Article
Immunology
Amita Gupta, Michael D. Hughes, Jorge Leon Cruz, Anchalee Avihingsanon, Noluthando Mwelase, Patrice Severe, Ayotunde Omoz-Oarhe, Gaerolwe Masheto, Laura Moran, Constance A. Benson, Richard E. Chaisson, Susan Swindells
Summary: This study found that first-trimester exposure to isoniazid preventive therapy (IPT) was associated with a nearly two-fold increased risk of fetal demise, mostly spontaneous abortion. However, this association was attenuated when adjusted for factors related to the pregnancy outcome.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Endocrinology & Metabolism
Xinxin Chen, Qingyao Wang, Huanhuan Zang, Xiangguo Cong, Qiong Shen, Lei Chen
Summary: This study aimed to observe adverse neonatal outcomes in euthyroid pregnant women with positive thyroid peroxidase antibodies (TPOAb) and investigate the underlying risk factors. Results showed that approximately one in four euthyroid women with positive TPOAb had adverse neonatal outcomes. Measurement of soluble CD40 ligand (sCD40L) in the first trimester may have predictive value for adverse neonatal outcomes in these women.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Toxicology
Andrea Missanelli, Niccolo Lombardi, Alessandra Bettiol, Cecilia Lanzi, Francesco Rossi, Ilaria Pacileo, Lucia Donvito, Valentina Garofalo, Claudia Ravaldi, Alfredo Vannacci, Guido Mannaioni, Alessandra Pistelli
Summary: The study confirms that exposure to radio-diagnostic procedures in the first trimester of pregnancy at doses below 100 mSv does not increase the risk of embryo-fetal toxicity. Folic acid plays a protective role in preventing adverse pregnancy outcomes. Further research is needed to explore the relationship between maternal thyroid irradiation and small for gestational age infants.
CLINICAL TOXICOLOGY
(2022)
Article
Immunology
Sequoia Leuba, Daniel Westreich, Carl L. Bose, Kimberly A. Powers, Andy Olshan, Steve M. Taylor, Antoinette Tshefu, Adrien Lokangaka, Waldemar A. Carlo, Elwyn Chomba, Edward A. Liechty, Sherri L. Bucher, Fabian Esamai, Saleem Jessani, Sarah Saleem, Robert L. Goldenberg, Janet Moore, Tracy Nolen, Jennifer Hemingway-Foday, Elizabeth M. McClure, Marion Koso-Thomas, Richard J. Derman, Matthew Hoffman, Melissa Bauserman
Summary: The prevalence of first-trimester malaria varies by study site in sub-Saharan Africa, and no consistent predictors have been identified, suggesting that routine parasite screening in early pregnancy may be needed to mitigate first-trimester malaria.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Obstetrics & Gynecology
Monica Minopoli, Laure Noel, Anna Meroni, Margaret Mascherpa, Alex Frick, Basky Thilaganathan
Summary: The objective of this study is to evaluate the positive predictive value (PPV) of first-trimester combined PE screening for various placenta-mediated adverse pregnancy outcomes. The findings suggest that women at high risk for preterm PE are also at increased risk for other adverse outcomes such as PTB, SGA birth, and stillbirth. Therefore, it is recommended to implement higher surveillance and interventions to mitigate these risks.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Medicine, General & Internal
Taner Gunay, Oguz Devrim Yardimci
Summary: Subchorionic hematoma (SCH) in pregnancy is associated with adverse pregnancy outcomes, especially large SCH is associated with increased risk of first trimester vaginal bleeding, early pregnancy loss, intrauterine growth restriction, placental abruption or preterm delivery.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Mette Sogaard, Flemming Skjoth, Peter Bronnum Nielsen, Jan Beyer-Westendorf, Torben Bjerregaard Larsen
Summary: According to a Danish study, fetal risk was lowest in pregnant women who were unexposed to any medications or exposed to low-molecular-weight heparin (LMWH). Compared to unexposed women, those exposed to vitamin K antagonists (VKA) had an increased risk of preterm and very preterm births, as well as lower mean gestational age and birthweight.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Obstetrics & Gynecology
Brenna L. Hughes, Grecio J. Sandoval, Torri D. Metz, Rebecca G. Clifton, William A. Grobman, George R. Saade, Tracy A. Manuck, Monica Longo, Amber Sowles, Kelly Clark, Hyagriv N. Simhan, Dwight J. Rouse, Hector Mendez-Figueroa, Cynthia Gyamfi-Bannerman, Jennifer Bailit, Maged M. Costantine, Harish M. Sehdev, Alan T. N. Tita, George A. Macones
