Article
Chemistry, Analytical
Xing Huang, Meng Chen, Zhan Huang, Yanfei Zhang, Taorong Shen, Yakun Shi, Yanli Tong, Xiaoyong Zou, Si-Yang Liu, Jianhe Guo, Zong Dai
Summary: In this study, a novel DNA nanodevice was proposed for dual-biomarker sensing, enabling highly specific imaging of cancer cells. By performing transmembrane logic operations from the cell membrane to the cytoplasm, the nanodevice achieved reliable analysis of intracellular biomarkers such as nucleolin protein and microRNAs.
ANALYTICAL CHEMISTRY
(2023)
Review
Oncology
Onyisi Christiana Didamson, Rahul Chandran, Heidi Abrahamse
Summary: Cancer stem cells (CSCs) play a crucial role in tumor development and therapy. This review summarizes the application of gold nanoparticle bioconjugates in enhancing photodynamic therapy (PDT) and discusses the challenges in clinical settings.
Review
Chemistry, Multidisciplinary
Amaal Abdulraqeb Ali, Waad H. Abuwatfa, Mohammad H. Al-Sayah, Ghaleb A. Husseini
Summary: Researchers believe that gold nanoparticle (GNP) hybrid nanostructures are promising multimodal candidates for cancer therapy, as they can achieve chemotherapy, photothermal therapy, radiotherapy, and imaging using a single composite. However, there is currently a lack of reviews summarizing the use of GNP nanohybrids for cancer treatment. Therefore, this review provides a critical analysis of GNP nanohybrid use in cancer therapy, with a focus on synergistic approaches.
Article
Pharmacology & Pharmacy
Beatriz Giesen, Ann-Christin Nickel, Jun Barthel, Ulf Dietrich Kahlert, Christoph Janiak
Summary: Gold nanoparticles were used as delivery systems to enhance the effectiveness of the glutaminase1 inhibitor CB839 for tumor treatments. Despite the chemical inertness of CB839, Au NPs proved to be efficient carriers with a drug loading efficiency of up to 12%. The combination of CB839 with Au nanotechnology increased the efficacy of the drug in GSCs, showing potential for improved bioavailability in target sites.
Review
Biochemistry & Molecular Biology
Joao Franco Machado, Joao D. G. Correia, Tania S. Morais
Summary: This review surveys the main research efforts in the design and biological evaluation of target-specific ruthenium and gold complexes, with a focus on metal molecules targeting various membrane proteins and discussing the potential of some complexes in recognizing specific biological targets.
Article
Engineering, Biomedical
Biao Liu, Jiahao Liu, Xing Hu, Wei Xiang, Weibin Hou, Chao Li, Jinrong Wang, Kun Yao, Jin Tang, Zhi Long, Long Wang, Jianye Liu
Summary: Cancer stem cells (CSCs) have been a major challenge due to their resistance to chemotherapy and tumor relapse. Aptamers, as chemical anti-bodies, have emerged as a promising tool to target CSCs. They possess advantages such as lower immunogenicity and smaller size, making them superior to conventional antibodies. This review focuses on recent advances in aptamer-drug conjugates against CSCs and discusses the advantages and limitations of different aptamer-based targeted therapies.
MATERIALS TODAY BIO
(2023)
Article
Oncology
Sibi Raj, Sartaj Khurana, Ramesh Choudhari, Kavindra Kumar Kesari, Mohammad Amjad Kamal, Neha Garg, Janne Ruokolainen, Bhudev C. Das, Dhruv Kumar
Summary: Nanotechnology offers a promising approach for cancer diagnosis and treatment, providing specific and efficient drug delivery to target tissues while minimizing side effects. Various types of nanocarriers are being studied for potential use in cancer therapy.
