Article
Multidisciplinary Sciences
John M. M. O'Toole, Sean R. R. Mathieson, Sumit A. A. Raurale, Fabio Magarelli, William P. P. Marnane, Gordon Lightbody, Geraldine B. B. Boylan
Summary: This report presents a dataset of neonatal electroencephalogram (EEG) recordings graded based on the severity of abnormalities in the background pattern. The dataset includes 169 hours of multi-channel EEG from 53 neonates diagnosed with hypoxic-ischaemic encephalopathy (HIE). The grading system assesses attributes such as amplitude, continuity, sleep-wake cycling, symmetry and synchrony, and abnormal waveforms to categorize the background severity into 4 grades. The dataset can be used for reference, training, and algorithm development for neonatal EEG with HIE.
Review
Pediatrics
Greta Sibrecht, Franciszek Borys, Chiara Campone, Carlo Bellini, Peter Davis, Matteo Bruschettini
Summary: This review examined cooling methods during transport of newborn infants with HIE and found that servo-controlled active cooling was more effective in maintaining body temperature within the target range during transfer to a neonatal intensive care unit.
Article
Pediatrics
Ipsita Goswami, Daphne Kamino, Elysa Widjaja, Melissa Paniccia, Nicholas Mitsakakis, Aideen Moore, Emily W. Y. Tam
Summary: This study compares the longitudinal changes in heart rate variability (HRV) during therapeutic hypothermia in neonates with different subtypes of hypoxic-ischemic brain injury. The results show that neonates with watershed injury and mixed pattern injury have significant suppression of HRV during the first 48 hours of hypothermia therapy.
PEDIATRIC RESEARCH
(2022)
Article
Medical Laboratory Technology
Chao Sun, Ruijie Wang, Lanbo Zhao, Lu Han, Sijia Ma, Dongxin Liang, Lei Wang, Xiaoqian Tuo, Yu Zhang, Dexing Zhong, Qiling Li
Summary: A computer-aided diagnosis system for rapid recognition of fetal nucleated red blood cells (fNRBCs) was established based on a convolutional neural network.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2022)
Review
Neurosciences
Konstantina Tetorou, Claudia Sisa, Arzo Iqbal, Kim Dhillon, Mariya Hristova
Summary: Neonatal hypoxic-ischaemic brain damage is a major cause of child mortality and morbidity, often resulting from impaired cerebral perfusion due to issues with the uterus, placenta, or umbilical cord during delivery. Bacterial infection is a contributing factor that worsens neuronal damage in cases of hypoxic-ischaemic injury.
FRONTIERS IN SYNAPTIC NEUROSCIENCE
(2021)
Review
Biotechnology & Applied Microbiology
Yanyu Chen, Zhuhao Wu, Joseph Sutlive, Ke Wu, Lu Mao, Jiabao Nie, Xing-Zhong Zhao, Feng Guo, Zi Chen, Qinqin Huang
Summary: Noninvasive prenatal diagnosis (NIPD) is a method of detecting genetic disorders related to the fetus before birth by analyzing markers in the peripheral blood of pregnant women. Fetal-nucleated red blood cells (fNRBCs) can be used as biomarkers for NIPD due to their unique ability to carry the complete genetic information of the fetus. Recent advances in NIPD technologies are focused on isolating and analyzing fNRBCs, using both conventional and novel methods such as micro-/nanomaterials and microfluidic chips. The identification and clinical diagnostic potential of fNRBCs are also discussed, along with the challenges and future directions of using fNRBCs in NIPD treatment guidelines.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Obstetrics & Gynecology
A. E. Toern, S. Hesselman, K. Johansen, J. Agren, A. -K. Wikstroem, M. Jonsson
Summary: This study investigated the association of mild neonatal hypoxic ischaemic encephalopathy (HIE) with cerebral palsy, epilepsy, mental retardation, and death in childhood. The results showed that mild HIE was associated with neurological morbidity and mortality.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Cell Biology
Jung-Ho Noh, Ji-Seong Jeong, Sang-Jin Park, Kyung Jin Jung, Byoung-Seok Lee, Woo-Jin Kim, Ji-Seok Han, Min-Kyung Cho, Dong Kyung Sung, So Yoon Ahn, Yun Sil Chang, Hwa-Young Son, Eun Ju Jeong
Summary: The study evaluated the tissue distribution and potential toxicity of thrombin-preconditioned human Wharton's jelly-derived mesenchymal stem cells (th-hWJMSCs) in animal models before clinical trials, demonstrating their non-toxic and non-tumorigenic effects in rodent models, as well as their potential for treating hypoxic-ischaemic encephalopathy (HIE).
