Article
Chemistry, Medicinal
Santanu Hati, Marisa Zallocchi, Robert Hazlitt, Yuju Li, Sarath Vijayakumar, Jaeki Min, Zoran Rankovic, Sandor Lovas, Jian Zuo
Summary: This study introduced a new class of small molecules called PROTACs that can effectively degrade the CDK2 protein, with PROTAC-8 showing potential therapeutic activities. Experimental results demonstrated that PROTAC-8 can protect zebrafish from drug-induced auditory and neurotoxicity, indicating its promising role in treating hearing loss and cancer.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Hyunjun Woo, Min-Kyung Kim, Sohyeon Park, Seung-Hee Han, Hyeon-Cheol Shin, Byeong-gon Kim, Seung-Ha Oh, Myung-Whan Suh, Jun-Ho Lee, Moo-Kyun Park
Summary: Noise exposure is a well-known cause of hearing loss, and compounds like PFF-A and dieckol have been found to have antioxidant properties that can alleviate the adverse effects of noise exposure in mice.
Article
Health Care Sciences & Services
Hye-Yoon Seol, Seo-Hu Kim, Ga-Young Kim, Mini Jo, Young-Sang Cho, Sung-Hwa Hong, Il-Joon Moon
Summary: This study reveals that the noise-canceling technology in commercial earphones can significantly reduce sound pressure levels and improve hearing protection.
Review
Audiology & Speech-Language Pathology
Sheneen Meghji, John Phillips
Summary: This study aimed to explore the relationship between noise exposure and audiometric notching at specific frequencies, including 84 articles involving 1,438,987 individuals of different age groups. The results indicated that the relationship between noise exposure and 3-6 kHz audiometric notching is not straightforward, requiring further research.
Review
Neurosciences
Xue-min Chen, Xin-miao Xue, Ning Yu, Wei-wei Guo, Shuo-long Yuan, Qing-qing Jiang, Shi-ming Yang
Summary: This review summarizes the studies on susceptible genes related to noise-induced hearing loss (NIHL), including research on oxidative stress, potassium ion cycling, cilia structure, heat shock protein 70 (HSP70), DNA damage repair, and apoptosis. The insights provided in this review aim to contribute to further exploration of NIHL prevention and individual treatment.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Yingjun Wang, Wenping Xiong, Xiao Sun, Kunpeng Lu, Fujia Duan, Haibo Wang, Mingming Wang
Summary: This study aimed to evaluate the clinical characteristics and prognostic factors associated with unilateral sudden sensorineural hearing loss (SSNHL) related to environmental noise exposure before its onset. The findings showed that compared to unilateral SSNHL patients without exposure to obvious inducing factors before onset, patients exposed to environmental noise had a longer time to treatment, higher final pure-tone average, lower hearing gain, lower rate of vestibular dysfunction, and lower effective rate. Time to treatment and final pure-tone average were associated with the prognosis of patients exposed to environmental noise.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Environmental Sciences
Long Miao, Boshen Wang, Juan Zhang, Lihong Yin, Yuepu Pu
Summary: This study identified potential metabolic biomarkers associated with NIHL using metabolomics analysis and revealed several metabolic pathways related to NIHL. Further research indicated that the autophagy signal pathway may be involved in the occurrence and development of NIHL.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Immunology
Peifan Li, Tingting Qian, Shan Sun
Summary: The cochlea encodes sound stimuli and transmits them to the central nervous system. Damage to sensory cells and synapses in the cochlea leads to hearing loss. Recent studies have found the presence of resident macrophages in the cochlea, which are responsible for detecting and clearing cellular debris and pathogens. Insult to the cochlea can activate these macrophages to initiate immune responses. This review focuses on their distribution, functions, and potential therapeutic interventions for hearing loss.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Medicine, General & Internal
Nirvikalpa Natarajan, Shelley Batts, Konstantina M. Stankovic
Summary: Noise-induced hearing loss (NIHL) is the second most common cause of sensorineural hearing loss, affecting approximately 5% of the world's population. NIHL has significant physical, mental, social, and economic impacts. Diagnosis and screening involve reviewing patients' noise exposure history, audiograms, speech-in-noise test results, and measurements of otoacoustic emissions and auditory brainstem response. Prevention, early detection, and research on pharmacological treatment are essential for reducing the burden of NIHL. Future directions include personalized prevention and targeted treatments based on individual factors.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Xiaogang An, Renfeng Wang, Erfang Chen, Yang Yang, Bei Fan, Yao Li, Bang Han, Qiong Li, Zhenzhen Liu, Yu Han, Jun Chen, Dingjun Zha
Summary: This study developed a nanoparticle system that effectively delivered forskolin (FSK) to the inner ear through the targeting peptide LS19, providing significant protection against noise-induced hearing damage.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Biochemistry & Molecular Biology
Diana Tang, Yvonne Tran, Piers Dawes, Bamini Gopinath
Summary: Age-related hearing loss affects a significant proportion of adults aged 60 years and above, with a prevalence of 65%. This condition has a negative impact on both physical and mental well-being, and addressing modifiable lifestyle risk factors may provide an opportunity to prevent hearing loss.
