Pediatric Relapsed or Refractory Leukemia: New Pharmacotherapeutic Developments and Future Directions
Published 2013 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Pediatric Relapsed or Refractory Leukemia: New Pharmacotherapeutic Developments and Future Directions
Authors
Keywords
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Sorafenib, Hematopoietic Stem Cell Transplant, Bortezomib
Journal
DRUGS
Volume 73, Issue 5, Pages 439-461
Publisher
Springer Nature
Online
2013-04-08
DOI
10.1007/s40265-013-0026-2
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia
- (2012) G. L. Uy et al. BLOOD
- Bortezomib with chemotherapy is highly active in advanced B-precursor acute lymphoblastic leukemia: Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Study
- (2012) Y. H. Messinger et al. BLOOD
- Correlation of CD33 expression level with disease characteristics and response to gemtuzumab ozogamicin containing chemotherapy in childhood AML
- (2012) J. A. Pollard et al. BLOOD
- Cancer statistics, 2012
- (2012) Rebecca Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Hsp90 Molecular Chaperone Inhibitors: Are We There Yet?
- (2012) L. Neckers et al. CLINICAL CANCER RESEARCH
- Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia
- (2012) S. P. Glaser et al. GENES & DEVELOPMENT
- RAS mutations are frequent in FAB type M4 and M5 of acute myeloid leukemia, and related to late relapse: a study of the Japanese Childhood AML Cooperative Study Group
- (2012) Hirozumi Sano et al. INTERNATIONAL JOURNAL OF HEMATOLOGY
- Phase I Multidose-Escalation Study of the Anti-CD19 Maytansinoid Immunoconjugate SAR3419 Administered by Intravenous Infusion Every 3 Weeks to Patients With Relapsed/Refractory B-Cell Lymphoma
- (2012) Anas Younes et al. JOURNAL OF CLINICAL ONCOLOGY
- Pilot Study of Nelarabine in Combination With Intensive Chemotherapy in High-Risk T-Cell Acute Lymphoblastic Leukemia: A Report From the Children's Oncology Group
- (2012) Kimberly P. Dunsmore et al. JOURNAL OF CLINICAL ONCOLOGY
- Improved Survival for Children and Adolescents With Acute Lymphoblastic Leukemia Between 1990 and 2005: A Report From the Children's Oncology Group
- (2012) Stephen P. Hunger et al. JOURNAL OF CLINICAL ONCOLOGY
- Inotuzumab ozogamicin, an anti-CD22–calecheamicin conjugate, for refractory and relapsed acute lymphocytic leukaemia: a phase 2 study
- (2012) Hagop Kantarjian et al. LANCET ONCOLOGY
- Outcome in children with Down's syndrome and acute lymphoblastic leukemia: role of IKZF1 deletions and CRLF2 aberrations
- (2012) T D Buitenkamp et al. LEUKEMIA
- FLT3 mutation status is a predictor of early death in pediatric acute promyelocytic leukemia: A report from the Children's Oncology Group
- (2012) Matthew A. Kutny et al. PEDIATRIC BLOOD & CANCER
- Vincristine potentiates the anti-proliferative effect of an aurora kinase inhibitor, VE-465, in myeloid leukemia cells
- (2011) Kozue Yoshida et al. BIOCHEMICAL PHARMACOLOGY
- Phase 1 study of epigenetic priming with decitabine prior to standard induction chemotherapy for patients with AML
- (2011) J. M. Scandura et al. BLOOD
- Presence of FLT3-ITD and high BAALC expression are independent prognostic markers in childhood acute myeloid leukemia
- (2011) A. Staffas et al. BLOOD
