Evidence for a synchronous operative approach in the treatment of colorectal cancer with hepatic metastases: A case matched study

Background: Traditionally, a staged operative approach has been used for patients with synchronous colorectal cancer and liver metastases in the U.K. With improved outcomes from hepatic resection the role of a synchronous operative approach needs re-evaluated. Methods: 32 consecutive patients with colorectal cancer and hepatic metastases that underwent a synchronous operative approach were individually case matched (according to: age; sex; ASA grade; type of hepatic and colonic resection) with patients that had undergone a staged approach. The following variables were analysed: operative blood loss; in hospital morbidity and mortality; duration of hospital stay; disease free and overall survival. Results: Operative blood losses were: synchronous group, median 475 mL (range 150-850 mL) vs median 425 mL (range 50-1700 mL), (p > 0.050). There were no significant differences in morbidity: (34% synchronous group vs 59%, p = 0.690) with no recorded mortality. Synchronous group had a shorter hospital stay (median 12 days [range 8-21] vs 20 [range 7-51], p = 0.008). There were no statistical differences between synchronous and staged patients for disease free and overall survival: 10 months (95% CI 5.8-13.7) versus 14 (95% CI 12.2-16.3; p =0.487) and 21% versus 24% at 5 years (p = 0.838). Conclusion: This present study provides supporting evidence for synchronous operative procedures in patients with colorectal liver metastases. Crown Copyright (c) 2009 Published by Elsevier Ltd. All rights reserved.