Review
Endocrinology & Metabolism
Y. Wu, F. Wang, Z. Zhang
Summary: Bisphosphonates are safe and beneficial for maintaining bone mineral density in patients with spinal cord injury, reducing the risk of bone loss.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
R. El-Kotob, B. C. Craven, L. Thabane, A. Papaioannou, J. D. Adachi, L. M. Giangregorio
Summary: This study found that individuals with chronic SCI may have reached a plateau in trabecular bone loss, but cortical bone loss can continue into the chronic stages. The study highlights the importance of monitoring bone changes in individuals with SCI to prevent further bone loss.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Ashraf S. Gorgey, Refka E. Khalil, Tommy W. Sutor, Jacob A. Goldsmith, David X. Cifu
Summary: This study demonstrates that surface neuromuscular electrical stimulation (NMES) amplitude and repetitions of leg extension can differentiate between spinal cord injury (SCI) survivors with greater versus lower musculoskeletal qualities. This finding sheds light on the interplay between muscle and bone in persons with SCI.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Li Zhang, Yingchao Yin, Jialiang Guo, Lin Jin, Zhiyong Hou
Summary: This study demonstrated that chronic intermittent hypobaric hypoxia (CIHH) treatment ameliorates osteoporosis after spinal cord injury (SCI) by balancing osteoblast and osteoclast activities in rats. CIHH treatment can effectively improve bone density and structure in SCI rats. This may be achieved by enhancing the activity of hypoxia-inducible factor-1α (HIF-1α) signaling pathway.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Xin Zheng, Yanyan Qi, Hongjun Zhou, Haiqiong Kang, Yanming Tone, Lina Bi
Summary: This study found that bone mineral density (BMD) at the distal femur (DF), proximal tibia (PT), and hip in spinal cord injury (SCI) patients significantly decreased during the first year post-injury, with the most rapid loss occurring at the PT and DF compared to the hip. Age, gender, and 25OHD were identified as influencing factors on BMD levels.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Biology
Michelle A. Hook, Alyssa Falck, Ravali Dundumulla, Mabel Terminel, Rachel Cunningham, Arthur Sefiani, Kayla Callaway, Dana Gaddy, Cedric G. Geoffroy
Summary: Bone loss after spinal cord injury significantly affects rehabilitation and increases the risk of fractures and complications. While injury, age, and sex independently increase bone loss, their cumulative effects remain unclear. Aging reduces bone volume, and spinal injury also reduces bone volume, but does not worsen the effects of age. Partial weight-bearing does not reduce bone loss, but therapies that simulate full weight-bearing may be effective.
Article
Endocrinology & Metabolism
Laura E. Crack, Ifaz T. Haider, Narina Simonian, Joana Barroso, Leigh Gabel, Thomas J. Schnitzer, W. Brent Edwards
Summary: This study demonstrates that zoledronic acid can prevent bone loss at the hip following spinal cord injury. It provides a potential treatment option to reduce the risk of hip fractures and offers insights into preventive measures for bone loss.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Cell Biology
Jiheng Zhan, Dan Luo, Bingde Zhao, Shudon Chen, Jiyao Luan, Junhua Luo, Yu Hou, Yonghui Hou, Wenke Xu, Wanying Yan, Ji Qi, Xin Li, Qing Zhang, Dingkun Lin
Summary: PLD protects mice with chronic SCI against sublesional bone loss by modulating the activity of osteoclasts and osteoblasts, reducing oxidative stress and enzyme activity, and restoring the Wnt/β-catenin signaling pathway.
Article
Rehabilitation
Claire Shackleton, Robert Evans, Sacha West, Wayne Derman, Yumna Albertus
Summary: The study found that 24 weeks of robotic locomotor training can maintain hip bone mineral density, while activity-based training significantly reduces it. Both interventions improved arm fat-free soft tissue mass, but had no effect on leg fat-free soft tissue mass. The activity-based training group experienced a significant decrease in visceral adipose tissue and gynoid fat mass.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2022)
Review
Clinical Neurology
Zijian Ma, Mingling Ma, Yilang He, Hao Sun, Bin Yang, Hui Dong, Yongxiang Wang
Summary: In this meta-analysis of 7 randomized controlled trials, bisphosphonates were found to effectively alleviate bone loss in patients with acute spinal cord injury, particularly in the lumbar spine, femoral neck, and total hip. Early application of bisphosphonates is recommended.
