Article
Public, Environmental & Occupational Health
Juntao Wang, Yanlan Hu, Jun Zeng, Quan Li, Lanfen He, Wenjie Hao, Xingyue Song, Shijiao Yan, Chuanzhu Lv
Summary: This study used a two-sample Mendelian randomization to explore the correlation and causal relationship between body mass index (BMI) and sepsis. The results showed that increased BMI was associated with an increased risk of sepsis, supporting a causal relationship. Proper control of BMI may help prevent sepsis.
INTERNATIONAL JOURNAL OF PUBLIC HEALTH
(2023)
Article
Health Care Sciences & Services
Christina Hansen Edwards, Gunnhild Aberge Vie, Jonas Minet Kinge
Summary: This study used genetic variants as instruments to investigate the association between BMI and healthcare costs. The results showed that increased BMI led to significantly higher general practitioner costs, but there was no significant association with specialist or total healthcare costs.
BMC HEALTH SERVICES RESEARCH
(2022)
Article
Endocrinology & Metabolism
Jingru Lu, Xiaoshuang Liu, Song Jiang, Shuyan Kan, Yu An, Chunxia Zheng, Xiang Li, Zhihong Liu, Guotong Xie
Summary: The study found that an increase in body mass index was causally associated with a higher risk of diabetic nephropathy and a lower eGFR level in type 2 diabetes patients. The impact of BMI on DN risk was greater in women, but there was no causal association with proteinuria.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Lijuan He, Tingting Yu, Wei Zhang, Baojian Wang, Yufeng Ma, Sen Li
Summary: The study used Mendelian randomization with genetic variants as instrumental variables to find a causal association between body mass index and the risk of AT. No causal relationship was found between other potential risk factors and AT.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Geriatrics & Gerontology
V. P. Narayan, S. Y. Yoon
Summary: This study found little evidence to support the protective effect of caffeine or coffee consumption against obesity, contradicting previous observational studies. It also highlights the dangers of ignoring genetic testing and relying solely on observational studies restricted to specific populations when making dietary policy recommendations.
JOURNAL OF NUTRITION HEALTH & AGING
(2022)
Article
Infectious Diseases
G. Butler-Laporte, A. Harroud, V Forgetta, J. B. Richards
Summary: Elevated BMI is associated with increased risk of both infectious disease admissions and mortality, particularly for skin and soft tissue infections and pneumonia. The impact on sepsis mortality is less clear and warrants further investigation.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Endocrinology & Metabolism
Changwei Zheng, Xin Wei, Xiaochuan Cao
Summary: This study used a two-sample Mendelian randomization analysis to assess the causal association of body mass index (BMI) and abdominal obesity with diabetic retinopathy (DR). The results showed that increased BMI, waist circumference, and hip circumference were associated with an increased risk of DR, as well as different stages of DR. These findings suggest that controlling obesity may be effective in preventing the development of DR.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Rheumatology
Sizheng Steven Zhao, Michael Holmes, Jie Zheng, Eleanor Sanderson, Alice R. Carter
Summary: There is a causal relationship between educational attainment and risk of RA, with smoking and BMI playing a role as potential mediators. However, a large proportion of the effect of education on RA remains unexplained.
Article
Medicine, General & Internal
Jing Hu, Quan Gan, Dong Zhou, Xing Xia, Wei Xiang, Rong Xiao, Jing Tang, Jie Li
Summary: This study used Mendelian randomization to evaluate the risk of sepsis associated with obesity phenotypes. The findings showed that increased body mass index (BMI) and waist circumference (WC) predicted a higher risk of sepsis, while WC adjusted for BMI (WCadjBMI) did not have a causal effect on sepsis risk. This study suggests that obesity management might be beneficial for reducing the risk of sepsis.
