Article
Biochemistry & Molecular Biology
Jelena Nikolic, Katarina Vukojevic, Violeta Soljic, Josip Miskovic, Martina Orlovic Vlaho, Mirna Saraga-Babic, Natalija Filipovic
Summary: We studied the expression of serotonin receptors 5-HT1A, 5-HT2A, and 5-HT3A at different stages of fetal lung development. The receptors were strongly expressed in the epithelium of the proximal airways and vascular walls during early and mid-fetal development. In the later stages, they were also expressed in type I and type II pneumocytes. The expression of 5-HT2A decreased while 5-HT3A expression increased toward the final stage of lung development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Social Sciences, Interdisciplinary
Surabhi Gupta, William S. Harvey
Summary: This article discusses the challenges faced by researchers in conducting elite interviews and offers theoretical and practical insights. It focuses on interviewing legal experts and provides suggestions for researchers at different stages of their field research. The article also highlights that uncomfortable conversations can be an indication of a high-quality elite interview.
INTERNATIONAL JOURNAL OF QUALITATIVE METHODS
(2022)
Review
Biochemistry & Molecular Biology
Joachim Neumann, Britt Hofmann, Stefan Dhein, Ulrich Gergs
Summary: Serotonin controls human cardiac contractile function solely through 5-HT4-receptors, leading to positive inotropic and chronotropic effects, as well as arrhythmias. This review focuses on the potential effects of 5-HT4-receptors in sepsis, ischemia, and reperfusion. The formation and inactivation of serotonin in the heart, as well as its role in cardiovascular diseases, are discussed. Mechanisms of cardiac signal transduction through 5-HT4-receptors and potential roles in cardiac diseases are addressed, along with future research directions and potential animal models. The potential clinical utility of 5-HT4-receptor agonists or antagonists is also discussed, considering the extensive studies on serotonin over the years.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Motohiro Okada, Ryusuke Matsumoto, Yoshimasa Yamamoto, Kouji Fukuyama
Summary: This study investigated the effects of lurasidone, vortioxetine, and escitalopram on 5-HT7R function and found that chronic administration of these drugs leads to downregulation of 5-HT7R in the thalamus. Furthermore, it was observed that vortioxetine and lurasidone induce more rapid downregulation of 5-HT7R through direct inhibition, while escitalopram's downregulation is slower due to its indirect elevation of extracellular serotonin levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Di Ye, Huanji Xu, Qiulin Tang, Hongwei Xia, Chenliang Zhang, Feng Bi
Summary: The metabolism of serotonin is closely linked to tumorigenesis and tumor progression, with studies showing its role in regulating various biological processes of tumors. Reprogramming of 5-HT metabolism in different types of tumors has paved the way for new approaches in developing cancer therapies targeting this pathway. Information on the role of 5-HT metabolism in cancer is limited, but recent advances have shed light on potential targeted therapies.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Medicine, Research & Experimental
Elias B. Nascimento Jr., R. L. Romero, Marcela M. G. B. Dutra, Bernd L. Fiebich, Igor D. G. Duarte, Marcio M. Coelho
Summary: The activation of 5-HT1D and 5-HT7 receptors plays a role in mechanical allodynia induced by 5-HT in mice, while peripheral 5-HT3 receptors have an inhibitory role in the nociceptive response induced by 5-HT or carrageenan.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Multidisciplinary
Johannes Morstein, Giovanna Romano, Belinda E. Hetzler, Ambrose Plante, Caleb Haake, Joshua Levitz, Dirk Trauner
Summary: This study develops tools for optical control of serotonin receptors, providing a new method for studying receptor function. By constructing a repeatable and reversible optical control system, this study lays the foundation for extending photopharmacology to the serotonin receptor family.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Biochemistry & Molecular Biology
Nina K. Popova, Anton S. Tsybko, Vladimir S. Naumenko
Summary: This article reviews the neurobiological links between aggression, depression, and suicidal behavior, focusing on the involvement of different types of 5-HT receptors. It provides evidence that specific 5-HT receptors are associated with depression-related and aggression-related behaviors, and highlights the potential of targeting these receptors for treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ning Liu, Shiqiang Sun, Pengjie Wang, Yanan Sun, Qingjuan Hu, Xiaoyu Wang
Summary: Serotonin, also known as 5-hydroxytryptamine (5-HT), is a crucial neurotransmitter synthesized and secreted by enterochromaffin (EC) cells in the gastrointestinal tract. Gut microbiota, nutrients, and hormones play key roles in regulating 5-HT secretion. Understanding the regulatory mechanisms of 5-HT in the immune system can potentially provide therapeutic strategies for treating intestinal diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Natalia Kreshchenko, Nadezhda Terenina, Artem Ermakov
Summary: This study investigates the localization of serotonin and 5-HT7 type serotonin receptors in larvae of parasitic flatworms using immunocytochemical methods and confocal laser scanning microscopy. The results indicate the presence of 5-HT7 immunoreactivity in specific structures of the worms, suggesting its importance in the motor control system of flatworms.
Article
Chemistry, Medicinal
Dilip K. Tosh, Maggie M. Calkins, Marko S. Ivancich, Hailey A. Bock, Ryan G. Campbell, Sarah A. Lewicki, Eric Chen, Zhan-Guo Gao, John D. Mccorvy, Kenneth A. Jacobson
Summary: Derivatives of (N)-Methanocarba adenosine were modified to target 5-HT2B serotonin receptors as antagonists, showing affinity enhancement with the bicyclic ring system. Compound 43 (MRS7925) exhibited potential for anti-fibrotic therapy due to its affinity and moderate 5-HT2BR binding selectivity. The compounds also demonstrated dual action as 5-HT2B antagonists and A(1)AR agonists.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Sean M. Collins, Christopher J. O'Connell, Evan L. Reeder, Sophia V. Norman, Kainat Lungani, Poornima Gopalan, Gary A. Gudelsky, Matthew J. Robson
Summary: Various forms of TBI are a leading cause of disability in the US, with the generation of neuropsychiatric complications such as depression and anxiety. This study found that mild TBI can lead to selective alterations in cortical 5-HT2A receptor signaling, which may be targeted for the development of pharmacotherapies to alleviate TBI-induced neuropsychiatric disorders.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Rafael Pazinatto de Aguiar, Adrian Newman-Tancredi, Jos Prickaerts, Rubia Maria Weffort de Oliveira
Summary: This review focuses on the roles and mechanisms of 5-HT1A receptors in neuroprotection in experimental models of cerebral ischemia, with experimental evidence suggesting that 5-HT1A receptor agonists can prevent neuronal damage and promote functional recovery induced by ischemia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Natalie Hesselgrave, Timothy A. Troppoli, Andreas B. Wulff, Anthony B. Cole, Scott M. Thompson
Summary: Psilocybin has shown promising rapid and persistent antidepressant effects in mice, possibly through enhancing excitatory synapses in the hippocampus, independent of 5-HT2A receptor activation. Further research is needed to explore the potential combination of psychedelic compounds and 5-HT2AR antagonists for clinical utility in human depression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Pharmacology & Pharmacy
Daniela-Madalina Ciuca Anghel, Ana-Maria Vlasceanu, Gheorghe Tudor, Anne-Marie Ciobanu, Miriana Stan, Gabriela Viorela Nitescu, Dimitra Florou, Aristidis M. Tsatsakis, Daniela Luiza Baconi
Summary: The aim of our study was to evaluate the differences among different groups of drug users, focusing on hematological, biochemical, urinary, and cardiological aspects. A retrospective study was conducted on 2572 hospitalized patients in Bucharest, Romania from 2015 to 2021. The study group was characterized based on demographic data, personal history/co-morbidities, consumption history, and substitution treatment. The analysis of medical records revealed correlations between GGT levels and alcohol intake as well as contagious diseases, a decrease in MCH and MCHC levels across the entire study group, and correlations between specific cardiological events and certain substance groups. The study provides important information on different types of drug users and supports future research on the chemical structures of consumed compounds.