Review
Cardiac & Cardiovascular Systems
Avelyn Aw, Mechteld C. de Jong, Shriya Varghese, James Lee, Roger Foo, Rajeev Parameswaran
Summary: This review assessed the features and outcomes of pheochromocytoma-induced takotsubo cardiomyopathy (PCC-TCM), comparing typical and atypical subtypes. It found that atypical subtype patients were younger and had more severe clinical presentations and lower pre-operative mortality rates. However, the study also highlighted the need for further research to draw more reliable conclusions.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Review
Medicine, General & Internal
Yashendra Sethi, Hamsa Murli, Oroshay Kaiwan, Vidhi Vora, Pratik Agarwal, Hitesh Chopra, Inderbir Padda, Manasa Kanithi, Mihaela Simona Popoviciu, Simona Cavalu
Summary: Broken Heart Syndrome, also known as Takotsubo Syndrome (TS), is a sudden and transient dysfunction of the left and/or right ventricle, often resembling Acute Coronary Syndrome (ACS). It was first described in Japan in the 1990s and has since gained attention from researchers worldwide. Recent evidence suggests that TS may have serious complications and mortality rates similar to ACS. The exact etiology of TS is still poorly understood, but it can be classified into primary and secondary types. Primary TS occurs due to symptoms of myocardial damage preceded by emotional stress, while secondary TS occurs as a complication of other medical conditions. Pathophysiological mechanisms include adrenergic hormones/stress, decreased estrogen levels, altered microcirculation, and disturbances in the brain-heart axis. More research is needed to understand the molecular mechanisms and develop individualized treatments for TS.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Takumi Osawa, Kazuko Tajiri, Masaki Ieda, Tomoko Ishizu
Summary: This study revealed significant associations between previous or active cancer and an increased risk of all-cause mortality and in-hospital adverse events in patients with TTS.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Anthony Matta, Clement Delmas, Francesco Campelo-Parada, Thibault Lhermusier, Frederic Bouisset, Meyer Elbaz, Vanessa Nader, Stephanie Blanco, Jerome Roncalli, Didier Carrie
Summary: Takotsubo cardiomyopathy is a clinical condition related to heart failure, with sympathetic nerve stimulation and catecholamine storm playing a role in its development. While the clinical course of the disease is generally mild, life-threatening complications can occur. Coronary angiography, left ventriculogram, transthoracic echocardiography and cardiac magnetic resonance imaging are key tools for diagnosis. Treatment usually involves conventional heart failure therapy, unless the patient is in critical condition or experiencing complications.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Eric Landa, Erika Vigandt, Luis Moron, Manveer Ubhi, Basilides Fermin
Summary: Takotsubo cardiomyopathy, commonly seen in postmenopausal women, is a condition characterized by left ventricular dysfunction induced by emotional stress. It mimics acute coronary syndrome in presentation, leading to clean or nonobstructive coronary arteries in most patients after left heart catheterization.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Feng Dong, Liya Yin, Hamayak Sisakian, Tatevik Hakobyan, Lacey S. Jeong, Hirva Joshi, Ellianna Hoff, Selena Chandler, Geetika Srivastava, Abdur Rahman Jabir, Kelly Kimball, Yeong-Renn Chen, Chwen-Lih Chen, Patrick T. Kang, Parisa Shabani, Lindsay Shockling, Thomas Pucci, Karlina Kegecik, Christopher Kolz, Zhenyu Jia, William M. Chilian, Vahagn Ohanyan
Summary: This study found that coronary microvascular dysfunction plays a key role in the development of Takotsubo syndrome, and abnormalities in flow regulation between the left ventricular apex and base contribute to ventricular dysfunction. Normalization of blood flow between these two regions restores ventricular function.
EUROPEAN HEART JOURNAL
(2023)
Review
Medicine, General & Internal
Jen-Li Looi, Christina Chan, Paul Bridgman, Andrew J. Kerr
Summary: Takotsubo syndrome is a stress-related cardiomyopathy characterized by reversible left ventricular dysfunction. It is increasingly recognized in New Zealand and studying patients in this region provides insights into the disease and its patterns.
