Article
Medicine, Research & Experimental
Ji-Hun Mo, Jin Hyeok Jeong, Tae Hoon Kim, Seon-Tae Kim, Soo Whan Kim, Kun Hee Lee, Seung-No Hong, Hyo Yeol Kim, Dae Woo Kim, Dong-Young Kim, Chang-Hoon Kim, Seok Hyun Cho, Chae-Seo Rhee
Summary: The study demonstrated that the slow-release form of bepotastine salicylate (HL151) was more effective than placebo in treating patients with perennial allergic rhinitis, with no significant differences in safety. Patients' compliance was also shown to be higher with HL151 due to its convenience.
Article
Ophthalmology
Shruti Ayyappanavar, Sriya Sridhar, Kiran Kumar, C. R. Jayanthi, Suresh Babu Gangasagara, B. L. Sujatha Rathod, B. Preethi, Preeti Mittal
Summary: A comparative study of 180 patients with mild to moderate allergic conjunctivitis showed that Alcaftadine, Olopatadine, and Bepotastine ophthalmic solutions were all effective in resolving symptoms. However, Bepotastine and Alcaftadine were found to be more effective than Olopatadine in alleviating the symptoms of allergic conjunctivitis.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2021)
Review
Immunology
Francesca Mori, Mattia Giovannini, Simona Barni, Rodrigo Jimenez-Saiz, Daniel Munblit, Benedetta Biagioni, Giulia Liccioli, Lucrezia Sarti, Lucia Liotti, Silvia Ricci, Elio Novembre, Umit Sahiner, Ermanno Baldo, Davide Caimmi
Summary: The prevalence of food allergy, especially in children, has been increasing in recent years. Oral immunotherapy (OIT) has gained attention as a potential treatment for food allergy, with a focus on desensitization, however, there is still no definitive conclusion on its efficacy.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Dentistry, Oral Surgery & Medicine
E. Joury, S. Kisely, R. G. Watt, N. Ahmed, A. J. Morris, F. Fortune, K. Bhui
Summary: Poor physical health, including oral health, is a significant issue among individuals with mental disorders worldwide. The burden of oral diseases is high in this population, and it can exacerbate the personal, social, and economic impacts of mental disorders. This article summarizes the causes and relationship between mental disorders and oral diseases, reviews current evidence on interventions to reduce the burden of oral diseases, and suggests future research directions. However, effective and scalable interventions to address this issue have not yet been found. Transformative research and actions that involve biological, behavioral, and social sciences are needed to understand and tackle the complex relationship between mental disorders and oral diseases. The design and testing of complex interventions should prioritize research and be conducted in real-world settings by a transdisciplinary team. The importance of research in improving oral health and overall health in this disadvantaged group is paramount.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Agriculture, Multidisciplinary
Xiaolei Shi, Lina Zhao, Liyan Niu, Yixuan Yan, Qiushi Chen, Yongri Jin, Xuwen Li
Summary: A study investigated the role of narirutin in inducing oral tolerance by conducting in vivo and in vitro experiments, network pharmacology analysis, and molecular docking. It was found that narirutin affects B cell function, dendritic cells (DCs), and T cell response, thereby influencing oral tolerance. The molecular docking analysis suggested that weaker binding energy may be attributed to steric hindrance effects. This finding offers the potential of utilizing natural compounds to promote oral tolerance.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Rie Yanagisawa, Eiko Koike, Tin-Tin Win-Shwe, Hirohisa Takano
Summary: This study found that oral exposure to low-dose BPS may exacerbate allergic asthmatic responses by enhancing Th2-polarized responses and activating the MLN cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Health Care Sciences & Services
Jewel Kai Lin See, Xinyao Liu, Federica Canfora, Caroline Moore, Michael Mccullough, Tami Yap, Rita Paolini, Antonio Celentano
Summary: This study systematically reviewed the evidence on the therapeutic effects of vitamin supplementation for oral potentially malignant disorders (OPMDs) and oral cancer (OC). The results showed that vitamin K, vitamin C, vitamin A, vitamin B, and vitamin D all had therapeutic benefits. The research on oral cancer was extensive, with a focus on oral lichen planus and oral leukoplakia among the OPMDs. However, standardizing the study design and outcomes is needed to enhance future research.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Medicine, Research & Experimental
Antarikshya Das, Swadheena Patro, Faizan Zarreen Simnani, Dibyangshee Singh, Adrija Sinha, Khushbu Kumari, Patnala Vedika Rao, Sarita Singh, Nagendra Kumar Kaushik, Pritam Kumar Panda, Mrutyunjay Suar, Suresh K. Verma
Summary: A biofilm is a population of sessile microorganisms with organized structure and characteristics. Targeting and eliminating biofilm infections is difficult due to the self-produced matrix and antibiotic resistance. This review discusses various methods to modify biofilm ecology and prevent infections, as well as the role of biofilms in antibiotic resistance, implant contamination, dental caries, and periodontal disorders. Recent advances in nanotechnology may provide novel strategies for infection prevention and treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biotechnology & Applied Microbiology
Kai Wu, Jinrong Yan, Xiaojing Wang, Xinai Yin, Guixiang Shi, Lei Yang, Fangling Li, Junhai Huang, Lei Shao
Summary: The study successfully enhanced the activity towards bulky diaryl ketones by engineering ADH seq5 to produce the mutant seq5-D150I. By optimizing reaction conditions, high enantiomeric excess of (S)-4-chlorophenylpyridylmethanol and (R)-4-chlorobenzhydrol were successfully synthesized with significantly increased yields.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Allergy