- Integrated genomic analysis of relapsed childhood acute lymphoblastic leukemia reveals therapeutic strategies
- (2011) L. E. Hogan et al. BLOOD
- Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group
- (2011) J. Zhang et al. BLOOD
- Multi-institutional phase 2 clinical and pharmacogenomic trial of tipifarnib plus etoposide for elderly adults with newly diagnosed acute myelogenous leukemia
- (2011) J. E. Karp et al. BLOOD
- Phase 2 trial of clofarabine in combination with etoposide and cyclophosphamide in pediatric patients with refractory or relapsed acute lymphoblastic leukemia
- (2011) N. Hijiya et al. BLOOD
- Results from a randomized trial of salvage chemotherapy followed by lestaurtinib for patients with FLT3 mutant AML in first relapse
- (2011) M. Levis et al. BLOOD
- Dasatinib as first-line treatment for adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia
- (2011) R. Foa et al. BLOOD
- Early UK experience in the use of clofarabine in the treatment of relapsed and refractory paediatric acute lymphoblastic leukaemia
- (2011) David O’Connor et al. BRITISH JOURNAL OF HAEMATOLOGY
- AAML03P1, a pilot study of the safety of gemtuzumab ozogamicin in combination with chemotherapy for newly diagnosed childhood acute myeloid leukemia
- (2011) Todd M. Cooper et al. CANCER
- Efficacy and pharmacokinetic/pharmacodynamic evaluation of the Aurora kinase A inhibitor MLN8237 against preclinical models of pediatric cancer
- (2011) Hernan Carol et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- SAR3419: An Anti-CD19-Maytansinoid Immunoconjugate for the Treatment of B-Cell Malignancies
- (2011) V. Blanc et al. CLINICAL CANCER RESEARCH
- FLT3 mutation and expression did not adversely affect clinical outcome of childhood acute leukaemia-a study of 531 Southeast Asian children by the Ma-Spore study group
- (2011) Shuangjie Leow et al. HEMATOLOGICAL ONCOLOGY
- Phase I Pharmacokinetic and Pharmacodynamic Study of the Multikinase Inhibitor Sorafenib in Combination With Clofarabine and Cytarabine in Pediatric Relapsed/Refractory Leukemia
- (2011) Hiroto Inaba et al. JOURNAL OF CLINICAL ONCOLOGY
- Targeted Therapy With the T-Cell–Engaging Antibody Blinatumomab of Chemotherapy-Refractory Minimal Residual Disease in B-Lineage Acute Lymphoblastic Leukemia Patients Results in High Response Rate and Prolonged Leukemia-Free Survival
- (2011) Max S. Topp et al. JOURNAL OF CLINICAL ONCOLOGY
- A phase 1 trial dose-escalation study of tipifarnib on a week-on, week-off schedule in relapsed, refractory or high-risk myeloid leukemia
- (2011) M H Kirschbaum et al. LEUKEMIA
- Clinical significance of aberrant DNA methylation in childhood acute lymphoblastic leukemia
- (2011) Seisho Takeuchi et al. LEUKEMIA RESEARCH
- Targeting Axl and Mer Kinases in Cancer
- (2011) A. Verma et al. MOLECULAR CANCER THERAPEUTICS
- Leukemic mutations in the methylation-associated genes DNMT3A and IDH2 are rare events in pediatric AML: A report from the Children's Oncology Group
- (2011) Phoenix A. Ho et al. PEDIATRIC BLOOD & CANCER
- Inhibition of Histone Deacetylases 1 and 6 Enhances Cytarabine-Induced Apoptosis in Pediatric Acute Myeloid Leukemia Cells
- (2011) Xuelian Xu et al. PLoS One
- Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition
- (2010) P. S. Bachmann et al. BLOOD
- Postrelapse survival in childhood acute lymphoblastic leukemia is independent of initial treatment intensity: a report from the Children's Oncology Group
- (2010) D. R. Freyer et al. BLOOD
- Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia
- (2010) R. C. Harvey et al. BLOOD
- Molecular response to treatment redefines all prognostic factors in children and adolescents with B-cell precursor acute lymphoblastic leukemia: results in 3184 patients of the AIEOP-BFM ALL 2000 study
- (2010) V. Conter et al. BLOOD
- Promoter hypermethylation in MLL-r infant acute lymphoblastic leukemia: biology and therapeutic targeting
- (2010) E. Schafer et al. BLOOD
- Targeting paediatric acute lymphoblastic leukaemia: novel therapies currently in development
- (2010) Alisa B. Lee-Sherick et al. BRITISH JOURNAL OF HAEMATOLOGY
- Salvage therapy with nelarabine, etoposide, and cyclophosphamide in relapsed/refractory paediatric T-cell lymphoblastic leukaemia and lymphoma
- (2010) Leah A. Commander et al. BRITISH JOURNAL OF HAEMATOLOGY
- Cytotoxicity of the anti-CD22 immunotoxin HA22 (CAT-8015) against paediatric acute lymphoblastic leukaemia
- (2010) Francis Mussai et al. BRITISH JOURNAL OF HAEMATOLOGY
- Targeting SYK kinase-dependent anti-apoptotic resistance pathway in B-lineage acute lymphoblastic leukaemia (ALL) cells with a potent SYK inhibitory pentapeptide mimic
- (2010) Fatih M. Uckun et al. BRITISH JOURNAL OF HAEMATOLOGY
- The Notch/Hes1 Pathway Sustains NF-κB Activation through CYLD Repression in T Cell Leukemia
- (2010) Lluis Espinosa et al. CANCER CELL
- Mechanisms of Synergistic Antileukemic Interactions between Valproic Acid and Cytarabine in Pediatric Acute Myeloid Leukemia
- (2010) C. Xie et al. CLINICAL CANCER RESEARCH
- Target of Rapamycin Signaling in Leukemia and Lymphoma
- (2010) C. Vu et al. CLINICAL CANCER RESEARCH
- Spleen tyrosine kinase as a molecular target for treatment of leukemias and lymphomas
- (2010) Fatih M Uckun et al. Expert Review of Anticancer Therapy
- The mammalian target of rapamycin inhibitor RAD001 (everolimus) synergizes with chemotherapeutic agents, ionizing radiation and proteasome inhibitors in pre-B acute lymphocytic leukemia
- (2010) P. Saunders et al. HAEMATOLOGICA
- The synthetic heat shock protein 90 (Hsp90) inhibitor EC141 induces degradation of Bcr-Abl p190 protein and apoptosis of Ph-positive acute lymphoblastic leukemia cells
- (2010) Wei-Gang Tong et al. INVESTIGATIONAL NEW DRUGS
- Phase I/II Study of Combination Therapy With Sorafenib, Idarubicin, and Cytarabine in Younger Patients With Acute Myeloid Leukemia
- (2010) Farhad Ravandi et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase II Window Study on Rituximab in Newly Diagnosed Pediatric Mature B-Cell Non-Hodgkin's Lymphoma and Burkitt Leukemia
- (2010) Andrea Meinhardt et al. JOURNAL OF CLINICAL ONCOLOGY
- Chemoimmunotherapy With a Modified Hyper-CVAD and Rituximab Regimen Improves Outcome in De Novo Philadelphia Chromosome–Negative Precursor B-Lineage Acute Lymphoblastic Leukemia
- (2010) Deborah A. Thomas et al. JOURNAL OF CLINICAL ONCOLOGY
- Long-Term Outcome in Children With Relapsed Acute Lymphoblastic Leukemia After Time-Point and Site-of-Relapse Stratification and Intensified Short-Course Multidrug Chemotherapy: Results of Trial ALL-REZ BFM 90
