Article
Oncology
Pamela Trillo, Jose Sandoval, Dario Trapani, Eleonora Nicolo, Paola Zagami, Federica Giugliano, Paolo Tarantino, Grazia Vivanet, Liliana Ascione, Alex Friedlaender, Angela Esposito, Carmen Criscitiello, Giuseppe Curigliano
Summary: The study retrospectively analyzed data of patients with recurrent invasive lobular carcinoma (ILC) and found discordance in the expression of ER, PgR, and HER2 between primary tumors and metastases. These findings suggest that phenotypic switch during metastasis may have implications for treatment decisions and prognosis in patients with ILC.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Jason A. Mouabbi, Akshara Singareeka Raghavendra, Roland L. Bassett Jr, Matthias Christgen, Lavinia Middleton, Mediget Teshome, Azadeh Nasrazadani, Gabriel Hortobagyi, Amy Hassan, Debasish Tripathy, Rachel M. Layman
Summary: The aim of this study was to determine if the outcomes of patients with the co-occurrence of ipsilateral lobular carcinoma in situ (LCIS) and invasive lobular carcinoma (ILC) are similar to pure ILC, and if the presence of LCIS is a prognostic factor for ILC. The results showed that patients in the ILC+LCIS group had better distant recurrence-free and overall survival rates compared to the ILC alone group, suggesting that the absence of LCIS is an independent poor prognostic factor for ILC.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Jason A. Mouabbi, Wei Qaio, Yu Shen, Akshara Singareeka Raghavendra, Debasish Tripathy, Rachel M. Layman
Summary: In hormone receptor-positive, HER2-negative metastatic invasive lobular breast cancer, the response to chemotherapy differs from invasive ductal cancer. A study demonstrated that single-agent capecitabine showed improved progression-free survival compared to taxanes in patients with endocrine therapy-refractory disease.
Review
Oncology
Amy E. McCart Reed, Lauren Kalinowski, Peter T. Simpson, Sunil R. Lakhani
Summary: Invasive lobular carcinoma is a common type of breast cancer with distinct characteristics, such as lack of E-cadherin function and luminal molecular subtype. Recent research has focused on pathology, disease management, and potential therapeutic options for this tumor type, leading to a significant increase in research output.
BREAST CANCER RESEARCH
(2021)
Review
Oncology
Jason A. Mouabbi, Amy Hassan, Bora Lim, Gabriel N. Hortobagyi, Debasish Tripathy, Rachel M. Layman
Summary: Invasive lobular carcinoma (ILC) is the second most common subtype of breast cancer, with conflicting outcomes compared to invasive ductal carcinoma (IDC). Recent studies have shown that ILC and IDC are distinct entities.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Medicine, General & Internal
Andrew A. Davis, Lorenzo Gerratana, Katherine Clifton, Arielle J. Medford, Marko Velimirovic, Whitney L. Hensing, Leslie Bucheit, Ami N. Shah, Paolo D'Amico, Carolina Reduzzi, Qiang Zhang, Charles S. Dai, Elyssa N. Denault, Nusayba A. Bagegni, Mateusz Opyrchal, Foluso O. Ademuyiwa, Ron Bose, William J. Gradishar, Amir Behdad, Cynthia X. Ma, Aditya Bardia, Massimo Cristofanilli
Summary: This study analyzed genomic differences in circulating tumor DNA (ctDNA) among patients with invasive lobular carcinoma (ILC), invasive ductal carcinoma (IDC), and mixed histology. The results showed that ILC was associated with specific HR+ HER2 negative and HER2 low characteristics. Higher levels of single nucleotide variations (SNVs) were observed in ILC patients compared to IDC or mixed histology patients. Mutations in CDFII, ERBB2, and PTEN genes were significantly associated with HR+ HER2 negative ILC. Additionally, mutations in the PI3K pathway genes were more common in ILC patients. These findings have implications for histologic classification and precision medicine treatment.
Article
Radiology, Nuclear Medicine & Medical Imaging
Seongkyun Jeong, Tae Hee Kim
Summary: The visibility of invasive lobular carcinoma (ILC) on diffusion-weighted imaging (DWI) is lower compared to invasive carcinoma of no special type (NST). ILC exhibits higher quantitative apparent diffusion coefficient (ADC) values and higher ADC difference values.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Anesthesiology
Y. H. Ke, K. Y. Hwang, T. N. Thin, Y. E. Sim, H. R. Abdullah
Summary: This study evaluated the accuracy of non-invasive haemoglobin measurement using Rad-67 Rainbow and found that it performed better in men compared to women, but still lacks sensitivity for detecting pre-operative anaemia. Further technological advancements are needed before it can be recommended as a routine pre-operative screening test.
