Marijuana,Spice'herbal high', and early neural development: implications for rescheduling and legalization

Cannabinoid Receptor 1 Signaling in Embryo Neurodevelopment

(2012) Delphine Psychoyos et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Detection and disposition of JWH-018 and JWH-073 in mice after exposure to “Magic Gold” smoke

(2012) Justin L. Poklis et al.   FORENSIC SCIENCE INTERNATIONAL

Detection and Quantification of New Designer Drugs in Human Blood: Part 1 - Synthetic Cannabinoids

(2012) J. Ammann et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

Dysfunction in Fatty Acid Amide Hydrolase Is Associated with Depressive-Like Behavior in Wistar Kyoto Rats

(2012) K. Yaragudri Vinod et al.   PLoS One

Spice drugs are more than harmless herbal blends: A review of the pharmacology and toxicology of synthetic cannabinoids

(2012) Kathryn A. Seely et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors

(2011) J. R. Savinainen et al.   Acta Physiologica

Structure characterisation of urinary metabolites of the cannabimimetic JWH-018 using chemically synthesised reference material for the support of LC-MS/MS-based drug testing

(2011) Simon Beuck et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Quantitative Measurement of JWH-018 and JWH-073 Metabolites Excreted in Human Urine

(2011) Cindy L. Moran et al.   ANALYTICAL CHEMISTRY

The design, synthesis and biological evaluation of novel URB602 analogues as potential monoacylglycerol lipase inhibitors

(2011) Monika Szabo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Fatty acid amide hydrolase inhibitors. 3: Tetra-substituted azetidine ureas with in vivo activity

(2011) Stephen D. Roughley et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of a Novel Cannabimimetic Phenylacetylindole, Cannabipiperidiethanone, as a Designer Drug in a Herbal Product and Its Affinity for Cannabinoid CB1 and CB2 Receptors

(2011) Nahoko Uchiyama et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Commentary: Functional Neuronal CB2 Cannabinoid Receptors in the CNS

(2011) E. S. Onaivi   Current Neuropharmacology

Intrauterine cannabis exposure leads to more aggressive behavior and attention problems in 18-month-old girls

(2011) Hanan El Marroun et al.   DRUG AND ALCOHOL DEPENDENCE

CP47,497-C8 and JWH073, commonly found in ‘Spice’ herbal blends, are potent and efficacious CB1 cannabinoid receptor agonists

(2011) Brady K. Atwood et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Development and Validation of a Liquid Chromatography-Tandem Mass Spectrometry Method for the Identification and Quantification of JWH-018, JWH-073, JWH-019, and JWH-250 in Human Whole Blood

(2011) S. L. Kacinko et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

Synthetic Cannabinoids in Oral Fluid

(2011) C. Coulter et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

Dual Inhibition of α/β-Hydrolase Domain 6 and Fatty Acid Amide Hydrolase Increases Endocannabinoid Levels in Neurons

(2011) William R. Marrs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure–Activity Relationship of a New Series of Reversible Dual Monoacylglycerol Lipase/Fatty Acid Amide Hydrolase Inhibitors

(2011) José A. Cisneros et al.   JOURNAL OF MEDICINAL CHEMISTRY

Activation of Orexin 1 Receptors in the Periaqueductal Gray of Male Rats Leads to Antinociception via Retrograde Endocannabinoid (2-Arachidonoylglycerol)-Induced Disinhibition

(2011) Y.-C. Ho et al.   JOURNAL OF NEUROSCIENCE

Survey of current trends in the abuse of psychotropic substances and plants in Japan

(2011) Ruri Kikura-Hanajiri et al.   Legal Medicine

Marijuana-based Drugs: Innovative Therapeutics or Designer Drugs of Abuse?

(2011) K. A. Seely et al.   MOLECULAR INTERVENTIONS

Cannabinoid receptor activation modifies NMDA receptor mediated release of intracellular calcium: Implications for endocannabinoid control of hippocampal neural plasticity

(2011) Robert E. Hampson et al.   NEUROPHARMACOLOGY

Enhancement of the behavioral effects of endogenous and exogenous cannabinoid agonists by phenylmethyl sulfonyl fluoride

(2011) R.E. Vann et al.   NEUROPHARMACOLOGY

Cytotoxicity of synthetic cannabinoids found in “Spice” products: The role of cannabinoid receptors and the caspase cascade in the NG 108-15 cell line

(2011) Kenichi Tomiyama et al.   TOXICOLOGY LETTERS

Beyond THC: The New Generation of Cannabinoid Designer Drugs

(2011) Liana Fattore et al.   Frontiers in Behavioral Neuroscience

JWH018, a common constituent of ‘Spice’ herbal blends, is a potent and efficacious cannabinoid CB1receptor agonist

(2010) Brady K Atwood et al.   BRITISH JOURNAL OF PHARMACOLOGY

Enol Carbamates as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) Endowed with High Selectivity for FAAH over the Other Targets of the Endocannabinoid System

(2010) Sonia Gattinoni et al.   ChemMedChem

Screening for the synthetic cannabinoid JWH-018 and its major metabolites in human doping controls

(2010) Ines Möller et al.   Drug Testing and Analysis

Requirement of cannabinoid CB1 receptors in cortical pyramidal neurons for appropriate development of corticothalamic and thalamocortical projections

(2010) Chia-Shan Wu et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Chemical analysis of synthetic cannabinoids as designer drugs in herbal products

(2010) Nahoko Uchiyama et al.   FORENSIC SCIENCE INTERNATIONAL

CB1Cannabinoid Receptors Increase Neuronal Precursor Proliferation through AKT/Glycogen Synthase Kinase-3β/β-Catenin Signaling