SEMINARS IN CANCER BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Mahdi Ahmadi, Monireh Mahmoodi, Maryam Shoaran, Fereshteh Nazari-Khanamiri, Jafar Rezaie
Summary: New therapeutic approaches are urgently needed for combating metastatic cancers, which cause over 8 million deaths per year worldwide. Mesenchymal stem cells (MSCs) have shown potential as a novel treatment option for cancer, with their exosomes playing a crucial role in regulating tumor progression. However, there is still controversy surrounding the exact association between MSC-derived exosomes and tumors. Nevertheless, the use of MSC-derived exosomes as drug delivery systems and standalone therapeutics is actively being explored, and engineering these exosomes to target tumor cells shows promise in improving the efficacy of antitumor therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biophysics
David Limon, Silvia Vila, Anahi Herrera-Olivas, Rodrigo Vera, Josefa Badia, Laura Baldoma, Marta Planas, Lidia Feliu, Lluisa Perez-Garcia
Summary: Conjugation of cytostatic drugs to nanomaterials aims to improve their bioavailability and selectivity. Water-soluble gold nanoparticles were synthesized as transporters for synthetic cyclic peptides, showing stability and higher toxicity towards cancer cells with improved uptake.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Pharmacology & Pharmacy
Amir Hossein Meisami, Milad Abbasi, Sareh Mosleh-Shirazi, Arezo Azari, Ali Mohammad Amani, Ahmad Vaez, Ali Golchin
Summary: Cancer is a dangerous and life-threatening disease, and micro/nanomotors play an important role in cancer treatment. This paper introduces the progress of micro/nanomotors in cancer detection and treatment, including targeted drug delivery and imaging-guided therapy, as well as discussing the challenges encountered in the medical process. Furthermore, this paper explores the potential growth of micro/nanomotors in medical applications and future research directions.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Huiqun Huang, Ronghui Liu, Jie Yang, Jing Dai, Shuhao Fan, Jiang Pi, Yubo Wei, Xinrong Guo
Summary: Cancer immunotherapy is a novel approach to enhance the immune system's ability to detect and eliminate cancer cells. Gold nanoparticles (AuNPs) have been explored as drug carriers in immunotherapy due to their stability, surface versatility, and optical properties. This review summarizes the synthesis routes and utilization of AuNPs as drug carriers, focusing on drug loading, targeting strategies, and drug release mechanisms in AuNP-based immunotherapy. The application and therapeutic efficacy of AuNPs in combination with cancer immunotherapy are also briefly discussed.
Article
Chemistry, Multidisciplinary
Merle Scherf, Florian Scheffler, Christopher Maffeo, Ulrich Kemper, Jingjing Ye, Aleksei Aksimentiev, Ralf Seidel, Uta Reibetanz
Summary: The development of DNA origami technique has inspired the use of three-dimensional DNA cages for targeted drug delivery. This study presents a method using DNA origami nanotubes for efficient loading and retention of cargo molecules within the DNA cages.
Article
Pharmacology & Pharmacy
Eduardo Garcia-Garrido, Marco Cordani, Alvaro Somoza
Summary: This study developed a gold nanoparticle modification technique for efficient delivery of Gapmer targeting mutant p53 proteins. These nanoparticles can effectively reduce mutant p53 protein levels, alter related molecular markers, and show promising results in overcoming chemoresistance to gemcitabine in pancreatic cancer treatment.
Article
Pharmacology & Pharmacy
Lidia Cunha, Silvia Castro Coelho, Maria do Carmo Pereira, Manuel A. N. Coelho
Summary: Gold nanoparticles were used to enhance the antioxidant efficacy of Epigallocatechin-3-gallate (EGCG) in cancer treatment. The conjugation of EGCG with gold nanoparticles showed better inhibition of cell growth and enhanced apoptosis in pancreatic cancer cells.
Review
Instruments & Instrumentation
Jin Cao, Shubhmita Bhatnagar, Jiawei Wang, Xueyong Qi, Swayam Prabha, Jayanth Panyam
Summary: Cancer stem cells (CSCs) are a small portion of cancer cells with high tumorigenic activity and multilineage differentiation potential. Targeting CSCs is believed to be crucial in improving the efficacy of cancer therapies, as standard treatments are ineffective against CSCs.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)