaqub
Summary: The Dawson-type sulfate polyoxometalate (POM) was successfully entrapped in polypyrrole (PPy) films on glassy carbon electrode (GCE) surfaces. The film-coated electrodes showed good electrocatalytic response towards the reduction of iodate.
Review
Materials Science, Multidisciplinary
Baljit Singh, Shiliang Ma, Tony O. O. Hara, Sargun Singh
Summary: Cancer, specifically prostate cancer, remains a significant challenge despite advances in detection methods, therapeutic agents, and biomarkers. This article reviews recent achievements in utilizing nanomaterials and nanotechnology for the development of biosensors targeting various biomarkers, including prostate-specific antigen (PSA), sarcosine oxidase, prostate cancer antigen 3 (PCA3), vascular endothelial growth factor (VEGF), and prostate-specific membrane antigen (PSMA). The integration of nanotechnology and different biomarkers is providing insights into the development of biosensors for prostate cancer diagnostics.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Review
Chemistry, Analytical
Baljit Singh, Abhijnan Bhat, Lesa Dutta, Kumari Riya Pati, Yaroslav Korpan, Isha Dahiya
Summary: Antibiotics have developed resistance due to excessive use, leading to environmental pollution and health risks. Electrochemical biosensors are considered as a cost-effective, rapid, and portable alternative for antibiotic detection.
Review
Chemistry, Analytical
Zina Fredj, Baljit Singh, Mohamed Bahri, Peiwu Qin, Mohamad Sawan
Summary: Neurotransmitters (NTs) play a crucial role in regulating the functions of the nervous system and imbalances in their concentrations are linked to various neurological and psychotic disorders. Electrochemical biosensors, particularly those utilizing enzymes as recognition elements, have shown great potential for rapid and sensitive detection of NTs. This review highlights recent advances in enzymatic electrochemical biosensors for NTs detection, covering electrode materials, electroanalytical techniques, and applications in complex matrices and in vivo monitoring. Challenges and future prospects for the development of enzyme-based electrochemical biosensors for NTs detection are also discussed.
Review
Engineering, Environmental
Abhijnan Bhat, Tony O. Hara, Furong Tian, Baljit Singh
Summary: This article provides an overview of various analytical techniques for arsenic determination in drinking water, and will enhance awareness and appreciation of their role in informing and protecting our environment and water resources, globally.
ENVIRONMENTAL SCIENCE-ADVANCES
(2023)
Article
Biotechnology & Applied Microbiology
Grace Halpin, Karen Herdman, Eithne Dempsey
Summary: The study successfully developed a lactate biosensor using chitosan and a crosslinker, optimizing the linear range, sensitivity, and detection limit for lactate. By utilizing graphite ink as an underlying conductive layer for LOx enzyme immobilisation, the detection performance was further enhanced.
SENSORS AND ACTUATORS REPORTS
(2021)
Review
Environmental Sciences
Tony O. Hara, Baljit Singh
Summary: This review highlights the progress made in the development of electrochemical biosensors for environmental toxicants (such as pesticides and heavy metals) over the past seven years. Emphasizing the importance of developing rapid, reliable, and sensitive analytical detection systems, the review discusses current challenges and potential directions for future research.
Article
Chemistry, Analytical
Camilo Menezes, Irene Malo-Estepa, Dayle Johnston, Aoife Delaney, Mark Crowe, Michael Diskin, Eithne Dempsey
Article
Chemistry, Multidisciplinary
Dhouha Jemmeli, Chadlia Mchiri, Cherif Dridi, Habib Nasri, Eithne Dempsey