POSTGRADUATE MEDICAL JOURNAL
(2023)
Article
Oncology
Wen Zhou, Geoffrey Liu, Rayjean J. Hung, Philip C. Haycock, Melinda C. Aldrich, Angeline S. Andrew, Susanne M. Arnold, Heike Bickeboeller, Stig E. Bojesen, Paul Brennan, Hans Brunnstrom, Olle Melander, Neil E. Caporaso, Maria Teresa Landi, Chu Chen, Gary E. Goodman, David C. Christiani, Angela Cox, John K. Field, Mikael Johansson, Lambertus A. Kiemeney, Stephen Lam, Philip Lazarus, Loic Le Marchand, Gad Rennert, Angela Risch, Matthew B. Schabath, Sanjay S. Shete, Adonina Tardon, Shanbeh Zienolddiny, Hongbing Shen, Christopher I. Amos
Summary: The study found a positive causal effect of high BMI on small cell lung cancer risk, but a negative effect on lung adenocarcinoma. Smoking behaviors play a mediator role in the association between BMI and lung cancer.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Dentistry, Oral Surgery & Medicine
Jingya Dong, Yixuan Gong, Tengda Chu, Lixia Wu, Sisi Li, Hui Deng, Rongdang Hu, Yi Wang
Summary: This study investigated the potential causal association between obesity and periodontal diseases using Mendelian randomization. The results suggest that obesity may be causally associated with an increased risk of periodontitis and loose teeth, but not with the single trait periodontitis.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2022)
Article
Endocrinology & Metabolism
Xuelun Zou, Leiyun Wang, Linxiao Xiao, Zihao Xu, Tianxing Yao, Minxue Shen, Yi Zeng, Le Zhang
Summary: The study revealed a significant positive association between obesity class I and II and ischemic stroke, while obesity class III was not related. Obesity was strongly associated with large artery stroke and cardioembolic stroke among all ischemic stroke subtypes in the obese population.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Clinical Neurology
Eric L. Harshfield, Marios K. Georgakis, Rainer Malik, Martin Dichgans, Hugh S. Markus
Summary: Genetic studies show that education level, smoking, and body mass index are causally associated with the risk of ischemic stroke, with their effects acting independently. These findings suggest that modifying lifestyle factors may reduce the risk of stroke.
Article
Genetics & Heredity
Yi Liu, Zhihan Xiao, Kun Ye, Linlin Xu, Yanping Zhang
Summary: Observational evidence has shown that smoking, alcohol consumption, type 2 diabetes, and BMI are risk factors for peptic ulcer disease. This study uses Mendelian randomization to examine causal associations between these factors and the risks of gastric and duodenal ulcers. The results suggest that genetic predisposition to smoking and higher BMI are causally associated with an increased risk of these ulcers.
FRONTIERS IN GENETICS
(2023)
Article
Obstetrics & Gynecology
Alvaro Hernaez, Robyn E. Wootton, Christian M. Page, Karoline H. Skara, Abigail Fraser, Tormod Rogne, Per Magnus, Pal R. Njolstad, Ole A. Andreassen, Stephen Burgess, Deborah A. Lawlor, Maria Christine Magnus
Summary: Smoking intensity in women is associated with increased infertility odds, while later smoking initiation and smoking cessation are linked to decreased infertility in women. However, the association between greater smoking intensity in men and infertility is not robust.
FERTILITY AND STERILITY
(2022)
Article
Environmental Sciences
Ana K. Rosen Vollmar, Caroline H. Johnson, Clarice R. Weinberg, Nicole C. Deziel, Donna D. Baird, Allen J. Wilcox, Anne Marie Z. Jukic
Summary: This study investigates the impact of pregnancy on creatinine excretion and its implications for biomarker measurement in assessing environmental exposures. The findings suggest that pregnancy leads to a decrease in urinary creatinine concentration, which may introduce errors in exposure assessment. While there is a small underestimation in analyte concentrations when using pooled creatinine adjustment, overall agreement between pooled and individually-adjusted assessments is good.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2021)
Article
Psychiatry
Maria C. Magnus, Alexandra Havdahl, Nils-Halvdan Morken, Knut-Arne Wensaas, Allen J. Wilcox, Siri E. Haberg
Summary: Studies have shown that women diagnosed with psychiatric disorders have an increased risk of miscarriage, with various psychiatric diagnoses associated with different levels of risk. This highlights the importance of awareness and surveillance in antenatal care for this particular risk group.
BRITISH JOURNAL OF PSYCHIATRY
(2021)
Article
Obstetrics & Gynecology
Maria C. Magnus, Allen J. Wilcox, Elin A. Fadum, Hakon K. Gjessing, Signe Opdahl, Petur B. Juliusson, Liv Bente Romundstad, Siri E. Haberg
Summary: Children conceived by ART are shorter and lighter at birth, but experience more rapid growth and surpass naturally conceived children in height and weight by age 3. However, by age 17, there are no significant differences in height and weight between ART and naturally conceived children.
HUMAN REPRODUCTION
(2021)
Article
Pediatrics
Marianne S. Strom, Mette C. Tollanes, Allen J. Wilcox, Rolv Terje Lie, Ingeborg Forthun, Dag Moster
Summary: The study found that mothers with autoimmune disorders during pregnancy were associated with an increased risk of cerebral palsy in offspring, while no increased risk was seen for offspring of fathers with chronic conditions.
