Journal
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
Volume 72, Issue 5, Pages 1413-1424Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2008.11.003
Keywords
Antioxidant enzymes; Critical O-2 tension; Heart function; Hypoxia; Metabolic rate; Nile tilapia; Organophosphate; Oxidative stress; Trichlorfon; Ventilatory parameters
Categories
Funding
- CAPES/Brazilian Ministry of Education
- Paulo State Research Foundation (FAPESP)
- National Council for the Development of Research and Technology (CNPq)
Ask authors/readers for more resources
The cardio-respiratory function, oxidative stress and fish antioxidants were analyzed in juvenile Nile tilapia exposed for 96 h to a sublethal trichlorfon (TRC-Neguvon (R), Bayer) concentration of 0.5 mg L-1. The exposure to TRC induced oxidative stress in the heart, as manifested by the glutathione S-transferase depletion and hydroperoxide elevation, and was the most sensitive organ when compared to the liver and gills, in which the antioxidant mechanisms against TRC exposure were sufficient to remove reactive oxygen species (ROS), preventing the increase of lipid peroxidation. TRC exposure also reduced O-2 uptake ((V) over dotO(2)) and increased the critical oxygen tension (PcO2), reducing the species capacity to survive prolonged hypoxic conditions. The heart rate and force contraction were significantly impaired, making the heart the most sensitive organ when exposed to the TRC. (C) 2008 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available