Next-Generation Phosphate Binders: Focus on Iron-Based Binders

Ferric Citrate Hydrate for the Treatment of Hyperphosphatemia in Nondialysis-Dependent CKD

(2014) K. Yokoyama et al.   Clinical Journal of the American Society of Nephrology

A phase III study of the efficacy and safety of a novel iron-based phosphate binder in dialysis patients

(2014) Jürgen Floege et al.   KIDNEY INTERNATIONAL

Sevelamer Versus Calcium Carbonate in Incident Hemodialysis Patients: Results of an Open-Label 24-Month Randomized Clinical Trial

(2013) Biagio Di Iorio et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Dose-Response and Efficacy of Ferric Citrate to Treat Hyperphosphatemia in Hemodialysis Patients: A Short-term Randomized Trial

(2013) Jamie P. Dwyer et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Ferric Citrate Hydrate, a New Phosphate Binder, Prevents the Complications of Secondary Hyperparathyroidism and Vascular Calcification

(2013) Akio Iida et al.   AMERICAN JOURNAL OF NEPHROLOGY

Efficacy and safety of SBR759, a novel calcium-free, iron (III)-based phosphate binder, versus placebo in chronic kidney disease stage V Japanese patients on maintenance renal replacement therapy

(2013) Masafumi Fukagawa et al.   Clinical and Experimental Nephrology

Correction of hypocalcemia allows optimal recruitment of FGF-23-dependent phosphaturic mechanisms in acute hyperphosphatemia post-phosphate enema

(2013) Carolina Gracia-Iguacel et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Use of phosphate-binding agents is associated with a lower risk of mortality

(2013) Jorge B. Cannata-Andía et al.   KIDNEY INTERNATIONAL

Hypomagnesemia is a significant predictor of cardiovascular and non-cardiovascular mortality in patients undergoing hemodialysis

(2013) Yusuke Sakaguchi et al.   KIDNEY INTERNATIONAL

The demise of calcium-based phosphate binders

(2013) Alberto Ortiz et al.   LANCET

Effect of calcium-based versus non-calcium-based phosphate binders on mortality in patients with chronic kidney disease: an updated systematic review and meta-analysis

(2013) Sophie A Jamal et al.   LANCET

Fibroblast growth factor-23: what we know, what we don't know, and what we need to know

(2013) C. P. Kovesdy et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

A comparison of calcium acetate/magnesium carbonate and sevelamer-hydrochloride effects on fibroblast growth factor-23 and bone markers: post hoc evaluation from a controlled, randomized study

(2013) Adrian Covic et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The effects of colestilan versus placebo and sevelamer in patients with CKD 5D and hyperphosphataemia: a 1-year prospective randomized study

(2013) F. Locatelli et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

A randomized trial of JTT-751 versus sevelamer hydrochloride in patients on hemodialysis

(2013) K. Yokoyama et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Phosphate control in end-stage renal disease: barriers and opportunities

(2013) A. A. Waheed et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Calcium Supplements and Fracture Prevention

(2013) Douglas C. Bauer   NEW ENGLAND JOURNAL OF MEDICINE

Associations among total and food additive phosphorus intake and carotid intima-media thickness – a cross-sectional study in a middle-aged population in Southern Finland

(2013) Suvi T Itkonen et al.   Nutrition Journal

Use of Nicotinamide to Treat Hyperphosphatemia in Dialysis Patients

(2013) Aurélie Lenglet et al.   Drugs in research & development

Effect of Oral JTT-751 (Ferric Citrate) on Hyperphosphatemia in Hemodialysis Patients: Results of a Randomized, Double-Blind, Placebo-Controlled Trial

(2012) Keitaro Yokoyama et al.   AMERICAN JOURNAL OF NEPHROLOGY

Phosphate: a stealthier killer than previously thought?