- (2010) Gesche Tallen et al. JOURNAL OF CLINICAL ONCOLOGY
- Identification of Patients With Acute Myeloblastic Leukemia Who Benefit From the Addition of Gemtuzumab Ozogamicin: Results of the MRC AML15 Trial
- (2010) Alan K. Burnett et al. JOURNAL OF CLINICAL ONCOLOGY
- Effect of mitoxantrone on outcome of children with first relapse of acute lymphoblastic leukaemia (ALL R3): an open-label randomised trial
- (2010) Catriona Parker et al. LANCET
- Complete remission after blinatumomab-induced donor T-cell activation in three pediatric patients with post-transplant relapsed acute lymphoblastic leukemia
- (2010) R Handgretinger et al. LEUKEMIA
- Histone deacetylase inhibitors induce FPGS mRNA expression and intracellular accumulation of long-chain methotrexate polyglutamates in childhood acute lymphoblastic leukemia: implications for combination therapy
- (2010) G J Leclerc et al. LEUKEMIA
- Molecular alterations of the IDH1 gene in AML: a Children's Oncology Group and Southwest Oncology Group study
- (2010) P A Ho et al. LEUKEMIA
- Consequent and intensified relapse therapy improved survival in pediatric AML: results of relapse treatment in 379 patients of three consecutive AML-BFM trials
- (2010) A Sander et al. LEUKEMIA
- Activity of the Aurora Kinase Inhibitor VX-680 against Bcr/Abl-Positive Acute Lymphoblastic Leukemias
- (2010) F. Fei et al. MOLECULAR CANCER THERAPEUTICS
- Stage 2 Combination Testing of Rapamycin with Cytotoxic Agents by the Pediatric Preclinical Testing Program
- (2010) P. J. Houghton et al. MOLECULAR CANCER THERAPEUTICS
- Safety and Efficacy of INCB018424, a JAK1 and JAK2 Inhibitor, in Myelofibrosis
- (2010) Srdan Verstovsek et al. NEW ENGLAND JOURNAL OF MEDICINE
- Outcome for children treated for relapsed or refractory acute myelogenous leukemia (rAML): A therapeutic advances in childhood leukemia (TACL) consortium study
- (2010) Matthew F. Gorman et al. PEDIATRIC BLOOD & CANCER
- Remission re-induction chemotherapy with clofarabine, topotecan, thiotepa, and vinorelbine for patients with relapsed or refractory leukemia
- (2010) Peter G. Steinherz et al. PEDIATRIC BLOOD & CANCER
- Phase I study of bortezomib combined with chemotherapy in children with relapsed childhood acute lymphoblastic leukemia (ALL): A report from the therapeutic advances in childhood leukemia (TACL) consortium
- (2010) Yoav Messinger et al. PEDIATRIC BLOOD & CANCER
- Chemokine/chemokine receptor interactions in extramedullary leukaemia of the skin in childhood AML: Differential roles for CCR2, CCR5, CXCR4 and CXCR7
- (2010) Claudia M.J.M. Faaij et al. PEDIATRIC BLOOD & CANCER
- Phase 1 trial and pharmacokinetic study of the farnesyl transferase inhibitor tipifarnib in children and adolescents with refractory leukemias: A report from the Children's Oncology Group
- (2010) Brigitte C. Widemann et al. PEDIATRIC BLOOD & CANCER
- STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress
- (2010) F. M. Uckun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Complete resolution of leukemia cutis with sorafenib in an acute myeloid leukemia patient with FLT3-ITD mutation
- (2009) Sung Ho Lee et al. AMERICAN JOURNAL OF HEMATOLOGY
