Article
Chemistry, Analytical
Jun Tang, Xiaopeng Yang, Jinsa Li, Di Zhang, Yanliang Wang, Yong Ye
Summary: The study designed new fluorescent probes HSP and MSP to improve the accuracy and sensitivity of fluorescent probes. HSP exhibited red fluorescence emission after binding with Human Serum Albumin (HSA), while the recognition effect of MSP on HSA was less obvious compared to HSP. Furthermore, the HSP/HSA hybrid was also effective in detecting SO2.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Physical
Irina I. Grankina, Igor A. Borovoy, Sergey Petrushenko, Svitlana S. Hrankina, Vladimir P. Semynozhenko, Svetlana L. Yefimova, Alexander Sorokin
Summary: The aggregation behavior of amphiphilic pseudoisocyanine (amphi-PIC) dye in solutions with bovine serum albumin (BSA) was studied. The results showed that BSA molecules can form complexes with amphi-PIC J-aggregates, improving their spectral properties and increasing their stability and photostability.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Spectroscopy
Sudhanshu Sharma, Dineshbabu Takkella, Pintu Kumar, Krishna Gavvala
Summary: This study reported the interaction of rifampicin with Bovine Serum Albumin (BSA) by monitoring the fluorescence properties of tryptophan residue in BSA. The fluorescence intensity of BSA was significantly quenched by rifampicin, specifically affecting the Trp-213 residue. Molecular docking studies confirmed the proximity of rifampicin to the Trp-213 residue in the drug-protein complex.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Biochemistry & Molecular Biology
Piyush Verma, Lajpreet Kaur, Priyanka Aswal, Anju Singh, Himanshu Ojha, Afreen Jahan Rahman, Rahul Singhal, Anjani K. Tiwari, Mallika Pathak
Summary: This study investigates the binding of VDG with serum protein BSA using spectroscopic techniques. The results show that VDG forms a static quenching complex with BSA, and the binding affinity is determined using a computational approach. The study also reveals that VDG binding causes conformational changes in BSA and enhances its stability.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Luciana M. Sergio, Yandara A. Martins, Jackson L. Amaral, Victor L. B. Franca, Camila F. de Freitas, Antonio Medina Neto, Noboru Hioka, Maria Ravanelli, Cecilia Mareze-Costa, Silvio Claudio da Costa, Valder N. Freire, Kellen Brunaldi
Summary: The study found that steviol and its glycosides interact with bovine serum albumin, involving spontaneous binding reactions with hydrogen bonds and van der Waals interactions as well as water reorganization around the complex. The findings suggest that steviol's enhanced hydrophobicity and small size compared to its derivatives may favor its binding to BSA.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Optics
E. S. Gorodnichev, A. A. Kuleshova, O. Volkova, A. M. Saletsky
Summary: The study investigates the spectral and kinetic characteristics of fluorescence of bovine serum albumin (BSA) solutions and dyes (CAPIDAN and BR) in BSA solutions at different pH levels. It reveals distinct fluorescence attenuation patterns and binding mechanisms for CAPIDAN and BR with BSA molecules. The interactions between the dyes and BSA are influenced by factors like conformational changes and electrostatic forces, demonstrating the pH-dependent nature of the binding mechanisms.
Article
Optics
Sony Udayan, Drishya Elizebath, D. R. Sherin, Vakayil K. Praveen, Sini Sunny, Purushothaman Jayamurthy, T. K. Manojkumar, V. P. N. Nampoori, Sheenu Thomas
Summary: This study demonstrates the use of a hexamethine hemicyanine dye as a thermo-optical probe for serum albumin, revealing significant alterations in optical and thermal properties upon binding with the protein. Spectroscopic techniques and molecular docking methods were utilized to investigate the interaction between the dye and serum albumin, indicating enhanced stability of proteins and reduced thermal diffusivity of the dye when bound with the albumin.