(2012) Emilio Gonzalez-Parra et al.   CARDIOVASCULAR PATHOLOGY

Mortality in Kidney Disease Patients Treated with Phosphate Binders: A Randomized Study

(2012) B. Di Iorio et al.   Clinical Journal of the American Society of Nephrology

Randomized Clinical Trial of the Iron-Based Phosphate Binder PA21 in Hemodialysis Patients

(2012) R. P. Wuthrich et al.   Clinical Journal of the American Society of Nephrology

Rationale and study design of a three-period, 58-week trial of ferric citrate as a phosphate binder in patients with ESRD on dialysis

(2012) Kausik Umanath et al.   Hemodialysis International

Summary of the KDIGO guideline on anemia and comment: reading between the (guide)line(s)

(2012) Tilman B. Drüeke et al.   KIDNEY INTERNATIONAL

Magnesium prevents phosphate-induced calcification in human aortic vascular smooth muscle cells

(2012) L. Louvet et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The Safety and Tolerability of Ferric Citrate as a Phosphate Binder in Dialysis Patients

(2012) Marvin Sinsakul et al.   NEPHRON CLINICAL PRACTICE

Phosphate Transporters in Renal, Gastrointestinal, and Other Tissues

(2011) Ian Forster et al.   ADVANCES IN CHRONIC KIDNEY DISEASE

Phosphate: The new cholesterol? The role of the phosphate axis in non-uremic vascular disease

(2011) Timothy J. Ellam et al.   ATHEROSCLEROSIS

PA21: a novel phosphate binder for the treatment of hyperphosphatemia in chronic kidney disease

(2011) P. Geisser et al.   CLINICAL NEPHROLOGY

The Inflammatory Cytokines TWEAK and TNF  Reduce Renal Klotho Expression through NF B

(2011) J. A. Moreno et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Efficacy and safety of SBR759, a novel calcium-free, iron(III)-based phosphate binder, in Asian patients undergoing hemodialysis: A 12-week, randomized, open-label, dose-titration study versus sevelamer hydrochloride

(2011) JIN-BOR CHEN et al.   NEPHROLOGY

Lanthanum carbonate reduces FGF23 in chronic kidney disease Stage 3 patients

(2011) E. Gonzalez-Parra et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Effect of Lanthanum Carbonate Treatment on Bone in Japanese Dialysis Patients With Hyperphosphatemia

(2011) Takashi Shigematsu et al.   THERAPEUTIC APHERESIS AND DIALYSIS

Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging

(2010) Mutsuko Ohnishi et al.   FASEB JOURNAL

Efficacy and safety of SBR759, a new iron-based phosphate binder

(2010) Geoffrey A. Block et al.   KIDNEY INTERNATIONAL

Ironing out the phosphorus problem

(2010) Joshua J. Zaritsky et al.   KIDNEY INTERNATIONAL

Evaluation of calcium acetate/magnesium carbonate as a phosphate binder compared with sevelamer hydrochloride in haemodialysis patients: a controlled randomized study (CALMAG study) assessing efficacy and tolerability

(2010) Angel L.M. de Francisco et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Oral Phosphate Binders in Patients with Kidney Failure

(2010) Marcello Tonelli et al.   NEW ENGLAND JOURNAL OF MEDICINE

Iron-Magnesium Hydroxycarbonate (Fermagate): A Novel Non-Calcium-Containing Phosphate Binder for the Treatment of Hyperphosphatemia in Chronic Hemodialysis Patients

(2009) C. W. McIntyre et al.   Clinical Journal of the American Society of Nephrology

Effects of Treatment of Renal Osteodystrophy on Bone Histology

(2008) H. H. Malluche et al.   Clinical Journal of the American Society of Nephrology

Salivary Phosphate-Binding Chewing Gum Reduces Hyperphosphatemia in Dialysis Patients

(2008) V. Savica et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Efficacy and safety of sevelamer hydrochloride and calcium acetate in patients on peritoneal dialysis

(2008) P. Evenepoel et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION