Nuclear receptors and endobiotics glucuronidation: the good, the bad, and the UGT

Human UDP-glucuronosyltransferases: Feedback loops between substrates and ligands of their transcription factors

(2012) Karl Walter Bock   BIOCHEMICAL PHARMACOLOGY

Pregnane-x-receptor controls hepatic glucuronidation during pregnancy and neonatal development in humanized UGT1 mice

(2012) Shujuan Chen et al.   HEPATOLOGY

Nuclear Receptors as Modulators of the Tumor Microenvironment

(2011) M. H. Sherman et al.   Cancer Prevention Research

Profile of Serum Bile Acids in Noncholestatic Volunteers: Gender-Related Differences in Response to Fenofibrate

(2011) J Trottier et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Eponym

(2011) Andrew Fretzayas et al.   EUROPEAN JOURNAL OF PEDIATRICS

Deletions of the Androgen-MetabolizingUGT2BGenes Have an Effect on Circulating Steroid Levels and Biochemical Recurrence after Radical Prostatectomy in Localized Prostate Cancer

(2011) Geneviève Nadeau et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Differential Expression of the Androgen-Conjugating UGT2B15 and UGT2B17 Enzymes in Prostate Tumor Cells during Cancer Progression

(2011) Sophie Pâquet et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Transcriptional diversity at the UGT2B7 locus is dictated by extensive pre-mRNA splicing mechanisms that give rise to multiple mRNA splice variants

(2011) Vincent Ménard et al.   Pharmacogenetics and Genomics

Bilirubin Injury to Neurons and Glial Cells: New Players, Novel Targets, and Newer Insights

(2011) Dora Brites   SEMINARS IN PERINATOLOGY

Pilot study: fenofibrate for patients with primary biliary cirrhosis and an incomplete response to ursodeoxycholic acid

(2010) C. Levy et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Shared Regulation of UGT1A7 by Hepatocyte Nuclear Factor (HNF) 1  and HNF4 

(2010) U. Ehmer et al.   DRUG METABOLISM AND DISPOSITION

Pregnane X Receptor and Constitutive Androstane Receptor at the Crossroads of Drug Metabolism and Energy Metabolism

(2010) J. Gao et al.   DRUG METABOLISM AND DISPOSITION

Alternatively Spliced Products of the UGT1A Gene Interact with the Enzymatically Active Proteins to Inhibit Glucuronosyltransferase Activity In Vitro

(2010) J. Bellemare et al.   DRUG METABOLISM AND DISPOSITION

Pharmacotherapy of cholestatic liver diseases

(2010) Gustav PAUMGARTNER   Journal of Digestive Diseases

Regulation of the human bile acid UDP-glucuronosyltransferase 1A3 by the farnesoid X receptor and bile acids

(2010) Thomas J. Erichsen et al.   JOURNAL OF HEPATOLOGY

Extensive splicing of transcripts encoding the bile acid-conjugating enzyme UGT2B4 modulates glucuronidation

(2010) Eric Lévesque et al.   Pharmacogenetics and Genomics

Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor

(2010) P. A. Watson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Correlation between circulatory, local prostatic, and intra-prostatic androgen levels

(2010) Mats Olsson et al.   PROSTATE

Chronic bilirubin encephalopathy: diagnosis and outcome

(2010) Steven M. Shapiro   Seminars in Fetal & Neonatal Medicine

Induction of Mouse UDP-Glucuronosyltransferase mRNA Expression in Liver and Intestine by Activators of Aryl-Hydrocarbon Receptor, Constitutive Androstane Receptor, Pregnane X Receptor, Peroxisome Proliferator-Activated Receptor  , and Nuclear Factor Erythroid 2-Related Factor 2

(2009) D. B. Buckley et al.   DRUG METABOLISM AND DISPOSITION

Up-Regulation of UDP-Glucuronosyltransferase (UGT) 1A4 by 17 -Estradiol: A Potential Mechanism of Increased Lamotrigine Elimination in Pregnancy

