Article
Engineering, Environmental
Xiangsheng Hong, Rui Chen, Le Zhang, Liang Yan, Jiajing Xin, Jiasu Li, Jinmiao Zha
Summary: This study investigated the long-term neurotoxic effects of residual antidepressant citalopram on zebrafish. The results showed that continuous exposure to citalopram led to decreased motor function, learning, and memory in both larval and adult zebrafish. However, the effects were reversible in larval zebrafish after transferring to a clean medium. The study provides insights into the neurotoxic mechanisms of citalopram and its potential environmental and health risks.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Microbiology
Ning Tang, Pianpian Fan, Xiaogang Yu, Rui Ma, Yexuan Tao, Weiye Wang, Fengxiu Ouyang
Summary: Long-term exposure to high concentration of TCS may reduce the diversity and alter the composition of microbiota in the gastrointestinal tract of zebrafish, while short-term exposure has a minor impact.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yu-Jen Tseng, Fu- Lu, Su Mei Wu
Summary: This study found that BPA and DEP chemicals can affect the angle of CH in embryo development, and potentially influence estrogen signaling pathways and gene expressions related to NCCs migration.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Toxicology
Yang Yang, Jinhe Chang, Donghui Wang, Hao Ma, Yuanbo Li, Yongquan Zheng
Summary: The study investigated the neuroendocrine disruption potential of fungicide thifluzamide on non-targeted aquatic organisms, using zebrafish embryos as a model. Results indicated that exposure to thifluzamide affected the development, behavior, and neurotransmitter levels in zebrafish embryos, suggesting developmental programming impact of this fungicide.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Environmental Sciences
Liqiao Zhong, He Zhang, Luyin Wu, Huijun Ru, Nian Wei, Fan Yao, Zhaohui Ni, Xinbin Duan, Yunfeng Li
Summary: This study found that cadmium (Cd2+) and mercury (Hg2+) have destructive effects on the thyroid of zebrafish embryos/larvae, leading to developmental abnormalities. The effects of Cd2+ were most significant at a concentration of 100 μg/L, while Hg2+ disrupted thyroid function at a concentration as low as 0.1 μg/L.
Article
Environmental Sciences
E. Guzzolino, M. S. Milella, F. Forini, M. Borso, G. Rutigliano, F. Gorini, R. Zucchi, A. Saba, F. Bianchi, G. Iervasi, L. Pitto
Summary: This study using the zebrafish model revealed an important synergistic toxic effect of cadmium and dibenzothiophene on embryonic development and thyroid morphology, impacting the Hypothalamic-Pituitary-Thyroid Axis and thyroid disposal processes. The pollutants also influenced heart geometry and function through different mechanisms.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Engineering, Environmental
Chan-Wei Yu, Tin Chi Luk, Vivian Hsiu-Chuan Liao
Summary: The study reveals that long-term exposure to nanoplastics can lead to multi and transgenerational reproductive decline in Caenorhabditis elegans, potentially associated with germline toxicity and epigenetic regulation.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Environmental Sciences
Kun Qiao, Tiantian Hu, Yao Jiang, Jianping Huang, Jingjin Hu, Wenjun Gui, Qingfu Ye, Shuying Li, Guonian Zhu
Summary: The study suggests that chlorpyrifos can induce neurotoxicity and affect thyroid metabolism in zebrafish, including inhibition of acetylcholinesterase, alteration of thyroid hormone levels and gene expression. This effect can be partially reversed by atropine, indicating a potential mechanism for the disturbance of thyroid signaling in zebrafish.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
Giuditta Rurale, Ilaria Gentile, Camilla Carbonero, Luca Persani, Federica Marelli
Summary: In this study, the effects of BaP on thyroid development and function were tested using zebrafish as a model system. The results showed that exposure to BaP significantly affects thyroid function in zebrafish, with the primary toxic effects occurring at the hypothalamic-pituitary level, creating a model of central hypothyroidism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Ana Luisa Pires Moreira, Juliana Alves Costa Ribeiro Souza, Jessica Ferreira de Souza, Joao Paulo Medeiros Mamede, Davi Farias, Ana Carolina Luchiari
Summary: Exposure to BP-3 during embryonic development in zebrafish resulted in anxiety-like behavior and reduced social preference, with no change in aggressiveness. Overall, BP-3 exposure led to altered enzymatic activity, persisting into adulthood. GST activity increased in embryos and adults, while CAT activity decreased in both life stages. AChE activity was enhanced only in the larval stage (96 hpf).
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Chemistry, Multidisciplinary
Xiao Guan, Guo-rong Dan, Yao Yang, Yan Ji, Wen-jing Lai, Fang-jie Wang, Meng Meng, Bang-hui Mo, Pei Huang, Ting-ting You, Ya-fei Deng, Liang Song, Wei Guo, Ping Yi, Jian-hua Yu, Yuan Gao, Wei-nian Shou, Bing-bo Chen, You-cai Deng, Xiao-hui Li
Summary: The study demonstrates that prenatal inflammatory exposure leads to multi-generational inheritance of hypertension in rat descendants, causing vascular remodeling and vasoconstrictor dysfunction. Furthermore, prenatal inflammatory exposure also results in global alteration of DNA methylome in the thoracic aorta of rat descendants.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Reproductive Biology
O. Jaka, I. Iturria, C. Marti, J. Hurtado de Mendoza, MJ. Mazon-Moya, C. Rummel, A. M. J. Weiner, A. Muriana
Summary: Thyroid disruption is a growing concern in the use and development of chemicals and new drugs. This study presents a tiered approach using zebrafish embryos for medium-throughput screening to assess the thyroid-disrupting potential of chemicals. By analyzing fluorescence levels and measuring thyroid hormone levels, the study identifies the thyroid disruption effects of chemicals.
