Article
Chemistry, Multidisciplinary
Klaudia Kvakova, Martin Ondra, Jiri Schimer, Milos Petrik, Zbynek Novy, Helena Raabova, Marian Hajduch, Petr Cigler
Summary: This study developed a sensitive approach using fluorescent nanodiamonds for visualizing tumor-draining sentinel lymph nodes. The results showed that the modified nanodiamonds have potential as a tracer for cancer diagnostics and fluorescence-guided surgery.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Urology & Nephrology
Michael Korten, Randi M. Pose, Markus Graefen, Derya Tilki, Uwe Michl, Sophie Knipper, Burkhard Beyer
Summary: This study assesses the impact of preprostatic lymph node invasion on the outcome of prostate cancer patients after radical prostatectomy. The results suggest that preprostatic lymph node invasion has a similar harmful effect as pelvic lymph node invasion, indicating the importance of histological analysis when removing preprostatic tissue.
WORLD JOURNAL OF UROLOGY
(2022)
Article
Oncology
Maria Cristina Leonardi, Camilla Arrobbio, Sara Gandini, Stefania Volpe, Francesca Colombo, Eliana La Rocca, Viviana Galimberti, Sabrina Kahler-Ribeiro-Fontana, Cristiana Fodor, Samantha Dicuonzo, Damaris Patricia Rojas, Maria Alessia Zerella, Anna Morra, Emilia Montagna, Marco Colleoni, Giovanni Mazzarol, Laura Lavinia Travaini, Mattia Zaffaroni, Paolo Veronesi, Roberto Orecchia, Barbara Alicja Jereczek-Fossa
Summary: This study aimed to evaluate the rate of positive non-sentinel lymph nodes in breast cancer patients after neoadjuvant systemic therapy following positive sentinel lymph node biopsy. Positive non-SLNs were found in 62.3% of cases and were significantly associated with older age, clinically positive lymph nodes, SLN extracapsular extension, and a higher ratio of positive SLNs/total SLNs. ECE and higher nodal ratio were independent predictors of III axillary level positivity.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Xinrui Liang, Yu Wang, Guanghua Fu, Pingmig Fan, Ke Ma, Xu-Chen Cao, Guang-Xun Lin, Wu-ping Zheng, Peng-fei Lyu
Summary: This study uses bibliometric tools to analyze the most influential literature, the top 100 cited articles in the field of sentinel lymph node biopsy (SLNB), to provide researchers and physicians with research priorities and hotspots.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Lara C. Burg, Ellen M. Hengeveld, Joanna in 't Hout, Johan Bulten, Peter Bult, Petra L. M. Zusterzeel
Summary: The study aimed to evaluate the impact of ultrastaging on the detection rate of sentinel lymph node metastases in endometrial cancer patients. Results showed that ultrastaging can increase the detection rate of sentinel lymph node metastases, but different methods of analysis can affect the detection effectiveness.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2021)
Review
Oncology
Tamadar Aldoheyan, Julianne Klein
Summary: The study investigated the results of IOC of axillary sentinel lymph node in breast cancer patients. In imprint cytology, microscopic examination was limited to a maximum of three slides, with an average turnaround time slightly longer than the goal time. False negative events during surgery were mainly attributed to sampling errors.
Article
Cell Biology
Johanna Elversang, Birgitte Gronkaer Toft, Kim Predbjorn Krarup, Jakob K. Jakobsen
Summary: The study investigated the impact of rigorous step-sectioning of sentinel lymph nodes in penile cancer patients, revealing more metastases and confirming the importance of this procedure. The results further emphasized the need for histopathological routines and guidelines in these cases.
Article
Cell Biology
Soulaimane Aboulouard, Maxence Wisztorski, Marie Duhamel, Philippe Saudemont, Tristan Cardon, Fabrice Narducci, Anne-Sophie Lemaire, Firas Kobeissy, Eric Leblanc, Isabelle Fournier, Michel Salzet
Summary: The study identifies significant variations in the SLN protein landscape in EC and shows correlation between SLN and tumor grade, emphasizing the potential of certain proteins as markers for overall survival. Five major proteins for EC and SLN were identified and validated, improving stratification and diagnosis of individuals with EC.
