Article
Oncology
Susanne Merkel, Maximilian Brunner, Carol-Immanuel Geppert, Robert Gruetzmann, Klaus Weber, Abbas Agaimy
Summary: One of the most important prognostic factors for patients with colon cancer is the anatomical extent at the time of surgery. This retrospective study suggests that a subclassification of T3, based on the depth of tumor invasion, can help predict prognosis and optimize treatment in colon cancer patients. A three-level subdivision of T3 into T3a, T3b, and T3c is recommended.
Article
Medicine, General & Internal
Satoru Munakata, Takahiro Ito, Takuya Asano, Tsuyoshi Yamashita
Summary: Inspired by the classification proposed by TCGA, this study investigated the expression of CD8-positive T-cells, DNA mismatch repair proteins, and p53 proteins in endometrial carcinoma, and developed a new classification system (ICEC) to predict prognosis. The ICEC classification showed significant prognostic significance in overall survival and disease-free survival.
Article
Immunology
Chengxing Wang, Zhenyu Zhao, Yuhao Zhang, Weijun Liang, Chaorong Zhou, Weixing Lin, Yu He, Meimei Wu, Zijie Meng, Yuehua Liao, Min Li, Mariya El Akkawi, Jinglin Zhao, Yaoming He
Summary: This study investigates the potential role of the CUL7 gene in different tumors and highlights its association with prognosis in colon adenocarcinoma. It suggests that CUL7 may serve as a prognostic marker for COAD.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Qingyu Liang, Jianqi Wu, Xin Zhao, Shuai Shen, Chen Zhu, Tianqi Liu, Xiao Cui, Ling Chen, Chunmi Wei, Peng Cheng, Wen Cheng, Anhua Wu
Summary: This study systematically investigated inflammasome signaling in different types of tumors and found that tumors with activated inflammasome signaling exhibited immunosuppression and resistance to ICB treatment. Evaluation of inflammasome signaling was proposed to be important for tumor classification and relevant therapeutic regimens could be improved based on this evaluation.
Article
Cell Biology
Jiawei Rao, Wen Li, Chuangqi Chen
Summary: The study identified two PYG-mediated molecular subtypes in colon cancer, affecting the composition of the tumor microenvironment; the infiltration of immune cells was significantly different between the low and high PY-score groups; patients in the low PY-score group showed better survival advantage and were more sensitive to certain treatments.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Microbiology
Alessandro Tanca, Marcello Abbondio, Giovanni Fiorito, Giovanna Pira, Rosangela Sau, Alessandra Manca, Maria Rosaria Muroni, Alberto Porcu, Antonio Mario Scanu, Paolo Cossu-Rocca, Maria Rosaria De Miglio, Sergio Uzzau
Summary: This pilot study utilizes metaproteomics to examine the relationship between gut microbiota and clinicopathological features of colon cancer. The results suggest that certain microbial taxa and functional features are associated with the stage and grade of colon cancer. This study provides valuable insights into the potential prognostic value of the gut microbiota in colon cancer progression.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Immunology
Giovanni Monteleone, Claudia Maresca, Marco Colella, Teresa Pacifico, Daniele Congiu, Edoardo Troncone, Irene Marafini
Summary: This article reviews the current understanding of the involvement of interleukin-34 (IL-34) and its receptor, macrophage colony-stimulating factor-1 receptor (MCSF-1R), in colorectal cancer (CRC). It highlights the role of the IL-34/MCSF-1R axis in controlling tumor-associated macrophages (TAMs) and promoting cancer resistance to chemotherapy and immunotherapy. The findings suggest that targeting IL-34/MCSF-1R could be a potential therapeutic intervention in CRC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pathology
Federica Torricelli, Giacomo Santandrea, Cecilia Botti, Moira Ragazzi, Silvia Vezzani, Andrea Frasoldati, Angelo Ghidini, Davide Giordano, Eleonora Zanetti, Teresa Rossi, Davide Nicoli, Alessia Ciarrocchi, Simonetta Piana
Summary: Due to the lack of a standardized tool for risk stratification, the International Medullary Carcinoma Grading System (IMTCGS) and risk stratification study using the Surveillance, Epidemiology, and End Results (SEER) database have been validated for medullary thyroid carcinomas (MTCs). The validation study on 66 MTC cases found that high-grade patients had a lower survival probability and angioinvasion was significantly correlated with metastasis and death. Overall, these results confirm the prognostic performance of IMTCGS and SEER-based risk score and emphasize the important role of angioinvasion in prognosis.