WORLD NEUROSURGERY
(2023)
Article
Medicine, General & Internal
Piera Lalli, Claudia Mautino, Chiara Busso, Francesca Bardesono, Marco Di Monaco, Lorenzo Lippi, Marco Invernizzi, Marco Alessandro Minetto
Summary: This study investigates the reproducibility and accuracy of REMS for femoral BMD estimation and the reproducibility and discriminative power of the REMS-derived femoral fragility score. The results show excellent test-retest reproducibility for REMS, but minimal to poor diagnostic concordance between DXA and REMS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Christopher M. M. Cirnigliaro, Michael F. F. La Fountaine, J. Scott Parrott, Steven C. C. Kirshblum, Susan J. J. Sauer, Sue A. A. Shapses, Isa A. A. McClure, William A. A. Bauman
Summary: In participants with subacute spinal cord injury, the decrease in bone mineral density after discontinuation of denosumab was similar between the denosumab and placebo groups. This highlights the importance of additional trials to understand the effect of continued administration of denosumab after subacute SCI in order to prevent demineralization.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Yan Yang, Jing Zeng, Tingting Zhang, Jinjing Wang, Xiaojing Fan, Qiaomin Wang, Xuan Wang, Zhengrong Qi, Yi Fang
Summary: This cross-sectional study investigated the potential association between resolved HBV infection and femoral and spinal BMD in adults in the United States. The study found a negative association between resolved HBV infection and femoral and spinal BMD in adult men.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Da Liu, Bo Wang, Min Qiu, Ying Huang
Summary: miR-19b-3p is involved in bone loss after SCI by inhibiting osteogenesis through the PTEN/Akt/mTOR signaling pathway, regulating autophagy to affect the osteogenic differentiation of BMSCs.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Review
Medicine, General & Internal
Mahmoud M. Sobh, Mohamed Abdalbary, Sherouk Elnagar, Eman Nagy, Nehal Elshabrawy, Mostafa Abdelsalam, Kamyar Asadipooya, Amr El-Husseini
Summary: Secondary osteoporosis is a global problem caused by osteoporosis and can be triggered by various reasons. Kidney, diabetes, thyroid and parathyroid disorders, gastrointestinal diseases, liver disease, inflammatory disorders, and medications can all contribute to the development of secondary osteoporosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Necmettin Yildiz, Yesim Akkoc, Murat Ersoz, Berrin Gunduz, Belgin Erhan, Hilal Yesil, Ayse Nur Bardak, Senay Ozdolap, Hakan Tunc, Kurtulus Koklu, Ebru Alemdaroglu, Ender Erden, Ulas Sungur, Ozlem Satir, Cagdas Erdogan, Hakan Alkan
NEUROLOGICAL SCIENCES
(2017)
Article
Urology & Nephrology
Yesim Akkoc, Haydar Gok, Hale Karapolat, Murat Ersoz, Ulas Sungur, Kurtulus Koklu, Ebru Alemdaroglu, Hakan Tunc, Ahmet Acarer, Inci Sule Ozer, Cenk Akbostanci, Berna Arli, Tahir Kurtulus Yoldas
NEUROUROLOGY AND URODYNAMICS
(2017)
Article
Clinical Neurology
Xavier Bonfill, David Rigau, Manuel Esteban-Fuertes, Juana M. Barrera-Chacon, Maria L. Jauregui-Abrisqueta, Sebastian Salvador, Carolina M. Aleman-Sanchez, Albert Borau, Manuel Bea-Munoz, Begona Hidalgo, Maria J. Andrade, Juan R. Espinosa, Maria Jose Martinez-Zapata
Article
Clinical Neurology
Hilal Yesil, Yesim Akkoc, Hale Karapolat, Ayse Guler, Ulas Sungur, Dilek Evyapan, Figen Gokcay
NEUROREHABILITATION
(2017)
Article
Rehabilitation
Yesim Akkoc, Ayse Nur Bardak, Murat Ersoz, Bilge Yilmaz, Necmettin Yildiz, Belgin Erhan, Hakan Tunc, Kurtulus Koklu, Ebru Alemdaroglu, Asuman Dogan, Zuhal Ozisler, Engin Koyuncu, Nilgun Simsir Atalay, Berrin Gunduz, Ridvan Isik, Ayse Guler, Merve Sekizkardes, Yasin Demir, Evren Yasar, Ezgi Sasmaz, Ozlem Satir
TOPICS IN STROKE REHABILITATION
(2019)
Article
Rehabilitation