CELL REPORTS MEDICINE
(2021)
Editorial Material
Oncology
Amanda W. Lund
Summary: An objective approach was used to study the sentinel lymph node landscape in patients with stage I-III cutaneous melanoma, revealing that micrometastasis is associated with progressive immune dysfunction. Tumor-induced lymph node dysfunction may lead to new hypotheses for neoadjuvant therapy that aims to reinvigorate the body's own anti-tumor immunity.
CLINICAL CANCER RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Binge Deng, Yaohui Wang, Yifan Wu, Wenjin Yin, Jinsong Lu, Jian Ye
Summary: The nontoxic Raman nanoparticle tracer GERTs allows for accurate identification of SLNs within 10 minutes in white New Zealand rabbit models, providing surgeons with over 4 hours to distinguish between SLNs and 2nd LNs. Additionally, GERTs have ultrahigh sensitivity, allowing for preoperative positioning information for minimally invasive surgery with no significant toxicity demonstrated in biosafety evaluations.
Article
Oncology
Tomohiro Miyake, Masafumi Shimoda, Tomonori Tanei, Naofumi Kagara, Yasuto Naoi, Seung Jin Kim, Kenzo Shimazu, Shinzaburo Noguchi
Summary: The study found that patients with suspicious lymph nodes can be treated with sentinel lymph node biopsy alone if they meet the criteria of ACOSOG Z-0011, even if preoperative fine-needle aspiration cytology yields positive results.
Article
Biotechnology & Applied Microbiology
Yanfeng Dai, Xiang Yu, Yuehong Leng, Xingzhou Peng, Junjie Wang, Yifan Zhao, Juan Chen, Zhihong Zhang
Summary: We report a melittin-loaded and hyaluronic acid (HA)-conjugated high-density lipoprotein (HDL) mimic phospholipid scaffold nanoparticle (MLT-HA-HPPS) that targets both breast cancer and its metastasis to lymph nodes. This nanoparticle effectively delivers the melittin peptide to breast cancer cells and inhibits their growth. Moreover, the delivery of MLT-HA-HPPS to lymph nodes can be monitored by NIR fluorescence imaging, which is beneficial for prognosis and treatment of lymph node metastasis in breast cancer.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Oncology
Dongwon Kim, Bumjin Lim, Jungyo Suh, Dalsan You, In Gab Jeong, Jun Hyuk Hong, Hanjong Ahn
Summary: This study investigated the role of radical prostatectomy in clinical nodal metastasis prostate cancer and the benefits of histological confirmation of lymph node metastasis through surgery. The results showed that although pathological diagnosis did not affect the time to BCR and CRPC, it did influence BCR rate, CRPC rate, and CSS, suggesting that accurate pathological diagnosis obtained through surgery is beneficial in the treatment of clinical nodal metastasis prostate cancer.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Stefano Restaino, Alessandro Buda, Andrea Puppo, Vito Andrea Capozzi, Giulio Sozzi, Jvan Casarin, Vitalba Gallitelli, Ferdinando Murgia, Giuseppe Vizzielli, Alessandro Baroni, Giacomo Corrado, Tina Pasciuto, Debora Ferrari, Antonia Novelli, Roberto Berretta, Francesco Legge, Enrico Vizza, Vito Chiantera, Fabio Ghezzi, Fabio Landoni, Giovanni Scambia, Francesco Fanfani
Summary: This study aimed to evaluate the anatomical distribution of sentinel lymph nodes (SLNs) and the most frequent locations of nodal metastasis in endometrial cancer patients. The majority of SLNs and positive SLNs were found at the external iliac and obturator level. Older age, higher body mass index, and non-endometrioid histology negatively impacted SLN mapping.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Article
Oncology
Katherine M. Marsh, Courtney M. Lattimore, Christopher L. Cramer, Craig L. Slingluff, Lynn T. Dengel
Summary: This study reports cases of primary melanoma draining to subcostal lymph nodes and provides characterization of the locations of these nodes. The study found that subcostal nodes are typically located under ribs 10-12 and have size limitations.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Yuchao Liu, Zijia Liu, Liangyan Zhang, Yuelun Zhang, Ningchen Zhang, Yue Han, Le Shen
Summary: This study found an association between preoperative 6-min walk distance and postoperative complications in patients undergoing laparoscopic gastrointestinal cancer surgery.