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Computer Science, Artificial Intelligence
Mark E. O'Sullivan, Gordon Lightbody, Sean R. Mathieson, William P. Marnane, Geraldine B. Boylan, John M. O'Toole
Summary: The study aims to develop and evaluate algorithms for detecting neonatal EEG artefacts and assessing their application in automated EEG grading of neonatal hypoxic-ischemic encephalopathy (HIE). The study used machine learning and deep learning methods, with a deep learning convolutional neural network achieving the best performance for artefact detection. The inclusion of artefact detection in the grading algorithm slightly improved its accuracy.
EXPERT SYSTEMS WITH APPLICATIONS
(2023)
Article
Pediatrics
Paolo Montaldo, Simona Puzone, Elisabetta Caredda, Francesca Galdo, Umberto Pugliese, Anna Maietta, Serena Ascione, Mario Diplomatico, Ferdinando Spagnuolo, Vincenzina Roma, Massimiliano De Vivo, Mauro Carpentieri, Sabino Moschella, Lucio Giordano, Alessandra D'Amico, Carlo Capristo, Laura Travan, Giovanni Chello, Emanuele Miraglia del Giudice, Mario Cirillo
Summary: This study investigated the effect of therapeutic hypothermia on MRI biomarkers and neurological outcomes in infants with mild HIE and seizures. The results showed significant differences in cerebral metabolite perturbations and white matter injury scores between infants with and without progression of HIE. There was no evidence that therapeutic hypothermia reduced adverse outcomes in infants with progression.
Review
Medicine, General & Internal
Elissa Yozawitz
Summary: New recommendations and expanded genetic testing have changed the classification and treatment of neonatal seizures. This review highlights the importance of EEG monitoring and discusses treatment and prognosis.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Pediatrics
Katsumi Hayakawa, Koichi Tanda, Masakazu Nishimoto, Akira Nishimura, Daisuke Kinoshita, Yuko Sano
Summary: The apparent diffusion coefficient (ADC) values in different brain structures of newborns can predict the neurological outcome for hypoxic-ischaemic encephalopathy (HIE). Specifically, the ADC values in the thalamus during the first week after birth can serve as a predictive marker.
Article
Pediatrics
Aled Picton, Ruchi Nadar, Alexandra Pelivan, Vidya Garikapati, Vrinda Saraff
Summary: Hypophosphatasia (HPP) is a rare inherited disorder affecting bone and teeth development, with perinatal HPP being the most severe form. This study presents a rare case of a baby boy who developed respiratory distress, hypotonia, and seizures shortly after birth, leading to a diagnosis of HPP through low ALP activity and abnormal bone mineralization. Early recognition of HPP's clinical and biochemical features is crucial for timely initiation of life-saving treatment.
ARCHIVES OF DISEASE IN CHILDHOOD
(2021)
Article
Clinical Neurology
Gergo Erdi-Krausz, Ruben Rocha, Alice Brown, Archana Myneni, Finn Lennartsson, Andrea Romsauerova, Rina Cianfaglione, Caroline. J. Edmonds, Brigitte Vollmer
Summary: The study found that children with neonatal HIE treated with hypothermia may be more likely to develop MND and motor difficulties, while inattention may affect motor performance. Predictive value of neonatal MRI and toddler age assessment of motor development for school-age outcomes is limited.
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Catherine Mooney, Daragh O'Boyle, Mikael Finder, Boubou Hallberg, Brian H. Walsh, David C. Henshall, Geraldine B. Boylan, Deirdre M. Murray
Summary: Machine learning algorithms were used to predict the occurrence of HIE in infants with perinatal asphyxia, identifying the infant's condition at birth, need for resuscitation, and first postnatal measures of pH, lactate, and base deficit as the strongest predictors. Random Forest models combining multiple features showed high sensitivity and specificity in predicting HIE.
