Article
Environmental Sciences
Min Li, Yayao Wang, Lu Ma, Xingfu Yan, Qian Lei
Summary: In the study, the acute toxicity of 30 haloquinolines was assessed using Vibrio fischeri, with varying levels of toxicity observed. The presence of larger substituents at the 2/8-positions and less negative charge at the 4/5/6/8-positions in the quinoline derivative rings correlated positively with their toxicity towards V. fischeri.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
M. Pilar Garralaga, Laura Lomba, Alejandro Leal-Duaso, Sara Gracia-Barberan, Elisabet Pires, Beatriz Giner
Summary: The growing interest in more sustainable alternatives to non-renewable solvents has led to the development of deep eutectic solvents (DES), which have favorable physicochemical properties for various applications. However, the toxicological impact of DES has not been sufficiently studied. This study conducted acute ecotoxicity tests on different eutectic solvents composed of glycerol or glycerol-derived ethers and choline chloride (ChCl) or N,N,N-triethyl-N-(2,3-dihydroxypropyl) ammonium chloride (N00Cl) to assess their aquatic toxicity. The preliminary results indicated a favorable eco-toxicological behavior of glycerol-derived DES, but further studies are recommended for a complete understanding of their toxicological profiles.
Article
Environmental Sciences
Diego Errazquin, Aminou Mohamadou, Laurent Dupont, Yannick De Gaetano, Cristina B. Garcia, Laura Lomba, Beatriz Giner
Summary: The study found that the toxicity of different bromide-based ionic liquids towards environmental biomodels varies, with ammonium ionic liquids generally being more toxic than phosphonium-based ones. Predictions suggest significant toxicity but not genotoxic or nongenotoxic carcinogenicity for the studied ionic liquids.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Ana M. O. Azevedo, Andre G. Vilaranda, Ana F. D. C. Neves, Maria Joao Sousa, Joao L. M. Santos, M. Lucia M. F. S. Saraiva
Summary: Saccharomyces cerevisiae was used as a eukaryotic model organism to study the toxic effects of various compounds in an automated spectrophotometric method. The results showed that GUMBOS exhibited higher toxicity to yeast cells and could be promising antimicrobial candidates, while DESs were less toxic than ILs. The automated methodology demonstrated satisfactory repeatability and reproducibility, aligning with Green Chemistry principles.
Article
Biochemistry & Molecular Biology
Feng Wu, Xinhua Zhang, Zhengjun Fang, Xinliang Yu
Summary: This paper proposes a global classification model for the toxicity of organic compounds to Vibrio fischeri. The model utilizes a large dataset and a range of molecular descriptors to predict the toxicity. The support vector machine model shows higher prediction accuracy compared to binary logistic regression.
Article
Chemistry, Multidisciplinary
Yui Kato, Takuya Uto, Daisuke Tanaka, Kojiro Ishibashi, Akiko Kobayashi, Masaharu Hazawa, Richard W. Wong, Kazuaki Ninomiya, Kenji Takahashi, Eishu Hirata, Kosuke Kuroda
Summary: Cell cryopreservation is essential for long-term storage, but some cell lines cannot be efficiently cryopreserved. Research shows that a synthetic zwitterion solution can achieve good cryopreservation, but not with high efficiency for certain cells. Further study on the cryoprotective effects and mechanisms of zwitterions is needed for optimization and better results.
COMMUNICATIONS CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Yui Kato, Yuya Matsuda, Takuya Uto, Daisuke Tanaka, Kojiro Ishibashi, Takeru Ishizaki, Akio Ohta, Akiko Kobayashi, Masaharu Hazawa, Richard W. Wong, Kazuaki Ninomiya, Kenji Takahashi, Eishu Hirata, Kosuke Kuroda
Summary: During long-term cell storage, the addition of cryoprotectants to inhibit ice crystal formation is necessary. However, the high osmotic pressure and dehydration caused by non-cell-permeable cryoprotectants often damage cells. In this study, researchers developed a poly(zwitterion) isotonic cryoprotectant that forms a firm matrix around cells, preventing the influx of ice crystal nuclei without the need for high osmotic pressure and dehydration.