- RAD001 (Everolimus) induces autophagy in acute lymphoblastic leukemia
- (2009) Roman Crazzolara et al. Autophagy
- Association of high-level MCL-1 expression with in vitro and in vivo prednisone resistance in MLL-rearranged infant acute lymphoblastic leukemia
- (2009) R. W. Stam et al. BLOOD
- AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)
- (2009) P. P. Zarrinkar et al. BLOOD
- Compassionate use of sorafenib in FLT3-ITD-positive acute myeloid leukemia: sustained regression before and after allogeneic stem cell transplantation
- (2009) S. Metzelder et al. BLOOD
- Quantitative DNA methylation predicts survival in adult acute myeloid leukemia
- (2009) L. Bullinger et al. BLOOD
- Mer receptor tyrosine kinase is a novel therapeutic target in pediatric B-cell acute lymphoblastic leukemia
- (2009) R. M. A. Linger et al. BLOOD
- Potentiating effects of RAD001 (Everolimus) on vincristine therapy in childhood acute lymphoblastic leukemia
- (2009) R. Crazzolara et al. BLOOD
- DNA methylation for subtype classification and prediction of treatment outcome in patients with childhood acute lymphoblastic leukemia
- (2009) L. Milani et al. BLOOD
- Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies
- (2009) T. E. Fandy et al. BLOOD
- Clofarabine, cyclophosphamide and etoposide as single-course re-induction therapy for children with refractory/multiple relapsed acute lymphoblastic leukaemia
- (2009) Franco Locatelli et al. BRITISH JOURNAL OF HAEMATOLOGY
- The impact of risk stratification by early bone-marrow response in childhood lymphoblastic leukaemia: results from the United Kingdom Medical Research Council trial ALL97 and ALL97/99
- (2009) Christopher Mitchell et al. BRITISH JOURNAL OF HAEMATOLOGY
- Mammalian target of rapamycin inhibitors and their potential role in therapy in leukaemia and other haematological malignancies
- (2009) David T. Teachey et al. BRITISH JOURNAL OF HAEMATOLOGY
- FBXW7andNOTCH1mutations in childhood T cell acute lymphoblastic leukaemia and T cell non-Hodgkin lymphoma
- (2009) Myoung-Ja Park et al. BRITISH JOURNAL OF HAEMATOLOGY
- Down-regulation of the Notch pathway mediated by a γ-secretase inhibitor induces anti-tumour effects in mouse models of T-cell leukaemia
- (2009) J Tammam et al. BRITISH JOURNAL OF PHARMACOLOGY
- Proteomic and Genetic Approaches Identify Syk as an AML Target
- (2009) Cynthia K. Hahn et al. CANCER CELL
- AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance
- (2009) Thomas O'Hare et al. CANCER CELL
- Bcl-2 Inhibitors: Targeting Mitochondrial Apoptotic Pathways in Cancer Therapy
- (2009) M. H. Kang et al. CLINICAL CANCER RESEARCH
- Therapeutic targeting of microenvironmental interactions in leukemia: Mechanisms and approaches
- (2009) Marina Konopleva et al. DRUG RESISTANCE UPDATES
- Aurora-A kinase: a novel target both for cellular immunotherapy and molecular target therapy against human leukemia
- (2009) Toshiki Ochi et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- The DNA methylome of pediatric acute lymphoblastic leukemia
- (2009) Josef Davidsson et al. HUMAN MOLECULAR GENETICS
- Accelerated Approval of Cancer Drugs: Improved Access to Therapeutic Breakthroughs or Early Release of Unsafe and Ineffective Drugs?