Article
Radiology, Nuclear Medicine & Medical Imaging
Mina Ghaffari, Gihan Samarasinghe, Michael Jameson, Farhannah Aly, Lois Holloway, Phillip Chlap, Eng-Siew Koh, Arcot Sowmya, Ruth Oliver
Summary: This study developed an automated method for brain tumour segmentation using multimodal brain scans and manual annotations, achieving high accuracy through ensemble learning and data transfer techniques even with a small dataset.
MAGNETIC RESONANCE IMAGING
(2022)
Article
Oncology
Medha Suman, Pierre-Antoine Dugue, Ee Ming Wong, JiHoon Eric Joo, John L. Hopper, Tu Nguyen-Dumont, Graham G. Giles, Roger L. Milne, Catriona McLean, Melissa C. Southey
Summary: This study investigated the genome-wide variability of DNA methylation levels across invasive lobular breast cancer (ILBC) tumors and found that methylation at several genes may serve as a potential biomarker for survival in ILBC patients.
CLINICAL EPIGENETICS
(2021)
Article
Oncology
Roi Weiser, Efstathia Polychronopoulou, Sandra S. Hatch, Waqar Haque, Hafiz A. Ghani, Jing He, Yong-Fang Kuo, William J. Gradishar, V. Suzanne Klimberg
Summary: The Oncotype recurrence score (RS) has prognostic and predictive value in invasive lobular carcinoma (ILC) patients. Patients with ILC who have a high RS are treated less often with chemotherapy compared with similar patients who have invasive ductal carcinoma (IDC).
Article
Oncology
Thijmen Sijnesael, Francois Richard, Max A. K. Ratze, Thijs Koorman, Blessing Bassey-Archibong, Christa Rohof, Juliet Daniel, Christine Desmedt, Patrick W. B. Derksen
Summary: This study found that the anchorage-independent and ILC-specific transcriptional program, identified as the Kaiso-specific ART (KART) 33-gene signature, correlated with histological and clinical variables in breast cancer. The KART signature showed associations with the ILC breast cancer type, younger age, and smaller tumors, as well as favorable long-term prognosis in both ILC and IDC-NST. This mRNA expression signature based on canonical Kaiso target genes provides valuable insights into the biology and etiology of ILC.
JOURNAL OF PATHOLOGY
(2023)
Article
Oncology
Mary Kathryn Abel, Heather Greenwood, Tatiana Kelil, Ruby Guo, Case Brabham, Nola Hylton, Jasmine Wong, Michael Alvarado, Cheryl Ewing, Laura J. Esserman, Judy C. Boughey, Rita A. Mukhtar
Summary: Breast MRI after neoadjuvant therapy in patients with ILC showed low accuracy in predicting nodal status, but may help identify patients with a high burden of nodal disease (>= 4 positive nodes), potentially impacting pre-operative systemic therapy decisions. Further studies are needed to evaluate other imaging modalities for nodal disease assessment following neoadjuvant therapy in ILC patients.
Review
Oncology
Katelyn Schumacher, Marc Inciardi, Maura O'Neil, Jamie L. Wagner, Ishani Shah, Amanda L. Amin, Christa R. Balanoff, Kelsey E. Larson
Summary: There is a significant difference between clinical and pathologic N-stage in ILC patients. MRI is the most sensitive method for identifying pN2-N3 patients, and should be considered as part of routine axillary imaging evaluation for ILC patients.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Review
Health Care Sciences & Services
Alicia M. Pereslucha, Danielle M. Wenger, Michael F. Morris, Zeynep Bostanci Aydi
Summary: Invasive lobular cancer (ILC) is a challenging type of breast cancer to detect due to its unique growth pattern. MRI and contrast-enhanced mammogram (CEM) have shown superior sensitivity, specificity, and detection accuracy for ILC compared to conventional breast imaging. Both MRI and CEM have been found to improve surgical outcomes for patients with newly diagnosed ILC.
