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Title
On- and Off-Target Pharmacology of Torcetrapib
Authors
Keywords
-
Journal
DRUGS
Volume 72, Issue 4, Pages 491-507
Publisher
Springer Nature
Online
2012-02-23
DOI
10.2165/11599310-000000000-00000
References
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- (2008) Frank Hermann et al. THROMBOSIS RESEARCH
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