Article
Biochemistry & Molecular Biology
Zhihui Cai, Yutian Zhang, Weijie Zhang, Jinmin Ye, Qinjie Ling, Zhi Xing, Sichun Zhang, Peter R. Hoffmann, Youbin Liu, Weidong Yang, Zhi Huang
Summary: Arsenic contamination in drinking water is a global public health problem. Selenium deficiency is associated with an increased risk of arsenism. This study found that low Se status impairs redox homeostasis, leading to increased As retention in erythrocytes and subsequent phagocytosis by splenic macrophages, resulting in increased inflammatory response.
Article
Environmental Sciences
Juliana dos Santos Mendonca, Julio Cesar Neves de Almeida, Lucelia Goncalves Vieira, Liria Queiroz Luz Hirano, Andre Luiz Quagliatto Santos, Denis Vieira Andrade, Guilherme Malafaia, Robson Jose de Oliveira Jr, Marcelo Emilio Beletti
Summary: Pesticides, especially glyphosate and fipronil, have mutagenic and toxic effects on neonates of Podocnemis expansa, causing histopathological damage and genetic alterations. The presence of blebbed nuclei, moved nuclei, and notched nuclei indicate the increased frequency of erythrocyte nuclear abnormalities. Exposure to fipronil leads to congestion and inflammatory infiltrate in the liver tissue and congestion and necrosis in the encephalon. This study highlights the significance of using different biomarkers to evaluate the ecotoxicological effects of pesticides on oviparous animals.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Krishnasamy Sekar Rajkumar, Palaniyappan Sivagaami, Arunachalam Ramkumar, Anbazhagan Murugadas, Veeran Srinivasan, Sridhar Arun, Ponnusamy Senthil Kumar, Ramasamy Thirumurugan
Summary: This study aimed to investigate the toxicity of zinc oxide nanoparticles (ZnO NPs) in freshwater fish. The results showed that exposure to ZnO NPs altered the hematological parameters of the fish and induced the production of reactive oxygen species (ROS), leading to an increase in the activity of antioxidant enzymes. Histopathological analysis also revealed tissue damage in the gills, liver, and muscles. Furthermore, the study found changes in the expression of related genes after exposure to ZnO NPs.
Article
Fisheries
Asma W. Al-Thomali, Hend M. Tag, Amaal Mohammadein, Nahla S. El-Shenawy, Mohamed Salah El-Naggar
Summary: The study revealed that exposure to mercaptophos had negative effects on the endocrine system and liver tissue of Cyprinus carpio, leading to exacerbated oxidative stress reactions, alterations in hormone levels, and pathological changes in liver and pancreatic cells.
AQUACULTURE REPORTS
(2022)
Article
Environmental Sciences
Nazish Iftikhar, Rabeea Zafar, Imran Hashmi
Summary: This study investigated the bioaccumulation and sub-lethal toxicity of sulfamethoxazole in Cyprinus carpio. It was found that sulfamethoxazole accumulated in the fish muscle tissues and induced oxidative stress and histopathology. The production of reactive oxygen species (ROS) and the severity of tissue damage were dose and time dependent.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Pharmacology & Pharmacy
Wei Liu, Zechang Li, Xiaoyu Cui, Fang Luo, Chunyan Zhou, Jiangyu Zhang, Liguo Xing
Summary: The genotoxicity of nitenpyram (NIT) has been evaluated using human bone marrow mesenchymal stem cells (hBMSCs), showing potential genotoxic effects through oxidative stress and dysregulation of various signaling pathways. Although the risk of NIT alone to human health is low, the synergistic or additive effects with other pesticides should be considered.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Environmental Sciences
Merve Becit, Sule Cilekar, Mustafa Mert Basaran, Halit Bugra Koca, Sefa Celik, Sevtap Aydin Dilsiz
Summary: Workers in marble processing plants are at high risk of exposure to marble dust containing silica, which may result in immunotoxic and genotoxic effects. Oxidative stress and immune system parameters were significantly affected in workers exposed to marble dust.
ENVIRONMENTAL RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Davoud Malekzadeh, Asadollah Asadi, Arash Abdolmaleki, Gholamreza Dehghan
Summary: This study reports the therapeutic efficacy of fullerene C60 nanoparticles (FC60 NPs) in animals with aluminum-induced oxidative stress. The effects of FC60 NPs on neurobiochemical enzymes and oxidative parameters in brain and liver tissues were evaluated. Results showed a significant improvement in the markers, suggesting FC60 NPs as a potential therapeutic option for neurodegenerative diseases.