OPTICS AND LASER TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sakthiprabha Sampath, Sangilimuthu Alagar Yadav, Manjunath Meti, Sundaram Kaveri, Ravi Subban, Rajagopal Subramanyam
Summary: This study investigated the binding interactions between the Rhodanine derivative P4OC and Bovine Serum Albumin (BSA) using biophysical approaches and molecular docking. The results showed that P4OC has good drug binding properties and can cause secondary structural changes in BSA. This study is important for understanding drug-protein binding mechanisms and assessing the pharmacological activity of P4OC.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Spectroscopy
Qi Zhou, Deyuan Yang, Xiujuan Huang, Yuanyuan Chen, Yifeng Tu, Jilin Yan
Summary: A convenient and sensitive fluorescent assay for trypsin detection was developed in this study. The combination of bovine serum albumin with copper ions acted as a peroxidase mimic and significantly accelerated the reaction rate. Trypsin decreased the catalytic effect, resulting in a decrease in fluorescence signal. The method exhibited good selectivity and was successfully applied to real sample detection.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Biochemistry & Molecular Biology
Zhe-Ying Hu, Wan-Jun Wang, Lu Hu, Jie-Hua Shi, Shao-Liang Jiang
Summary: Dacomitinib, a tyrosine kinase inhibitor, was found to quench the endogenous fluorescence of bovine serum albumin (BSA) through static quenching. It preferentially inserted into the hydrophobic cavity of the BSA subdomain IA (site III), forming a 1:1 DAC-BSA complex. DAC had a higher affinity for BSA, and non-radiative energy transfer occurred between them. Hydrogen bonds, van der Waals forces, and hydrophobic forces played a significant role in the insertion of DAC into the hydrophobic cavity of BSA. DAC affected the secondary structure of BSA, leading to a slight decrease in the alpha-helix content. The microenvironment around tyrosine residues was affected by the DAC-BSA combination, while the microenvironment around tryptophan residues remained unaffected. Molecular docking and molecular dynamics simulation confirmed the insertion of DAC into site III of BSA, with hydrogen energy and van der Waals energy contributing to the stability of the DAC-BSA complex. The influence of metal ions on the system's affinity was also explored.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Spectroscopy
Bahadir Duman, Cem Erkmen, Md. Zahirul Kabir, Lim Ching Yi, Saharuddin B. Mohamad, Bengi Uslu
Summary: This study examined the binding mechanisms of two pesticides, propazine and quinoxyfen, with bovine serum albumin using fluorescence, absorption, and molecular docking methods. The fluorescence of bovine serum albumin was quenched in the presence of propazine and quinoxyfen, indicating the formation of static quenching complexes. The thermodynamic data and molecular docking analysis further supported the spontaneous and non-covalent binding interactions between the pesticides and bovine serum albumin.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Biochemistry & Molecular Biology
Abhishek Udnoor, Manjunath Lokolkar, Basappa C. Yallur, Raju Kale, Muttanagoud N. Kalasad, Umesha Katrahalli, Devagondanahalli H. Manjunatha
Summary: Inducing bio-functionalization in noble metal nanoparticles is crucial for their biocompatibility in biological activities. In this study, ZnO/Ag nanoparticles were synthesized and their interaction with bovine serum albumin was evaluated. The results showed that ZnO/Ag nanoparticles significantly reduced the intrinsic fluorescence intensity of bovine serum albumin and induced conformational modifications.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Spectroscopy
Afreen Jahan Rahman, Deepti Sharma, Deepanshu Kumar, Mallika Pathak, Anju Singh, Vinod Kumar, Raman Chawla, Himanshu Ojha
Summary: Phosmet exerts its neurotoxicity by inhibiting acetylcholinesterase, while the binding interactions with bovine serum albumin (BSA) influenced the free concentration of Phosmet. The study confirmed non-covalent binding interactions between Phosmet and BSA.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Biochemistry & Molecular Biology
Elham Ziaee, Behzad Shareghi, Sadegh Farhadian, Lida Momeni, Fatemeh Heibati-Goojani
Summary: Serum albumins are abundant plasma proteins that act as carriers for compounds like drugs. Polyamines like putrescine can interact with negatively charged molecules and affect the structure of bovine serum albumin. The formation of a complex between putrescine and bovine serum albumin alters its hydrophobicity and is found to have a spontaneous binding process.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Chemistry, Applied
Jiali Gu, Siyao Zheng, Xiyao Huang, Qian He, Ting Sun
Summary: The study found that the binding of BHA to serum albumin occurs through static quenching, forming a relatively stable complex with hydrophobic interactions as the main binding mechanism. BHA has the capability to bind to specific sites on BSA, and the presence of other food additives weakens the binding of BHA to BSA.