- (2009) Elizabeth A. Richey et al. JOURNAL OF CLINICAL ONCOLOGY
- Phase II Study of Clofarabine in Pediatric Patients With Refractory or Relapsed Acute Myeloid Leukemia
- (2009) Sima Jeha et al. JOURNAL OF CLINICAL ONCOLOGY
- Improved Early Event-Free Survival With Imatinib in Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia: A Children's Oncology Group Study
- (2009) Kirk R. Schultz et al. JOURNAL OF CLINICAL ONCOLOGY
- Outcome of Patients Treated for Relapsed or Refractory Acute Lymphoblastic Leukemia: A Therapeutic Advances in Childhood Leukemia Consortium Study
- (2009) Richard H. Ko et al. JOURNAL OF CLINICAL ONCOLOGY
- Multicenter, Phase II Study of Decitabine for the First-Line Treatment of Older Patients With Acute Myeloid Leukemia
- (2009) Amanda F. Cashen et al. JOURNAL OF CLINICAL ONCOLOGY
- Successful induction therapy with decitabine in refractory childhood acute lymphoblastic leukemia
- (2009) L Yánez et al. LEUKEMIA
- A multi-center phase I study of clofarabine, etoposide and cyclophosphamide in combination in pediatric patients with refractory or relapsed acute leukemia
- (2009) N Hijiya et al. LEUKEMIA
- Rearrangement of CRLF2 in B-progenitor– and Down syndrome–associated acute lymphoblastic leukemia
- (2009) Charles G Mullighan et al. NATURE GENETICS
- Deletion ofIKZF1and Prognosis in Acute Lymphoblastic Leukemia
- (2009) Charles G. Mullighan et al. NEW ENGLAND JOURNAL OF MEDICINE
- Treating Childhood Acute Lymphoblastic Leukemia without Cranial Irradiation
- (2009) Ching-Hon Pui et al. NEW ENGLAND JOURNAL OF MEDICINE
- A phase II study of Campath-1H in children with relapsed or refractory acute lymphoblastic leukemia: A Children's Oncology Group report
- (2009) Anne L. Angiolillo et al. PEDIATRIC BLOOD & CANCER
- Initial testing (stage 1) of vorinostat (SAHA) by the pediatric preclinical testing program
- (2009) Nino Keshelava et al. PEDIATRIC BLOOD & CANCER
- Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia
- (2009) A. Yoda et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- JAK mutations in high-risk childhood acute lymphoblastic leukemia
- (2009) C. G. Mullighan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Notch Signaling in Leukemia
- (2008) Jon C. Aster et al. Annual Review of Pathology-Mechanisms of Disease
- Active oral regimen for elderly adults with newly diagnosed acute myelogenous leukemia: a preclinical and phase 1 trial of the farnesyltransferase inhibitor tipifarnib (R115777, Zarnestra) combined with etoposide
- (2008) J. E. Karp et al. BLOOD
- CD20 up-regulation in pediatric B-cell precursor acute lymphoblastic leukemia during induction treatment: setting the stage for anti-CD20 directed immunotherapy
- (2008) M. N. Dworzak et al. BLOOD
- Dasatinib crosses the blood-brain barrier and is an efficient therapy for central nervous system Philadelphia chromosome-positive leukemia
- (2008) K. Porkka et al. BLOOD
- Prognostic significance of CD20 expression in adults with de novo precursor B-lineage acute lymphoblastic leukemia
- (2008) D. A. Thomas et al. BLOOD
- Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML
- (2008) Z. Zeng et al. BLOOD
- Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100
- (2008) B. Nervi et al. BLOOD
- Abundant anti-apoptotic BCL-2 is a molecular target in leukaemias with t(4;11) translocation
- (2008) Blaine W. Robinson et al. BRITISH JOURNAL OF HAEMATOLOGY
- Heat shock protein 90 inhibition is cytotoxic to primary AML cells expressing mutant FLT3 and results in altered downstream signalling
- (2008) Laila Al Shaer et al. BRITISH JOURNAL OF HAEMATOLOGY
- Prevalence and clinical correlates ofJAK2mutations in Down syndrome acute lymphoblastic leukaemia
- (2008) Amos Gaikwad et al. BRITISH JOURNAL OF HAEMATOLOGY