Article
Oncology
Sabrina Blondy, Stephanie Durand, Aurelie Lacroix, Niki Christou, Charline Bouchaud, Maud Peyny, Serge Battu, Alain Chauvanel, Vincent Carre, Marie-Odile Jauberteau, Fabrice Lalloue, Muriel Mathonnet
Summary: Studies have shown that the ColoSTEM Dx kit can predict the prognosis of colon cancer patients earlier and more accurately by detecting the specific glycan patterns expressed by colon cancer stem cells. The kit demonstrates good diagnostic sensitivity and specificity in clinical settings.
FRONTIERS IN ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Wei Chen, Romain Desert, Xiaodong Ge, Hui Han, Zhuolun Song, Sukanta Das, Dipti Athavale, Hong You, Natalia Nieto
Summary: This study identified 80 matrisome genes associated with HBV-related HCC, along with four significant matrisome gene modules and two patient subgroups. Additionally, four liver-specific matrisome genes involved in HBV-related HCC progression and prognosis were discovered.
HEPATOLOGY COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Le Li, Zheng Chao, Un Waikeong, Jun Xiao, Yue Ge, Yanan Wang, Zezhong Xiong, Sheng Ma, Zhihua Wang, Zhiquan Hu, Xing Zeng
Summary: This study proposed a new metabolic classification method for renal cell carcinoma and revealed associations between metabolic profiles and immune infiltration. The subcluster with low metabolic profiles had the worst prognosis, highest invasiveness, enhanced immune infiltration but suppressive immunophenotypes. ACAA2 was identified as a tumor suppressor gene associated with increased immune infiltration and elevated PD-1 expression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Jinlai Zhao, Yigang Wang, Jianchao Gao, Yang Wang, Xuan Zhong, Xiaotang Wu, Hua Li
Summary: This study established a risk predication model based on 9 genes to effectively predict the prognosis of colon carcinoma patients. The high-risk group showed lower survival rates according to Kaplan-Meier curve, and significant differences in biological pathways were observed between high and low-risk groups through GSEA analysis. The model could efficiently predict prognosis in patients of different ages and stages, laying a foundation for further research on the molecular mechanisms of colon carcinoma development.
Article
Immunology
Yile Xie, Huimin Chen, Jing-Yuan Fang
Summary: Amino acid metabolism is closely related to the occurrence and development of colon adenocarcinoma. By analyzing the characteristics of amino acid metabolism, two distinct subtypes of COAD were identified with different clinical features, mutation landscapes, metabolic activities, immune infiltration, and therapy sensitivities. Additionally, single-cell data analysis provided insights into the metabolic activities of different cell types. Furthermore, a classifier based on 60 amino acid metabolism-related genes was developed for clinical decision-making and prognosis prediction.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Qi Zhang, Xiao Feng, Mingming Zhang, Wenjing Sun, Yuqing Zhai, Shuangshuang Qing, Ying Liu, Haoran Zhao, Jing Sun, Yi Zhang, Chaoqun Ma
Summary: This study systematically analyzed the gene expression and clinical information of colon cancer patients, identifying five pivotal genes related to plasma cells that have excellent prognostic value and significance in immunotherapy.