Article
Audiology & Speech-Language Pathology
Zhuang Jiang, Botao Fa, Xunmiao Zhang, Jiping Wang, Yanmei Feng, Haibo Shi, Yue Zhang, Daoyuan Sun, Hui Wang, Shankai Yin
Summary: This study utilized machine learning models to identify NIHL-susceptible and NIHL-resistant groups based on extreme phenotypes, leading to the discovery of 12 risk variants associated with NIHL susceptibility through whole-exome sequencing. Meta-analyses revealed significant associations between CDH23 rs41281334 A allele and WHRN rs12339210 C allele with increased risk of NIHL after adjusting for confounding factors.
Article
Neurosciences
Qixuan Wang, Lu Yang, Minfei Qian, Yingying Hong, Xueling Wang, Zhiwu Huang, Hao Wu
Summary: This study aimed to identify the acute high-intensity recreational noise-induced effects on auditory function, particularly cochlear synaptopathy-related audiological metrics, in young adults with normal hearing. The results showed no significant impact on auditory metrics like PTA thresholds, DPOAE amplitudes, CS on TEOAEs, or MHINT SNRs post outdoor music festival noise exposure, with the exception of a decrease in ABR wave I amplitudes at 1 day post-exposure. This decrease in ABR wave I amplitudes was correlated with changes in MHINT SNR, highlighting the importance of auditory electrophysiological metrics in noise-induced cochlear synaptic dysfunction.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Neurosciences
Amy S. Graham, Benneth Ben-Azu, Marie-Eve Tremblay, Peter Torre, Marjanne Senekal, Barbara Laughton, Andre van der Kouwe, Marcin Jankiewicz, Mamadou Kaba, Martha J. Holmes
Summary: Hearing loss has a significant impact on healthcare resources worldwide and affects the quality of life for those affected. The connection between gut microbes and the brain, known as the gut-brain axis, has been established in various diseases, but its role in other parts of the body is not well explored. This review aims to explore the potential mechanisms that connect the auditory system to the gut-brain axis. The review identifies several potential key players and suggests that further research may lead to effective interventions for treating hearing loss.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Medicine, General & Internal
Po-Hsiung Chang, Chia-Wei Liu, Shih-Han Hung, Yi-No Kang
Summary: This study conducted a systematic review and meta-analysis to evaluate the effect of N-acetyl-cysteine on the prevention of noise-induced hearing loss. The results demonstrated that N-acetyl-cysteine has a significant protective effect. However, more large-scale randomized controlled trials are needed for further investigation and confirmation.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Review
Oncology
Elke De Schutter, Lieselot Croes, Joe Ibrahim, Patrick Pauwels, Ken Op de Beeck, Peter Vandenabeele, Guy Van Camp
Summary: GSDME, originally involved in hereditary hearing loss, has been associated with various cancers and may act as a tumor suppressor; differential methylation and gene expression patterns of GSDME are closely related to tumorigenesis and hold potential as detection and prognostic biomarkers in cancer; while GSDME protein expression is considered unsuitable as a biomarker, it still plays a role in tumor immunogenicity.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Genetics & Heredity
Lisse J. M. Tavernier, Erik Fransen, Hanne Valgaeren, Guy Van Camp
Summary: Otosclerosis is a common cause of hearing impairment, often resulting from abnormal bone remodeling in the middle and inner ear. It can be familial, oligogenic, or monogenic in nature. Recent studies have identified genetic factors and variants associated with the disease, offering potential insights into its pathogenesis.