Yesim Akkoc, Necmettin Yildiz, Ayse Nur Bardak, Murat Ersoz, Hakan Tunc, Kurtulus Koklu, Ebru Alemdaroglu, Ayse Guler, Ezgi Sasmaz, Asuman Dogan, Zuhal Ozisler, Engin Koyuncu
TURKISH JOURNAL OF PHYSICAL MEDICINE AND REHABILITATION
(2019)
Article
Urology & Nephrology
Hilal Yesil, Yesim Akkoc, Necmettin Yildiz, Funda Atamaz Calis, Alperen Inceoglu, Emrullah Fatih Yildiz
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2020)
Article
Clinical Neurology
Hilal Yesil, Yesim Akkoc, Necmettin Yildiz, Haydar Gok, Ayse Nur Bardak, Murat Ersoz, Sehim Kutlay, Derya Bugdayci, Nurdan Paker, Hakan Tunc, Kurtulus Koklu, Ebru Alemdaroglu, Engin Koyuncu, Zuhal Ozisler, Secilay Gunes, Hakan Alkan, Tevfik Tezer, Aysenur Bas, Meryem Burcu Turkoglu, Zeynep Yazar, Simin Hepguler
Summary: A study on nocturnal polyuria prevalence in spinal cord injury patients found no significant differences in nocturnal polyuria among patients in different phases of mobilization. Night and 24-hour urine volumes also did not differ significantly among the groups.
JOURNAL OF SPINAL CORD MEDICINE
(2021)
Review
Clinical Neurology
Yesim Akkoc
Summary: This systematic review evaluated the efficacy and safety of mirabegron in patients with neurogenic detrusor overactivity due to spinal cord injury (SCI) or multiple sclerosis (MS). The results showed that mirabegron had similar clinical efficacy to anticholinergics in MS patients, but did not provide satisfactory results in terms of urodynamic parameters in SCI patients. Mirabegron had a good safety profile with mild cardiovascular side effects.
Article
Clinical Neurology
Yesim Akkoc, Ayse Nur Bardak, Necmettin Yildiz, Aysun Ozlu, Belgin Erhan, Burak Yuru, Saadet Nur Sena Oztekin, Meryem Burcu Turkoglu, Nurdan Paker, Yasemin Yumusakhuylu, Sibel Canbaz Kabay, Ozgul Ekmekci, Hayriye Elbi, Ayse Nur Yuceyar
Summary: This study investigated the relationship between the severity of overactive bladder (OAB) symptoms and cognitive function, anxiety and depression in patients with multiple sclerosis (MS). The results showed that the severity of OAB symptoms was associated with worsening of information processing speed and an increase in depression and anxiety. Additionally, the use of anticholinergic drugs, especially oxybutynin, had a significant impact on information processing speed, visual learning, and memory.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Clinical Neurology
Ece Cinar, Yesim Akkoc, Funda Calis, Musa Baklaci, Ozgul Ekmekci, Ayse Nur Yuceyar
Summary: This study tested the reliability and validity of the Multiple Sclerosis Knowledge Questionnaire (MSKQ) in Turkish patients and found that patients have better knowledge about the general characteristics of the disease compared to diagnostic and treatment options. This highlights the need for more educational resources, especially regarding treatment options.
NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY
(2022)
Article
Rehabilitation
Yesim Akkoc, Murat Ersoz, Ece Cinar, Haydar Gok
Summary: The study aimed to determine current trends in evaluation and management of neurogenic bladder secondary to SCI among PMR specialists in Turkey. The results showed differences in practice among specialists, highlighting the need for guidelines and continuous medical education activities.
TURKISH JOURNAL OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Rehabilitation
Gulbin Alkan, Yesim Akkoc, Berrin Zengin, Gokhan Keser, Yasemin Kabasakal, Nurullah Akkoc
TURKISH JOURNAL OF PHYSICAL MEDICINE AND REHABILITATION
(2020)
Article
Medicine, Research & Experimental
Ulas Sungur, Yesim Akkoc, Nur Yuceyar, Ozgul Ekmekci
CLINICAL AND EXPERIMENTAL HEALTH SCIENCES
(2019)
Article
Urology & Nephrology
Hale Karapolat, Yesim Akkoc, Sibel Eyigor, Goksel Tanigor
TURKISH JOURNAL OF UROLOGY
(2018)