Journal
DRUG TESTING AND ANALYSIS
Volume 3, Issue 2, Pages 132-137Publisher
WILEY
DOI: 10.1002/dta.207
Keywords
molecularly imprinted polymers; potentiometric sensor; 2-aminopyridine; piroxicam
Funding
- Iran National Science Foundation (INSF)
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A molecularly imprinted polymer-based potentiometric sensor was fabricated for determination of 2-aminopyridine (2-AP). The electroactive component is the 2-APH(+). To form this specie the determination is carried out in a bufferic solution at pH 4.5 in which 2-AP is prevalently monoprotonated. Under these conditions, the membrane potential, increases with 2-AP concentration over a wide range of concentration (5 mu to 100 mM) with a near Nernstian response of 54.1 mV/decade and detection limit of 2.0 mu M. The response time is less than 5 s and the sensor can be used for more than 3 months without any significant divergence in response. The selectivity coefficients of the proposed sensor were evaluated and exhibited good selectivity to 2-AP with respect to the electrode based on a non-imprinted polymer. The utility of the sensor was successfully tested by examining of 2-AP in piroxicam (PX) as a potential impurity. Copyright (c) 2010 John Wiley & Sons, Ltd.
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