Article
Genetics & Heredity
Allan Thomas Hojland, Lisse J. M. Tavernier, Isabelle Schrauwen, Manou Sommen, Vedat Topsakal, Isabelle Schatteman, Ingeborg Dhooge, Alex Huber, Diego Zanetti, Henricus P. M. Kunst, Alexander Hoischen, Michael B. Petersen, Guy Van Camp, Erik Fransen
Summary: This study identified significant associations between ACAN gene variants and otosclerosis risk, with multiple independent signals. The variants include both predisposing and protective alleles, spanning different populations. Exonic variants in the ACAN gene are mainly located in the CS domain, with a wide range of effect sizes and population frequencies.
Review
Cell Biology
Elke De Schutter, Ria Roelandt, Franck B. Riquet, Guy Van Camp, Andy Wullaert, Peter Vandenabeele
Summary: The GSDM family consists of six gene clusters with a unique N-terminal domain, capable of executing plasma membrane permeabilization. The activity of GSDME and GSDMD, the most widely expressed and best-studied GSDMs, is directly regulated by protease-and kinase-dependent mechanisms. Evolutionary forces and a unique position of the PJVK gene are associated with complex inner-ear development in vertebrates.
TRENDS IN CELL BIOLOGY
(2021)
Review
Neurosciences
Dorien Verdoodt, Noa Peeleman, Guy Van Camp, Vincent Van Rompaey, Peter Ponsaerts
Summary: This study conducted a systematic review on cochlear gene therapy, with a focus on transduction efficiency in preclinical studies. While gene therapy shows promise in treating sensorineural hearing loss, the methodological heterogeneity hinders the identification of the most promising tools for future use in inner ear therapies.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Genetics & Heredity
Maria Pina Concas, Anna Morgan, Fabrizio Serra, Andries Paul Nagtegaal, Berthe C. Oosterloo, Sudha Seshadri, Nancy Heard-Costa, Guy Van Camp, Erik Fransen, Margherita Francescatto, Giancarlo Logroscino, Rodolfo Sardone, Nicola Quaranta, Paolo Gasparini, Giorgia Girotto
Summary: Through a Genome-Wide Association Study meta-analysis, approximately 375 genes related to hearing function were identified, with 15 being successfully replicated as promising candidates such as BNIP3L, ELP5, and MAP3K20. These findings contribute significantly to our understanding of the genetic basis of hearing function.
Article
Multidisciplinary Sciences
Francois Sipieter, Benjamin Cappe, Aymeric Leray, Elke De Schutter, Jolien Bridelance, Paco Hulpiau, Guy Van Camp, Wim Declercq, Laurent Heliot, Pierre Vincent, Peter Vandenabeele, Franck B. Riquet
Summary: This study investigates the involvement of ERK1/2 in cell death processes and demonstrates the distinct roles of ERK1/2 in apoptosis and necroptosis. The findings highlight the importance of ERK1/2 signaling dynamics in determining cellular responses to different cell death programs. Additionally, the study reveals a unique necroptotic ERK1/2 activity profile and its downstream regulation by the final executioner of necroptosis, MLKL.
Article
Oncology
Gitta Boons, Timon Vandamme, Laura Marien, Willem Lybaert, Geert Roeyen, Tim Rondou, Konstantinos Papadimitriou, Katrien Janssens, Bart Op de Beeck, Marc Simoens, Wim Demey, Isabel Dero, Guy Van Camp, Marc Peeters, Ken Op de Beeck
Summary: This study aimed to investigate the biomarker potential of genome-wide molecular profiling of plasma cell-free DNA (cfDNA) in patients with neuroendocrine neoplasms (NENs). The results showed that cfDNA had high specificity and could be used for diagnosis, prognosis, and follow-up of NENs.
