Journal
DRUG DISCOVERY TODAY
Volume 18, Issue 15-16, Pages 748-755Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2013.04.005
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Funding
- Ministry of Human Resource Development, Government of India
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Insulin has an important role in the maintenance of blood sugar. It is the only available therapeutic agent for the treatment of type 1 diabetes mellitus and there is a dire need for an oral substitute. Different categories of compounds including mono and di substituted benzoquinones, vanadium based compounds and natural products have been reported to cause insulin-like effects either by increasing phosphorylation of insulin receptor (IR) or inhibiting the protein tyrosine phosphatases. This review summarizes the development of various insulin mimetics with special emphasis on their structure-activity relationships and various biological actions they produce.
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