(2009) H. Chen et al.   DRUG METABOLISM AND DISPOSITION

Regulation of endobiotics glucuronidation by ligand-activated transcription factors: physiological function and therapeutic potential

(2009) Mélanie Verreault et al.   DRUG METABOLISM REVIEWS

UGT genomic diversity: beyond gene duplication

(2009) Chantal Guillemette et al.   DRUG METABOLISM REVIEWS

Suppression of AhR signaling pathway is associated with the down-regulation of UDP-glucuronosyltransferases during BBN-induced urinary bladder carcinogenesis in mice

(2009) Katsuyuki Iida et al.   JOURNAL OF BIOCHEMISTRY

Modulation of the Human Glucuronosyltransferase UGT1A Pathway by Splice Isoform Polypeptides Is Mediated through Protein-Protein Interactions

(2009) Judith Bellemare et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid-activated transcription factors control bile acid glucuronidation

(2009) Olivier Barbier et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Estrogen Receptor  , Fos-Related Antigen-2, and c-Jun Coordinately Regulate Human UDP Glucuronosyltransferase 2B15 and 2B17 Expression in Response to 17 -Estradiol in MCF-7 Cells

(2009) D. G. Hu et al.   MOLECULAR PHARMACOLOGY

Alternative-splicing forms of the major phase II conjugating UGT1A gene negatively regulate glucuronidation in human carcinoma cell lines

(2009) J Bellemare et al.   PHARMACOGENOMICS JOURNAL

Introducing the “TCDD-Inducible AhR-Nrf2 Gene Battery”

(2009) Ronnie L. Yeager et al.   TOXICOLOGICAL SCIENCES

Bile acids: Chemistry, physiology, and pathophysiology

(2009) Maria J Monte et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Aryl hydrocarbon receptor-mediated regulation of the human estrogen and bile acid UDP-glucuronosyltransferase 1A3 gene

(2008) Tim O. Lankisch et al.   ARCHIVES OF TOXICOLOGY

Gilbert syndrome, UGT1A1*28 allele, and cardiovascular disease risk: Possible protective effects and therapeutic applications of bilirubin

(2008) Harvey A. Schwertner et al.   ATHEROSCLEROSIS

Activators of the farnesoid X receptor negatively regulate androgen glucuronidation in human prostate cancer LNCAP cells

(2008) Jenny Kaeding et al.   BIOCHEMICAL JOURNAL

Effect of Retinoids on UDP-Glucuronosyltransferase 2B7 mRNA Expression in Caco-2 Cells

(2008) Yuan Lu et al.   Drug Metabolism and Pharmacokinetics

Coordinated induction of drug transporters and phase I and II metabolism in human liver slices

(2008) P. Olinga et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

The efficacy of ursodeoxycholic acid and bezafibrate combination therapy for primary biliary cirrhosis: A prospective, multicenter study

(2008) Shinji Iwasaki et al.   HEPATOLOGY RESEARCH

Inactivation by UDP-glucuronosyltransferase enzymes: The end of androgen signaling

(2008) Sarah Chouinard et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Calcitrol (1 ,25-dihydroxyvitamin D3) inhibits androgen glucuronidation in prostate cancer cells

(2008) J. Kaeding et al.   MOLECULAR CANCER THERAPEUTICS

Androgen receptor mediates the expression of UDP-glucuronosyltransferase 2 B15 and B17 genes

(2008) Bo-Ying Bao et al.   PROSTATE

The Tangle of Nuclear Receptors that Controls Xenobiotic Metabolism and Transport: Crosstalk and Consequences

(2007) Jean-Marc Pascussi et al.   Annual Review of Pharmacology and Toxicology

Novel identification of UDP-glucuronosyltransferase 1A10 as an estrogen-regulated target gene

(2007) Athena Starlard-Davenport et al.   STEROIDS