CLINICAL CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Dorien Verdoodt, Noa Peeleman, Krystyna Szewczyk, Guy Van Camp, Peter Ponsaerts, Vincent Van Rompaey
Summary: The absence of Coch has a protective influence on hearing thresholds after noise exposure, but it is not related to reduced inner ear inflammation in the knockout mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Joe Ibrahim, Ken Op de Beeck, Erik Fransen, Marc Peeters, Guy Van Camp
Summary: This study utilized DNA methylation data from the human epigenome to identify pan-cancer and tumor-specific CpG markers through a three-step computational approach. The identified markers can accurately differentiate between different cancer types and show promising applicability in new minimally invasive cancer detection assays.
MOLECULAR ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Julio Cesar Rodriguez-Gonzalez, Ivones Hernandez-Balmaseda, Ken Declerck, Claudina Perez-Novo, Emilie Logie, Claudia Theys, Patrycja Jakubek, Olga Luisa Quinones-Maza, Geovanni Dantas-Cassali, Diego Carlos dos Reis, Guy Van Camp, Miriam Teresa Lopes Paz, Idania Rodeiro-Guerra, Rene Delgado-Hernandez, Wim Vanden Berghe
Summary: The phytopharmaceutical mangiferin (MGF) treatment demonstrates dose-dependent tumor regression, reduced lung metastasis, and increased overall survival in a syngeneic immunocompetent allograft mouse model of murine colon carcinoma. MGF also shows antimetastatic and antiangiogenic effects in human in vitro models and in a mouse implant model. Transcriptome pathway analysis reveals that MGF targets multiple signaling pathways to inhibit tumor growth, metastasis, and angiogenesis, with a focus on mitochondrial energy metabolism in the tumor microenvironment.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Oncology
Joe Ibrahim, Marc Peeters, Guy Van Camp, Ken Op de Beeck
Summary: The recent increase in cancer biomarker research has led to new insights in the field. Technological breakthroughs, such as long read sequencing and microarrays, have enabled high throughput profiling of biomarkers, while advances in bioinformatic tools have made reliable and accurate biomarkers a reality. These changes have renewed interest in biomarker research and provided opportunities for enhancing cancer management and early disease detection.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Medicine, General & Internal
Lisse J. M. Tavernier, Thomas Vanpoucke, Isabelle Schrauwen, Guy Van Camp, Erik Fransen
Summary: Otosclerosis is a common cause of hearing loss in young adults, with a prevalence of 0.3-0.4% in the European population. A recent genome-wide association study identified 15 new risk loci and confirmed the regions of three previously reported candidate genes. This study resequenced seven candidate genes and found that five of them were associated with the disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Oncology
Katleen Janssens, Chinouk Lambrechts, Barbara Geerinckx, Ken Op de Beeck, Guy Van Camp, Helena Oliveres, Hans Prenen, Timon Vandamme, Marc Peeters
Summary: One of the major challenges in digestive oncology is selecting the optimal therapy for RAS-mutated metastatic colorectal cancer (mCRC). Recent developments in targeting the RAS-pathway have shown promising results and may lead to clinical benefits for patients in the coming years. Although resistance remains a concern, strategic combination regimens have been developed to overcome this issue. In this review, we summarize the standard of care and discuss emerging therapies for RAS-mutated mCRC.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2023)
Review
Oncology
Laura Marien, Odeta Islam, Siddharth Chhajlani, Willem Lybaert, Marc Peeters, Guy Van Camp, Ken Op de Beeck, Timon Vandamme
Summary: Given the considerable heterogeneity in neuroendocrine neoplasms, there is a need for multiple biomarkers to capture different aspects of these tumors. Circulating biomarkers, such as NETest and ctDNA-based analysis, show promise in enhancing accuracy of diagnosis, prognosis determination, and therapy prediction and monitoring.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2023)