Review
Oncology
Matteo Pavone, Rosa Autorino, Nicolo Bizzarri, Giuditta Chilorio, Vincenzo Valentini, Giacomo Corrado, Gabriella Ferrandina, Gabriella Macchia, Maria Antonietta Gambacorta, Giovanni Scambia, Denis Querleu
Summary: Ovarian transposition is an established method for protecting the ovaries from radiation, while surgical procedures for protecting the uterus are still under investigation. This study conducted a systematic review of uterine displacement techniques and performed dose simulation to assess the radiation dose received by the uterus. The results showed that the transposition approach was the most protective.
Article
Oncology
Silvia Ministrini, Maria Bencivenga, Federica Filippini, Gianni Mura, Carlo Milandri, Maria Antonietta Mazzei, Giulio Bagnacci, Mattia Berselli, Manlio Monti, Paolo Morgagni, Leonardo Solaini, Daniele Marrelli, Stefania Piccioni, Stefano De Pascale, Luigina Graziosi, Rossella Reddavid, Fausto Rosa, Claudio Belluco, Guido Tiberio
Summary: The Italian Research Group for Gastric Cancer developed a prospective database to evaluate the impact of a pragmatic attitude on the management of stage IV gastric cancer patients. The study found that different metastatic sites did not affect survival rates, but multiple metastatic sites were associated with worse survival. Patients who could undergo curative resection had better survival rates. A more accurate diagnostic workup and staging had a favorable impact on survival.
Article
Oncology
Luca Lambertini, Fabrizio Di Maida, Anna Cadenar, Samuele Nardoni, Antonio Andrea Grosso, Francesca Valastro, Pietro Spinelli, Riccardo Fantechi, Agostino Tuccio, Gianni Vittori, Andrea Mari, Lorenzo Masieri, Andrea Minervini
Summary: The aim of this study was to evaluate the functional outcomes of Florence intracorporeal neobladder (FloRIN) configuration technique performed with a stentless procedure. The results showed that the stentless procedure was associated with shorter console time and lower estimated blood loss compared to the stent group. There were no significant differences in terms of perioperative features and mid-term functional outcomes between the two groups.
Article
Oncology
Geun-Jeon Kim, Jooin Bang, Hyun-Il Shin, Sang-Yeon Kim, Dong -Il Sun
Summary: This study evaluated the outcome of tonsillar cancer managed with neoadjuvant chemotherapy followed by surgery. The results showed that neoadjuvant chemotherapy reduced tumor volume and pathological adverse features, significantly decreasing the need for adjuvant therapy. A greater reduction in tumor volume predicted a complete pathologic response. There was no significant difference in survival rates between the groups.
Article
Oncology
Alexandra Nassar, Stylianos Tzedakis, Ugo Marchese, Gaanan Naveendran, Remy Sindayigaya, Martin Gaillard, Francois Cauchy, Mickael Lesurtel, Brice Gayet, Olivier Soubrane, David Fuks
Summary: This study identified recurrence between the two stages and a larger tumor size in the future liver remnant as critical factors contributing to the failure of two-stage hepatectomy for bilobar colorectal liver metastases. These findings have important clinical implications for the selection and evaluation of TSH surgery.
Letter
Oncology
Michele Fiore, Gian Marco Petrianni, Gabriele D'Ercole, Pasquale Trecca, Sara Ramella
Review
Oncology
Harry Farrow, Oliver J. Pickering, James A. Gossage, Philip H. Pucher
Summary: The inclusion or exclusion of the thoracic duct in radical esophagectomy for esophageal cancer is a controversial issue. While removing the thoracic duct may increase lymph node yield, it may also lead to higher morbidity without any survival benefit.
Article
Oncology
Xiaokun Li, Siyuan Luan, Chi Zhang, Weili Kong, Xin Xiao, Haowen Zhang, Jianfeng Zhou, Yushang Yang, Yang Xu, Yong Qiang, Pinhao Fang, Yi Shen, Yong Yuan
Summary: This study proposes a new staging system based on ypTNM stage and cN status for early stage ESCC patients after nCRT. The new ypTNM-cN staging system demonstrates superior predictive ability and classification efficacy compared to the AJCC 8th ypTNM staging system. It provides new insights for accurately stratifying ypI stage ESCC patients.