Article
Environmental Sciences
Ricardo Camarinho, Patricia Ventura Garcia, Hyunok Choi, Armindo Santos Rodrigues
Summary: Recent studies have shown that exposure to hydrothermal emissions may have a negative impact on the respiratory system. The study, conducted in a non-eruptive volcanically active environment, found that mice exposed to hydrothermal emissions exhibited increased oxidative stress and apoptotic cells in their lungs. This study highlights the potential respiratory health risks associated with chronic exposure to hydrothermal emissions, emphasizing the importance of monitoring residents in volcanic areas.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Marine & Freshwater Biology
Serdar Yedier, Seda Kontas Yalcinkaya, Derya Bostanci
Summary: The occurrence of microplastic accumulation in humans and wildlife is a serious concern globally, with limited understanding of their effects on freshwater fish. In this study, Cyprinus carpio was exposed to polypropylene (PP) microplastics through water and diet over a period of 1-7 days. The results showed that microplastic exposure caused oxidative stress in fish, as indicated by increased levels of malondialdehyde (MDA) and glutathione (GSH) and decreased levels of total protein content (TPC) and catalase (CAT). The study provides valuable toxicological data on the effects of PP microplastics on freshwater fish and highlights the importance of understanding the impacts of microplastics on organisms in freshwater ecosystems.
AQUATIC TOXICOLOGY
(2023)
Article
Fisheries
Shuqun Xue, Jiawen Lin, Yue Han, Ying Han
Summary: Ammonia stress in common carp leads to oxidative stress and apoptosis in the hepatopancreas, possibly mediated by the p53-BAX/BCL-2 apoptosis signal pathway.
AQUACULTURE INTERNATIONAL
(2021)
Article
Fisheries
Haoran Zhang, Fuqing Zhao, Xiaoxue Gai, Jingzeng Cai, Xintong Zhang, Xiaoming Chen, Yue Zhu, Ziwei Zhang
Summary: Cadmium is a common environmental pollutant that has toxic effects on fish head kidney lymphocytes. This study utilized an in vitro Cd exposure model and antioxidant treatment to demonstrate that Cd induced lymphocyte apoptosis, which could be alleviated by antioxidants.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Environmental Sciences
Bozidar Raskovic, Vesna Poleksic, Gorica Vukovic, Bojana Spirovic Trifunovic, Gavrilo Bozic, Dejana Cupic Miladinovic, Zoran Markovic, Dragica Brkic
Summary: S-metolachlor has potential toxic effects on common carp, as indicated by biomarker changes in the gills and liver. Exposure to higher concentrations of S-metolachlor resulted in mild alterations in these organs.
Article
Environmental Sciences
Jinxin Wang, Xuzhu Gao, Feixue Liu, Fang Wang, Jingquan Dong, Panpan Zhao
Summary: This study revealed that the widespread use of difenoconazole in fish culture in paddy fields can cause cardiotoxicity in common carp. The cardiotoxicity is regulated by multiple mechanisms including oxidative stress, inflammation, apoptosis, and autophagy.
Article
Fisheries
Xianfeng Wang, Xulu Chang, Lifeng Zhao, Junchang Feng, Hui Li, Junping Liang
Summary: The study revealed that trichlorfon induced more severe oxidative stresses in the liver than in the brain of common carp, potentially leading to neurotoxicity and affecting immune responses. In addition, neurotransmitter contents were reduced in the brain, while inflammatory cytokines increased in response to trichlorfon exposure. Histological observations also showed changes in melano-macrophage centers in the head kidney and spleen of exposed carp.