COMMUNICATIONS CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Malgorzata Musia, Edward Zorebski, Katarzyna Malarz, Michal Kuczak, Anna Mrozek-Wilczkiewicz, Johan Jacquemin, Marzena Dzida
Summary: The study revealed that imidazolium-based ILs combined with dialkyl phosphate anions or with the ethyl sulfate anion are the least cytotoxic. Some ILs can potentially be used as hydraulic fluids or efficient solvents, while others have potential as heat transfer media and base fluids.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Article
Chemistry, Physical
Beichen Liu, Wenxiao Guo, Matthew A. Gebbie
Summary: In this study, we investigate the influence of ionic correlations on the reaction rates and selectivity of CO2 electroreduction. Through experiments, we find that at intermediate concentrations, the reduction rates of CO2 are accelerated and the efficiency of CO production is enhanced. The acceleration of CO2 reduction is due to the amplification of potential-dependent driving forces, rather than changes in onset potential. These findings are applicable to both cocatalytic and noncatalytic ions.
Review
Biochemistry & Molecular Biology
Ana R. P. Goncalves, Xavier Paredes, A. F. Cristino, F. J. V. Santos, Carla S. G. P. Queiros
Summary: Ionic liquids were initially touted as environmentally friendly replacements for traditional solvents, but research on their interactions with organisms is lacking. Lipophilicity and the type of cation play key roles in toxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Madhur Babu Singh, Pallavi Jain, Preeti Chaudhary, Indra Bahadur, Kashmiri Lal, Vinod Kumar, Prashant Singh, Himani, Anirudh Pratap Singh Raman
Summary: Ionic liquids (ILs) have a wide range of features, uses, and environmentally friendly nature, making them potential substitutes for organic solvents in addressing pollution. ILs possess unique thermal, physical, chemical, and biological properties, which can be modified by altering their cationic and anionic parts. Their applications in protein stabilization, organic transformation, nanomaterials, etc., indicate their significant impact on research and development.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Environmental Sciences
Lingyun Fan, Jia Wang, Ying Huang, Limin Su, Chao Li, Yuan Hui Zhao, Christopher J. Martyniuk
Summary: Neonicotinoids are widely used pesticides that cause severe water pollution, with direct photolysis dominating the degradation process under simulated sunlight. The photolysis products of these compounds show different levels of photo-induced toxicity to Vibrio fischeri, affected by factors such as scavenging radicals and dissolved organic matters. Different photolysis pathways and mechanisms were observed for the four neonicotinoids, with reactive oxygen species playing important roles in the process.
Article
Environmental Sciences
Georgiana Amariei, Sara Jimenez-Jimenez, Maria Angeles Garcia, Maria Luisa Marina, Karina Boltes
Summary: This study investigated the enantiomer-specific stability and acute toxicity of ivabradine to marine bacterium, Vibrio fischeri, as well as its potential mechanism of action. The results showed that S-ivabradine exhibited enantioselective toxicity to the bacterium, causing serious damage to bacterial cells and disrupting enzymatic activity. The primary mechanism of S-ivabradine toxicity was shown to be oxidative stress. These findings emphasize the importance of further eco-toxicological evaluations of S-ivabradine on other aquatic organisms to determine the environmental risk.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Chemistry, Multidisciplinary
Marika Turek, Robert Biczak, Barbara Pawlowska, Ewa Rozycka-Sokolowska, Krzysztof Owsianik, Bernard Marciniak, Piotr Balczewski
Summary: The use of optically active forms of commercial chiral herbicides may be more effective and environmentally safer. This study synthesized a series of chiral quaternary ammonium salts and investigated their selective toxicity towards aquatic bacteria and terrestrial plants. The results showed that these salts exhibited enantioselective toxicity towards all tested organisms.
Article
Green & Sustainable Science & Technology
Sergio S. de Jesus, Rubens Maciel Filho
Summary: Ionic liquids are molten salts with excellent chemical and thermal stability, which have the potential to replace traditional organic solvents. However, their synthesis, toxicity, and biodegradability pose challenges to their environmentally friendly use. Analyzing the processes of synthesis, recovery and recycling, toxicity, and biodegradability reveals the need for further improvements in ionic liquid design to meet the principles of green chemistry.
