Article
Biochemistry & Molecular Biology
Yuan Yuan, Caihua Xue, Qiang Wu, Mengjie Wang, Jiahua Liu, Longfei Zhang, Qianwen Xing, Jingyan Liang, Hua Wu, Zhi Chen
Summary: Procyanidin B2 (PCB2) induces apoptosis in MCF-7 cells and affects the expression levels of CD36. MiR-145-5p regulates apoptosis in MCF-7 cells by targeting CD36. These findings provide theoretical and experimental support for the treatment of breast cancer.
Article
Environmental Sciences
Vijayakumar Gunasekaran, Rathinam Yuvakkumar, Ravi Ganesan, Surya Cholayil Palapetta, Harichandran Gurusamy
Summary: In this study, NBA and ABA were synthesized and evaluated for their cell multiplication inhibition activity against MCF-7 and HeLa cancer cell lines. The results showed that both NBA and ABA exhibited antiproliferative action against these cancer cell lines.
ENVIRONMENTAL RESEARCH
(2023)
Article
Polymer Science
Yedi Herdiana, Nasrul Wathoni, Shaharum Shamsuddin, Muchtaridi Muchtaridi
Summary: This study investigated the enhancement of cytotoxicity of alpha-mangostin (AMG) in breast cancer cells through the modification of chitosan molecular weight. Chitosan-based nanoparticles were developed, and their physicochemical characteristics and cytotoxicity were evaluated. The results showed that the prepared nanoparticles significantly enhanced the cytotoxicity of breast cancer cells compared to the non-nano particle formulation.
Article
Biochemistry & Molecular Biology
Wenping Wang, Irene Liparulo, Nicola Rizzardi, Paola Bolignano, Natalia Calonghi, Christian Bergamini, Romana Fato
Summary: The study demonstrated that cancer cells can adapt to energetic and oxidative stress caused by mitochondrial dysfunction by reshaping their metabolism. Depletion of CoQ in cells led to upregulation of glycolysis, increased glucose consumption, and changes in enzyme expression related to glutamine metabolism and the TCA cycle. Understanding the metabolic alterations in CoQ-depleted cells provides insights for targeting cancer metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Ying Chen, Zuqing Hu, Meilin Tang, Fan Huang, Yiren Xiong, Di Ouyang, Jiayi He, Shanshan He, Hongyi Xian, Dalin Hu
Summary: This study explores the mechanism by which Bisphenol A (BPA) promotes the proliferation and migration of cancer cells. The research shows that BPA exposure leads to decreased miR-26b expression and activation of the miR26b/Rab-31 pathway in MCF-7 cells, resulting in reduced lysosome activity and increased exosome secretion, ultimately enhancing cell proliferation and migration. Inhibition of exosome secretion through GW4869 treatment reverses these effects, suggesting that BPA's stimulation of cell proliferation and migration is mediated through lysosome-related exosome secretion via the miR-26b/Rab31 pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Multidisciplinary Sciences
Ola E. E. Abdel-Sattar, Rasha Mosa Allam, Ahmed M. M. Al-Abd, Bharathi Avula, Kumar Katragunta, Ikhlas A. A. Khan, Ahmed M. M. El-Desoky, Shanaz O. O. Mohamed, Ali El-Halawany, Essam Abdel-Sattar, Meselhy R. R. Meselhy
Summary: The genus Phyllanthus has potential in the treatment of various diseases, and its extracts showed cytotoxicity against breast cancer cells. The methylene chloride fraction exhibited the strongest cytotoxic activity among all tested fractions.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Tian Tian
Summary: In this study, the effects of a new Ag(I)curcuminoid-Gboxin analog complex were investigated using the MCF-7 breast carcinoma cell line. The results showed that Ag(I)FLLL49-GbA could up-regulate the expression of caspase-3, P53, and Bax in MCF-7 cells after 48 hours of treatment. However, it was puzzling because MCF-7 cells do not naturally express caspase-3. Appropriate modifications are suggested to strengthen the findings of this study.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Medicine, Research & Experimental
Mohammad Imran Ansari, Nuzhat Bano, K. M. Kainat, Vipendra Kumar Singh, Pradeep Kumar Sharma
Summary: Repeated exposures to low-dose BPA may induce metastatic aggression in ER alpha-positive breast cancer cells through PGC-1 alpha-mediated mitochondrial biogenesis and epithelial-mesenchymal plasticity.
