Article
Chemistry, Physical
Fangyu Jin, Shiqin Liao, Qingqing Wang, Huiying Shen, Chenyu Jiang, Jiawen Zhang, Qufu Wei, Reza A. Ghiladi
Summary: In this study, a scalable and facile method to immobilize long persistent phosphor and photosensitizer onto cotton fabric was reported. The resulting composite material exhibited superior antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureus under visible-light illumination. Mechanistic studies showed enhanced singlet oxygen production, resulting in effective pathogen inactivation. In addition, the composite fabric possessed excellent abrasion resistance, mechanical strength, and color fastness. These findings suggest the potential of using long persistent phosphors in composite fabrics for infection control applications.
APPLIED SURFACE SCIENCE
(2022)
Article
Chemistry, Applied
Loveleen Kaur Gulati, Gurleen Kaur Gulati, Satish Kumar
Summary: This article discusses the use of photochromism in photodynamic therapy, highlighting the potential of photochromic substances in three different roles to enhance efficacy: as photosensitizers, switches to conventional photosensitizers, and reserves of singlet oxygen.
Article
Chemistry, Multidisciplinary
Feng Xu, Haoying Ge, Ning Xu, Cheng Yang, Qichao Yao, Saran Long, Wen Sun, Jiangli Fan, Xinsheng Xu, Xiaojun Peng
Summary: In this study, a quartet photosensitizer Cy-DENT with high singlet oxygen quantum yield was reported, achieved through a radical enhanced inter-system crossing process. By introducing a TEMPO radical, over 20-fold enhancement of singlet oxygen quantum yield compared to Cy-DEN could be achieved under near infrared light irradiation. The electron-donating ability of the terminal substituent group can effectively control the production of singlet oxygen.
SCIENCE CHINA-CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Madhusudan Kamat, Kyle Moor, Gabrielle Langlois, Moshan Chen, Kimberly M. Parker, Kristopher McNeill, Samuel D. Snow
Summary: The low water solubility of fullerenes poses a challenge for their aqueous applications. The presence of iodide as a counterion in the synthesis practices complicates the photochemistry of cationic fullerene systems. Recent work reveals a potentiation effect when using photosensitizers to inactivate microorganisms with added potassium iodide, suggesting that iodide interferes with the photosensitization of singlet oxygen by cationic fulleropyrrolidinium ions and rose bengal.
Article
Chemistry, Applied
Ruth Prieto-Montero, Alejandro Prieto-Castaneda, Alberto Katsumiti, Rebeca Sola-Llano, Antonia R. Agarrabeitia, Miren P. Cajaraville, Maria J. Ortiz, Virginia Martinez-Martinez
Summary: Three different molecular designs based on BODIPY dye have been proposed as photosensitizers for photodynamic therapy, showing a good balance between singlet oxygen generation and fluorescence for potential applications. In vitro experiments in HeLa cells were conducted to elucidate the best potential candidate for PDT.
Article
Chemistry, Inorganic & Nuclear
Halise Yalazan, Ipek Omeroglu, Gonca celik, Halit Kantekin, Mahmut Durmus
Summary: This study examines the photophysical and photochemical properties of silicon and zinc phthalocyanines. Different phthalocyanine compounds were synthesized and characterized to study their concentration and solvent effects. The effects of the metal ion and the position of the substituted group on photodynamic therapy properties were also investigated. The results show that the fluorinated pyrazoline-linked axial silicon phthalocyanine (HY-SiPc) has the highest singlet oxygen production and can be a potential photosensitizer for PDT.
INORGANICA CHIMICA ACTA
(2023)
Article
Chemistry, Multidisciplinary
Xiaolong Hu, Shuna Wang, Qinghua Luo, Binghui Ge, Qin Cheng, Chen Dong, Jiahui Xu, Haizhen Ding, Mingsheng Xu, Antonio Claudio Tedesco, Xin Huang, Renquan Zhang, Hong Bi
Summary: A new core-shell structured Sn nanocluster@carbon dots photosensitizer with high O-1(2) quantum yield and fluorescence intensity is proposed. Upon light irradiation, this photosensitizer can effectively reduce cancer cell viability, with minimal impact on healthy cells and liver tissue.