Article
Chemistry, Applied
Leping Chen, Yanfen Wang, Tingyu Shi, Tiantian Ma, Yang Li, Huayu Qiu, Shouchun Yin, Meier Gu
Summary: This study successfully overcame the limitations of the heavy atom effect by introducing iodine atoms and innovatively enhancing the structure while weakening stacking behavior, achieving high efficiency and precision in photodynamic therapy and photothermal therapy.
Article
Chemistry, Applied
Bingpeng Guo, Honghan Sa, Peng Zhang, Guiwen Hao, Mengyu Li, Qingqing Jiang, Baoying Li, Wei Shu, Changxiang Shao
Summary: The design of ratiometric fluorescence probes with large Stokes shift is of great significance in detecting and imaging target substances in complex organisms. In this study, a novel fluorophore with a large Stokes shift was easily obtained, and a fluorescence probe based on it demonstrated rapid response, high selectivity, and sensitivity towards peroxynitrite. The probe also showed excellent biocompatibility and remarkable mitochondrial targeting ability, making it suitable for proportional imaging of peroxynitrite in living cells and zebrafish.
Review
Chemistry, Applied
Haidong Huang, Xiaohui Wang, Xinyang Li, Yichen Li, Guojin Liu, Lan Zhou, Jianzhong Shao
Summary: This article introduces the application of responsive photonic crystals in anti-counterfeiting technology, with a focus on the preparation principle, classification, and preparation methods.
Article
Chemistry, Applied
Yunpeng Wang, Tao Zhao, Xiaoye Bi, Chencheng Lv
Summary: In this study, three novel carbene dyes were designed to achieve environmentally friendly dyeing processes. The dyes formed covalent bonds with fibers and exhibited good dyeing performance and high color fastness. These findings highlight the potential of the novel carbene dyes in promoting green production in the textile industry.
Review
Chemistry, Applied
Yizhe Yan, Xiaopei Zhu, Jia-Xin Cao, Yuan He, Shaoqing Li, Jian-Yong Wang
Summary: In this paper, 1,3,5-triazine dyes were successfully synthesized and their photophysical properties were studied. Two probes were selected for further investigation, showing promising applications in various fields.
Article
Chemistry, Applied
Xin Hu, Tongsheng Huang, Lihua Chen, Weifeng Zhu, Fengjie Deng, Xiancai Li, Jianwen Tian, Meiying Liu, Xiaoyong Zhang, Yen Wei
Summary: This study presents the synthesis of fluorescent cyclomatrix polyphosphazene spheres with aggregation-induced emission (AIE) feature and biodegradable potential for controlled drug delivery. The resulting micelles exhibit high water dispersibility, desirable fluorescence performance, and high drug loading capacity. They can effectively release the encapsulated drug in physiological solution and show excellent biological imaging ability and cytotoxicity against cancer cells.
Article
Chemistry, Applied
Yanzhu Liu, Yanghui Lei, Dongyan Li, Guangkui Li, Dongping Li, Yongxiu Li
Summary: In this study, luminescent lanthanide nanoparticles were synthesized as a dual emission turn-off probe for detecting 2,6-pyridinedicarboxylic acid (DPA) in water. The nanoparticles showed good dispersion and water stability, and achieved low detection limits for DPA. They also exhibited high recoveries in various samples.