- Long-term outcome of initially homogenously treated and relapsed childhood acute lymphoblastic leukaemia in Austria - A population-based report of the Austrian Berlin-Frankfurt-Münster (BFM) Study Group
- (2008) Bettina Reismüller et al. BRITISH JOURNAL OF HAEMATOLOGY
- Mutation of Genes Affecting the RAS Pathway Is Common in Childhood Acute Lymphoblastic Leukemia
- (2008) M. Case et al. CANCER RESEARCH
- A Phase I Study of the Pan Bcl-2 Family Inhibitor Obatoclax Mesylate in Patients with Advanced Hematologic Malignancies
- (2008) A. D. Schimmer et al. CLINICAL CANCER RESEARCH
- Aurora Kinases as Anticancer Drug Targets
- (2008) O. Gautschi et al. CLINICAL CANCER RESEARCH
- Sprycel for Chronic Myeloid Leukemia and Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Resistant to or Intolerant of Imatinib Mesylate
- (2008) M. Brave et al. CLINICAL CANCER RESEARCH
- Proteasome Inhibitors in Cancer Therapy: Lessons from the First Decade
- (2008) R. Z. Orlowski et al. CLINICAL CANCER RESEARCH
- Nelarabine
- (2008) Mark Sanford et al. DRUGS
- In vitro validation of -secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia
- (2008) K. De Keersmaecker et al. HAEMATOLOGICA
- Safety and Efficacy of Gemtuzumab Ozogamicin in Combination With Chemotherapy for Pediatric Acute Myeloid Leukemia: A Report From The Children's Oncology Group
- (2008) Richard Aplenc et al. JOURNAL OF CLINICAL ONCOLOGY
- Reinduction Platform for Children With First Marrow Relapse of Acute Lymphoblastic Leukemia: A Children's Oncology Group Study
- (2008) Elizabeth A. Raetz et al. JOURNAL OF CLINICAL ONCOLOGY
- Mutant FLT3: A Direct Target of Sorafenib in Acute Myelogenous Leukemia
- (2008) Weiguo Zhang et al. JNCI-Journal of the National Cancer Institute
- Mechanism of Synergy of N-(4-Hydroxyphenyl)Retinamide and ABT-737 in Acute Lymphoblastic Leukemia Cell Lines: Mcl-1 Inactivation
- (2008) Min H. Kang et al. JNCI-Journal of the National Cancer Institute
- Genome-wide identification of aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia
- (2008) S-Q Kuang et al. LEUKEMIA
- Combining SDF-1/CXCR4 antagonism and chemotherapy in relapsed acute myeloid leukemia
- (2008) F A Fierro et al. LEUKEMIA
- CXCR4 antagonists: targeting the microenvironment in leukemia and other cancers
- (2008) J A Burger et al. LEUKEMIA
- Factors influencing survival after relapse from acute lymphoblastic leukemia: a Children's Oncology Group study
- (2008) K Nguyen et al. LEUKEMIA
- Sorafenib (Nexavar®) induces molecular remission and regression of extramedullary disease in a patient with FLT3-ITD+ acute myeloid leukemia
- (2008) N.N. Safaian et al. LEUKEMIA RESEARCH
- γ-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia
- (2008) Pedro J Real et al. NATURE MEDICINE
- Monoclonal Antibody Therapy for B-Cell Non-Hodgkin's Lymphoma
- (2008) Bruce D. Cheson et al. NEW ENGLAND JOURNAL OF MEDICINE
- FDA Drug Approval Summary: Nelarabine (Arranon(R)) for the Treatment of T-Cell Lymphoblastic Leukemia/Lymphoma
- (2008) M. H. Cohen et al. ONCOLOGIST
- Genomic Analysis of the Clonal Origins of Relapsed Acute Lymphoblastic Leukemia
- (2008) C. G. Mullighan et al. SCIENCE
- Trends in childhood cancer incidence in the U.S. (1992–2004)
- (2007) Amy M. Linabery et al. CANCER
- Initial testing (stage 1) of the proteasome inhibitor bortezomib by the pediatric preclinical testing program
- (2007) Peter J. Houghton et al. PEDIATRIC BLOOD & CANCER
- Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program
- (2007) Richard Lock et al. PEDIATRIC BLOOD & CANCER
- Initial testing (stage 1) of the mTOR inhibitor rapamycin by the pediatric preclinical testing program
- (2007) Peter J. Houghton et al. PEDIATRIC BLOOD & CANCER
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started