CHINESE CHEMICAL LETTERS
(2021)
Article
Spectroscopy
Jin Bai, Lei Zhang, Ying Qian
Summary: In this study, a novel NIR and lysosomal targeting thiophene-BODIPY photosensitizer SBOP-Lyso was synthesized to explore its potential applications in photodynamic therapy. SBOP-Lyso demonstrated high singlet oxygen yield, good biocompatibility, and effective inhibition of A549 cells migration. The unique lysosome-targeted properties of SBOP-Lyso make it a promising candidate for cancer cell PDT.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Review
Chemistry, Physical
Daniel A. Heredia, Andres M. Durantini, Javier E. Durantini, Edgardo N. Durantini
Summary: Functionalized fullerenes have shown promising biomedical applications as phototherapeutic agents, with their structures modified to improve photodynamic activity, especially in antimicrobial applications. By adjusting the structure of fullerenes, their performance in photodynamic activities can be enhanced.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY C-PHOTOCHEMISTRY REVIEWS
(2022)
Article
Chemistry, Inorganic & Nuclear
Chaochao Fan, Yue Wang, Jie Zhao, Yanxia Zhao, Dong Yang, Boyang Li, Le Yu, Xiao-Juan Yang, Biao Wu
Summary: In this study, two photoactive ligands were designed and used to construct sulfate complexes. These complexes can undergo oxygenation reactions under light, storing singlet oxygen, and partially recover the original structures after heating.
INORGANIC CHEMISTRY
(2022)
Article
Physics, Multidisciplinary
Pietro Delcanale, Stefania Abbruzzetti, Cristiano Viappiani
Summary: The current viral pandemic has emphasized the urgent need for effective and versatile treatments. Photodynamic effect is a potential method that relies on excited states of organic molecules to generate reactive oxygen species, which can be used for antimicrobial and antiviral treatments. However, there are challenges in terms of nanoscale molecular engineering and design of photoactive nanostructures.
RIVISTA DEL NUOVO CIMENTO
(2022)
Article
Chemistry, Applied
Pinar Sen, Rodah Soy, Sithi Mgidlana, John Mack, Tebello Nyokong
Summary: The emergence of antimicrobial resistance has made the development of photodynamic therapy (PDT) related applications essential, since microorganisms cannot develop resistance to this method. This study focuses on the synthesis, characterization, and evaluation of the utility of palladium porphyrins and their chitosan inclusion complexes as photosensitizer dye in photodynamic antimicrobial therapy (PACT). The photophysical-chemical studies showed that the immobilization of the porphyrins into the chitosan influenced their properties. Furthermore, the PACT activity of cationic porphyrin and its chitosan immobilization form were found to be effective in decreasing the number of viable cells up to 100% in vitro.
Article
Chemistry, Applied
Bingjie Hou, Wenyuan Zhang, Cuili Li, Xueqin Sun, Xiaoxia Feng, Jiacheng Liu
Summary: This study reports the synthesis and evaluation of four cationic porphyrins as potential photodynamic therapeutic agents. The results show that ZnP2 exhibits high phototoxicity towards cancer cells and low toxicity towards normal cells, making it a promising candidate for photodynamic therapy.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Alexander M. Firsov, Juergen Pfeffermann, Anton S. Benditkis, Tatyana I. Rokitskaya, Anton S. Kozlov, Elena A. Kotova, Alexander A. Krasnovsky, Peter Pohl, Yuri N. Antonenko
Summary: The goal of developing chemical compounds that can mimic the functions of biological molecular machineries has resulted in the creation of various artificial molecular motors (AMMs). These photoexcited monomolecular unidirectionally-rotating AMMs have been seen as potentially useful in pharmaceutical applications due to their ability to permeabilize biological membranes. However, the mechanical properties of lipid membranes cast doubt on the proposed drilling activity of AMMs. In this study, it was discovered that singlet oxygen released by a photoexcited molecular drill could oxidize unsaturated lipids in giant unilamellar vesicles, while liposomes made of saturated lipids remained unaffected. Further experiments showed that rather than mechanically destroying ion channels in lipid membranes, the AMMs photoinactivated them. This study suggests that the envisioned therapeutic and pharmaceutical applications of AMMs rely more on their photodynamic activity than their nanomechanical drilling abilities.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2023)
Review
Chemistry, Inorganic & Nuclear
E. Pang, Shaojing Zhao, Benhua Wang, Guangle Niu, Xiangzhi Song, Minhuan Lan
Summary: This article systematically summarizes various strategies to improve the generation efficiency of singlet oxygen (O-1(2)) in photosensitizers (PS) and discusses their advantages, disadvantages, and challenges.
COORDINATION CHEMISTRY REVIEWS
(2022)