Editorial Material
Urology & Nephrology
Hendrik Van Poppel, Renee Hogenhout, Peter Albers, Roderick C. N. van den Bergh, Jelle O. Barentsz, Monique J. Roobol
Article
Radiology, Nuclear Medicine & Medical Imaging
Melline G. M. Schilham, Patrik Zamecnik, Bastiaan M. Prive, Bas Israel, Mark Rijpkema, Tom Scheenen, Jelle O. Barentsz, James Nagarajah, Martin Gotthardt
Summary: Accurate assessment of lymph node metastases in prostate cancer patients is crucial. PSMA PET/CT and nano-MRI are imaging modalities with high potential for identifying LN metastases. This study compared the results of these modalities, finding that nano-MRI detected more suspicious LNs, especially smaller ones, across all anatomical regions of the pelvis. It suggests that nano-MRI could complement PSMA PET/CT in imaging PCa patients, but further investigation is needed.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Clare M. C. Tempany-Afdhal, Anwar Padhani, Jelle Barentsz, Jeffrey Weinreb
Editorial Material
Oncology
Jessie J. J. Gommers, Lucien E. M. Duijm, Peter Bult, Luc J. A. Strobbe, Toon P. Kuipers, Marianne J. H. Hooijen, Ritse M. Mann, Adri C. Voogd
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Emma J. Groen, Marieke E. M. van der Noordaa, Michael Schaapveld, Gabe S. Sonke, Ritse M. Mann, Mette S. van Ramshorst, Esther H. Lips, Marie-Jeanne T. F. D. Vrancken Peeters, Frederieke H. van Duijnhoven, Jelle Wesseling
Summary: This study evaluated the response of adjacent DCIS to NST-containing HER2-blockade in HER2-positive breast cancer patients and identified predictive factors for DCIS response, including absence of suspicious calcifications on pre-NST mammography, dual HER2-blockade treatment, near complete response on MRI, absence of calcifications and Ki-67 > 20% in DCIS on pre-NST biopsy. These findings suggest that mastectomy may not always be necessary for patients with extensive DCIS in HER2-positive breast cancer before NST.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
Bastiaan M. Prive, Steffie M. B. Peters, Constantijn H. J. Muselaers, Inge M. van Oort, Marcel J. R. Janssen, J. P. Michiel Sedelaar, Mark W. Konijnenberg, Patrik Zamecnik, Maike J. M. Uijen, Melline G. M. Schilham, Annemarie Eek, Tom W. J. Scheenen, J. Fred Verzijlbergen, Winald R. Gerritsen, Niven Mehra, Linda G. W. Kerkmeijer, Robert J. Smeenk, Diederik M. Somford, Jean-Paul A. Van Basten, Sandra Heskamp, Jelle O. Barentsz, Martin Gotthardt, J. Alfred Witjes, James Nagarajah
Summary: In this prospective study, Lu-177-PSMA appeared to be a feasible and safe treatment modality for patients with low-volume metastatic hormone-sensitive prostate cancer, showing good treatment effect and minimal adverse events.
CLINICAL CANCER RESEARCH
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wendelien B. G. Sanderink, Jonas Teuwen, Linda Appelman, Linda Moy, Laura Heacock, Elisabeth Weiland, Nico Karssemeijer, Pascal A. T. Baltzer, Ioannis Sechopoulos, Ritse M. Mann
Summary: Despite lower image quality and increased artifacts in the SMS-ss-EPI sequence, malignant lesions are better visualized using this sequence. Sensitivity and specificity were comparable between both sequences.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tobias Penzkofer, Anwar R. Padhani, Baris Turkbey, Masoom A. Haider, Henkjan Huisman, Jochen Walz, Georg Salomon, Ivo G. Schoots, Jonathan Richenberg, Geert Villeirs, Valeria Panebianco, Olivier Rouviere, Vibeke Berg Logager, Jelle Barentsz
Summary: Artificial intelligence is crucial for the successful deployment of community-wide MRI-driven prostate cancer diagnosis by ensuring high specificity, biopsy avoidance, and integration into radiologists' workflow. Further development efforts are needed to make AI systems as clinical decision-making tools for a wider adoption of the MRI-directed approach.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Suzanne L. van Winkel, Alejandro Rodriguez-Ruiz, Linda Appelman, Albert Gubern-Merida, Nico Karssemeijer, Jonas Teuwen, Alexander J. T. Wanders, Ioannis Sechopoulos, Ritse M. Mann
Summary: This study found that using artificial intelligence support system in wide-angle DBT reading can improve the accuracy of breast cancer detection and reduce reading time. The research also showed that the stand-alone performance of the AI system in detecting malignancies is comparable to the average radiologist.