REPRODUCTIVE TOXICOLOGY
(2023)
Article
Marine & Freshwater Biology
Jie Gu, Liangzhong Li, Xiaogang Yin, Mengyuan Liang, Yuanhui Zhu, Min Guo, Linjun Zhou, Deling Fan, Lili Shi, Guixiang Ji
Summary: This study investigated the effects of life-cycle exposure to environmental concentrations of BPF on zebrafish reproduction and offspring development. The results showed that BPF exposure increased oxidative stress levels, induced gonadal apoptosis, and reduced zebrafish spawning. Additionally, through maternal transfer, BPF significantly affected the development of the offspring, resulting in decreased hatching rate, spontaneous movements, heart rate, body length, and locomotor behavior. Gene expression related to oxidative stress, apoptosis, and neurodevelopment was also altered in the offspring.
AQUATIC TOXICOLOGY
(2022)
Article
Environmental Sciences
Pauline Pannetier, Rikke Poulsen, Lisa Goelz, Sara Coordes, Hanna Stegeman, Johannes Koegst, Luisa Reger, Thomas Braunbeck, Martin Hansen, Lisa Baumann
Summary: Thyroid hormones play a role in early vertebrate development, and environmental pollutants that disrupt the thyroid system can have negative effects on eye development. In a study on zebrafish embryos, it was found that exposure to THSDCs altered eye size, pigmentation, and cellular structure of the retina, but these effects were partially reversible.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2023)
Article
Neurosciences
Andrew B. Hawkey, Dilanaz Unal, Zade R. Holloway, Edward D. Levin
Summary: This study evaluated the neurobehavioral effects of two neonicotinoid insecticides on zebrafish during embryonic exposure. The results showed that low concentrations of these insecticides affected the locomotion of larvae, while higher concentrations affected the activity and predator avoidance ability of adult fish. These effects were persistent and continued into adulthood.
Article
Engineering, Environmental
Qianqian Cui, Yitao Pan, Hongxia Zhang, Nan Sheng, Jianshe Wang, Yong Guo, Jiayin Dai
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2018)
Article
Engineering, Environmental
Xiujuan Zhou, Jianshe Wang, Nan Sheng, Ruina Cui, Yiqun Deng, Jiayin Dai
JOURNAL OF HAZARDOUS MATERIALS
(2018)
Article
Biochemistry & Molecular Biology
Ruichuan Yin, Jiezhen Mo, Jiayin Dai, Hailin Wang
Article
Nanoscience & Nanotechnology
Huichao Liu, Yongshou Liu, Jiayin Dai, Qian Cheng
MICROFLUIDICS AND NANOFLUIDICS
(2018)
Editorial Material
Chemistry, Medicinal
Jiayin Dai
CHEMICAL RESEARCH IN TOXICOLOGY
(2018)
Article
Environmental Sciences
Guohui Shi, Hua Guo, Nan Sheng, Qianqian Cui, Yitao Pan, Jinxing Wang, Yong Guo, Jiayin Dai
ENVIRONMENTAL POLLUTION
(2018)
Article
Engineering, Environmental
Hongxia Zhang, Xiujuan Zhou, Nan Sheng, Ruina Cui, Qianqian Cui, Hua Guo, Yong Guo, Yan Sun, Jiayin Dai
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2018)
Article
Environmental Sciences
Ruina Cui, Chenyang Li, Jianshe Wang, Jiayin Dai
ENVIRONMENTAL POLLUTION
(2019)
Article
Engineering, Environmental
Jinghua Wang, Yitao Pan, Qianqian Cui, Bing Yao, Jianshe Wang, Jiayin Dai
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2018)
Article
Environmental Sciences
Sujie Sun, Hua Guo, Jianshe Wang, Jiayin Dai
ENVIRONMENTAL POLLUTION
(2019)
Article
Environmental Sciences
Guohui Shi, Jinxing Wang, Hua Guo, Nan Sheng, Qianqian Cui, Yitao Pan, Yong Guo, Yan Sun, Jiayin Dai
SCIENCE OF THE TOTAL ENVIRONMENT
(2019)
Article
Biochemistry & Molecular Biology
Miaomiao Zhang, Bing Wang, Tingfang Li, Rui Liu, Yingnan Xiao, Xin Geng, Guang Li, Qiang Liu, Carolyn M. Price, Yang Liu, Feng Wang
NUCLEIC ACIDS RESEARCH
(2019)
Article
Cell Biology
Rui Liu, Jing Liu, Shuqing Wang, Yinsong Wang, Tao Zhang, Yang Liu, Xin Geng, Feng Wang
CELL DEATH & DISEASE
(2019)
Article
Biochemistry & Molecular Biology
Xiaotong Zhao, Manman Zhang, Jinhan Wang, Kaihua Ji, Yan Wang, Xiaohui Sun, Chang Xu, Qin Wang, Ningning He, Huijuan Song, Liqing Du, Feng Wang, Hao Huang, Yang Liu, Qiang Liu
Summary: The risk of cancer increases with age, and radiotherapy often causes intestinal damage. NRF2, a key protective factor, decreases with aging. NRF2 deficiency worsens cellular DNA damage and intestinal pathological damage. SIRT6 or SIRT7 overexpression improves cell proliferation and protects against radiation damage in NRF2 KO cells. Supplementation of NMN increases SIRT6 and SIRT7 levels, reduces cellular ROS, and ameliorates DNA damage in NRF2 KO cells. Long-term oral NMN administration attenuates radiation-induced jejunum injury, increases the number of intestinal stem cells, and promotes intestinal proliferation in NRF2-/- mice.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Meeting Abstract
Chemistry, Multidisciplinary
Jiayin Dai, Yitao Pan, Hongxia Zhang, Qianqian Cui
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2018)