Article
Environmental Sciences
Karina Ruiz-Lara, Sandra Garcia-Medina, Marcela Galar-Martinez, Israel Parra-Ortega, Israel Morales-Balcazar, Nancy Aline Hernandez-Rosas, Sergio Esteban Moreno-Vazquez, Misael Hernandez-Diaz, Selene Cano-Viveros, Eduardo Osel Olvera-Roldan, Leobardo Manuel Gomez-Olivan, Eloy Gasca-Perez, Alba Lucero Garcia-Medina
Summary: Environmental pollution is one of the most important causes of disease and premature death worldwide. The Mexico City Metropolitan Area is severely affected by air and water pollution, which has negative impacts on human health. The study found that chronic exposure to air and water pollutants was significantly associated with elevated levels of lipoperoxidation, indicating the presence of oxidative stress.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Letter
Environmental Sciences
Karina Elisa Rosales-Perez, Gustavo Axel Elizalde-Velazquez, Leobardo Manuel Gomez-Olivan, Jose Manuel Orozco-Hernandez, Jesus Daniel Cardoso-Vera, Gerardo Heredia-Garcia, Hariz Islas-Flores, Sandra Garcia-Medina, Marcela Galar-Martinez
Article
Environmental Sciences
Paulina Tenorio-Chavez, Gustavo Axel Elizalde-Velazquez, Leobardo Manuel Gomez-Olivan, Maria Dolores Hernandez-Navarro
Summary: Tetracycline (TC) is a widely consumed antibiotic that has been found in aquatic environments and shown to have toxic effects on various organisms. This study aimed to assess the embryotoxic and oxidative damage caused by environmentally relevant concentrations of TC on Danio rerio embryos. The results showed that TC at concentrations of 50-500 ng/L induced deformities and mortality in the embryos, as well as oxidative damage. However, an enriched diet with spirulina was found to reduce the toxicity of TC and alleviate the observed effects.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Sindy San Juan-Reyes, Leobardo Manuel Gomez-Olivan, Nely San Juan-Reyes, Hariz Islas-Flores, Octavio Dublan-Garcia, Jose Manuel Orozco-Hernandez, Itzayana Perez-alvarez, Alejandro Mejia-Garcia
Summary: Oxidative imbalance is a known pathophysiological mechanism in pregnant women with preeclampsia and their newborns, with similar effects seen in individuals exposed to air pollution. This study aimed to investigate the biomarkers of oxidative stress and their association with neonatal diseases in premature babies born to mothers with preeclampsia and exposed to air pollution during pregnancy. Results showed higher levels of oxidative stress markers in preeclamptic women and their newborns exposed to higher levels of air pollutants during the first and second trimesters. Neonatal diseases such as intrauterine growth restriction and necrotizing enterocolitis were significantly correlated with prooxidant agents and antioxidant enzyme activity in preeclampsia. The findings suggest increased oxidative damage in both maternal and fetal circulation in preeclamptic women exposed to air pollution, leading to worse outcomes in preterm infants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Food Science & Technology
Francisco Antonio Lopez-Medina, Octavio Dublan-Garcia, Ana Gabriela Morachis-Valdez, Leobardo Manuel Gomez-Olivan, Hariz Islas-Flores, Maria Dolores Hernandez-Navarro
Summary: The jumbo squid in Mexico is a commercially valuable mollusk with 80% of its body being edible. By using foam-aided pH-shift processing, the functional and physicochemical properties of the muscle protein can be improved, and a protein extract with desirable attributes such as foaming, emulsifying, or gelling capacities can be produced.
JOURNAL OF FOOD SCIENCE
(2023)
Article
Reproductive Biology
Itzayana Perez-Alvarez, Hariz Islas-Flores, Livier Mireya Sanchez-Aceves, Leobardo Manuel Gomez-Olivan, German Chamorro-Cevallos
Summary: This study aimed to evaluate if Spirulina reduces the damage induced by a mixture of Cd and DCF in Xenopus laevis at early life stages. The results showed that Spirulina promotes growth, reduces mortality, malformations, and oxidative stress.
REPRODUCTIVE TOXICOLOGY
(2023)
Article
Environmental Sciences
Idalia Casas-Hinojosa, Leobardo Manuel Gomez-Olivan, Veronica Margarita Gutierrez-Noya, Sandra Gracia-Medina, Karina Elisa Rosales-Perez, Jose Manuel Orozco-Hernandez, Gustavo Axel Elizalde-Velazquez, Marcela Galar-Martinez, Octavio Dublan-Garcia, Maria Dolores Hernandez-Navarro, Hariz Islas-Flores
Summary: This study aimed to investigate the effects of environmentally relevant concentrations of caffeine on the embryonic development and oxidative stress-related gene expression patterns in common carp. The results showed that caffeine concentrations above 500 ng/L can induce teratogenic effects and cause morphological abnormalities in the heart, somite, pericardium, and chorda. Additionally, caffeine was found to induce oxidative damage and up-regulate genes related to antioxidant activity. In conclusion, environmentally relevant concentrations of caffeine can alter the embryonic development of common carp through the oxidative stress pathway.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Public, Environmental & Occupational Health
Ana Maria Tellez-Lopez, Isis Beatriz Bermudez-Camps, Ivette Reyes-Hernandez, Claudia Fegadolli, Leobardo Manuel Gomez-Olivan
Summary: This systematic review explores the theoretical and methodological approaches to phenomenology in understanding patients' experiences with medication use. The findings show that qualitative research approaches and techniques, such as in-depth interviews and thematic analysis, are applicable in describing people's experiences with medication. Phenomenology serves as a useful framework to explain the meaning and perceptions of disease and medication use in qualitative research.