Article
Public, Environmental & Occupational Health
Marianna Cortese, Dag Moster, Allen J. Wilcox
Summary: In term babies, lower birth weights below 3.5 kg are associated with an increased risk of a wide variety of neurodevelopmental disabilities. The study emphasizes that reduced fetal growth serves as a powerful predictor for neurodevelopmental disabilities independent of preterm delivery.
Article
Pediatrics
Laura L. Oakley, Annette K. Regan, Deshayne B. Fell, Sarah Spruin, Inger Johanne Bakken, Jeffrey C. Kwong, Gavin Pereira, Natasha Nassar, Kari M. Aaberg, Allen J. Wilcox, Siri E. Haberg
Summary: This study found that maternal influenza infection during pregnancy may increase the risk of childhood seizures, particularly febrile seizures. Children exposed to influenza infection in utero had a higher risk of seizures in the second and third trimester of pregnancy.
ARCHIVES OF DISEASE IN CHILDHOOD
(2022)
Article
Nutrition & Dietetics
Jonathan Groot, Tanja G. Petersen, Pal Suren, Anne Lise Brantsoeter, Peter Uldall, Torben Martinussen, Charlotta Granstrom, Sjurdur F. Olsen, Allen J. Wilcox, Katrine Strandberg-Larsen
Summary: The study found that periconceptional folate supplementation was not associated with cerebral palsy (CP), while supplementation during gestational weeks 9-12 was linked to a reduced risk of CP. Midpregnancy supplementation or dietary folate alone did not show a significant association with CP. Strong inverse associations were observed with low gross motor function impairment, suggesting potential benefits of folate intake during gestational weeks 9-12 for reducing the risk of CP.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Obstetrics & Gynecology
Shruthi Mahalingaiah, Victoria Fruh, Erika Rodriguez, Sai Charan Konanki, Jukka-Pekka Onnela, Alexis de Figueiredo Veiga, Genevieve Lyons, Rowana Ahmed, Huichu Li, Nicola Gallagher, Anne Marie Z. Jukic, Kelly K. Ferguson, Donna D. Baird, Allen J. Wilcox, Christine L. Curry, Sanaa Suharwardy, Tyler Fischer-Colbrie, Gracee Agrawal, Brent A. Coull, Russ Hauser, Michelle A. Williams
Summary: The Apple Women's Health Study aims to gain a better understanding of the relationship between menstrual cycles, health, and behavior. The first 10,000 participants in this study were diverse in demographic characteristics and all used Apple iPhones.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Lise A. Arge, Siri E. Haberg, Allen J. Wilcox, Oyvind Naess, Olga Basso, Maria C. Magnus
Summary: History of miscarriage is associated with decreased fecundability, while subfertility is linked to higher risk of miscarriage in subsequent pregnancies.
HUMAN REPRODUCTION
(2022)
Article
Public, Environmental & Occupational Health
Ellen O. Carlsen, Quaker Harmon, Maria C. Magnus, Helle M. Meltzer, Iris Erlund, Lars C. Stene, Siri E. Haberg, Allen J. Wilcox
Summary: This study found that among women without a history of diabetes, higher HbA1c levels at 18 weeks of pregnancy were associated with important perinatal outcomes, including birth weight, large-for-gestational age, preterm delivery, and preeclampsia.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Multidisciplinary Sciences
Jenna Nobles, Lindsay Cannon, Allen J. Wilcox
Summary: US state legislatures have proposed laws to ban abortion once the earliest embryonic electrical activity is detectable, affecting specific population subgroups who may face difficulties in detecting pregnancy early due to irregular menstrual cycles and common health conditions. Individual physiological limitations may impact the ability to detect pregnancy before fetal cardiac activity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Letter
Public, Environmental & Occupational Health
Allen Wilcox, Olga Basso
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Maria C. Magnus, Alexandra Havdahl, Allen J. Wilcox, Alice Goisis
Summary: Parental time-to-pregnancy is modestly but robustly associated with neurodevelopmental delays and difficulties in offspring, with no additional impact of assisted reproductive technologies.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Editorial Material
Public, Environmental & Occupational Health
Allen J. Wilcox, Rolv Skjaerven
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2022)
Article
Obstetrics & Gynecology
Ana K. Rosen Vollmar, Clarice R. Weinberg, Donna D. Baird, Allen J. Wilcox, Antonia M. Calafat, Nicole C. Deziel, Caroline H. Johnson, Anne Marie Z. Jukic
Summary: Urinary phenol concentrations of 2,5-dichlorophenol were associated with an increased odds of early pregnancy loss, while higher concentrations of butylparaben and triclosan were associated with an increase in fecundability. This study is the first to investigate the associations between phenol exposure and fecundability and early pregnancy loss using repeated pooled measures, providing important insights for future research on reproductive health.
HUMAN REPRODUCTION
(2023)