EUROPEAN RADIOLOGY
(2021)
Letter
Urology & Nephrology
Hendrik Van Poppel, Renee Hogenhout, Peter Albers, Roderick C. N. Van den Bergh, Jelle O. Barentsz, Monique J. Roobol
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Ritse M. Mann
Article
Radiology, Nuclear Medicine & Medical Imaging
Stefanie G. A. Veenhuizen, Stephanie de Lange, Marije F. Bakker, Ruud M. Pijnappel, Ritse M. Mann, Evelyn M. Monninkhof, Marleen J. Emaus, Petra K. De Koekkoek-Doll, Robertus H. C. Bisschops, Marc B. Lobbes, Mathijn D. F. de Jong, Katya M. Duvivier, Jeroen Veltman, Nico Karssemeijer, Harry J. de Koning, Paul J. van Diest, Willem P. T. M. Mali, Maurice A. A. J. van den Bosch, Carla H. van Gils, Wouter B. Veldhuis
Summary: In the second round of the DENSE trial, there was a lower cancer detection rate but a reduced false-positive rate compared to the first round.
Article
Urology & Nephrology
Bas Israel, Jos Immerzeel, Marloes van der Leest, Gerjon Hannink, Patrik Zamecnik, Joyce Bomers, Ivo G. Schoots, Jean-Paul Van Basten, Frans Debruyne, Inge van Oort, Michiel Sedelaar, Jelle Barentsz
Summary: The study evaluated the outcomes of pre-biopsy MRI pathways in biopsy-naive men with suspicion of prostate cancer in routine clinical practice. The results showed that pre-biopsy MRI can be used as a decision tool without compromising cancer detection rates and with a higher biopsy avoidance rate. There were comparable cancer detection and complication rates between TR- and TP-MRDB.
Article
Radiology, Nuclear Medicine & Medical Imaging
Francesco Sardanelli, Rubina M. Trimboli, Nehmat Houssami, Fiona J. Gilbert, Thomas H. Helbich, Marina Alvarez Benito, Corinne Balleyguier, Massimo Bazzocchi, Peter Bult, Massimo Calabrese, Julia Camps Herrero, Francesco Cartia, Enrico Cassano, Paola Clauser, Andrea Cozzi, Danubia A. de Andrade, Marcos F. de Lima Docema, Catherine Depretto, Valeria Dominelli, Gabor Forrai, Rossano Girometti, Steven E. Harms, Sarah Hilborne, Raffaele Ienzi, Marc B. Lobbes, Claudio Losio, Ritse M. Mann, Stefania Montemezzi, Inge-Marie Obdeijn, Umit A. Ozcan, Federica Pediconi, Katja Pinker, Heike Preibsch, Jose L. Raya Povedano, Daniela Sacchetto, Gianfranco P. Scaperrotta, Simone Schiaffino, Margrethe Schlooz, Botond K. Szabo, Donna B. Taylor, Ozden S. Ulus, Mireille Van Goethem, Jeroen Veltman, Stefanie Weigel, Evelyn Wenkel, Chiara Zuiani, Giovanni Di Leo
Summary: Preoperative breast MRI can lead to higher mastectomy rates but also provide valuable information for surgical planning in patients with breast cancer.
EUROPEAN RADIOLOGY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Kay J. J. van der Hoogt, Robert J. Schipper, Gonneke A. Winter-Warnars, Leon C. ter Beek, Claudette E. Loo, Ritse M. Mann, Regina G. H. Beets-Tan
Summary: This review highlights the technical, clinical, and epidemiological heterogeneity in breast DWI-MRI studies for identifying breast cancer patients with pCR on NST. Variability was observed in study population, treatment type, DWI acquisition technique, post-processing methods, and follow-up timing, leading to inconsistent results in predicting pCR accurately.
INSIGHTS INTO IMAGING
(2021)
Article
Oncology
Yuchao Liu, Zijia Liu, Liangyan Zhang, Yuelun Zhang, Ningchen Zhang, Yue Han, Le Shen
Summary: This study found an association between preoperative 6-min walk distance and postoperative complications in patients undergoing laparoscopic gastrointestinal cancer surgery.