RESEARCH IN SOCIAL & ADMINISTRATIVE PHARMACY
(2023)
Article
Marine & Freshwater Biology
Gustavo Axel Elizalde-Velazquez, Leobardo Manuel Gomez-Olivan, Selene Elizabeth Herrera-Vazquez, Karina Elisa Rosales-Perez, Nely SanJuan-Reyes, Sandra Garcia-Medina, Marcela Galar-Martinez
Summary: Despite misleading data due to the use of high concentrations in previous studies, our research aimed to determine the effects of realistic concentrations of BPA on biochemical and blood parameters in Danio rerio as well as to identify the most affected organs. The findings showed that environmentally relevant concentrations of BPA induced oxidative stress and inflammation in all organs, leading to polychromasia and liver dysfunction in fish.
AQUATIC TOXICOLOGY
(2023)
Article
Environmental Sciences
Gerardo Heredia-Garcia, Gustavo Axel Elizalde-Velazquez, Leobardo Manuel Gomez-Olivan, Hariz Islas-Flores, Sandra Garcia-Medina, Marcela Galar-Martinez, Octavio Dublan-Garcia
Summary: This study aimed to assess the neurotoxic effects of acute BPA exposure at environmentally relevant concentrations in adult zebrafish. Results showed that exposure to 1500 ng/L of BPA reduced swimming distance and increased freezing time. Biomarker evaluation revealed the production of reactive oxygen species and increased acetylcholinesterase activity in the zebrafish brain. Gene expression analysis also indicated overexpression of mbp, alpha 1-tubulin, and manf. Based on these findings, it can be concluded that environmentally relevant concentrations of BPA can cause anxiety-like behavior and neurotoxic effects in adult zebrafish.
Article
Environmental Sciences
Francisco Javier Ramirez-Moreno, Leobardo Manuel Gomez-Olivan, Hariz Islas-Flores, Sandra Garcia-Medina, Jose Felix Aguirre-Garrido, Luis Mario Hernandez-Soto
Summary: Hospital effluents containing toxic substances can cause oxidative stress and changes in gene expression in aquatic organisms. This study evaluated the effects of different proportions of hospital effluent treated by a wastewater treatment plant on the liver, gut, and gills of Danio rerio. Significant increases in oxidative stress markers and antioxidant enzyme activity were observed, and gene expression related to antioxidant processes, detoxification, and apoptosis was upregulated. Additionally, pathogenic bacterial genera were identified using a metataxonomic approach.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Francisco Javier Ramirez-Moreno, Leobardo Manuel Gomez-Olivan, Sandra Garcia-Medina, Marcela Galar-Martinez, Luis Alberto Orozco-Hernandez, Jose Manuel Orozco-Hernandez
Summary: The discharge of hospital effluents containing various substances can have negative effects on ecosystems and biota. This study aimed to investigate the impact of hospital effluents treated by a wastewater treatment plant on Danio rerio brain, including oxidative stress, behavioral alterations, neurotoxicity, and disruption of gene expression. The results showed that exposure to hospital effluent induced anxiety-like behavior, altered swimming behavior, increased oxidative damage biomarkers, inhibited acetylcholinesterase activity, and disrupted genes related to antioxidant response, apoptosis, and detoxification. These findings suggest that hospital effluents promote an oxidative environment and may damage the brain of D. rerio.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Veronica Margarita Gutierrez-Noya, Leobardo Manuel Gomez-Olivan, Idalia Casas-Hinojosa, Sandra Garcia-Medina, Karina Elisa Rosales-Perez, Jose Manuel Orozco-Hernandez, Gustavo Axel Elizalde-Velazquez, Marcela Galar-Martinez, Octavio Dublan-Garcia, Hariz Islas-Flores
Summary: In recent years, the consumption of dexamethasone (DXE) has increased due to the Covid-19 pandemic, resulting in its release in aquatic environments and causing harmful effects on aquatic organisms. This study aimed to investigate the short-term effects of DXE exposure on embryonic development and oxidative stress-related gene expression patterns in Cyprinus carpio. Common carp embryos were exposed to realistic concentrations of DXE, and alterations in embryonic development and oxidative stress were evaluated. The results showed that DXE concentrations above 35 ng/L caused alterations in embryonic development and induced oxidative damage in the embryos of C. carpio.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Jose Manuel Orozco-Hernandez, Gustavo Axel Elizalde-Velazquez, Leobardo Manuel Gomez-Olivan, Guadalupe Ofelia Santamaria-Gonzalez, Karina Elisa Rosales-Perez, Sandra Garcia-Medina, Marcela Galar-Martinez, Nely San Juan-Reyes
Summary: This study evaluated the potential toxicological effects of fluoxetine exposure on Danio rerio fish at environmentally significant concentrations. The results showed that fluoxetine induced oxidative stress in various organs of the fish and significantly impacted blood parameters. These findings suggest that fluoxetine is harmful to the overall health status of fish, leading to the development of liver disease, anemia, and other associated illnesses.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
