The fourth mammalian molybdenum enzyme mARC: current state of research

Reduction ofNω-hydroxy-L-arginine by the mitochondrial amidoxime reducing component (mARC)

(2010) Jürke Kotthaus et al.   BIOCHEMICAL JOURNAL

Molybdenum enzymes in higher organisms

(2010) Russ Hille et al.   COORDINATION CHEMISTRY REVIEWS

Prodrug Design to Improve Pharmacokinetic and Drug Delivery Properties: Challenges to the Discovery Scientists

(2010) S. Jana et al.   CURRENT MEDICINAL CHEMISTRY

Effects of Ketoconazole on the In Vivo Biotransformation and Hepatobiliary Transport of the Thrombin Inhibitor AZD0837 in Pigs

(2010) E. M. Matsson et al.   DRUG METABOLISM AND DISPOSITION

Reduction of N-Hydroxy-sulfonamides, Including N-Hydroxy-valdecoxib, by the Molybdenum-Containing Enzyme mARC

(2010) A. Havemeyer et al.   DRUG METABOLISM AND DISPOSITION

Integrating proteomic and transcriptomic high-throughput surveys for search of new biomarkers of colon tumors

(2010) Michal Mikula et al.   FUNCTIONAL & INTEGRATIVE GENOMICS

Role for CysJ Flavin Reductase in Molybdenum Cofactor-Dependent Resistance of Escherichia coli to 6-N-Hydroxylaminopurine

(2010) S. G. Kozmin et al.   JOURNAL OF BACTERIOLOGY

Biochemical and Spectroscopic Characterization of the Human Mitochondrial Amidoxime Reducing Components hmARC-1 and hmARC-2 Suggests the Existence of a New Molybdenum Enzyme Family in Eukaryotes

(2010) Bettina Wahl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aldehyde Oxidase: An Enzyme of Emerging Importance in Drug Discovery

(2010) David C. Pryde et al.   JOURNAL OF MEDICINAL CHEMISTRY

Efficient Hypoxic Activation of the Anticancer Agent AQ4N by CYP2S1 and CYP2W1

(2010) C. R. Nishida et al.   MOLECULAR PHARMACOLOGY

Biological, clinical and population relevance of 95 loci for blood lipids

(2010) Tanya M. Teslovich et al.   NATURE

Diamidine Activity Against Trypanosomes: The State of the Art

(2010) M. Soeiro et al.   Current Molecular Pharmacology

New Treatment Option for Second-Stage African Sleeping Sickness: In Vitro and In Vivo Efficacy of Aza Analogs of DB289

(2009) T. Wenzler et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Genomewide Association Study of Movement-Related Adverse Antipsychotic Effects

(2009) Karolina Åberg et al.   BIOLOGICAL PSYCHIATRY

Molybdenum and tungsten enzymes: a crystallographic and mechanistic overview

(2009) Maria João Romão   DALTON TRANSACTIONS

Oral direct thrombin inhibitor AZD0837 for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation: a randomized dose-guiding, safety, and tolerability study of four doses of AZD0837 vs. vitamin K antagonists

(2009) G. Y.H. Lip et al.   EUROPEAN HEART JOURNAL

New direct thrombin inhibitors

(2009) Alessandro Squizzato et al.   Internal and Emergency Medicine

Genome-Wide Association for Methamphetamine Dependence

(2008) George R. Uhl et al.   ARCHIVES OF GENERAL PSYCHIATRY

Orally active factor Xa inhibitors: Investigation of a novel series of 3-amidinophenylsulfonamide derivatives using an amidoxime prodrug strategy

(2008) Masahiko Uchida et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and synthesis of amidoxime derivatives for orally potent C-alkylamidine-based antimalarial agents

(2008) Mahama Ouattara et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Oral Serine Protease Inhibitor WX-671 – First Experience in Patients with Advanced Head and Neck Carcinoma

(2008) Jens E. Meyer et al.   Breast Care

A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology

(2008) David J. Pagliarini et al.   CELL

Comparison of in Vitro Bioactivation of Flutamide and Its Cyano Analogue: Evidence for Reductive Activation by Human NADPH:Cytochrome P450 Reductase

(2008) Bo Wen et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Defining thein VivoRole for Cytochromeb5in Cytochrome P450 Function through the Conditional Hepatic Deletion of Microsomal Cytochromeb5

(2008) Robert D. Finn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding of Sulfurated Molybdenum Cofactor to the C-terminal Domain of ABA3 fromArabidopsis thalianaProvides Insight into the Mechanism of Molybdenum Cofactor Sulfuration

(2008) Silke Wollers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Fourth Molybdenum Containing Enzyme mARC: Cloning and Involvement in the Activation ofN-Hydroxylated Prodrugs

(2008) Sanja Gruenewald et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molybdoproteomes and Evolution of Molybdenum Utilization

(2008) Yan Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY

YcbX and yiiM, two novel determinants for resistance of Escherichia coli to N-hydroxylated base analogues

(2008) Stanislav G. Kozmin et al.   MOLECULAR MICROBIOLOGY

Prodrugs: design and clinical applications

(2008) Jarkko Rautio et al.   NATURE REVIEWS DRUG DISCOVERY