Review
Oncology
Matteo Pavone, Rosa Autorino, Nicolo Bizzarri, Giuditta Chilorio, Vincenzo Valentini, Giacomo Corrado, Gabriella Ferrandina, Gabriella Macchia, Maria Antonietta Gambacorta, Giovanni Scambia, Denis Querleu
Summary: Ovarian transposition is an established method for protecting the ovaries from radiation, while surgical procedures for protecting the uterus are still under investigation. This study conducted a systematic review of uterine displacement techniques and performed dose simulation to assess the radiation dose received by the uterus. The results showed that the transposition approach was the most protective.
Article
Oncology
Silvia Ministrini, Maria Bencivenga, Federica Filippini, Gianni Mura, Carlo Milandri, Maria Antonietta Mazzei, Giulio Bagnacci, Mattia Berselli, Manlio Monti, Paolo Morgagni, Leonardo Solaini, Daniele Marrelli, Stefania Piccioni, Stefano De Pascale, Luigina Graziosi, Rossella Reddavid, Fausto Rosa, Claudio Belluco, Guido Tiberio
Summary: The Italian Research Group for Gastric Cancer developed a prospective database to evaluate the impact of a pragmatic attitude on the management of stage IV gastric cancer patients. The study found that different metastatic sites did not affect survival rates, but multiple metastatic sites were associated with worse survival. Patients who could undergo curative resection had better survival rates. A more accurate diagnostic workup and staging had a favorable impact on survival.
Article
Oncology
Luca Lambertini, Fabrizio Di Maida, Anna Cadenar, Samuele Nardoni, Antonio Andrea Grosso, Francesca Valastro, Pietro Spinelli, Riccardo Fantechi, Agostino Tuccio, Gianni Vittori, Andrea Mari, Lorenzo Masieri, Andrea Minervini
Summary: The aim of this study was to evaluate the functional outcomes of Florence intracorporeal neobladder (FloRIN) configuration technique performed with a stentless procedure. The results showed that the stentless procedure was associated with shorter console time and lower estimated blood loss compared to the stent group. There were no significant differences in terms of perioperative features and mid-term functional outcomes between the two groups.
Article
Oncology
Geun-Jeon Kim, Jooin Bang, Hyun-Il Shin, Sang-Yeon Kim, Dong -Il Sun
Summary: This study evaluated the outcome of tonsillar cancer managed with neoadjuvant chemotherapy followed by surgery. The results showed that neoadjuvant chemotherapy reduced tumor volume and pathological adverse features, significantly decreasing the need for adjuvant therapy. A greater reduction in tumor volume predicted a complete pathologic response. There was no significant difference in survival rates between the groups.
Article
Oncology
Alexandra Nassar, Stylianos Tzedakis, Ugo Marchese, Gaanan Naveendran, Remy Sindayigaya, Martin Gaillard, Francois Cauchy, Mickael Lesurtel, Brice Gayet, Olivier Soubrane, David Fuks
Summary: This study identified recurrence between the two stages and a larger tumor size in the future liver remnant as critical factors contributing to the failure of two-stage hepatectomy for bilobar colorectal liver metastases. These findings have important clinical implications for the selection and evaluation of TSH surgery.
Letter
Oncology
Michele Fiore, Gian Marco Petrianni, Gabriele D'Ercole, Pasquale Trecca, Sara Ramella
Review
Oncology
Harry Farrow, Oliver J. Pickering, James A. Gossage, Philip H. Pucher
Summary: The inclusion or exclusion of the thoracic duct in radical esophagectomy for esophageal cancer is a controversial issue. While removing the thoracic duct may increase lymph node yield, it may also lead to higher morbidity without any survival benefit.
Article
Oncology
Xiaokun Li, Siyuan Luan, Chi Zhang, Weili Kong, Xin Xiao, Haowen Zhang, Jianfeng Zhou, Yushang Yang, Yang Xu, Yong Qiang, Pinhao Fang, Yi Shen, Yong Yuan
Summary: This study proposes a new staging system based on ypTNM stage and cN status for early stage ESCC patients after nCRT. The new ypTNM-cN staging system demonstrates superior predictive ability and classification efficacy compared to the AJCC 8th ypTNM staging system. It provides new insights for accurately stratifying ypI stage ESCC patients.