Justine Calise, Hannah DeBerg, Nahir Garabatos, Sugandhika Khosa, Veronique Bajzik, Lorena Botero Calderon, Kelly Aldridge, Mario Rosasco, Brian C. Ferslew, Tong Zhu, Ronald Smulders, Lisa M. Wheatley, Tanya M. Laidlaw, Tielin Qin, Gurunadh R. Chichili, Daniel C. Adelman, Mary Farrington, David Robinson, David Jeong, Stacie M. Jones, Srinath Sanda, David Larson, William W. Kwok, Carolyn Baloh, Gerald T. Nepom, Erik Wambre
Summary: This study found that inherent qualities of cell response at baseline can influence the response to peanut oral immunotherapy in peanut-allergic individuals. Peanut allergy can be broadly classified into at least two subtypes based on the proportion of specific T-cell subsets, with distinct immunologic and clinical characteristics. Stratifying patients based on their peanut-specific T-cell profile may help identify which immunotypes will respond best to different therapies in clinical settings.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Immunology
Pei Han, Jian-Qing Gu, Li-Sha Li, Xue-Yan Wang, Hong-Tian Wang, Yan Wang, Christopher Chang, Jin-Lyu Sun
Summary: The incidence of allergic disorders is increasing in industrialized countries. The pathogenesis of allergic diseases is complex and involves genetic, environmental factors. The association between intestinal microbiota and allergic diseases is significant, but the precise mechanisms are still unknown.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Chemistry, Medicinal
Patricia Batista, Manuela Pintado, Patricia Oliveira-Silva
Summary: Mental disorders are increasing worldwide, leading to the development of multidisciplinary research groups that combine knowledge from different areas to promote prevention strategies. Excessive antipsychotic consumption is a public health problem, and innovative strategies are needed. Oral films, as a recent delivery system, offer advantages for mental health treatment and prevention, but regulatory guidelines are necessary to ensure their quality and safety. This review provides a critical overview of the strengths, weaknesses, opportunities, and threats associated with the implementation of oral films in the treatment of mental disorders.
Review
Neurosciences
Kolsoum Dehdar, Mohammad Reza Raoufy
Summary: Psychiatric disorders are common in patients with allergic asthma, and recent studies suggest that immune-brain communication mechanisms may contribute to the alterations in brain structure and function that lead to anxiety in these patients. This paper comprehensively reviews the research on asthma-induced brain alterations and highlights the importance of addressing neuropsychiatric disorders in asthma clinical guidelines for improved patient quality of life. Understanding the mechanisms underlying psychiatric comorbidities in asthma could lead to more effective treatments.
BRAIN RESEARCH BULLETIN
(2023)
Article
Allergy
Mathias Hornef, Oliver Pabst, Isabella Annesi-Maesano, Manja Fleddermann, Erika von Mutius, Monika Schaubeck, Alessandro Fiocchi
Summary: The early postnatal period is crucial for lifelong host-microbiome interaction, where innate and adaptive immune cells interact to induce and maintain oral tolerance. Factors in human milk play a role in supporting tolerance induction and protection against infection and allergies.
WORLD ALLERGY ORGANIZATION JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Barbara Misme-Aucouturier, Marion De Carvalho, Erwan Delage, Eleonore Dijoux, Martin Klein, Carole Brosseau, Marie Bodinier, Laurence Guzylack-Piriou, Gregory Bouchaud
Summary: The prevalence of allergic diseases is increasing worldwide, and this can be attributed to the growing chemical pollution of the environment. This study investigates the effects of Bisphenol A (BPA) on food allergies, revealing its impact on the immune system, gut microbiota, and barrier functions. The findings indicate that BPA exposure leads to increased markers of food allergy and intestinal permeability, as well as dysbiosis and decreased microbial diversity.
Correction
Pharmacology & Pharmacy
Katherine A. Lyseng-Williamson
CLINICAL DRUG INVESTIGATION
(2020)
Review
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Katherine A. Lyseng-Williamson
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Katherine A. Lyseng-Williamson
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(2020)
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Esther S. Kim, Katherine A. Lyseng-Williamson
DRUGS & THERAPY PERSPECTIVES
(2020)
Correction
Pharmacology & Pharmacy
Katherine A. Lyseng-Williamson
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Caroline Fenton, Katherine A. Lyseng-Williamson
DRUGS & THERAPY PERSPECTIVES
(2020)
Correction
Pharmacology & Pharmacy
Katherine A. Lyseng-Williamson
DRUGS & THERAPY PERSPECTIVES
(2020)
Correction
Pharmacology & Pharmacy
Katherine A. Lyseng-Williamson
DRUGS & THERAPY PERSPECTIVES
(2019)
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Hannah A. Blair, Katherine A. Lyseng-Williamson
DRUGS & THERAPY PERSPECTIVES
(2019)
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Katherine A. Lyseng-Williamson
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(2019)
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Emma H. McCafferty, Katherine A. Lyseng-Williamson
DRUGS & THERAPY PERSPECTIVES
(2019)
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Katherine A. Lyseng-Williamson
DRUGS & THERAPY PERSPECTIVES
(2019)
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Pharmacology & Pharmacy
Katherine Ann Lyseng-Williamson
DRUGS & THERAPY PERSPECTIVES
(2019)
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Katherine A. Lyseng-Williamson
DRUGS & THERAPY PERSPECTIVES
(2020)
Article
Pharmacology & Pharmacy
Esther S. Kim Bullet, Katherine A. Lyseng-Williamson
DRUGS & THERAPY PERSPECTIVES
(2020)