Article
Chemistry, Applied
Jung Jae Do, Jong Ryeol Kwon, Donghan Kim, Jae Woong Jung
Summary: This study presents a defect passivation approach using coumarin dye as a multi-functional passivating agent of perovskite films to boost power conversion efficiency and operating stability of PSCs. The incorporation of coumarin dye improves the film morphology, enhances carrier extraction/transport, and suppresses trap-assisted recombination in the perovskite films. The optimized device demonstrates impressive reliability and practical applicability, maintaining over 90% of its initial PCE after being exposed to continuous indoor lighting irradiation for 2000 hours.
Article
Chemistry, Applied
Gang Wang, Yu-Chang Wang, Jing Lu, Wen-Fu Yan, Juan Jin, Yuan-Peng Wang, Jia-Jia Zhang, Hui-Jie Zhang, Hao Dong, Xi-Guang Liu
Summary: A new Ni(II) compound with good solid-state fluorescence performance and stability was synthesized, and it showed outstanding detection properties for various substances in aqueous solutions. This compound has the potential to be a multifunctional sensor.
Article
Chemistry, Applied
Luyao Wei, Shenglong Shang, Yu Zheng, Jie Liu, Ping Zhu
Summary: This study developed a facile method to create high saturation and durable structural colors on cotton fabrics. The colors are regulated by adjusting the size of magnetic particles and can be conveniently printed on fabrics using photo masks on transparent films.
Article
Chemistry, Applied
Zhao Jiang, Qing Zhang, Zhaoyu Kong, Ruijie Qiao, Zichuan Liu, Linzhou Song, Senqiang Zhu, Rui Liu, Hongjun Zhu
Summary: Three heteroleptic Ir(III) complexes with different electron-donating aryl groups were synthesized and their optical properties were investigated. It was found that all three complexes exhibited aggregation-induced phosphorescence emission (AIPE) behaviors, and the relationship between the size of organic ligands and AIPE behaviors was characterized. Ir-PhCz showed the best imaging of latent fingerprints due to its green light emission and high quantum yield.
Article
Chemistry, Applied
Zhijun Ruan, Chunxia Fan, Xuanrong Wang, Dong Shao, Xiaodong Yang, Wentao He, Tao Xu, Junqi Lin, Zhengfang Tian
Summary: A novel thioketal-based probe has been designed for rapid and accurate detection of mercury (II) ions, showing different fluorescence characteristics in various states. The probe exhibits excellent selectivity and specificity, making it suitable for Hg2+ detection in water solutions.
Article
Chemistry, Applied
Jianjun Huang, Xuan Zhao, Daniel Escudero, Luc Van Meervelt, Dongbin Zheng, Yuyu Fang, Wim Dehaen
Summary: A series of BOAHY compounds were successfully synthesized and showed versatile applications as a platform for designing novel fluorescent probes, especially in selective recognition.
Article
Chemistry, Applied
Roman V. Larkovich, Victoria E. Shambalova, Savva A. Ponomarev, Alexander S. Aldoshin, Boris N. Tarasevich, Konstantin A. Lyssenko, Valentine G. Nenajdenko
Summary: An efficient synthetic protocol for the preparation of novel 1,7-difluorinated BODIPYs was elaborated. Their photophysical properties were studied and the effect of 2,6-substituents was evaluated using DFT calculations.
Article
Chemistry, Applied
Haneul Kim, Byungjin Koo
Summary: In this study, a lithium ion sensing methodology based on fluorinated naphthalene compounds using 19F NMR and UV-vis spectroscopy is reported. The binding of lithium ions to the compounds is confirmed by changes in chemical shifts and peak broadening. Additionally, the effect of different crown ether ring sizes on the binding ability is observed. This study provides a new method for lithium ion sensing using spectroscopy.