Journal
DRUGS OF THE FUTURE
Volume 35, Issue 8, Pages 635-641Publisher
PROUS SCIENCE, SAU-THOMSON REUTERS
DOI: 10.1358/dof.2010.035.08.1520865
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Funding
- American Heart Association
- NIH/NIDDK
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The famesoid X receptor (FXR) is a member of the nuclear receptor superfamily and plays an important role in maintaining bile acid, lipid and glucose homeostasis. Bile acids are endogenous ligands for FXR. However, bile acids may also activate pathways independent of FXR. The development of specific FXR agonists has provided important insights into the role of FXR in metabolism. Recent data have demonstrated that FXR is a therapeutic target for the treatment of certain metabolic disorders. This review will focus on recent advances in the role of FXR in metabolic disease.
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