Editorial Material
Pediatrics
Sampsa Vanhatalo, Nathan J. Stevenson, Ronit M. Pressler, Nicholas S. Abend, Stephane Auvin, Francesco Brigo, M. Roberta Cilio, Cecil D. Hahn, Hans Hartmann, Lena Hellstrom-Westas, Terrie E. Inder, Solomon L. Moshe, Magda L. Nunes, Renee A. Shellhaas, Kollencheri P. Vinayan, Linda S. de Vries, Jo M. Wilmshurst, Elissa Yozawitz, Geraldine B. Boylan
Summary: Brain monitoring plays a crucial role in neonatal neurocritical care, but recent research failed to prove its effectiveness in seizure treatment.
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Chelsea B. Munster, Hoda El-Shibiny, Eniko Szakmar, Edward Yang, Brian H. Walsh, Terrie E. Inder, Mohamed El-Dib
Summary: The aim of this study was to determine if the routine use of MRV in term-born infants receiving hypothermia is associated with the diagnosis of CSVT. The study found that including routine MRV in the imaging protocol did not increase the detection of CSVT in this population.
PEDIATRIC RESEARCH
(2023)
Editorial Material
Pediatrics
Antoine Giraud, Carol M. Stephens, Geraldine B. Boylan, Brian H. Walsh
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Kirsten R. Thiim, Aisling A. Garvey, Elizabeth Singh, Brian Walsh, Terrie E. Inder, Mohamed El-Dib
Summary: Defining neonatal encephalopathy clinically is challenging for therapeutic hypothermia qualification. This study evaluates magnetic resonance imaging outcomes of 39 infants with mild encephalopathy who did not meet cooling criteria. Infants evaluated for therapeutic hypothermia are at risk for brain injury and may benefit from neuroimaging and follow-up.
JOURNAL OF PEDIATRICS
(2023)
Article
Clinical Neurology
Andreea M. Pavel, John M. O'Toole, Jacopo Proietti, Vicki Livingstone, Subhabrata Mitra, William P. Marnane, Mikael Finder, Eugene M. Dempsey, Deirdre M. Murray, Geraldine B. Boylan, ANSeR Consortium
Summary: The study aimed to assess whether early clinical and electroencephalography (EEG) features can predict seizures in infants with hypoxic-ischemic encephalopathy (HIE). Machine learning models were developed using clinical and EEG parameters to predict infants at high risk of seizures. The results showed that the combination of clinical and EEG analysis can accurately predict seizure development in HIE infants.
Article
Pediatrics
Mary Anne J. Ryan, Sean R. Mathieson, Vicki Livingstone, Marc Paul O'Sullivan, Eugene M. Dempsey, Geraldine B. Boylan
Summary: This prospective observational study examines the nocturnal sleep architecture of healthy moderate to late preterm infants at 36 weeks post menstrual age. The study finds that sleep state architecture is dependent on birth GA, with infants born at lower GA having less active sleep and more quiet sleep. These findings may have implications for the neurodevelopment of the infants.
PEDIATRIC RESEARCH
(2023)
Review
Pediatrics
Mohamed El-Dib, Nicholas S. J. Abend, Topun Austin, Geraldine Boylan, Valerie Chock, M. Roberta Cilio, Gorm Greisen, Lena Hellstroem-Westas, Petra Lemmers, Adelina Pellicer, Ronit Pressler, Arnold Sansevere, Tammy Tsuchida, Sampsa Vanhatalo, Courtney J. Wusthoff
Summary: The development of neonatal neurocritical care in the past decade has shown significant progress in neuromonitoring and neuroprotection. Commonly used brain monitoring tools in the neonatal intensive care unit (NICU) include amplitude integrated EEG (aEEG), full multichannel continuous EEG (cEEG), and near-infrared spectroscopy (NIRS). However, there is no consensus on the consistent and efficient use of these modalities in common NICU scenarios. This review summarizes current evidence for the best utilization of neuromonitoring modalities in neonates with encephalopathy or possible seizures.