Review
Oncology
Aroosha Raja, Farhan Haq
Summary: This review extensively summarizes current information on molecular classification of HCC, providing insight for understanding the development mechanisms and treatment options for liver cancer patients globally.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Letter
Gastroenterology & Hepatology
P. Mroczkowski
COLORECTAL DISEASE
(2018)
Article
Oncology
Nina C. A. Vermeer, Yvette H. M. Claassen, Marloes G. M. Derks, Lene H. Iversen, Elizabeth van Eycken, Marianne G. Guren, Pawel Mroczkowski, Anna Martling, Robert Johansson, Tamara Vandendael, Arne Wibe, Bjorn Moller, Hans Lippert, Johanneke E. . A. Portielje, Gerrit Jan Liefers, Koen C. M. J. Peeters, Cornelis J. H. van de Velde, Esther Bastiaannet
Article
Gastroenterology & Hepatology
Lukasz Dziki, Ronny Otto, Hans Lippert, Pawel Mroczkowski, Olof Jannasch
GASTROENTEROLOGY RESEARCH AND PRACTICE
(2018)
Article
Oncology
Yvette H. M. Claassen, Nina C. A. Vermeer, Lene H. Iversen, Elizabeth van Eycken, Marianne G. Guren, Pawel Mroczkowski, Anna Martling, Antonio Codina Cazador, Robert Johansson, Tamara Vandendael, Arne Wibe, Bjorn Moller, Hans Lippert, Harm J. T. Rutten, Johanneke E. A. Portielje, Gerrit J. Liefers, Fabian A. Holman, Cornelis J. H. van de Velde, Esther Bastiaannet
BRITISH JOURNAL OF CANCER
(2018)
Letter
Surgery
P. Mroczkowski
BRITISH JOURNAL OF SURGERY
(2019)
Letter
Surgery
A. Zaborowski, A. Stakelum, D. C. Winter
BRITISH JOURNAL OF SURGERY
(2019)
Letter
Surgery
P. Mroczkowski, L. Dziki
BRITISH JOURNAL OF SURGERY
(2020)
Letter
Medicine, General & Internal
Pawel Mroczkowski
DEUTSCHES ARZTEBLATT INTERNATIONAL
(2021)
Letter
Medicine, General & Internal
Pawel Mroczkowski
DEUTSCHES ARZTEBLATT INTERNATIONAL
(2021)
Letter
Gastroenterology & Hepatology
Pawel Mroczkowski, Radoslaw Zajdel
COLORECTAL DISEASE
(2022)
Letter
Gastroenterology & Hepatology
Pawel Mroczkowski
COLORECTAL DISEASE
(2022)
Letter
Oncology
Pawel Mroczkowski, Radoslaw Zajdel
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Pawel Mroczkowski, Lukasz Dziki, Tereza Vosikova, Ronny Otto, Anna Merecz-Sadowska, Radoslaw Zajdel, Karolina Zajdel, Hans Lippert, Olof Jannasch
Summary: This study examines the number of lymph nodes removed during rectal cancer surgery and the validity of the commonly recommended minimum of 12 nodes. Factors such as age, gender, and pre-therapeutic stage can affect the number of nodes removed. The study found that the probability of finding a positive lymph node increased with the number of nodes examined.
Letter
Surgery
Pawel Mroczkowski, Olof Jannasch
Letter
Medicine, General & Internal
Pawel Mroczkowski
DEUTSCHES ARZTEBLATT INTERNATIONAL
(2020)
Article
Oncology
Yuchao Liu, Zijia Liu, Liangyan Zhang, Yuelun Zhang, Ningchen Zhang, Yue Han, Le Shen
Summary: This study found an association between preoperative 6-min walk distance and postoperative complications in patients undergoing laparoscopic gastrointestinal cancer surgery.
Review
Oncology
Matteo Pavone, Rosa Autorino, Nicolo Bizzarri, Giuditta Chilorio, Vincenzo Valentini, Giacomo Corrado, Gabriella Ferrandina, Gabriella Macchia, Maria Antonietta Gambacorta, Giovanni Scambia, Denis Querleu
Summary: Ovarian transposition is an established method for protecting the ovaries from radiation, while surgical procedures for protecting the uterus are still under investigation. This study conducted a systematic review of uterine displacement techniques and performed dose simulation to assess the radiation dose received by the uterus. The results showed that the transposition approach was the most protective.