RENEWABLE & SUSTAINABLE ENERGY REVIEWS
(2022)
Article
Environmental Sciences
Ana M. O. Azevedo, Andre G. Vilaranda, Ana F. D. C. Neves, Maria Joao Sousa, Joao L. M. Santos, M. Lucia M. F. S. Saraiva
Summary: Saccharomyces cerevisiae was used as a eukaryotic model organism to study the toxic effects of various compounds in an automated spectrophotometric method. The results showed that GUMBOS exhibited higher toxicity to yeast cells and could be promising antimicrobial candidates, while DESs were less toxic than ILs. The automated methodology demonstrated satisfactory repeatability and reproducibility, aligning with Green Chemistry principles.
Article
Chemistry, Multidisciplinary
A. Raquel F. Costa, Andreia R. A. Sousa, Paula C. A. G. Pinto, Marieta L. C. Passos, M. Lucia M. F. S. Saraiva
Summary: This study evaluated the impact of different ionic liquids on copper-catalyzed chemiluminescence reactions, with imidazolium ILs enhancing sensitivity and pyridinium and pyrrolidinium ILs decreasing it. The promising IL for this reaction was identified as 1-ethyl-3-methylimidazolium trifluoromethanesulfonate.
Article
Spectroscopy
Rafael C. Castro, Ricardo N. M. J. Pascoa, M. Lucia M. F. S. Saraiva, Joao L. M. Santos, David S. M. Ribeiro
Summary: A sensing platform combining carbon dots and thiomalic acid-capped AgInS2 quantum dots was developed for the determination of ibandronic acid. The platform showed efficient PL quenching of AgInS2 quantum dots in the presence of IBAN while the PL of carbon dots remained unaffected, providing a self-reference fluorophore. A visual sensing approach based on RGB images was proposed for rapid IBAN screening.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Biochemistry & Molecular Biology
Sarah A. P. Pereira, A. Catarina L. Baptista, Lorenzo Biancalana, Fabio Marchetti, Paul J. Dyson, M. Lucia M. F. S. Saraiva
Summary: A novel automated method based on sequential injection analysis was developed to evaluate the activity of GST P1-1 in organometallic complexes with potential anticancer activity. The method is simple, robust, reliable, and efficient, requiring only 5 minutes per analysis with fewer reagents used.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Fatima A. R. Mota, Sarah A. P. Pereira, Andre R. T. S. Araujo, Beatriz Gullon, Marieta L. C. Passos, Maria Lucia M. F. S. Saraiva
Summary: The aim of this study is to develop an automated method for evaluating myeloperoxidase (MPO) activity and test the inhibitory effects of different plant extracts on this enzyme. The study optimized an automatic sequential injection analysis system and demonstrated its accuracy and precision. The study also found that Arbutus unedo L. extract exhibited the highest inhibitory activity on MPO based on its phenolic compound content. The results support the potential use of these plant species for treating infection and inflammation.
Article
Chemistry, Analytical
Ana M. O. Azevedo, Clara Sousa, Mi Chen, Caitlan E. Ayala, Rocio L. Perez, Joao L. M. Santos, Isiah M. Warner, M. Lucia M. F. S. Saraiva
Summary: This study synthesized four novel EB-based GUMBOS and assessed their potential for protein discrimination. The results showed that these materials could successfully discriminate single proteins and their mixtures under different pH conditions.
Article
Chemistry, Applied
Ana M. O. Azevedo, Clara Sousa, S. Sofia M. Rodrigues, Mi Chen, Caitlan E. Ayala, Rocio L. Perez, Joao L. M. Santos, Isiah M. Warner, M. Lucia M. F. S. Saraiva
Summary: In this study, a phosphonium-erythrosin B-based nanoGUMBOS was synthesized using an ultrasound-assisted reprecipitation method, and its ability to discriminate and quantify proteins was evaluated. The results showed that the synthesized nanoGUMBOS could accurately discriminate and quantify different proteins.