INTERNAL MEDICINE JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Ju Yan, Mahesutihan Madina, Changjiang Deng, Qianru Yuan, Shixiong Cao, Xiang Xie, Yitong Ma
Summary: Takotsubo syndrome is a group of clinical syndromes characterized by emotional or somatic stimulation and chest pain as the main symptoms, with generally good prognosis and few serious complications.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Hamada Alsheikh, Nour Shaheen, Wageih Saber, Mostafa Meshref, Yara Amro, Ahmed Shaheen, Mahmoud Galal Ahmed, Sarya Swed
Summary: A patient with high-risk myocardial infarction was retroactively diagnosed with TCM after normal epicardial coronaries were revealed in coronary angiography. The patient underwent surgical repair of VSR and had a good recovery.
Article
Medicine, General & Internal
Maria Casagrande, Giuseppe Forte, Francesca Favieri, Francesca Agostini, Jasmine Giovannoli, Luca Arcari, Ilaria Passaseo, Raffaella Semeraro, Giovanni Camastra, Viviana Langher, Mariella Pazzaglia, Luca Cacciotti
Summary: This study found that patients with Takotsubo syndrome (TTS) had a more negative subjective impact of life events and reported more stressful triggers before disease onset compared to patients with acute myocardial infarction (AMI). Individual responses to life events are associated with the onset of TTS.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Lorraine Lok-Wing Chiang, Shek Long Tsang, Jing Xian Lee, Mengqi Gong, Tong Liu, Gary Tse, Dong Chang, Ishan Lakhani, Ka Hou Christien Li
Summary: Reduced LVEF, both as a categorical and continuous variable, is associated with increased mortality risk in Takotsubo cardiomyopathy patients. However, the presence of apical ballooning did not show a significant link with mortality risk.
HEART FAILURE REVIEWS
(2021)
Article
Cardiac & Cardiovascular Systems
Toni Paetz, Francesco Santoro, Rosa Cetera, Ilaria Ragnatela, Ibrahim El-Battrawy, Matthias Mezger, Elias Rawish, Mireia Andres-Villarreal, Manuel Almendro-Delia, Manuel Martinez-Selles, Aitor Uribarri, Alberto Perez-Castellanos, Federico Guerra, Giuseppina Novo, Enrica Mariano, Maria Beatrice Musumeci, Luca Arcari, Luca Cacciotti, Roberta Montisci, Ibrahim Akin, Holger Thiele, Natale Daniele Brunetti, Oscar Vedia, Ivan J. Nunez-Gil, Ingo Eitel, Thomas Stiermaier
Summary: The type of trigger for Takotsubo syndrome influences the clinical conditions and mortality rate of patients. Patients with emotional triggers are younger, more likely to be female, and have a lower prevalence of comorbidities, while patients with physical triggers are the opposite. Age, gender, diabetes, malignancy, neurological disorders, chest pain, and treatment with angiotensin-converting enzyme inhibitors/angiotensin receptor blockers are predictors of long-term mortality in patients with Takotsubo syndrome.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Sofia Schino, Andrea Bezzeccheri, Alessandro Russo, Michela Bonanni, Joseph Cosma, Giuseppe Sangiorgi, Gaetano Chiricolo, Eugenio Martuscelli, Francesco Santoro, Enrica Giuliana Mariano
Summary: Takotsubo syndrome is an acute, transient episode of left ventricular dysfunction that occurs predominantly in postmenopausal women following significant physical or emotional stress. It can be diagnosed based on clinical symptoms and the absence of coronary artery disease on angiography. Despite being transient, complications occur in almost half of the patients and the mortality rate is significant. It can also lead to permanent myocardial damage.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Magnus To, Yolanda Zhang, Alexander Tompkins, Ruby Chen, Kaustubh Patankar, Sandeep Sangodkar
Summary: Takotsubo cardiomyopathy is a non-ischemic condition characterized by temporary heart dysfunction. Its overall prevalence is estimated to be around 2%, but around 10% for women with symptoms of acute coronary syndrome. The mechanism of this condition is still unknown, but treatment appears to be similar to congestive heart failure.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Review
Immunology
Kenji Rowel Q. Lim, Douglas L. Mann, Tsuneaki Kenzaka, Tomohiro Hayashi
Summary: Takotsubo syndrome (TTS) is characterized by the temporary dysfunction of the heart with abnormal regional wall motion, primarily caused by a sudden increase in catecholamines. Inflammation plays a crucial role in determining patient outcomes and the early pathogenesis of the disorder.
FRONTIERS IN IMMUNOLOGY
(2023)