Summary: This study aimed to evaluate whether the risk of SARS-CoV-2 infection during pregnancy persists after an acute maternal illness. The results showed that SARS-CoV-2 infection before 28 weeks of gestation was associated with an increased risk of fetal or neonatal death, preterm birth, and hypertensive disorders of pregnancy. However, there was no significant association between SARS-CoV-2 infection during pregnancy and low birth weight or major congenital malformations.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Ping Li, Jinhui Cui, Ling Li, Xinjuan Chen, Liping Ouyang, Jianhui Fan, Shuo Lin
Summary: This study aimed to evaluate the association between isolated maternal hypothyroxinemia (IMH) during the first trimester and adverse pregnancy outcomes in southern Chinese women. The study found that the IMH group had a higher prevalence of prepregnancy obesity and a higher incidence of large for gestational age (LGA). However, after adjusting for confounding factors, only LGA was shown to be associated with increased risk in IMH women.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Biology
Francisco Brenes-Martin, Victoria Melero-Jimenez, Miguel Angel Lopez-Guerrero, Maria Mercedes Calero-Ruiz, Luis Vazquez-Fonseca, Jessica Abalos-Martinez, Rocio Quintero-Prado, Rafael Torrejon, Francisco Visiedo, Fernando Bugatto
Summary: Maternal adipose tissue growth during pregnancy can increase metabolic risk and gestational problems. The distribution of fat, particularly visceral fat, is more closely linked to cardiovascular disease and metabolic syndrome. This study aims to examine the association between maternal visceral fat thickness, as determined by first-trimester ultrasound, and poor pregnancy outcomes. The findings suggest that greater levels of maternal visceral fat are associated with increased risk of complications, especially gestational diabetes.
Article
Reproductive Biology
Aminkeng Zawuo Leke, Helen Dolk, Maria Loane, Karen Casson, Vera Nelen, Ingeborg Barisic, Ester Garne, Anke Rissman, Mary O'Mahony, Amanda J. Neville, Anna Pierini, Jorieke E. H. Bergman, Kari Klungsoyr, Anna Materna-Kiryluk, Anna Latos Bielenska, Clara Cavero Carbonell, Marie-Claude Addor, David Tucker
Summary: This study found that the first trimester use of macrolide antibiotics and lincosamides did not significantly increase the risk of congenital heart defects (CHD), but was significantly associated with an increased risk of atrioventricular septal defect. Further research is needed to investigate the specific congenital anomalies (CA) associated with the use of these antibiotics in the first trimester, especially relevant for the potential use of azithromycin in the treatment of COVID-19.
REPRODUCTIVE TOXICOLOGY
(2021)
Article
Infectious Diseases
Yan Ma, Zhenli Shan, Yicun Gu, Yiying Huang
Summary: This study aimed to investigate the safety and immunogenicity of the inactivated COVID-19 vaccines in early pregnant women. The study found that vaccination did not increase the risk of adverse maternal-fetal outcomes and effectively produced neutralizing antibodies against SARS-CoV-2.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Nutrition & Dietetics
Anne-Sophie Resseguier, Candy Guiguet-Auclair, Anne Debost-Legrand, Anne-Francoise Serre-Sapin, Laurent Gerbaud, Francoise Vendittelli, Marc Ruivard
Summary: This study aimed to estimate the prevalence of anemia in the third trimester of pregnancy and identify predictive parameters for anemia in the first trimester. The results showed that clinical, social, and biochemical parameters were not effective in predicting anemia in the third trimester. It was suggested to perform a simple blood count in the first trimester and offer oral iron supplementation for women with Hb < 120 g/L.
Article
Obstetrics & Gynecology
N. la Cour Freiesleben, P. Egerup, K. V. R. Hviid, E. R. Severinsen, A. M. Kolte, D. Westergaard, L. Fich Olsen, L. Praetorius, A. Zedeler, A-M H. Christiansen, J. R. Nielsen, D. Bang, S. Berntsen, J. Olle-Lopez, A. Ingham, J. Bello-Rodriguez, D. M. Storm, J. Ethelberg-Findsen, E. R. Hoffmann, C. Wilken-Jensen, F. S. Jorgensen, H. Westh, H. L. Jorgensen, H. S. Nielsen
Summary: The study found that maternal infection with SARS-CoV-2 in the first trimester did not significantly affect nuchal translucency thickness or increase the risk of pregnancy loss. These results suggest that the virus may not pose a significant threat to pregnant women and their fetuses in the early stages of pregnancy.
HUMAN REPRODUCTION
(2021)
Review
Obstetrics & Gynecology
Makenzie Perdue, Laura Felder, Vincenzo Berghella
Summary: This study presents a case of first-trimester uterine rupture and conducts a systematic review to identify common presentations, risk factors, and management strategies. The results show that uterine rupture is uncommon but should be considered in patients with an acute abdomen in early pregnancy.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