Article
Chemistry, Analytical
Sarah A. P. Pereira, Lorenzo Biancalana, Fabio Marchetti, Paul J. Dyson, M. Lucia M. F. S. Saraiva
Summary: In this study, a new miniaturized micro sequential injection coupled with the lab-on-valve technique was used for DHFR inhibitory studies on metal-based anticancer compounds. The system provided IC50 values for the metal complexes, with half falling in the low micro M range. The mu SIA-LOV system is versatile, robust, rapid, and easy to operate, with automated determination of DHFR inhibition.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Physical
Fabio M. S. Costa, M. Lucia M. F. S. Saraiva, Marieta L. C. Passos
Summary: Antimicrobial resistance is a growing concern caused by the overuse and misuse of antimicrobial drugs, as well as the lack of development of new drugs. It leads to significant economic costs and challenges in the healthcare system. Inadequate conditions and poor sanitation further contribute to the spread of drug-resistant pathogens. Strategies to combat antimicrobial resistance include the synthesis and evaluation of new compounds, combination therapy, and nanotechnology.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Analytical
Rafael C. Castro, Ricardo N. M. J. Pascoa, M. Lucia M. F. S. Saraiva, Rui A. S. Lapa, Jose O. Fernandes, Sara C. Cunha, Joao L. M. Santos, David S. M. Ribeiro
Summary: Upon exposure to Reactive Oxygen Species (ROS), Aflatoxin B1 forms a highly fluorescent derivative, which was utilized for the determination of AFB1 in food samples. Cd-free AgInS2 ternary quantum dots were used as ROS generators, and kinetic photoluminescence data (PL) was collected throughout AFB1 photocatalysis to accurately determine AFB1 even in the presence of unknown interfering species not included in the calibration set. This approach allows the quantification of AFB1 in rice samples in compliance with EU regulations.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Physical
Marieta L. C. Passos, Aleksandra Wicinska, Mafalda Sarraguca, M. Lucia M. F. S. Saraiva
Summary: Studies have shown the importance and challenges of using ionic liquids (IL) and deep eutectic solvents (DES) in biocatalysis. By adjusting the design of these compounds through changing the anion and cation in ILs or the hydrogen bond donor and acceptor in DES, the enzyme activity and selectivity can be modified. Furthermore, a correlation between the structures and the effect on the enzyme elastase was established, emphasizing the need to consider these properties as an integrated view. A developed LSIA-LOV system proved to be a versatile tool for accurate control of reaction conditions, reducing reagent consumption and environmental impact.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Analytical
Rafael C. Castro, Ricardo N. M. J. Pascoa, M. Lucia M. F. S. Saraiva, Joao L. M. Santos, David S. M. Ribeiro
Summary: The combination of multiple quantum dots provides a promising sensing scheme for determining specific analytes. In this study, a kinetic fluorometric method using dual CdTe/AgInS2 quantum dots was developed for acetylsalicylic acid determination. The obtained data were processed using different chemometric methods, including unfolded partial least squares, N-way partial least squares, multilayer feed-forward neural networks, and radial basis function neural networks.
Article
Biochemistry & Molecular Biology
Fabio M. S. Costa, Andreia Granja, Rocio L. Perez, Isiah M. Warner, Salette Reis, Marieta L. C. Passos, M. Lucia M. F. S. Saraiva
Summary: Antimicrobial resistance is a global public health concern, and strategic therapies are needed to replace ineffective antibacterials. GUMBOS, a group of uniform materials based on organic salts, provide a promising alternative approach by combining antibacterials with adjuvants to treat infections caused by resistant bacteria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Inorganic & Nuclear
Sarah A. P. Pereira, Jan Romano-deGea, Ana Isabel Barbosa, Sofia A. Costa A. Lima, Paul J. J. Dyson, M. Lucia M. F. S. Saraiva
Summary: The study demonstrates that ruthenium-based compounds, especially [Ru(& eta;(6)-toluene)(PPh3)(2)Cl]Cl, show high selectivity and cytotoxicity against breast cancer cells. This compound has potential as a promising candidate for breast cancer treatment.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Alberto Gobbo, Sarah A. P. Pereira, Lorenzo Biancalana, Stefano Zacchini, M. Lucia M. F. S. Saraiva, Paul J. Dyson, Fabio Marchetti
Summary: Compared with Ru-II-arene compounds, the medicinal potential of homologous Ru-II-tpm compounds [tpm = tris(pyrazolyl)methane] is not well explored. A series of [RuCl(kappa(3)-tpm)(PPh3)(L)]Cl complexes were synthesized by reacting pyridine, 4-pyridinemethanol, and four functionalized pyridines with the precursor [RuCl(kappa(3)-tpm)(PPh3)(2)]Cl. The complexes exhibited antiproliferative activity against cancerous cell lines and inhibition towards COX-2 and GSTP1 enzymes.
DALTON TRANSACTIONS
(2022)