Article
Biology
Miriam Buehler, Jeanine Fahrlaender, Alexander Sauter, Markus Becker, Elisa Wistorf, Matthias Steinfath, Ailine Stolz
Summary: This study reveals the significant role of environment estrogen-activated GPER1 in colorectal cancer development by inducing centrosome amplification and consequent chromosomal instability, promoting the transformation of normal cells into cancer cells.
LIFE SCIENCE ALLIANCE
(2022)
Article
Chemistry, Multidisciplinary
Xiyan Mu, Suzhen Qi, Jia Liu, Lilai Yuan, Ying Huang, Jiaying Xue, Le Qian, Chengju Wang, Yingren Li
Summary: Research found that co-exposure of bisphenol analogues and polystyrene microplastics increased mortality rate among larvae, with little effect on embryos. Microplastics accumulated in the gastrointestinal area of larvae but not in embryos. Combined exposure led to stronger behavioral effects compared to single pollutant exposure.
ENVIRONMENTAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Medicinal
Mariam M. Fakhry, Kazem Mahmoud, Mohamed S. Nafie, Ahmad O. Noor, Rawan H. Hareeri, Ismail Salama, Safaa M. Kishk
Summary: In this study, a novel series of EGFR/HER2 dual inhibitors were designed and synthesized, which showed strong anti-proliferative activity against MCF-7 breast cancer cells and were validated for their enzyme activity. Additionally, these compounds promoted apoptotic cell death in breast cancer cells, demonstrating their potential as anticancer agents.
Article
Biophysics
Xiaojuan Wang, Tingting Guo, Yang Shu, Jianhua Wang
Summary: Choline-based ionic liquids with different anions were studied for their toxicity, revealing that choline chloride had minimal toxicity, while choline bitartrate and choline dihydrogen citrate showed higher toxicity to cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Eric Chekwube Aniogo, Blassan P. George, Heidi Abrahamse
Summary: The study utilized photodynamic therapy to treat MCF-7 cells overexpressed with P-glycoprotein, resulting in cell apoptosis with increased externalisation of phosphatidylserine protein and changes in apoptotic protein expression.
Article
Biochemistry & Molecular Biology
Dominika Komorowska, Agnieszka Gajewska, Pawel Hikisz, Grzegorz Bartosz, Aleksandra Rodacka
Summary: Resveratrol was found to significantly increase the sensitivity of breast cancer cells to ionizing radiation, leading to apoptosis. The combination of resveratrol and IR had a higher cytotoxic effect on MCF-7 cells compared to using other compounds or radiation alone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Shoib Sarwar Siddiqui, Rawad Hodeify, Shimy Mathew, Seba Alsawaf, Anood Alghfeli, Rachel Matar, Maxime Merheb, John Marton, Hussain AbdulKarim Al Zouabi, Dhiviya Prabaa Muthuirulandi Sethuvel, Naveen Kumar Devanga Ragupathi, Cijo George Vazhappilly
Summary: At a lower concentration, cyclosporine A (CsA) inhibits cell growth and induces DNA damage and apoptosis in MCF-7 breast cancer cells. At a higher concentration, CsA leads to differential expression of autophagy-related genes and apoptosis-associated markers, indicating a dose-response effect on cell death mechanisms. Additionally, the combination of CsA with SHP2/PI3K-AKT inhibitors shows potential for reducing MCF-7 cell growth.
INFLAMMOPHARMACOLOGY
(2023)