(2010) Stefania Trazzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sensitive and rapid quantification of the cannabinoid receptor agonist naphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-018) in human serum by liquid chromatography–tandem mass spectrometry

(2010) Jörg Teske et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Potency Trends of Δ9-THC and Other Cannabinoids in Confiscated Cannabis Preparations from 1993 to 2008*

(2010) Zlatko Mehmedic et al.   JOURNAL OF FORENSIC SCIENCES

Differential Subcellular Recruitment of Monoacylglycerol Lipase Generates Spatial Specificity of 2-Arachidonoyl Glycerol Signaling during Axonal Pathfinding

(2010) E. Keimpema et al.   JOURNAL OF NEUROSCIENCE

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

(2010) William R Marrs et al.   NATURE NEUROSCIENCE

Δ9-tetrahydrocannabinol is a full agonist at CB1 receptors on GABA neuron axon terminals in the hippocampus

(2010) Nora Laaris et al.   NEUROPHARMACOLOGY

Developmental consequences of perinatal cannabis exposure: behavioral and neuroendocrine effects in adult rodents

(2010) Patrizia Campolongo et al.   PSYCHOPHARMACOLOGY

Origin, Early Commitment, Migratory Routes, and Destination of Cannabinoid Type 1 Receptor-Containing Interneurons

(2009) Yury M. Morozov et al.   CEREBRAL CORTEX

The Polarised Life of the Endocannabinoid System in CNS Development

(2009) Sharon Anavi-Goffer et al.   CHEMBIOCHEM

Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain

(2009) Kay Ahn et al.   CHEMISTRY & BIOLOGY

The endocannabinoid system and the regulation of neural development: potential implications in psychiatric disorders

(2009) Ismael Galve-Roperh et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

The synthesis and biological evaluation of para-substituted phenolic N-alkyl carbamates as endocannabinoid hydrolyzing enzyme inhibitors

(2009) Anna Minkkilä et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Spice: A never ending story?

(2009) Rainer Lindigkeit et al.   FORENSIC SCIENCE INTERNATIONAL

‘Spice’ and other herbal blends: harmless incense or cannabinoid designer drugs?

(2009) Volker Auwärter et al.   JOURNAL OF MASS SPECTROMETRY

Blockade of 2-Arachidonoylglycerol Hydrolysis by Selective Monoacylglycerol Lipase Inhibitor 4-Nitrophenyl 4-(Dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances Retrograde Endocannabinoid Signaling

(2009) B. Pan et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Prenatal Marijuana Exposure and Intelligence Test Performance at Age 6

(2009) LIDUSH GOLDSCHMIDT et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

A pilot study using nabilone for symptomatic treatment in Huntington's disease

(2009) Adrienne Curtis et al.   MOVEMENT DISORDERS

Identification of distinct telencephalic progenitor pools for neuronal diversity in the amygdala

(2009) Tsutomu Hirata et al.   NATURE NEUROSCIENCE

Endocannabinoid-Mediated Control of Synaptic Transmission

(2009) Masanobu Kano et al.   PHYSIOLOGICAL REVIEWS

Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyond

(2008) Roger G. Pertwee   ADDICTION BIOLOGY

Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase

(2008) John M. Keith et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A cannabinoid analogue of Δ9-tetrahydrocannabinol disrupts neural development in chick

(2008) Delphine Psychoyos et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Maternal Periconceptional Illicit Drug Use and the Risk of Congenital Malformations

(2008) Marleen M. H. J. van Gelder et al.   EPIDEMIOLOGY

The type 1 cannabinoid receptor is highly expressed in embryonic cortical projection neurons and negatively regulates neurite growthin vitro

(2008) Tania Vitalis et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Ian: A 7-Year Old With Prenatal Drug Exposure and Early Exposure to Family Violence

(2008) Martin T. Stein et al.   JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS

Regulation of neural progenitor cell development in the nervous system

(2008) Joshua G. Corbin et al.   JOURNAL OF NEUROCHEMISTRY

Cannabinoids Inhibit Network-Driven Synapse Loss between Hippocampal Neurons in Culture

(2008) H. J. Kim et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

N-Arachidonyl Maleimide Potentiates the Pharmacological and Biochemical Effects of the Endocannabinoid 2-Arachidonylglycerol through Inhibition of Monoacylglycerol Lipase

(2008) J. J. Burston et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Diffusion abnormalities in adolescents and young adults with a history of heavy cannabis use

(2008) Manzar Ashtari et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Endocannabinoid functions controlling neuronal specification during brain development

(2008) Tibor Harkany et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Signaling via CNS cannabinoid receptors

(2008) Ken Mackie   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A novel role for the endocannabinoid system during zebrafish development

(2008) B. Migliarini et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The endocannabinoid receptor, CB1, is required for normal axonal growth and fasciculation

(2008) Sheona Watson et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

(2008) Jonathan Z Long et al.   Nature Chemical Biology

Structure-guided inhibitor design for human FAAH by interspecies active site conversion

(2008) M. Mileni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning

(2008) J. Mulder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of perinatal exposure to delta-9-tetrahydrocannabinol on the emotional reactivity of the offspring: a longitudinal behavioral study in Wistar rats

(2008) Viviana Trezza et al.   PSYCHOPHARMACOLOGY

Rapid CB1 cannabinoid receptor desensitization defines the time course of ERK1/2 MAP kinase signaling

(2007) Tanya L. Daigle et al.   NEUROPHARMACOLOGY

Multiple pathways involved in the biosynthesis of anandamide

(2007) Jie Liu et al.   NEUROPHARMACOLOGY