Article
Oncology
Silvia Ministrini, Maria Bencivenga, Federica Filippini, Gianni Mura, Carlo Milandri, Maria Antonietta Mazzei, Giulio Bagnacci, Mattia Berselli, Manlio Monti, Paolo Morgagni, Leonardo Solaini, Daniele Marrelli, Stefania Piccioni, Stefano De Pascale, Luigina Graziosi, Rossella Reddavid, Fausto Rosa, Claudio Belluco, Guido Tiberio
Summary: The Italian Research Group for Gastric Cancer developed a prospective database to evaluate the impact of a pragmatic attitude on the management of stage IV gastric cancer patients. The study found that different metastatic sites did not affect survival rates, but multiple metastatic sites were associated with worse survival. Patients who could undergo curative resection had better survival rates. A more accurate diagnostic workup and staging had a favorable impact on survival.
Article
Oncology
Luca Lambertini, Fabrizio Di Maida, Anna Cadenar, Samuele Nardoni, Antonio Andrea Grosso, Francesca Valastro, Pietro Spinelli, Riccardo Fantechi, Agostino Tuccio, Gianni Vittori, Andrea Mari, Lorenzo Masieri, Andrea Minervini
Summary: The aim of this study was to evaluate the functional outcomes of Florence intracorporeal neobladder (FloRIN) configuration technique performed with a stentless procedure. The results showed that the stentless procedure was associated with shorter console time and lower estimated blood loss compared to the stent group. There were no significant differences in terms of perioperative features and mid-term functional outcomes between the two groups.
Article
Oncology
Geun-Jeon Kim, Jooin Bang, Hyun-Il Shin, Sang-Yeon Kim, Dong -Il Sun
Summary: This study evaluated the outcome of tonsillar cancer managed with neoadjuvant chemotherapy followed by surgery. The results showed that neoadjuvant chemotherapy reduced tumor volume and pathological adverse features, significantly decreasing the need for adjuvant therapy. A greater reduction in tumor volume predicted a complete pathologic response. There was no significant difference in survival rates between the groups.
Article
Oncology
Alexandra Nassar, Stylianos Tzedakis, Ugo Marchese, Gaanan Naveendran, Remy Sindayigaya, Martin Gaillard, Francois Cauchy, Mickael Lesurtel, Brice Gayet, Olivier Soubrane, David Fuks
Summary: This study identified recurrence between the two stages and a larger tumor size in the future liver remnant as critical factors contributing to the failure of two-stage hepatectomy for bilobar colorectal liver metastases. These findings have important clinical implications for the selection and evaluation of TSH surgery.
Letter
Oncology
Michele Fiore, Gian Marco Petrianni, Gabriele D'Ercole, Pasquale Trecca, Sara Ramella
Review
Oncology
Harry Farrow, Oliver J. Pickering, James A. Gossage, Philip H. Pucher
Summary: The inclusion or exclusion of the thoracic duct in radical esophagectomy for esophageal cancer is a controversial issue. While removing the thoracic duct may increase lymph node yield, it may also lead to higher morbidity without any survival benefit.
Article
Oncology
Xiaokun Li, Siyuan Luan, Chi Zhang, Weili Kong, Xin Xiao, Haowen Zhang, Jianfeng Zhou, Yushang Yang, Yang Xu, Yong Qiang, Pinhao Fang, Yi Shen, Yong Yuan
Summary: This study proposes a new staging system based on ypTNM stage and cN status for early stage ESCC patients after nCRT. The new ypTNM-cN staging system demonstrates superior predictive ability and classification efficacy compared to the AJCC 8th ypTNM staging system. It provides new insights for accurately stratifying ypI stage ESCC patients.