PEDIATRIC RESEARCH
(2023)
Review
Pediatrics
Mohamed El-Dib, Nicholas S. Abend, Topun Austin, Geraldine Boylan, Valerie Chock, M. Roberta Cilio, Gorm Greisen, Lena Hellstrom-Westas, Petra Lemmers, Adelina Pellicer, Ronit M. Pressler, Arnold Sansevere, Eniko Szakmar, Tammy Tsuchida, Sampsa Vanhatalo, Courtney J. Wusthoff
Summary: Neonatal intensive care has shifted focus from cardiorespiratory care to a holistic approach that emphasizes brain health. The most commonly used tools in the neonatal intensive care unit (NICU) to monitor brain function and physiology are amplitude-integrated EEG, full multichannel continuous EEG, and near-infrared spectroscopy. Each of these tools has unique characteristics and functions, but there is no consensus on the optimal approach to neuromonitoring in the NICU. This review examines current evidence to guide the use of these neuromonitoring tools for neuroprotective care in extremely premature infants and critically ill neonates.
PEDIATRIC RESEARCH
(2023)
Review
Public, Environmental & Occupational Health
Sonia Marie Lenehan, Leanna Fogarty, Cathal O'Connor, Sean Mathieson, Geraldine B. Boylan
Summary: This review investigates the development of early childhood sleep and its association with neurodevelopment. Results show changes in sleep architecture during the first two years, with sleep playing a critical role in memory, learning, and socio-emotional development. Future studies should focus on sleep architecture at each month of life, especially during periods of rapid neurodevelopment between 7-24 months.
MATERNAL AND CHILD HEALTH JOURNAL
(2023)
Article
Pediatrics
Marc Paul O. Sullivan, Vicki Livingstone, Irina Korotchikova, Eugene M. Dempsey, Deirdre M. Murray, Geraldine B. Boylan
Summary: Unconditional reference centiles for sleep parameters were established in infants 4-16 weeks of age based on data from a randomized controlled trial. The results showed that total sleep duration in a 24-hour period, night-time sleep duration in a 12-hour period, and longest sleep episode duration increased from 4 to 16 weeks, while daytime sleep duration in a 12-hour period decreased.
ARCHIVES OF DISEASE IN CHILDHOOD
(2023)
Article
Clinical Neurology
Soraia Ventura, Sean R. Mathieson, Marc P. O'Sullivan, John M. O'Toole, Vicki Livingstone, Ronit M. Pressler, Eugene M. Dempsey, Deirdre M. Murray, Geraldine B. Boylan
Summary: The study aims to examine the impact of parent-led massage on the sleep electroencephalogram (EEG) features of typically developing term-born infants at 4 months. The results show that parent-led massage is associated with distinct functional brain changes in the sleep EEG at 4 months.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
John M. M. O'Toole, Sean R. R. Mathieson, Sumit A. A. Raurale, Fabio Magarelli, William P. P. Marnane, Gordon Lightbody, Geraldine B. B. Boylan
Summary: This report presents a dataset of neonatal electroencephalogram (EEG) recordings graded based on the severity of abnormalities in the background pattern. The dataset includes 169 hours of multi-channel EEG from 53 neonates diagnosed with hypoxic-ischaemic encephalopathy (HIE). The grading system assesses attributes such as amplitude, continuity, sleep-wake cycling, symmetry and synchrony, and abnormal waveforms to categorize the background severity into 4 grades. The dataset can be used for reference, training, and algorithm development for neonatal EEG with HIE.
Review
Pediatrics
Antoine Giraud, Carol M. Stephens, Joel Fluss, Manoeurolle Kossorotoff, Brian H. Walsh, Stephane Chabrier
Summary: This study aims to summarize the long-term developmental conditions following neonatal arterial ischemic stroke (NAIS) to support parental information. The study found that most children had good long-term developmental conditions, allowing them to be integrated into regular school programs, participate in physical activities, and have a good quality of life.
ARCHIVES DE PEDIATRIE
(2023)
Article
Allergy
Cathal O'Connor, Vicki Livingstone, Jonathan O'B Hourihane, Alan D. Irvine, Geraldine Boylan, Deirdre Murray
Summary: This large birth cohort study examined the relationship between emollient bathing at 2 months and the trajectory of atopic dermatitis (AD) in the first 2 years of life. The results showed that infants who had emollient baths at 2 months had a higher prevalence of AD, suggesting that early use of emollients may increase the risk of AD.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)